Statistics
| Female Case | Female Control | % Female |
|---|---|---|
| 4683 | 245174 | 49% |
| Male Case | Male Control | % Male |
|---|---|---|
| 4809 | 205528 | 51% |
Phenotype Definition
A structural anomaly of the glomerulus. [Eurenomics:ewuehl]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 417 | 30423 | 44.52 | 2.512e-11 | 0.7155 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 506 | 35701 | 43.59 | 4.05e-11 | 0.739 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 726 | 47953 | 37.86 | 7.616e-10 | 0.7877 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 293 | 21781 | 34.48 | 4.309e-09 | 0.7055 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 294 | 21698 | 33.15 | 8.521e-09 | 0.7106 |
| chr6:475489 | rs12210050 | - | C>T | 2100 | 100284 | 29.11 | 6.831e-08 | 1.144 |
| chr1:1220954 | rs12751100 | SCNN1D | G>A | 428 | 29078 | 27.09 | 1.947e-07 | 0.7722 |
| chr7:113116165 | rs12537382 | - | T>C | 139 | 11342 | 26.44 | 2.714e-07 | 0.645 |
| chr1:65112588 | rs12061466 | CACHD1 | G>A | 650 | 41917 | 26.15 | 3.165e-07 | 0.8115 |
| chr7:113102172 | rs12705876 | - | T>C | 145 | 11715 | 26.15 | 3.162e-07 | 0.6523 |
| chr11:25137683 | rs11028435 | - | A>G | 3965 | 223357 | 25.31 | 4.872e-07 | 0.9006 |
| chr3:123419733 | rs3732486 | MYLK | A>G | 199 | 15003 | 25.2 | 5.157e-07 | 0.6977 |
| chr5:33951826 | rs35398 | SLC45A2 | G>T | 115 | 9720 | 25.01 | 5.708e-07 | 0.6265 |
| chr11:113111861 | rs45542138 | NCAM1 | T>C | 505 | 21549 | 24.64 | 6.902e-07 | 1.257 |
| chr1:29783282 | rs6676357 | - | T>C | 58 | 5767 | 23.62 | 1.171e-06 | 0.5311 |
| chr23:140967165 | rs11095909 | MAGEC3 | T>C | 869 | 54009 | 23.61 | 1.177e-06 | 0.8404 |
| chr15:47578804 | rs72623944 | SEMA6D | A>G | 173 | 13232 | 23.6 | 1.186e-06 | 0.6887 |
| chr7:113052230 | rs28397921 | - | C>T | 215 | 15800 | 23.36 | 1.345e-06 | 0.716 |
| chr11:92306609 | rs642303 | FAT3 | A>G | 1125 | 68392 | 23.25 | 1.425e-06 | 0.8573 |
| chr4:106389388 | rs72668268 | PPA2 | G>A | 485 | 20785 | 22.9 | 1.71e-06 | 1.252 |
| chr6:475489 | rs12210050 | - | C>T | 2071 | 99062 | 21.07 | 4.419e-06 | 1.122 |
| chr2:230020507 | rs17614185 | PID1 | A>G | 878 | 39547 | 21.02 | 4.543e-06 | 1.178 |
| chr8:107579569 | rs7826722 | OXR1 | C>T | 169 | 6211 | 20.97 | 4.654e-06 | 1.431 |
| chr4:18147151 | rs11934728 | - | T>C | 562 | 35450 | 20.88 | 4.896e-06 | 0.8187 |
| chr9:12833755 | rs35509513 | - | A>C | 696 | 30804 | 20.64 | 5.545e-06 | 1.198 |
| chr4:171807535 | rs7673440 | - | A>C | 1584 | 74334 | 20.63 | 5.581e-06 | 1.136 |
| chr4:106389388 | rs72668268 | PPA2 | G>A | 480 | 20541 | 20.08 | 7.413e-06 | 1.236 |
| chr11:113111861 | rs45542138 | NCAM1 | T>C | 494 | 21187 | 20.07 | 7.48e-06 | 1.233 |
| chr4:39084173 | rs12503506 | KLHL5 | G>C | 4555 | 227187 | 19.62 | 9.435e-06 | 1.097 |
| chr12:15972355 | rs17416335 | EPS8 | T>C | 1155 | 53456 | 19.41 | 1.054e-05 | 1.15 |
| chr13:64595940 | rs9598706 | - | G>A | 1670 | 79223 | 19.27 | 1.134e-05 | 1.127 |
| chr7:1480280 | rs58636013 | MICALL2 | C>T | 658 | 29143 | 19.14 | 1.212e-05 | 1.196 |
| chr1:19133990 | rs6603912 | - | A>G | 2823 | 158312 | 18.93 | 1.353e-05 | 0.9058 |
| chr11:121964569 | rs664409 | - | G>A | 3586 | 177013 | 18.82 | 1.436e-05 | 1.098 |
| chr12:104145103 | rs117269760 | STAB2 | C>T | 354 | 14740 | 18.76 | 1.484e-05 | 1.267 |
| chr4:39055644 | rs12648581 | KLHL5 | G>A | 4693 | 234351 | 18.59 | 1.62e-05 | 1.094 |
| chr19:24149545 | rs2195987 | - | T>C | 2357 | 114137 | 18.36 | 1.825e-05 | 1.109 |
| chr5:142535913 | rs6887887 | ARHGAP26 | G>A | 1292 | 60390 | 18.33 | 1.855e-05 | 1.138 |
| chr1:73962827 | rs17511652 | - | C>G | 831 | 37683 | 18.32 | 1.863e-05 | 1.17 |
| chr16:55507127 | rs62026818 | MMP2 | T>C | 2501 | 121451 | 18.26 | 1.927e-05 | 1.106 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:149470256 | rs62425913 | - | A>G | 2055 | 79962 | 25.86 | 3.672e-07 | 1.136 |
| chr6:149453174 | rs4385337 | - | G>A | 3922 | 158530 | 25.6 | 4.206e-07 | 1.111 |
| chr6:149437341 | rs4897083 | - | C>T | 4003 | 162133 | 24.0 | 9.631e-07 | 1.106 |
| chr2:8099955 | rs2111073 | - | T>C | 3493 | 140359 | 23.67 | 1.142e-06 | 1.108 |
| chr24:14902414 | rs20321 | USP9Y | G>A | 277 | 8981 | 23.08 | 1.557e-06 | 1.35 |
| chr19:2866830 | Affx-15747942 | - | CA>C | 1012 | 37709 | 22.99 | 1.625e-06 | 1.174 |
| chr8:102280484 | rs62518041 | - | G>T | 302 | 9891 | 22.92 | 1.692e-06 | 1.327 |
| chr12:53044267 | rs638043 | KRT2 | C>T | 1618 | 62522 | 22.44 | 2.163e-06 | 1.139 |
| chr9:26222710 | rs4977696 | - | G>A | 2208 | 103983 | 22.01 | 2.719e-06 | 0.8922 |
| chr8:54802780 | rs72655192 | RGS20 | C>T | 277 | 9033 | 21.57 | 3.41e-06 | 1.331 |
| chr7:80829539 | rs61247183 | - | C>T | 150 | 9410 | 21.46 | 3.615e-06 | 0.6826 |
| chr2:240299176 | rs11124195 | HDAC4 | G>C | 3650 | 147678 | 21.42 | 3.692e-06 | 1.102 |
| chr15:27564975 | rs12914579 | GABRG3 | A>G | 1285 | 62463 | 21.39 | 3.745e-06 | 0.8699 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 188 | 11294 | 21.07 | 4.419e-06 | 0.7124 |
| chr9:10695314 | rs13297271 | - | C>A | 574 | 20486 | 20.99 | 4.617e-06 | 1.221 |
| chr5:55978422 | rs78615316 | - | T>C | 393 | 13476 | 20.77 | 5.169e-06 | 1.268 |
| chr3:13622987 | rs7615835 | FBLN2 | A>G | 4356 | 177773 | 20.71 | 5.34e-06 | 1.097 |
| chr20:60883191 | rs45576934 | ADRM1 | C>T | 195 | 6070 | 20.44 | 6.161e-06 | 1.392 |
| chr19:53408165 | rs7258315 | ZNF888 | G>C | 2108 | 99123 | 20.26 | 6.76e-06 | 0.8946 |
| chr12:3417813 | rs729914 | - | G>T | 100 | 6722 | 20.06 | 7.486e-06 | 0.6378 |
| chr6:149437341 | rs4897083 | - | C>T | 3789 | 151484 | 26.02 | 3.374e-07 | 1.114 |
| chr2:8099955 | rs2111073 | - | T>C | 3331 | 132362 | 24.55 | 7.237e-07 | 1.114 |
| chr6:149453174 | rs4385337 | - | G>A | 3737 | 150010 | 24.04 | 9.428e-07 | 1.11 |
| chr6:149470256 | rs62425913 | - | A>G | 1964 | 76268 | 21.71 | 3.176e-06 | 1.127 |
| chr24:14902414 | rs20321 | USP9Y | G>A | 273 | 8881 | 20.91 | 4.807e-06 | 1.334 |
| chr11:134177205 | rs12272129 | GLB1L3 | G>T | 2155 | 84304 | 20.41 | 6.265e-06 | 1.118 |
| chr20:60883191 | rs45576934 | ADRM1 | C>T | 192 | 5929 | 20.07 | 7.45e-06 | 1.391 |
| chr9:26222710 | rs4977696 | - | G>A | 1969 | 92037 | 19.81 | 8.539e-06 | 0.8925 |
| chr2:216913164 | rs72952617 | PECR | G>A | 348 | 11722 | 19.74 | 8.875e-06 | 1.278 |
| chr8:54802780 | rs72655192 | RGS20 | C>T | 273 | 8920 | 19.72 | 8.964e-06 | 1.318 |
| chr5:55978422 | rs78615316 | - | T>C | 383 | 13066 | 19.64 | 9.339e-06 | 1.264 |
| chr11:21082995 | rs1516755 | NELL1 | A>G | 2301 | 90546 | 19.61 | 9.493e-06 | 1.113 |
| chr19:2866830 | Affx-15747942 | - | CA>C | 991 | 36993 | 19.56 | 9.733e-06 | 1.162 |
| chr8:102280484 | rs62518041 | - | G>T | 291 | 9616 | 19.38 | 1.072e-05 | 1.304 |
| chr12:53044267 | rs638043 | KRT2 | C>T | 1562 | 60233 | 19.36 | 1.081e-05 | 1.131 |
| chr2:100835734 | rs10865035 | - | G>A | 4754 | 193977 | 18.89 | 1.383e-05 | 1.094 |
| chr19:46795067 | rs11671319 | - | T>C | 1098 | 53058 | 18.72 | 1.514e-05 | 0.8693 |
| chr3:13622987 | rs7615835 | FBLN2 | A>G | 4248 | 172466 | 18.27 | 1.917e-05 | 1.093 |
| chr1:226113729 | rs115099524 | - | A>G | 166 | 5093 | 18.13 | 2.058e-05 | 1.401 |
| chr3:141891385 | rs73236075 | GK5 | C>A | 1005 | 48709 | 18.12 | 2.077e-05 | 0.8665 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: C440 | Skin of lip | 5/20 |
| ICD: H530 | Amblyopia ex anopsia | 5/20 |
| ICD: R296 | Tendency to fall, not elsewhere classified | 8/20 |
| ICD: W199 | Unspecified place | 4/20 |