Statistics
| Case | Control |
|---|---|
| 16837 | 443357 |
Phenotype Definition
An abnormality of the conjunctiva. [HPO:curators]
Phenotype Comment
The conjunctiva is a thin, sparsely vascularized transparent membrane that covers and protects the sclera (the bulbar conjunctiva), and forms the inner lining of the eyelids (the tarsal conjunctiva).
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:149232489 | rs7652887 | - | C>T | 678 | 13503 | 48.07 | 4.111e-12 | 1.316 |
| chr8:116631902 | rs7823278 | TRPS1 | C>A | 553 | 10806 | 44.77 | 2.214e-11 | 1.34 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 525 | 10501 | 40.76 | 1.718e-10 | 1.333 |
| chr10:1411012 | rs12762472 | ADARB2 | G>C | 480 | 9409 | 37.82 | 7.744e-10 | 1.335 |
| chr9:129979758 | rs3780318 | RALGPS1 | G>A | 746 | 15495 | 37.71 | 8.194e-10 | 1.261 |
| chr1:207782889 | rs17047661 | CR1 | A>G | 666 | 13653 | 37.5 | 9.137e-10 | 1.277 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 873 | 18504 | 36.71 | 1.37e-09 | 1.236 |
| chr16:17200685 | rs8046024 | XYLT1 | C>T | 889 | 18888 | 36.51 | 1.52e-09 | 1.233 |
| chr16:17200759 | rs8044934 | XYLT1 | G>A | 877 | 18618 | 36.33 | 1.667e-09 | 1.234 |
| chr9:129984107 | rs3739553 | RALGPS1 | G>A | 709 | 14704 | 36.19 | 1.791e-09 | 1.262 |
| chr2:8097884 | rs6431913 | - | A>G | 887 | 18872 | 36.03 | 1.941e-09 | 1.232 |
| chr2:237189869 | rs10184445 | - | A>G | 809 | 17057 | 35.76 | 2.227e-09 | 1.243 |
| chr9:8716797 | rs7854391 | PTPRD | G>T | 1235 | 27165 | 35.39 | 2.705e-09 | 1.192 |
| chr18:7327773 | rs28493149 | - | G>C | 927 | 19851 | 35.28 | 2.854e-09 | 1.224 |
| chr12:53817956 | rs784894 | AMHR2 | C>A | 527 | 10577 | 35.02 | 3.269e-09 | 1.304 |
| chr1:173579034 | rs12065033 | AL139142.2 | C>T | 703 | 14638 | 34.74 | 3.77e-09 | 1.258 |
| chr23:42913158 | rs5991558 | - | C>T | 704 | 14927 | 34.56 | 4.126e-09 | 1.258 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 817 | 17328 | 34.04 | 5.386e-09 | 1.235 |
| chr12:50412911 | rs615382 | RACGAP1 | A>C | 3656 | 86829 | 33.88 | 5.856e-09 | 1.109 |
| chr1:196552378 | rs28620995 | KCNT2 | G>A | 594 | 12194 | 33.08 | 8.824e-09 | 1.275 |
| chr6:32594998 | rs116518618 | - | C>T | 2740 | 79604 | 28.25 | 1.066e-07 | 0.8979 |
| chr6:32626119 | rs28584179 | - | C>T | 2737 | 79425 | 27.51 | 1.566e-07 | 0.8991 |
| chr6:32577973 | rs532965 | - | T>G | 6749 | 167918 | 26.11 | 3.229e-07 | 1.074 |
| chr6:32582650 | rs3104413 | - | C>G | 6687 | 166507 | 25.64 | 4.124e-07 | 1.073 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 7064 | 176226 | 25.15 | 5.304e-07 | 1.071 |
| chr12:118266021 | rs78565925 | KSR2 | T>C | 666 | 14424 | 24.76 | 6.504e-07 | 1.22 |
| chr6:32583357 | rs6931277 | - | A>T | 6591 | 164365 | 24.47 | 7.56e-07 | 1.072 |
| chr11:49185524 | rs10839234 | FOLH1 | T>C | 14286 | 364586 | 23.85 | 1.044e-06 | 1.057 |
| chr6:32944094 | rs15912 | BRD2 | G>C | 3414 | 82855 | 22.28 | 2.353e-06 | 1.091 |
| chr14:45671944 | rs117966323 | - | A>G | 960 | 29421 | 22.17 | 2.494e-06 | 0.8551 |
| chr17:74712886 | rs1014390 | JMJD6 | G>A | 2902 | 83109 | 22.05 | 2.653e-06 | 0.9114 |
| chr6:32923988 | rs1431393 | HLA-DMA | G>A | 3499 | 85378 | 21.49 | 3.559e-06 | 1.088 |
| chr11:49370834 | rs4144700 | - | A>C | 14374 | 367252 | 21.42 | 3.693e-06 | 1.053 |
| chr6:32911127 | rs3101944 | AL645941.2 | C>T | 3559 | 86965 | 21.27 | 3.987e-06 | 1.087 |
| chr6:32954689 | rs3097646 | - | A>C | 3514 | 85803 | 21.1 | 4.361e-06 | 1.087 |
| chr6:32577380 | rs660895 | - | A>G | 7474 | 187493 | 21.02 | 4.557e-06 | 1.063 |
| chr6:32203537 | rs3130299 | - | A>G | 7604 | 209804 | 20.98 | 4.637e-06 | 0.941 |
| chr6:32923993 | rs1431394 | HLA-DMA | T>G | 3497 | 85449 | 20.97 | 4.668e-06 | 1.087 |
| chr6:32914297 | rs3130595 | AL645941.2 | G>A | 3492 | 85318 | 20.8 | 5.09e-06 | 1.087 |
| chr6:32200147 | rs3134926 | - | C>G | 9287 | 254417 | 20.75 | 5.234e-06 | 0.945 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:85863537 | rs1074688 | - | G>A | 4549 | 8766 | 23.16 | 1.494e-06 | 0.9095 |
| chr8:11697442 | rs1296026 | - | C>T | 9201 | 15499 | 21.67 | 3.237e-06 | 1.074 |
| chr2:220573195 | rs513212 | - | T>C | 9180 | 17145 | 21.04 | 4.505e-06 | 0.9326 |
| chr1:76588532 | rs1335738 | ST6GALNAC3 | G>A | 14034 | 24011 | 20.99 | 4.625e-06 | 1.066 |
| chr8:93586384 | rs2595612 | - | C>T | 1387 | 2849 | 20.9 | 4.846e-06 | 0.8582 |
| chr6:30415111 | rs1419687 | - | G>C | 13014 | 24022 | 20.77 | 5.188e-06 | 0.9383 |
| chr6:30421502 | rs2524198 | - | G>A | 12837 | 23698 | 20.46 | 6.079e-06 | 0.9385 |
| chr14:88718412 | rs75918257 | KCNK10 | T>C | 3475 | 6746 | 20.21 | 6.949e-06 | 0.9054 |
| chr6:30361193 | rs3094698 | - | T>C | 15651 | 26891 | 19.84 | 8.411e-06 | 1.063 |
| chr6:32954689 | rs3097646 | - | A>C | 3514 | 5697 | 19.83 | 8.444e-06 | 1.106 |
| chr6:30410832 | rs1264517 | - | A>T | 13045 | 24054 | 19.82 | 8.499e-06 | 0.9397 |
| chr6:32911127 | rs3101944 | AL645941.2 | C>T | 3559 | 5778 | 19.71 | 9.016e-06 | 1.105 |
| chr6:32944094 | rs15912 | BRD2 | G>C | 3414 | 5520 | 19.67 | 9.188e-06 | 1.107 |
| chr6:32923993 | rs1431394 | HLA-DMA | T>G | 3497 | 5674 | 19.49 | 1.01e-05 | 1.105 |
| chr6:30357176 | rs3130139 | - | T>C | 15241 | 26147 | 19.45 | 1.032e-05 | 1.063 |
| chr6:30412045 | rs1264514 | - | T>G | 13050 | 24053 | 19.29 | 1.124e-05 | 0.9405 |
| chr6:30361759 | rs3094040 | - | G>A | 15642 | 26872 | 19.29 | 1.125e-05 | 1.062 |
| chr6:32923988 | rs1431393 | HLA-DMA | G>A | 3499 | 5677 | 19.27 | 1.134e-05 | 1.105 |
| chr8:11702375 | rs3947 | CTSB | G>A | 9075 | 15330 | 19.26 | 1.141e-05 | 1.07 |
| chr6:30361893 | rs3130106 | - | A>G | 15646 | 26902 | 19.25 | 1.145e-05 | 1.062 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: H110 | Pterygium | 5/20 |