Recurrent urinary tract infections

0000010

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
46809	413385

Phenotype Definition

Repeated infections of the urinary tract. [HPO:probinson]

Phenotype Comment

The urinary tract comprises the kidneys, ureters, a bladder, and a urethra.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr2:44066247	Affx-20090007	ABCG8	G>C	7978	55315	468.1	8.453e-104	1.309
chr2:44065090	Affx-20089987	ABCG5	G>A	7633	53459	411.8	1.485e-91	1.294
chr2:44073656	rs41360247	ABCG8	T>C	7711	54250	400.1	5.31e-89	1.287
chr15:48426484	rs1426654	SLC24A5	A>G	2170	25356	153.4	3.146e-35	0.7563
chr15:48392165	rs1834640	-	A>G	2585	29039	133.7	6.38e-31	0.7866
chr2:44073881	rs6544713	ABCG8	C>T	29465	277778	128.3	9.606e-30	0.9203
chr2:44074431	rs4245791	ABCG8	T>C	29708	279779	125.9	3.164e-29	0.9212
chr1:159174683	rs2814778	ACKR1	T>C	1508	17869	117.0	2.912e-27	0.7473
chr8:145639681	rs1871534	SLC39A4	G>C	1416	16729	107.7	3.1e-25	0.7495
chr19:42393286	rs717225	ARHGEF1	A>G	1763	20180	105.7	8.377e-25	0.7733
chr19:42392441	rs16975619	ARHGEF1	T>C	1595	18415	102.0	5.459e-24	0.7671
chr15:45491394	rs1648299	SHF	T>C	1343	15816	99.38	2.088e-23	0.7525
chr23:128718936	rs2362937	OCRL	T>C	1672	18279	98.7	2.943e-23	0.7742
chr19:42391425	rs28521795	ARHGEF1	G>A	1498	17324	96.94	7.162e-23	0.7661
chr17:58508582	rs8071181	C17orf64	G>A	1194	14223	95.83	1.255e-22	0.744
chr1:173579034	rs12065033	AL139142.2	C>T	1190	14151	94.22	2.817e-22	0.7454
chr11:61095368	rs7397033	DDB1	T>C	1158	13768	91.51	1.109e-21	0.7457
chr9:140957557	rs11137360	CACNA1B	A>G	1710	19296	90.88	1.528e-21	0.785
chr2:135911422	Affx-17900027	RAB3GAP1	T>C	23084	217522	89.54	2.998e-21	0.9278
chr2:136407479	rs1446585	R3HDM1	A>G	25657	240741	89.32	3.35e-21	0.9303
chr2:44066247	Affx-20090007	ABCG8	G>C	7704	52898	459.1	7.731e-102	1.312
chr2:44065090	Affx-20089987	ABCG5	G>A	7341	50767	411.9	1.386e-91	1.301
chr2:44073656	rs41360247	ABCG8	T>C	7360	50930	409.9	3.878e-91	1.3
chr2:44074431	rs4245791	ABCG8	T>C	28696	269645	148.7	3.41e-34	0.913
chr2:44073881	rs6544713	ABCG8	C>T	28415	267029	146.2	1.181e-33	0.9134
chr2:44081042	rs4077440	ABCG8	C>T	39493	362626	95.2	1.725e-22	0.9341
chr4:151199080	rs2290846	LRBA	G>A	27881	235981	63.08	1.981e-15	1.062
chr2:44043135	rs10208987	ABCG5	T>G	7801	62992	60.32	8.048e-15	1.102
chr4:151206319	rs6817154	LRBA	T>C	30640	260418	59.55	1.192e-14	1.058
chr4:151207127	rs3749574	LRBA	C>T	30641	260453	58.83	1.716e-14	1.058
chr8:59388565	rs2081687	-	C>T	32271	275686	48.82	2.808e-12	1.052
chr2:44788309	rs72790077	CAMKMT	C>G	1948	14636	46.49	9.21e-12	1.181
chr4:151172930	rs59435073	DCLK2	G>A	28538	243188	45.78	1.32e-11	1.052
chr4:151148930	rs28405622	DCLK2	C>T	29356	250479	44.29	2.833e-11	1.051
chr4:151242312	rs11737450	LRBA	C>T	24566	208754	43.23	4.862e-11	1.053
chr2:43980631	rs17336182	PLEKHH2	T>C	7202	59023	38.52	5.423e-10	1.084
chr2:136594158	rs2236783	LCT	A>G	18999	174669	35.34	2.764e-09	0.9504
chr1:78623626	rs17391694	-	C>T	13402	112535	35.19	2.986e-09	1.06
chr2:136643555	rs309125	-	C>T	19763	181531	34.97	3.349e-09	0.9513
chr2:136407479	rs1446585	R3HDM1	A>G	21908	200552	33.69	6.454e-09	0.9539

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr2:44066247	Affx-20090007	ABCG8	G>C	7978	20501	361.2	1.555e-80	1.297
chr2:44065090	Affx-20089987	ABCG5	G>A	7633	19832	314.7	2.025e-70	1.281
chr2:44073656	rs41360247	ABCG8	T>C	7711	20173	299.2	4.856e-67	1.271
chr1:159174683	rs2814778	ACKR1	T>C	1508	7814	278.3	1.764e-62	0.6256
chr15:48426484	rs1426654	SLC24A5	A>G	2170	10392	272.2	3.719e-61	0.6759
chr8:145639681	rs1871534	SLC39A4	G>C	1416	7268	250.4	2.138e-56	0.6317
chr15:48392165	rs1834640	-	A>G	2585	11807	247.0	1.171e-55	0.7085
chr19:42393286	rs717225	ARHGEF1	A>G	1763	8575	239.4	5.383e-54	0.6664
chr23:128718936	rs2362937	OCRL	T>C	1672	7608	233.2	1.191e-52	0.6607
chr19:42392441	rs16975619	ARHGEF1	T>C	1595	7813	224.0	1.199e-50	0.6623
chr17:58508582	rs8071181	C17orf64	G>A	1194	6178	218.2	2.264e-49	0.6275
chr23:64367019	rs7064929	-	G>A	1532	7002	217.8	2.68e-49	0.6585
chr5:33951693	rs16891982	SLC45A2	G>C	6089	24386	216.2	6.058e-49	0.8046
chr19:42391425	rs28521795	ARHGEF1	G>A	1498	7360	213.3	2.626e-48	0.6606
chr23:71628912	rs3012642	AL133500.1	A>G	1965	8535	212.8	3.357e-48	0.6921
chr1:173579034	rs12065033	AL139142.2	C>T	1190	6128	212.5	3.952e-48	0.6307
chr11:61095368	rs7397033	DDB1	T>C	1158	6000	212.4	4.021e-48	0.627
chr23:106146349	rs5962774	MORC4	T>C	895	4572	210.0	1.369e-47	0.5903
chr15:45491394	rs1648299	SHF	T>C	1343	6718	208.9	2.403e-47	0.6492
chr9:117110112	Affx-52344420	AKNA	T>TG	1132	5861	207.5	4.755e-47	0.6272
chr2:44066247	Affx-20090007	ABCG8	G>C	7704	19486	346.5	2.4e-77	1.297
chr2:44073656	rs41360247	ABCG8	T>C	7360	18751	310.0	2.21e-69	1.285
chr2:44065090	Affx-20089987	ABCG5	G>A	7341	18710	309.1	3.409e-69	1.285
chr2:44074431	rs4245791	ABCG8	T>C	28696	98727	147.2	6.943e-34	0.9066
chr2:44073881	rs6544713	ABCG8	C>T	28415	97757	143.8	4.023e-33	0.9074
chr2:44081042	rs4077440	ABCG8	C>T	39493	132294	85.86	1.93e-20	0.9322
chr2:44043135	rs10208987	ABCG5	T>G	7801	22993	48.85	2.76e-12	1.1
chr4:151199080	rs2290846	LRBA	G>A	27881	86439	41.18	1.389e-10	1.054
chr14:94838142	rs112635299	-	G>T	2144	5941	36.19	1.789e-09	1.165
chr4:151206319	rs6817154	LRBA	T>C	30640	95498	35.98	1.997e-09	1.049
chr4:151207127	rs3749574	LRBA	C>T	30641	95484	35.46	2.599e-09	1.049
chr4:151172930	rs59435073	DCLK2	G>A	28538	88878	32.71	1.071e-08	1.048
chr14:94844947	rs28929474	SERPINA1	C>T	2069	5778	31.45	2.049e-08	1.156
chr2:44788309	rs72790077	CAMKMT	C>G	1948	5427	30.95	2.649e-08	1.16
chr2:43980631	rs17336182	PLEKHH2	T>C	7202	21563	30.18	3.942e-08	1.081
chr8:59388565	rs2081687	-	C>T	32271	100980	29.66	5.157e-08	1.044
chr4:151148930	rs28405622	DCLK2	C>T	29356	91646	29.51	5.574e-08	1.045
chr10:45992470	rs12249012	MARCHF8	G>A	23058	71641	28.86	7.795e-08	1.048
chr10:46013277	rs970548	MARCHF8	A>C	23737	73867	26.95	2.089e-07	1.046
chr2:44099433	Affx-20090607	ABCG8	C>A	17742	54833	26.94	2.097e-07	1.051

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: A09	Diarrhoea and gastro-enteritis of presumed infectious origin	6/20
ICD: K801	Calculus of gallbladder with other cholecystitis	11/20
ICD: K802	Calculus of gallbladder without cholecystitis	14/20
ICD: K804	Calculus of bile duct with cholecystitis	3/20
ICD: K805	Calculus of bile duct without cholangitis or cholecystitis	11/20
ICD: N390	Urinary tract infection, site not specified	1/20
ICD: O234	Unspecified infection of urinary tract in pregnancy	2/20

ID	Name	Top Correlation
ICD-10: B373	Candidiasis of vulva and vagina	0/20
ICD-10: L032	Cellulitis of face	0/20
ICD-10: M238	Other internal derangements of knee	0/20
ICD-10: M239	Internal derangement of knee, unspecified	0/20
ICD-10: N028	Other	0/20
ICD-10: N138	Other obstructive and reflux uropathy	0/20
ICD-10: N139	Obstructive and reflux uropathy, unspecified	0/20
ICD-10: N300	Acute cystitis	0/20
ICD-10: N302	Other chronic cystitis	0/20
ICD-10: N308	Other cystitis	0/20
ICD-10: N309	Cystitis, unspecified	0/20
ICD-10: N321	Vesicointestinal fistula	0/20
ICD-10: N368	Other specified disorders of urethra	0/20
ICD-10: N399	Disorder of urinary system, unspecified	0/20
ICD-10: Y846	Urinary catheterisation	0/20

Recurrent urinary tract infections

0000010

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Phenotype Comment

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ