Statistics
| Case | Control |
|---|---|
| 11249 | 448945 |
Phenotype Definition
Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 5298 | 184965 | 119.8 | 6.96e-28 | 1.189 |
| chr6:32582650 | rs3104413 | - | C>G | 4921 | 174148 | 88.02 | 6.489e-21 | 1.165 |
| chr6:32583357 | rs6931277 | - | A>T | 4855 | 171837 | 87.54 | 8.263e-21 | 1.165 |
| chr6:32577973 | rs532965 | - | T>G | 4958 | 175579 | 87.18 | 9.919e-21 | 1.163 |
| chr6:32577380 | rs660895 | - | A>G | 5535 | 198112 | 82.93 | 8.499e-20 | 1.152 |
| chr6:32581973 | rs521539 | - | G>A | 5530 | 198267 | 80.75 | 2.567e-19 | 1.15 |
| chr6:32667850 | rs9275356 | - | C>G | 2772 | 95564 | 66.14 | 4.202e-16 | 1.181 |
| chr6:32654714 | rs9275184 | - | T>C | 2738 | 94518 | 65.94 | 4.65e-16 | 1.182 |
| chr6:32303848 | rs28361060 | TSBP1 | G>A | 5729 | 208131 | 65.65 | 5.372e-16 | 1.132 |
| chr6:32667343 | rs9275338 | - | A>T | 3381 | 118467 | 65.57 | 5.61e-16 | 1.165 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 3321 | 116202 | 65.06 | 7.265e-16 | 1.165 |
| chr6:32681483 | rs7454108 | - | T>C | 2768 | 95493 | 64.9 | 7.898e-16 | 1.179 |
| chr9:6197377 | rs10975479 | - | A>G | 4315 | 153987 | 64.57 | 9.295e-16 | 1.147 |
| chr9:6193455 | rs2381416 | - | A>C | 6954 | 255724 | 64.32 | 1.059e-15 | 1.123 |
| chr6:32681530 | rs3957146 | - | T>C | 2765 | 95485 | 64.07 | 1.201e-15 | 1.178 |
| chr6:32257284 | rs9268145 | TSBP1 | T>G | 5716 | 207912 | 63.26 | 1.808e-15 | 1.13 |
| chr6:32333341 | rs9268362 | TSBP1 | A>G | 5735 | 208676 | 63.17 | 1.897e-15 | 1.13 |
| chr6:32675634 | rs9275532 | - | C>G | 2748 | 95055 | 62.83 | 2.256e-15 | 1.177 |
| chr6:32665728 | rs9275312 | - | A>G | 3472 | 122222 | 62.72 | 2.385e-15 | 1.159 |
| chr6:32282854 | rs6910071 | TSBP1 | A>G | 5706 | 207894 | 61.63 | 4.152e-15 | 1.128 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 5112 | 178178 | 116.2 | 4.386e-27 | 1.19 |
| chr6:32577380 | rs660895 | - | A>G | 5337 | 189630 | 88.57 | 4.908e-21 | 1.161 |
| chr6:32582650 | rs3104413 | - | C>G | 4770 | 168424 | 86.35 | 1.505e-20 | 1.166 |
| chr6:32581973 | rs521539 | - | G>A | 5331 | 189764 | 86.13 | 1.687e-20 | 1.159 |
| chr6:32583357 | rs6931277 | - | A>T | 4704 | 166252 | 85.33 | 2.529e-20 | 1.166 |
| chr6:32577973 | rs532965 | - | T>G | 4804 | 169863 | 84.74 | 3.402e-20 | 1.164 |
| chr9:6193455 | rs2381416 | - | A>C | 6498 | 236509 | 72.72 | 1.492e-17 | 1.135 |
| chr9:6190076 | rs1342326 | - | A>C | 4155 | 147052 | 70.05 | 5.768e-17 | 1.157 |
| chr9:6197377 | rs10975479 | - | A>G | 4175 | 147812 | 69.81 | 6.532e-17 | 1.156 |
| chr9:6192796 | rs2095044 | - | C>T | 6325 | 230657 | 67.63 | 1.972e-16 | 1.131 |
| chr6:32667343 | rs9275338 | - | A>T | 3189 | 110992 | 66.75 | 3.077e-16 | 1.171 |
| chr6:32665728 | rs9275312 | - | A>G | 3273 | 114485 | 63.51 | 1.595e-15 | 1.165 |
| chr6:32667850 | rs9275356 | - | C>G | 2670 | 91943 | 63.25 | 1.822e-15 | 1.181 |
| chr6:32654714 | rs9275184 | - | T>C | 2638 | 90978 | 62.51 | 2.651e-15 | 1.181 |
| chr6:32681483 | rs7454108 | - | T>C | 2665 | 91872 | 61.8 | 3.798e-15 | 1.179 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 3156 | 110204 | 61.78 | 3.832e-15 | 1.165 |
| chr6:32303848 | rs28361060 | TSBP1 | G>A | 5599 | 203638 | 61.17 | 5.236e-15 | 1.13 |
| chr6:32681530 | rs3957146 | - | T>C | 2662 | 91865 | 60.98 | 5.773e-15 | 1.177 |
| chr6:32668632 | rs9275375 | - | G>A | 6053 | 221126 | 60.28 | 8.244e-15 | 1.125 |
| chr6:32669084 | rs9275388 | - | T>C | 6048 | 221001 | 60.08 | 9.112e-15 | 1.125 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 5298 | 82712 | 115.3 | 6.725e-27 | 1.188 |
| chr6:32582650 | rs3104413 | - | C>G | 4921 | 77952 | 83.21 | 7.368e-20 | 1.162 |
| chr6:32577973 | rs532965 | - | T>G | 4958 | 78564 | 82.8 | 9.101e-20 | 1.161 |
| chr6:32583357 | rs6931277 | - | A>T | 4855 | 76892 | 82.63 | 9.873e-20 | 1.163 |
| chr6:32577380 | rs660895 | - | A>G | 5535 | 88562 | 80.06 | 3.628e-19 | 1.152 |
| chr6:32581973 | rs521539 | - | G>A | 5530 | 88622 | 78.25 | 9.088e-19 | 1.15 |
| chr6:32667343 | rs9275338 | - | A>T | 3381 | 52817 | 66.02 | 4.46e-16 | 1.168 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 3321 | 51788 | 65.7 | 5.241e-16 | 1.169 |
| chr6:32665728 | rs9275312 | - | A>G | 3472 | 54438 | 64.03 | 1.224e-15 | 1.163 |
| chr6:32667850 | rs9275356 | - | C>G | 2772 | 42743 | 63.41 | 1.675e-15 | 1.18 |
| chr6:32654714 | rs9275184 | - | T>C | 2738 | 42313 | 62.63 | 2.495e-15 | 1.18 |
| chr6:32681483 | rs7454108 | - | T>C | 2768 | 42693 | 62.53 | 2.625e-15 | 1.179 |
| chr9:6193455 | rs2381416 | - | A>C | 6954 | 114327 | 61.97 | 3.48e-15 | 1.122 |
| chr6:32681530 | rs3957146 | - | T>C | 2765 | 42691 | 61.73 | 3.946e-15 | 1.178 |
| chr6:32675634 | rs9275532 | - | C>G | 2748 | 42534 | 59.88 | 1.007e-14 | 1.176 |
| chr9:6197377 | rs10975479 | - | A>G | 4315 | 69078 | 58.55 | 1.979e-14 | 1.142 |
| chr6:32667107 | rs9275334 | - | T>C | 2682 | 41512 | 58.39 | 2.145e-14 | 1.175 |
| chr6:32428062 | rs9268833 | - | C>T | 7985 | 132719 | 57.12 | 4.104e-14 | 1.113 |
| chr9:6192796 | rs2095044 | - | C>T | 6831 | 112613 | 56.93 | 4.521e-14 | 1.118 |
| chr6:32682137 | Affx-28502500 | - | A>G | 2789 | 43338 | 56.36 | 6.025e-14 | 1.169 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 5112 | 79817 | 111.3 | 5.034e-26 | 1.189 |
| chr6:32577380 | rs660895 | - | A>G | 5337 | 84931 | 84.82 | 3.261e-20 | 1.16 |
| chr6:32581973 | rs521539 | - | G>A | 5331 | 84990 | 82.67 | 9.685e-20 | 1.158 |
| chr6:32582650 | rs3104413 | - | C>G | 4770 | 75480 | 81.95 | 1.395e-19 | 1.164 |
| chr6:32583357 | rs6931277 | - | A>T | 4704 | 74490 | 80.87 | 2.409e-19 | 1.165 |
| chr6:32577973 | rs532965 | - | T>G | 4804 | 76098 | 80.8 | 2.502e-19 | 1.162 |
| chr9:6193455 | rs2381416 | - | A>C | 6498 | 105890 | 70.11 | 5.597e-17 | 1.135 |
| chr9:6197377 | rs10975479 | - | A>G | 4175 | 66257 | 65.94 | 4.651e-16 | 1.154 |
| chr9:6192796 | rs2095044 | - | C>T | 6325 | 103231 | 65.68 | 5.315e-16 | 1.132 |
| chr9:6190076 | rs1342326 | - | A>C | 4155 | 65973 | 65.31 | 6.384e-16 | 1.154 |
| chr6:32667343 | rs9275338 | - | A>T | 3189 | 49658 | 65.13 | 7.026e-16 | 1.172 |
| chr6:32665728 | rs9275312 | - | A>G | 3273 | 51172 | 62.75 | 2.352e-15 | 1.167 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 3156 | 49230 | 61.58 | 4.25e-15 | 1.168 |
| chr6:32667850 | rs9275356 | - | C>G | 2670 | 41164 | 61.04 | 5.585e-15 | 1.181 |
| chr6:32681483 | rs7454108 | - | T>C | 2665 | 41115 | 59.94 | 9.8e-15 | 1.179 |
| chr6:32654714 | rs9275184 | - | T>C | 2638 | 40772 | 59.65 | 1.131e-14 | 1.179 |
| chr6:32681530 | rs3957146 | - | T>C | 2662 | 41114 | 59.11 | 1.492e-14 | 1.178 |
| chr6:32668632 | rs9275375 | - | G>A | 6053 | 99044 | 57.53 | 3.332e-14 | 1.124 |
| chr6:32669084 | rs9275388 | - | T>C | 6048 | 98988 | 57.33 | 3.676e-14 | 1.124 |
| chr6:32428062 | rs9268833 | - | C>T | 7652 | 126977 | 57.29 | 3.76e-14 | 1.116 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: J329 | Chronic sinusitis, unspecified | 3/20 |
| ICD: J330 | Polyp of nasal cavity | 14/20 |
| ICD: J338 | Other polyp of sinus | 9/20 |
| ICD: J339 | Nasal polyp, unspecified | 15/20 |