Statistics
| Case | Control |
|---|---|
| 25574 | 434620 |
Phenotype Definition
Loss of the ability to control the urinary bladder leading to involuntary urination. [HPO:sdoelken, PMID:12559262]
Phenotype Comment
Urinary incontinence can be defined as the complaint of any involuntary leakage of urine.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 3002 | 64056 | 140.1 | 2.542e-32 | 0.7968 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 1072 | 26454 | 137.4 | 9.624e-32 | 0.6928 |
| chr23:71628912 | rs3012642 | AL133500.1 | A>G | 927 | 21797 | 131.5 | 1.897e-30 | 0.6795 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 2534 | 54458 | 124.6 | 6.218e-29 | 0.793 |
| chr15:48392165 | rs1834640 | - | A>G | 1298 | 30326 | 119.2 | 9.387e-28 | 0.7319 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 824 | 19127 | 108.4 | 2.165e-25 | 0.6894 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 845 | 20525 | 98.31 | 3.572e-23 | 0.7053 |
| chr1:29783282 | rs6676357 | - | T>C | 332 | 9722 | 92.95 | 5.361e-22 | 0.5866 |
| chr5:147671850 | rs7724380 | - | G>A | 801 | 19382 | 90.82 | 1.573e-21 | 0.7085 |
| chr6:170242949 | rs9396958 | - | T>C | 610 | 15504 | 90.47 | 1.879e-21 | 0.6754 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 888 | 21055 | 88.97 | 4.012e-21 | 0.7229 |
| chr2:136407479 | rs1446585 | R3HDM1 | A>G | 13645 | 252753 | 88.85 | 4.264e-21 | 0.9084 |
| chr5:54280007 | rs1508890 | ESM1 | C>A | 721 | 17695 | 88.4 | 5.355e-21 | 0.6992 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 644 | 16096 | 87.47 | 8.549e-21 | 0.6866 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 4331 | 85777 | 86.77 | 1.221e-20 | 0.8596 |
| chr9:127267689 | rs3814134 | NR5A1 | A>G | 1246 | 27960 | 85.51 | 2.309e-20 | 0.7633 |
| chr14:33956209 | rs1012023 | NPAS3 | C>A | 1437 | 31623 | 84.74 | 3.405e-20 | 0.7779 |
| chr3:69230061 | rs9831516 | FRMD4B | A>G | 717 | 17438 | 83.5 | 6.367e-20 | 0.7055 |
| chr23:71819691 | rs7054230 | PHKA1 | A>G | 647 | 14956 | 82.58 | 1.014e-19 | 0.6937 |
| chr13:72463541 | rs1460465 | - | A>G | 624 | 15500 | 81.96 | 1.388e-19 | 0.6909 |
| chr22:19773308 | rs5993830 | GNB1L | T>C | 16808 | 295120 | 25.9 | 3.605e-07 | 0.9519 |
| chr17:7221385 | Affx-14329587 | AC026954.2 | A>G | 20327 | 355007 | 25.56 | 4.285e-07 | 0.954 |
| chr5:96797190 | rs10866781 | - | A>G | 25159 | 417574 | 25.22 | 5.105e-07 | 1.047 |
| chr6:168393886 | rs2130613 | - | T>C | 5205 | 94460 | 24.32 | 8.17e-07 | 0.9286 |
| chr20:38903864 | rs6029006 | - | C>T | 23197 | 384706 | 23.8 | 1.071e-06 | 1.046 |
| chr16:26717490 | rs77682898 | - | G>A | 820 | 11702 | 23.74 | 1.104e-06 | 1.194 |
| chr5:96823754 | rs1385583 | - | C>T | 18385 | 321823 | 23.55 | 1.219e-06 | 0.955 |
| chr2:136407479 | rs1446585 | R3HDM1 | A>G | 11902 | 210558 | 23.21 | 1.455e-06 | 0.9495 |
| chr17:7217463 | Affx-14329092 | GPS2 | C>T | 23012 | 400273 | 23.1 | 1.535e-06 | 0.9569 |
| chr4:117271792 | rs77100234 | - | T>G | 5520 | 99711 | 22.26 | 2.386e-06 | 0.9332 |
| chr15:63036226 | rs9806617 | TLN2 | C>G | 14509 | 254995 | 21.98 | 2.755e-06 | 0.9538 |
| chr10:6632391 | rs2435588 | - | A>G | 7046 | 126205 | 21.5 | 3.529e-06 | 0.9407 |
| chr20:51579018 | rs73134628 | - | T>C | 1276 | 24703 | 21.28 | 3.966e-06 | 0.8746 |
| chr22:19737621 | rs5993820 | - | C>T | 17046 | 280821 | 21.24 | 4.06e-06 | 1.046 |
| chr16:82686392 | rs8056787 | CDH13 | A>C | 23890 | 396437 | 21.12 | 4.32e-06 | 1.043 |
| chr23:83778956 | rs73241192 | - | A>C | 13099 | 200980 | 21.07 | 4.426e-06 | 1.051 |
| chr18:77682662 | rs56390815 | SLC66A2 | T>C | 10265 | 181396 | 20.96 | 4.682e-06 | 0.9491 |
| chr2:136643555 | rs309125 | - | C>T | 10779 | 190515 | 20.61 | 5.642e-06 | 0.9507 |
| chr20:10337546 | rs6104583 | - | A>G | 16179 | 283286 | 20.46 | 6.079e-06 | 0.9567 |
| chr1:201764737 | rs651103 | NAV1 | C>A | 16353 | 286298 | 20.24 | 6.821e-06 | 0.957 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 3337 | 10122 | 58.67 | 1.863e-14 | 0.8537 |
| chr2:44065090 | Affx-20089987 | ABCG5 | G>A | 3189 | 9649 | 54.2 | 1.81e-13 | 0.8561 |
| chr2:44073656 | rs41360247 | ABCG8 | T>C | 3206 | 9642 | 50.07 | 1.482e-12 | 0.8615 |
| chr15:63036226 | rs9806617 | TLN2 | C>G | 14509 | 39626 | 26.76 | 2.3e-07 | 0.9423 |
| chr10:82738983 | rs74783684 | - | C>T | 3928 | 9402 | 23.8 | 1.068e-06 | 1.101 |
| chr25:155183483 | rs73237015 | - | G>A | 9722 | 24146 | 23.63 | 1.166e-06 | 1.067 |
| chr16:82686392 | rs8056787 | CDH13 | A>C | 23890 | 60769 | 23.28 | 1.398e-06 | 1.052 |
| chr14:24302924 | rs76616116 | - | C>T | 634 | 1324 | 22.18 | 2.483e-06 | 1.256 |
| chr10:6632391 | rs2435588 | - | A>G | 7046 | 19573 | 21.51 | 3.512e-06 | 0.9329 |
| chr9:1082727 | rs10156621 | - | C>G | 16138 | 43735 | 20.93 | 4.753e-06 | 0.9502 |
| chr13:102592550 | rs16959479 | FGF14 | A>G | 5312 | 14889 | 20.93 | 4.764e-06 | 0.9256 |
| chr19:49228272 | rs2287921 | RASIP1 | C>T | 23900 | 60998 | 20.34 | 6.487e-06 | 1.048 |
| chr25:155104608 | rs5940618 | - | G>A | 10070 | 27600 | 20.33 | 6.517e-06 | 0.9429 |
| chr1:38550105 | rs571881 | - | A>G | 8463 | 23324 | 20.11 | 7.294e-06 | 0.9395 |
| chr8:81452090 | rs112679333 | - | G>C | 1040 | 2308 | 19.91 | 8.126e-06 | 1.183 |
| chr4:181032462 | rs13142052 | - | C>T | 1617 | 3713 | 19.87 | 8.294e-06 | 1.144 |
| chr1:25903525 | rs114706847 | - | C>T | 1424 | 4262 | 19.82 | 8.491e-06 | 0.8709 |
| chr15:63043547 | rs8031916 | TLN2 | C>T | 14568 | 39526 | 19.72 | 8.968e-06 | 0.9502 |
| chr1:14151718 | rs72637672 | - | T>C | 2642 | 6257 | 19.6 | 9.568e-06 | 1.111 |
| chr19:49232226 | rs2287922 | RASIP1 | A>G | 23893 | 60988 | 19.09 | 1.244e-05 | 1.047 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: N393 | Stress incontinence | 9/20 |
| ICD: N811 | Cystocele | 8/20 |
| ICD: R33 | Retention of urine | 9/20 |