Statistics
| Case | Control |
|---|---|
| 3659 | 456535 |
Phenotype Definition
Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr21:21519057 | rs17003463 | - | G>A | 518 | 52331 | 26.49 | 2.654e-07 | 1.265 |
| chr8:17555952 | rs415088 | MTUS1 | G>A | 1478 | 164714 | 26.47 | 2.674e-07 | 1.161 |
| chr1:58065660 | rs11207071 | DAB1 | T>G | 2270 | 260862 | 25.7 | 3.986e-07 | 1.136 |
| chr6:30900150 | rs3095151 | SFTA2 | G>T | 1438 | 203776 | 25.3 | 4.901e-07 | 0.8628 |
| chr6:30893941 | rs4678 | VARS2 | G>A | 1424 | 201377 | 25.25 | 5.025e-07 | 0.8623 |
| chr6:31448976 | rs3099844 | - | C>A | 935 | 136835 | 24.75 | 6.533e-07 | 0.8403 |
| chr6:31514247 | rs9267488 | ATP6V1G2-DDX39B | A>G | 891 | 130700 | 24.26 | 8.407e-07 | 0.8387 |
| chr6:31697387 | rs805305 | DDAH2 | C>G | 2590 | 352318 | 24.07 | 9.291e-07 | 0.888 |
| chr6:31697558 | rs707916 | DDAH2 | G>A | 2602 | 353629 | 24.02 | 9.539e-07 | 0.8882 |
| chr6:30855907 | rs1264323 | DDR1 | G>A | 2843 | 383898 | 23.98 | 9.711e-07 | 0.8904 |
| chr6:30864829 | rs1049623 | DDR1 | T>C | 2851 | 385162 | 23.86 | 1.038e-06 | 0.8907 |
| chr6:31465047 | rs3094005 | MICB | G>T | 900 | 131723 | 23.75 | 1.098e-06 | 0.8409 |
| chr6:31060219 | rs2535296 | - | A>G | 1229 | 175460 | 23.73 | 1.109e-06 | 0.859 |
| chr6:31688217 | rs805294 | MPIG6B | A>G | 2603 | 353388 | 23.71 | 1.122e-06 | 0.8889 |
| chr6:31698088 | rs805304 | DDAH2 | T>G | 2598 | 352968 | 23.69 | 1.13e-06 | 0.8889 |
| chr6:30899524 | rs3131787 | SFTA2 | T>C | 1430 | 202202 | 23.69 | 1.133e-06 | 0.8667 |
| chr6:30914552 | rs3130781 | SFTA2 | T>C | 1452 | 204428 | 23.04 | 1.591e-06 | 0.8691 |
| chr6:30951561 | rs1634714 | MUC21 | T>C | 1208 | 172232 | 22.87 | 1.733e-06 | 0.8605 |
| chr6:31688518 | rs805293 | MPIG6B | T>A | 3658 | 433900 | 22.63 | 1.968e-06 | 1.115 |
| chr10:43820236 | rs2493653 | - | A>G | 1623 | 226512 | 22.48 | 2.129e-06 | 0.8755 |
| chr6:30900150 | rs3095151 | SFTA2 | G>T | 1389 | 196265 | 26.98 | 2.051e-07 | 0.8562 |
| chr6:30893941 | rs4678 | VARS2 | G>A | 1384 | 194902 | 26.22 | 3.044e-07 | 0.8577 |
| chr6:30951561 | rs1634714 | MUC21 | T>C | 1189 | 169514 | 25.96 | 3.492e-07 | 0.8506 |
| chr6:30914552 | rs3130781 | SFTA2 | T>C | 1403 | 197452 | 25.8 | 3.786e-07 | 0.8596 |
| chr8:17555952 | rs415088 | MTUS1 | G>A | 1405 | 154967 | 25.76 | 3.859e-07 | 1.163 |
| chr6:30940989 | rs3132579 | - | T>C | 1190 | 169384 | 25.56 | 4.298e-07 | 0.8517 |
| chr6:30899524 | rs3131787 | SFTA2 | T>C | 1393 | 196275 | 25.54 | 4.33e-07 | 0.8599 |
| chr6:31448976 | rs3099844 | - | C>A | 904 | 131522 | 24.86 | 6.175e-07 | 0.8373 |
| chr6:31009055 | rs2517546 | - | C>T | 1069 | 153373 | 24.45 | 7.634e-07 | 0.8487 |
| chr6:31060219 | rs2535296 | - | A>G | 1192 | 169164 | 24.11 | 9.119e-07 | 0.8557 |
| chr6:31465047 | rs3094005 | MICB | G>T | 875 | 127297 | 23.99 | 9.701e-07 | 0.8379 |
| chr6:31514247 | rs9267488 | ATP6V1G2-DDX39B | A>G | 869 | 126437 | 23.9 | 1.013e-06 | 0.8377 |
| chr6:31697558 | rs707916 | DDAH2 | G>A | 2403 | 324649 | 23.44 | 1.288e-06 | 0.8861 |
| chr6:31697387 | rs805305 | DDAH2 | C>G | 2391 | 323374 | 23.43 | 1.297e-06 | 0.8859 |
| chr6:31610686 | rs1052486 | BAG6 | A>G | 3685 | 433387 | 23.09 | 1.544e-06 | 1.12 |
| chr6:31698088 | rs805304 | DDAH2 | T>G | 2400 | 323962 | 23.06 | 1.568e-06 | 0.8869 |
| chr6:31610529 | rs1077393 | BAG6 | A>G | 3681 | 434206 | 22.99 | 1.626e-06 | 1.119 |
| chr6:31505480 | rs2734583 | ATP6V1G2-DDX39B | A>G | 876 | 126861 | 22.56 | 2.034e-06 | 0.8424 |
| chr10:64580575 | rs224278 | EGR2 | C>T | 3178 | 371971 | 22.38 | 2.239e-06 | 1.119 |
| chr6:31327660 | rs1811197 | - | G>A | 1330 | 185895 | 22.35 | 2.275e-06 | 0.8661 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:30900150 | rs3095151 | SFTA2 | G>T | 1389 | 66312 | 29.17 | 6.635e-08 | 0.8499 |
| chr6:31060219 | rs2535296 | - | A>G | 1192 | 57507 | 28.44 | 9.653e-08 | 0.8433 |
| chr6:30951561 | rs1634714 | MUC21 | T>C | 1189 | 57323 | 28.22 | 1.082e-07 | 0.8437 |
| chr6:30893941 | rs4678 | VARS2 | G>A | 1384 | 65814 | 28.14 | 1.127e-07 | 0.852 |
| chr6:31448976 | rs3099844 | - | C>A | 904 | 44655 | 28.09 | 1.156e-07 | 0.827 |
| chr6:30914552 | rs3130781 | SFTA2 | T>C | 1403 | 66713 | 27.95 | 1.247e-07 | 0.8534 |
| chr6:30940989 | rs3132579 | - | T>C | 1190 | 57299 | 27.95 | 1.243e-07 | 0.8444 |
| chr6:31009055 | rs2517546 | - | C>T | 1069 | 52030 | 27.73 | 1.393e-07 | 0.8387 |
| chr6:30899524 | rs3131787 | SFTA2 | T>C | 1393 | 66306 | 27.62 | 1.474e-07 | 0.8538 |
| chr6:31465047 | rs3094005 | MICB | G>T | 875 | 43224 | 27.13 | 1.9e-07 | 0.8275 |
| chr6:31514247 | rs9267488 | ATP6V1G2-DDX39B | A>G | 869 | 42893 | 26.79 | 2.264e-07 | 0.828 |
| chr6:31697387 | rs805305 | DDAH2 | C>G | 2391 | 109211 | 26.29 | 2.933e-07 | 0.8787 |
| chr6:31697558 | rs707916 | DDAH2 | G>A | 2403 | 109620 | 26.25 | 2.996e-07 | 0.879 |
| chr6:31505480 | rs2734583 | ATP6V1G2-DDX39B | A>G | 876 | 43092 | 25.75 | 3.887e-07 | 0.8316 |
| chr6:31698088 | rs805304 | DDAH2 | T>G | 2400 | 109356 | 25.65 | 4.087e-07 | 0.8803 |
| chr21:21519057 | rs17003463 | - | G>A | 500 | 16783 | 25.6 | 4.19e-07 | 1.268 |
| chr6:31610686 | rs1052486 | BAG6 | A>G | 3685 | 145047 | 25.54 | 4.341e-07 | 1.127 |
| chr6:31610529 | rs1077393 | BAG6 | A>G | 3681 | 145342 | 25.54 | 4.339e-07 | 1.127 |
| chr6:32628698 | rs9273529 | HLA-DQB1 | C>T | 1675 | 78266 | 25.38 | 4.717e-07 | 0.8679 |
| chr6:31632134 | rs3130618 | GPANK1 | C>A | 1277 | 60786 | 25.08 | 5.487e-07 | 0.8557 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: R040 | Epistaxis | 12/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: D140 | Middle ear, nasal cavity and accessory sinuses | 0/20 |
| ICD-10: I720 | Aneurysm of carotid artery | 0/20 |
| ICD-10: I780 | Hereditary haemorrhagic telangiectasia | 0/20 |