Diminished motivation

0000745

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
6636	453558

Phenotype Definition

A reduction in goal-directed behavior, that is, motivation, the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action. [HPO:probinson, PMID:16030444]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr19:45422946	rs4420638	-	A>G	3341	179170	228.1	1.555e-51	1.351
chr19:45410002	rs769449	APOE	G>A	2283	115637	222.3	2.849e-50	1.408
chr19:45395714	rs157581	TOMM40	T>C	3758	211789	166.6	4.084e-38	1.28
chr19:45395619	rs2075650	TOMM40	A>G	2553	137858	156.4	6.836e-36	1.317
chr19:45382034	rs6859	NECTIN2	G>A	6330	402446	48.63	3.091e-12	1.126
chr19:45351516	rs41289512	NECTIN2	C>G	728	38825	44.08	3.155e-11	1.29
chr19:45395266	rs157580	TOMM40	A>G	5173	377001	40.11	2.403e-10	0.8947
chr19:45414451	rs439401	-	C>T	4810	349958	34.39	4.515e-09	0.9005
chr19:45382966	rs3852860	NECTIN2	C>T	5649	405276	28.27	1.053e-07	0.9122
chr10:20315463	rs12254394	PLXDC2	C>T	894	51255	27.25	1.786e-07	1.199
chr19:45403412	rs1160985	TOMM40	C>T	5844	418085	27.14	1.89e-07	0.9143
chr19:45410444	rs769450	APOE	G>A	5267	378542	26.93	2.11e-07	0.9131
chr23:106146349	rs5962774	MORC4	T>C	225	10801	25.03	5.637e-07	1.403
chr2:192338718	rs7592348	-	A>C	713	40541	23.19	1.465e-06	1.205
chr6:37696446	rs7740079	-	T>G	2184	134901	22.7	1.892e-06	1.118
chr1:2821127	rs78124468	-	G>T	203	9935	22.08	2.616e-06	1.397
chr2:153974661	rs28375749	-	A>C	455	24967	21.22	4.104e-06	1.247
chr20:19722107	rs808695	-	C>A	1283	98591	21.15	4.245e-06	0.8733
chr15:71836694	rs117241818	THSD4	T>C	242	12240	21.12	4.314e-06	1.35
chr15:101412688	rs12901792	-	G>A	3209	203031	20.74	5.253e-06	1.097
chr19:45422946	rs4420638	-	A>G	3179	170417	228.2	1.509e-51	1.362
chr19:45410002	rs769449	APOE	G>A	2218	112462	224.0	1.186e-50	1.419
chr19:45395619	rs2075650	TOMM40	A>G	2435	131332	158.4	2.5e-36	1.328
chr19:45395714	rs157581	TOMM40	T>C	3453	194974	158.3	2.631e-36	1.285
chr19:45382034	rs6859	NECTIN2	G>A	6006	381679	54.9	1.271e-13	1.139
chr19:45351516	rs41289512	NECTIN2	C>G	714	38299	43.23	4.864e-11	1.29
chr19:45395266	rs157580	TOMM40	A>G	4874	357780	39.75	2.882e-10	0.892
chr19:45414451	rs439401	-	C>T	4493	328826	32.24	1.364e-08	0.9004
chr19:45382966	rs3852860	NECTIN2	C>T	5224	378618	30.64	3.1e-08	0.9057
chr19:45403412	rs1160985	TOMM40	C>T	5417	391263	29.23	6.443e-08	0.9083
chr9:14349356	rs57582029	NFIB	T>C	539	45575	25.51	4.41e-07	0.8001
chr19:45410444	rs769450	APOE	G>A	4985	359043	22.56	2.037e-06	0.9178
chr15:71836694	rs117241818	THSD4	T>C	240	12076	22.54	2.062e-06	1.365
chr1:173017486	rs2236876	TNFSF18	G>A	3035	223196	21.08	4.415e-06	0.9089
chr10:6394456	rs75023418	-	G>T	835	48970	20.48	6.014e-06	1.177
chr20:19722107	rs808695	-	C>A	1235	95263	19.92	8.091e-06	0.8745
chr15:55520182	rs10518805	RAB27A	G>T	1003	78468	19.84	8.435e-06	0.8632
chr8:117643773	rs9650068	-	A>G	2148	160351	19.8	8.616e-06	0.8998
chr1:2821127	rs78124468	-	G>T	196	9785	19.46	1.026e-05	1.376
chr10:20495167	rs80261185	PLXDC2	A>G	606	34795	18.86	1.405e-05	1.2

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr19:45422946	rs4420638	-	A>G	3179	24564	222.7	2.296e-50	1.378
chr19:45410002	rs769449	APOE	G>A	2218	16257	209.8	1.54e-47	1.429
chr19:45395714	rs157581	TOMM40	T>C	3453	28232	151.0	1.035e-34	1.292
chr19:45395619	rs2075650	TOMM40	A>G	2435	19124	142.5	7.407e-33	1.327
chr19:45382034	rs6859	NECTIN2	G>A	6006	55171	59.38	1.3e-14	1.152
chr19:45395266	rs157580	TOMM40	A>G	4874	52300	42.23	8.104e-11	0.8846
chr19:45351516	rs41289512	NECTIN2	C>G	714	5614	36.66	1.409e-09	1.28
chr19:45382966	rs3852860	NECTIN2	C>T	5224	55371	33.63	6.679e-09	0.8976
chr19:45414451	rs439401	-	C>T	4493	47802	29.15	6.693e-08	0.9014
chr9:14349356	rs57582029	NFIB	T>C	539	6638	24.13	8.993e-07	0.7991
chr19:45403412	rs1160985	TOMM40	C>T	5417	56711	23.66	1.151e-06	0.9139
chr13:54634009	rs9596907	-	C>G	929	7941	20.56	5.779e-06	1.177
chr1:173017486	rs2236876	TNFSF18	G>A	3035	32492	20.0	7.727e-06	0.9078
chr15:71836694	rs117241818	THSD4	T>C	240	1772	19.1	1.239e-05	1.353
chr19:45410444	rs769450	APOE	G>A	4985	52105	18.95	1.339e-05	0.9214
chr1:170555234	rs7535455	-	G>C	4096	43059	18.67	1.557e-05	0.9184
chr15:39179819	rs7181891	-	T>G	3759	35061	18.65	1.566e-05	1.091
chr5:96746530	rs75858335	-	G>A	354	2772	18.48	1.715e-05	1.278
chr8:106079696	rs3110290	ZFPM2	A>G	890	10225	18.22	1.966e-05	0.8567
chr13:114556412	rs58799608	GAS6	G>A	706	5955	17.97	2.244e-05	1.189

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: F009	Dementia in Alzheimer's disease, unspecified	10/20
ICD: F028	Dementia in other specified diseases classified elsewhere	2/20
ICD: F03	Unspecified dementia	10/20
ICD: F050	Delirium not superimposed on dementia, so described	2/20
ICD: O721	Other immediate postpartum haemorrhage	2/20
ICD: R410	Disorientation, unspecified	6/20

ID	Name	Top Correlation
ICD-10: F023	Dementia in Parkinson's disease	0/20
ICD-10: F320	Mild depressive episode	0/20
ICD-10: O622	Other uterine inertia	0/20

Diminished motivation

0000745

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ