Behavioral abnormality

0000708

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
163581	296613

Phenotype Definition

An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities. [HPO:probinson]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr2:26113913	rs78404020	-	A>G	4508	9309	56.66	5.175e-14	0.8716
chr18:35156177	rs7243428	-	A>G	78240	137387	45.94	1.22e-11	1.035
chr22:42448761	rs5758563	WBP2NL	G>T	4745	9631	45.25	1.734e-11	0.8868
chr20:62337406	rs6011040	ARFRP1	G>A	112976	207894	44.54	2.491e-11	0.9704
chr20:62349586	rs4809330	ZGPAT	G>A	112249	206560	43.87	3.517e-11	0.9706
chr2:22541141	rs12478745	-	G>A	150237	275179	43.56	4.118e-11	0.9722
chr6:396321	rs12203592	IRF4	C>T	73070	128135	43.43	4.404e-11	1.035
chr2:22515568	rs12373752	-	A>G	164357	292130	42.31	7.795e-11	1.028
chr8:30847760	rs2042074	-	T>C	136511	241922	41.98	9.209e-11	1.029
chr15:40915190	rs8040502	KNL1	G>A	53374	99337	41.23	1.35e-10	0.9632
chr12:84560908	rs6539823	-	C>T	81905	151277	41.15	1.408e-10	0.9686
chr20:62309839	rs6010620	RTEL1	G>A	83923	154991	40.33	2.149e-10	0.9692
chr20:62343956	rs2315008	ZGPAT	G>T	113284	208214	40.07	2.452e-10	0.9719
chr11:44843134	rs11038167	TSPAN18	A>C	3420	7029	39.92	2.642e-10	0.8761
chr3:71542279	rs73093445	FOXP1	C>A	144794	265285	39.28	3.674e-10	0.9735
chr18:35171653	rs12956949	-	A>G	129340	229208	38.94	4.366e-10	1.028
chr16:30628333	rs12447859	ZNF689	G>A	4342	8757	38.45	5.609e-10	0.8906
chr2:22431110	rs1554268	-	T>C	143039	262049	38.35	5.923e-10	0.9738
chr20:62361737	rs2427530	ZGPAT	G>A	83278	153665	38.03	6.965e-10	0.97
chr8:73889320	rs9298210	-	A>C	163565	299095	37.94	7.299e-10	0.9742
chr6:396321	rs12203592	IRF4	C>T	72143	126772	55.43	9.685e-14	1.04
chr2:22515568	rs12373752	-	A>G	155411	277486	45.03	1.939e-11	1.03
chr18:35156177	rs7243428	-	A>G	74510	131765	38.89	4.478e-10	1.033
chr6:26285683	rs2393593	H4C8	C>T	154405	276155	35.67	2.338e-09	1.026
chr6:26276650	rs9393692	-	G>A	155094	277440	34.91	3.456e-09	1.026
chr18:77563334	rs11665567	-	G>A	69524	122982	34.49	4.286e-09	1.032
chr3:71542279	rs73093445	FOXP1	C>A	139609	256943	34.32	4.68e-09	0.9745
chr18:35171653	rs12956949	-	A>G	117700	209777	33.92	5.755e-09	1.027
chr18:35197862	rs35064785	-	G>A	113563	202323	33.78	6.174e-09	1.027
chr2:22594027	rs12616949	-	G>A	111621	198426	33.42	7.434e-09	1.028
chr18:53210302	rs613872	TCF4	T>G	55599	103635	33.29	7.948e-09	0.9672
chr2:22541141	rs12478745	-	G>A	145793	267947	33.04	9.012e-09	0.9751
chr12:133704743	rs10870581	ZNF891	T>C	22330	42370	32.6	1.132e-08	0.9522
chr6:26325888	rs2179152	-	C>T	123004	219482	32.58	1.145e-08	1.026
chr2:22431110	rs1554268	-	T>C	138648	255075	32.18	1.408e-08	0.9753
chr6:26318903	rs9467703	-	G>A	122791	219177	31.77	1.735e-08	1.026
chr6:26290377	rs4412192	-	A>G	162844	291700	31.54	1.957e-08	1.025
chr20:62337406	rs6011040	ARFRP1	G>A	107084	197579	31.44	2.055e-08	0.9743
chr6:26285560	rs2393592	H4C8	G>A	159792	286189	30.92	2.69e-08	1.025
chr6:26293338	rs7746807	-	A>C	159432	285469	30.77	2.899e-08	1.024

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr20:37732176	rs6129181	-	T>C	62016	12580	27.88	1.291e-07	0.944
chr6:25148497	rs116460689	-	G>A	9191	1992	21.68	3.223e-06	0.8897
chr5:136943476	rs13164929	-	T>C	133482	25205	21.3	3.92e-06	1.042
chr12:121482954	rs16950730	-	A>G	16192	3408	20.76	5.198e-06	0.9155
chr2:22634061	rs62124871	-	C>T	14653	2580	20.62	5.605e-06	1.104
chr20:38342206	rs79734409	-	C>T	6314	1394	20.34	6.472e-06	0.8739
chr2:80492900	rs318362	CTNNA2	A>G	121495	22943	20.05	7.541e-06	1.041
chr12:66394594	rs12368649	-	T>G	12220	2134	19.98	7.815e-06	1.113
chr17:56700153	rs117982431	TEX14	T>C	4110	661	19.85	8.398e-06	1.206
chr3:45683107	rs7648441	LIMD1	A>G	20241	3627	19.58	9.663e-06	1.086
chr3:45587050	rs76495123	LARS2	G>A	10083	1744	19.53	9.917e-06	1.123
chr11:82387459	rs61692542	-	A>G	26248	4752	19.5	1.005e-05	1.075
chr10:6281220	rs11599520	PFKFB3	A>G	12819	2718	19.49	1.013e-05	0.9092
chr5:77306390	rs3776924	AP3B1	C>T	84095	16811	19.34	1.094e-05	0.9576
chr9:6221246	rs16924144	IL33	T>C	107649	21403	18.68	1.542e-05	0.961
chr20:38413485	rs75658788	-	C>T	6243	1373	18.63	1.583e-05	0.8781
chr15:59226509	rs72745082	RNF111	C>T	14952	2650	18.27	1.918e-05	1.096
chr6:130349119	rs6569648	L3MBTL3	T>C	77943	15585	18.09	2.109e-05	0.958
chr9:31219985	rs10970215	-	A>G	135993	25746	17.89	2.341e-05	1.038
chr15:54336061	rs28681565	UNC13C	G>A	133031	26336	17.88	2.358e-05	0.9634

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: C441	Skin of eyelid, including canthus	1/20
ICD: F10	Mental and behavioural disorders due to use of alcohol	1/20
ICD: F100	Acute intoxication	1/20
ICD: F101	Harmful use	1/20
ICD: F102	Dependence syndrome	1/20
ICD: F103	Withdrawal state	1/20
ICD: F32	Depressive episode	1/20
ICD: R268	Other and unspecified abnormalities of gait and mobility	1/20
ICD: W199	Unspecified place	1/20

ID	Name	Top Correlation
ICD-10: A491	Streptococcal infection, unspecified	0/20
ICD-10: B449	Aspergillosis, unspecified	0/20
ICD-10: B80	Enterobiasis	0/20
ICD-10: B91	Sequelae of poliomyelitis	0/20
ICD-10: C029	Tongue, unspecified	0/20
ICD-10: C099	Tonsil, unspecified	0/20
ICD-10: C181	Appendix	0/20
ICD-10: C440	Skin of lip	0/20
ICD-10: C459	Mesothelioma, unspecified	0/20
ICD-10: C711	Frontal lobe	0/20
ICD-10: C781	Secondary malignant neoplasm of mediastinum	0/20
ICD-10: C782	Secondary malignant neoplasm of pleura	0/20
ICD-10: C859	Non-Hodgkin's lymphoma, unspecified type	0/20
ICD-10: D046	Skin of upper limb, including shoulder	0/20
ICD-10: D101	Tongue	0/20
ICD-10: D230	Skin of lip	0/20
ICD-10: D231	Skin of eyelid, including canthus	0/20
ICD-10: D232	Skin of ear and external auricular canal	0/20
ICD-10: D233	Skin of other and unspecified parts of face	0/20
ICD-10: D234	Skin of scalp and neck	0/20
ICD-10: D236	Skin of upper limb, including shoulder	0/20
ICD-10: D239	Skin, unspecified	0/20
ICD-10: D333	Cranial nerves	0/20
ICD-10: D361	Peripheral nerves and autonomic nervous system	0/20
ICD-10: D485	Skin	0/20
ICD-10: D699	Haemorrhagic condition, unspecified	0/20
ICD-10: E105	With peripheral circulatory complications	0/20
ICD-10: E115	With peripheral circulatory complications	0/20
ICD-10: E119	Without complications	0/20
ICD-10: E149	Without complications	0/20
ICD-10: E232	Diabetes insipidus	0/20
ICD-10: E274	Other and unspecified adrenocortical insufficiency	0/20
ICD-10: E662	Extreme obesity with alveolar hypoventilation	0/20
ICD-10: F009	Dementia in Alzheimer's disease, unspecified	0/20
ICD-10: F023	Dementia in Parkinson's disease	0/20
ICD-10: F028	Dementia in other specified diseases classified elsewhere	0/20
ICD-10: F03	Unspecified dementia	0/20
ICD-10: F050	Delirium not superimposed on dementia, so described	0/20
ICD-10: F051	Delirium superimposed on dementia	0/20
ICD-10: F058	Other delirium	0/20
ICD-10: F059	Delirium, unspecified	0/20
ICD-10: F06	Other mental disorders due to brain damage and dysfunction and to physical disease	0/20
ICD-10: F104	Withdrawal state with delirium	0/20
ICD-10: F112	Dependence syndrome	0/20
ICD-10: F121	Harmful use	0/20
ICD-10: F171	Harmful use	0/20
ICD-10: F172	Dependence syndrome	0/20
ICD-10: F20	Schizophrenia	0/20
ICD-10: F200	Paranoid schizophrenia	0/20
ICD-10: F220	Delusional disorder	0/20
ICD-10: F23	Acute and transient psychotic disorders	0/20
ICD-10: F259	Schizoaffective disorder, unspecified	0/20
ICD-10: F29	Unspecified nonorganic psychosis	0/20
ICD-10: F310	Bipolar affective disorder, current episode hypomanic	0/20
ICD-10: F311	Bipolar affective disorder, current episode manic without psychotic symptoms	0/20
ICD-10: F312	Bipolar affective disorder, current episode manic with psychotic symptoms	0/20
ICD-10: F313	Bipolar affective disorder, current episode mild or moderate depression	0/20
ICD-10: F319	Bipolar affective disorder, unspecified	0/20
ICD-10: F320	Mild depressive episode	0/20
ICD-10: F321	Moderate depressive episode	0/20
ICD-10: F322	Severe depressive episode without psychotic symptoms	0/20
ICD-10: F323	Severe depressive episode with psychotic symptoms	0/20
ICD-10: F331	Recurrent depressive disorder, current episode moderate	0/20
ICD-10: F332	Recurrent depressive disorder, current episode severe without psychotic symptoms	0/20
ICD-10: F333	Recurrent depressive disorder, current episode severe with psychotic symptoms	0/20
ICD-10: F339	Recurrent depressive disorder, unspecified	0/20
ICD-10: F402	Specific (isolated) phobias	0/20
ICD-10: F410	Panic disorder [episodic paroxysmal anxiety]	0/20
ICD-10: F411	Generalised anxiety disorder	0/20
ICD-10: F412	Mixed anxiety and depressive disorder	0/20
ICD-10: F419	Anxiety disorder, unspecified	0/20
ICD-10: F429	Obsessive-compulsive disorder, unspecified	0/20
ICD-10: F430	Acute stress reaction	0/20
ICD-10: F431	Posttraumatic stress disorder	0/20
ICD-10: F432	Adjustment disorders	0/20
ICD-10: F458	Other somatoform disorders	0/20
ICD-10: F603	Emotionally unstable personality disorder	0/20
ICD-10: F609	Personality disorder, unspecified	0/20
ICD-10: F801	Expressive language disorder	0/20
ICD-10: F99	Mental disorder, not otherwise specified	0/20
ICD-10: G119	Hereditary ataxia, unspecified	0/20
ICD-10: G20	Parkinson's disease	0/20
ICD-10: G245	Blepharospasm	0/20
ICD-10: G249	Dystonia, unspecified	0/20
ICD-10: G250	Essential tremor	0/20
ICD-10: G253	Myoclonus	0/20
ICD-10: G258	Other specified extrapyramidal and movement disorders	0/20
ICD-10: G318	Other specified degenerative diseases of nervous system	0/20
ICD-10: G35	Multiple sclerosis	0/20
ICD-10: G431	Migraine with aura [classical migraine]	0/20
ICD-10: G438	Other migraine	0/20
ICD-10: G439	Migraine, unspecified	0/20
ICD-10: G440	Cluster headache syndrome	0/20
ICD-10: G442	Tension-type headache	0/20
ICD-10: G454	Transient global amnesia	0/20
ICD-10: G470	Disorders of initiating and maintaining sleep [insomnias]	0/20
ICD-10: G471	Disorders of excessive somnolence [hypersomnias]	0/20
ICD-10: G473	Sleep apnoea	0/20
ICD-10: G478	Other sleep disorders	0/20
ICD-10: G479	Sleep disorder, unspecified	0/20
ICD-10: G500	Trigeminal neuralgia	0/20
ICD-10: G549	Nerve root and plexus disorder, unspecified	0/20
ICD-10: G552	Nerve root and plexus compressions in spondylosis	0/20
ICD-10: G571	Meralgia paraesthetica	0/20
ICD-10: G589	Mononeuropathy, unspecified	0/20
ICD-10: G590	Diabetic mononeuropathy	0/20
ICD-10: G610	Guillain-Barre syndrome	0/20
ICD-10: G618	Other inflammatory polyneuropathies	0/20
ICD-10: G628	Other specified polyneuropathies	0/20
ICD-10: G632	Diabetic polyneuropathy	0/20
ICD-10: G809	Infantile cerebral palsy, unspecified	0/20
ICD-10: G834	Cauda equina syndrome	0/20
ICD-10: G938	Other specified disorders of brain	0/20
ICD-10: G951	Vascular myelopathies	0/20
ICD-10: G952	Cord compression, unspecified	0/20
ICD-10: H028	Other specified disorders of eyelid	0/20
ICD-10: H113	Conjunctival haemorrhage	0/20
ICD-10: H358	Other specified retinal disorders	0/20
ICD-10: H490	Third [oculomotor] nerve palsy	0/20
ICD-10: H492	Sixth [abducent] nerve palsy	0/20
ICD-10: H500	Convergent concomitant strabismus	0/20
ICD-10: H501	Divergent concomitant strabismus	0/20
ICD-10: H509	Strabismus, unspecified	0/20
ICD-10: H523	Anisometropia and aniseikonia	0/20
ICD-10: H530	Amblyopia ex anopsia	0/20
ICD-10: H531	Subjective visual disturbances	0/20
ICD-10: H544	Blindness, one eye	0/20
ICD-10: H571	Ocular pain	0/20
ICD-10: H811	Benign paroxysmal vertigo	0/20
ICD-10: H812	Vestibular neuronitis	0/20
ICD-10: I214	Acute subendocardial myocardial infarction	0/20
ICD-10: I460	Cardiac arrest with successful resuscitation	0/20
ICD-10: I500	Congestive heart failure	0/20
ICD-10: I509	Heart failure, unspecified	0/20
ICD-10: I700	Atherosclerosis of aorta	0/20
ICD-10: I728	Aneurysm of other specified arteries	0/20
ICD-10: I73	Other peripheral vascular diseases	0/20
ICD-10: I792	Peripheral angiopathy in diseases classified elsewhere	0/20
ICD-10: I99	Other and unspecified disorders of circulatory system	0/20
ICD-10: J351	Hypertrophy of tonsils	0/20
ICD-10: J370	Chronic laryngitis	0/20
ICD-10: J382	Nodules of vocal cords	0/20
ICD-10: J383	Other diseases of vocal cords	0/20
ICD-10: J61	Pneumoconiosis due to asbestos and other mineral fibres	0/20
ICD-10: K076	Temporomandibular joint disorders	0/20
ICD-10: K149	Disease of tongue, unspecified	0/20
ICD-10: K292	Alcoholic gastritis	0/20
ICD-10: K319	Disease of stomach and duodenum, unspecified	0/20
ICD-10: K500	Crohn's disease of small intestine	0/20
ICD-10: K529	Non-infective gastro-enteritis and colitis, unspecified	0/20
ICD-10: K550	Acute vascular disorders of intestine	0/20
ICD-10: K565	Intestinal adhesions [bands] with obstruction	0/20
ICD-10: K580	Irritable bowel syndrome with diarrhoea	0/20
ICD-10: K589	Irritable bowel syndrome without diarrhoea	0/20
ICD-10: K591	Functional diarrhoea	0/20
ICD-10: K598	Other specified functional intestinal disorders	0/20
ICD-10: K599	Functional intestinal disorder, unspecified	0/20
ICD-10: K639	Disease of intestine, unspecified	0/20
ICD-10: K824	Cholesterolosis of gallbladder	0/20
ICD-10: L280	Lichen simplex chronicus	0/20
ICD-10: L309	Dermatitis, unspecified	0/20
ICD-10: L659	Nonscarring hair loss, unspecified	0/20
ICD-10: M060	Seronegative rheumatoid arthritis	0/20
ICD-10: M213	Wrist or foot drop (acquired)	0/20
ICD-10: M431	Spondylolisthesis	0/20
ICD-10: M436	Torticollis	0/20
ICD-10: M478	Other spondylosis	0/20
ICD-10: M479	Spondylosis, unspecified	0/20
ICD-10: M480	Spinal stenosis	0/20
ICD-10: M541	Radiculopathy	0/20
ICD-10: M548	Other dorsalgia	0/20
ICD-10: M5490	Dorsalgia, unspecified (Multiple sites in spine)	0/20
ICD-10: M5494	Dorsalgia, unspecified (Thoracic region)	0/20
ICD-10: M5496	Dorsalgia, unspecified (Lumbar region)	0/20
ICD-10: M5499	Dorsalgia, unspecified (Site unspecified)	0/20
ICD-10: M702	Olecranon bursitis	0/20
ICD-10: M706	Trochanteric bursitis	0/20
ICD-10: M792	Neuralgia and neuritis, unspecified	0/20
ICD-10: M796	Pain in limb	0/20
ICD-10: M950	Acquired deformity of nose	0/20
ICD-10: N039	Unspecified	0/20
ICD-10: N202	Calculus of kidney with calculus of ureter	0/20
ICD-10: N429	Disorder of prostate, unspecified	0/20
ICD-10: N62	Hypertrophy of breast	0/20
ICD-10: N648	Other specified disorders of breast	0/20
ICD-10: N739	Female pelvic inflammatory disease, unspecified	0/20
ICD-10: N943	Premenstrual tension syndrome	0/20
ICD-10: O351	Maternal care for (suspected) chromosomal abnormality in foetus	0/20
ICD-10: O622	Other uterine inertia	0/20
ICD-10: O700	First degree perineal laceration during delivery	0/20
ICD-10: O721	Other immediate postpartum haemorrhage	0/20
ICD-10: O758	Other specified complications of labour and delivery	0/20
ICD-10: Q211	Atrial septal defect	0/20
ICD-10: R065	Mouth breathing	0/20
ICD-10: R066	Hiccough	0/20
ICD-10: R068	Other and unspecified abnormalities of breathing	0/20
ICD-10: R071	Chest pain on breathing	0/20
ICD-10: R194	Change in bowel habit	0/20
ICD-10: R251	Tremor, unspecified	0/20
ICD-10: R253	Fasciculation	0/20
ICD-10: R258	Other and unspecified abnormal involuntary movements	0/20
ICD-10: R260	Ataxic gait	0/20
ICD-10: R262	Difficulty in walking, not elsewhere classified	0/20
ICD-10: R263	Immobility	0/20
ICD-10: R270	Ataxia, unspecified	0/20
ICD-10: R278	Other and unspecified lack of coordination	0/20
ICD-10: R296	Tendency to fall, not elsewhere classified	0/20
ICD-10: R35	Polyuria	0/20
ICD-10: R400	Somnolence	0/20
ICD-10: R410	Disorientation, unspecified	0/20
ICD-10: R42	Dizziness and giddiness	0/20
ICD-10: R440	Auditory hallucinations	0/20
ICD-10: R441	Visual hallucinations	0/20
ICD-10: R443	Hallucinations, unspecified	0/20
ICD-10: R451	Restlessness and agitation	0/20
ICD-10: R452	Unhappiness	0/20
ICD-10: R468	Other symptoms and signs involving appearance and behaviour	0/20
ICD-10: R470	Dysphasia and aphasia	0/20
ICD-10: R471	Dysarthria and anarthria	0/20
ICD-10: R490	Dysphonia	0/20
ICD-10: R498	Other and unspecified voice disturbances	0/20
ICD-10: R500	Fever with chills	0/20
ICD-10: R51	Headache	0/20
ICD-10: R521	Chronic intractable pain	0/20
ICD-10: R53	Malaise and fatigue	0/20
ICD-10: R630	Anorexia	0/20
ICD-10: R631	Polydipsia	0/20
ICD-10: R688	Other specified general symptoms and signs	0/20
ICD-10: R69	Unknown and unspecified causes of morbidity	0/20
ICD-10: R900	Intracranial space-occupying lesion	0/20
ICD-10: T404	Other synthetic narcotics	0/20
ICD-10: T424	Benzodiazepines	0/20
ICD-10: T430	Tricyclic and tetracyclic antidepressants	0/20
ICD-10: T432	Other and unspecified antidepressants	0/20
ICD-10: T435	Other and unspecified antipsychotics and neuroleptics	0/20
ICD-10: T450	Antiallergic and antiemetic drugs	0/20
ICD-10: T519	Alcohol, unspecified	0/20
ICD-10: T884	Failed or difficult intubation	0/20
ICD-10: W010	Home	0/20
ICD-10: W180	Home	0/20
ICD-10: X600	Home	0/20

Behavioral abnormality

0000708

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ