Statistics
| Case | Control |
|---|---|
| 24413 | 435781 |
Phenotype Definition
A type of anxiety disorder characterized by avoidance of public places, especially where crowds gather. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 1206 | 26320 | 46.92 | 7.383e-12 | 0.8156 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 2661 | 54331 | 46.73 | 8.14e-12 | 0.87 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 3169 | 63889 | 46.08 | 1.136e-11 | 0.8803 |
| chr6:22050187 | rs1736507 | - | C>A | 592 | 13921 | 43.65 | 3.917e-11 | 0.7573 |
| chr15:29223282 | rs8026324 | APBA2 | T>A | 1910 | 39766 | 43.35 | 4.584e-11 | 0.8547 |
| chr18:50737358 | rs62100766 | DCC | G>T | 20386 | 351521 | 42.27 | 7.939e-11 | 1.062 |
| chr2:26113913 | rs78404020 | - | A>G | 563 | 13254 | 41.42 | 1.226e-10 | 0.7576 |
| chr18:50597737 | rs4510098 | DCC | G>T | 20602 | 355675 | 40.63 | 1.838e-10 | 1.061 |
| chr23:71651365 | rs12007867 | AL133500.1 | C>T | 448 | 10223 | 39.51 | 3.265e-10 | 0.7379 |
| chr18:50683306 | rs4372758 | DCC | T>C | 22848 | 395934 | 39.41 | 3.427e-10 | 1.059 |
| chr2:34133881 | rs60775934 | - | C>T | 508 | 12024 | 38.72 | 4.885e-10 | 0.754 |
| chr7:22797207 | rs73276345 | - | A>G | 2729 | 54951 | 38.69 | 4.971e-10 | 0.8822 |
| chr16:28995057 | rs11859822 | SPNS1 | T>C | 1322 | 28114 | 38.67 | 5.03e-10 | 0.8377 |
| chr2:211717706 | rs12995612 | - | C>G | 696 | 15776 | 38.05 | 6.896e-10 | 0.7866 |
| chr6:3189788 | rs4327734 | - | C>T | 605 | 13950 | 37.93 | 7.35e-10 | 0.7737 |
| chr19:7694662 | rs3760675 | - | T>C | 619 | 14225 | 37.85 | 7.652e-10 | 0.7761 |
| chr15:48392165 | rs1834640 | - | A>G | 1433 | 30191 | 37.84 | 7.695e-10 | 0.8449 |
| chr19:7710854 | Affx-16268850 | STXBP2 | T>C | 738 | 16597 | 37.57 | 8.82e-10 | 0.7931 |
| chr6:93667780 | rs9363020 | - | G>A | 486 | 11505 | 37.17 | 1.084e-09 | 0.7537 |
| chr20:2315543 | rs6132532 | AL121899.2 | A>G | 2326 | 47208 | 36.96 | 1.208e-09 | 0.8763 |
| chr18:50683306 | rs4372758 | DCC | T>C | 21914 | 380474 | 27.78 | 1.358e-07 | 1.051 |
| chr18:50737358 | rs62100766 | DCC | G>T | 19823 | 343509 | 26.24 | 3.009e-07 | 1.05 |
| chr17:72177159 | rs75443985 | - | A>G | 6412 | 107815 | 25.0 | 5.743e-07 | 1.071 |
| chr18:50597737 | rs4510098 | DCC | G>T | 19876 | 344729 | 24.98 | 5.794e-07 | 1.049 |
| chr18:50622015 | rs35585120 | DCC | A>C | 8110 | 152360 | 24.02 | 9.544e-07 | 0.9406 |
| chr9:127932402 | rs7852933 | PPP6C | G>A | 14692 | 271515 | 23.76 | 1.09e-06 | 0.9517 |
| chr18:50729267 | rs60939828 | DCC | T>C | 21377 | 372376 | 23.75 | 1.096e-06 | 1.047 |
| chr1:147210993 | rs1342701 | - | G>A | 18769 | 344661 | 23.28 | 1.404e-06 | 0.9549 |
| chr17:72189602 | rs12603773 | - | C>A | 6203 | 104357 | 23.12 | 1.523e-06 | 1.07 |
| chr9:127816147 | rs600310 | SCAI | T>C | 16549 | 304676 | 22.94 | 1.671e-06 | 0.954 |
| chr7:5594385 | rs852536 | ACTB | T>C | 917 | 13958 | 22.21 | 2.441e-06 | 1.176 |
| chr1:201288982 | rs41269939 | PKP1 | C>A | 807 | 17031 | 22.04 | 2.665e-06 | 0.8434 |
| chr16:72934443 | rs6499595 | ZFHX3 | G>C | 18864 | 345998 | 22.04 | 2.673e-06 | 0.9561 |
| chr2:226273689 | rs2048936 | NYAP2 | C>T | 8696 | 162554 | 21.87 | 2.922e-06 | 0.9448 |
| chr4:5251069 | rs35682919 | STK32B | T>A | 4951 | 94230 | 21.86 | 2.939e-06 | 0.9306 |
| chr14:35857405 | rs61988300 | - | A>G | 9812 | 167787 | 21.32 | 3.881e-06 | 1.055 |
| chr17:42607368 | rs11079199 | - | C>T | 13977 | 258012 | 21.1 | 4.354e-06 | 0.9538 |
| chr6:142944380 | rs77266588 | - | G>C | 2505 | 40781 | 21.01 | 4.578e-06 | 1.102 |
| chr18:50595725 | rs9947974 | DCC | A>G | 10405 | 193386 | 20.77 | 5.188e-06 | 0.9496 |
| chr22:43283255 | rs2267463 | PACSIN2 | A>C | 24457 | 427425 | 20.45 | 6.129e-06 | 1.043 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr10:21415036 | rs72796574 | NEBL | G>A | 643 | 606 | 28.83 | 7.891e-08 | 0.7369 |
| chr25:2610494 | rs167453 | - | T>G | 16034 | 11712 | 26.84 | 2.213e-07 | 0.9253 |
| chr9:136511127 | rs117214842 | DBH | G>A | 3285 | 2598 | 26.68 | 2.397e-07 | 0.8687 |
| chr25:2685254 | rs311142 | - | C>T | 18565 | 13502 | 26.17 | 3.123e-07 | 0.9284 |
| chr25:154999134 | rs6642320 | - | G>A | 17566 | 11650 | 25.92 | 3.558e-07 | 1.08 |
| chr25:2645366 | rs311083 | - | C>G | 17558 | 12695 | 25.09 | 5.463e-07 | 0.9289 |
| chr25:155016369 | rs28425172 | - | T>C | 22058 | 15911 | 23.83 | 1.05e-06 | 0.933 |
| chr9:136478355 | rs3025343 | - | G>A | 5544 | 4230 | 23.66 | 1.151e-06 | 0.8996 |
| chr25:155053713 | rs28884873 | - | G>A | 7261 | 5452 | 23.42 | 1.302e-06 | 0.9099 |
| chr25:2644302 | rs1136470 | - | C>T | 6938 | 4402 | 23.16 | 1.488e-06 | 1.105 |
| chr8:78417479 | rs17378618 | - | T>C | 1141 | 972 | 22.39 | 2.22e-06 | 0.8114 |
| chr2:36089232 | rs10199460 | - | C>T | 1141 | 970 | 22.02 | 2.694e-06 | 0.8127 |
| chr8:78288331 | rs117641727 | - | C>T | 1176 | 996 | 21.94 | 2.816e-06 | 0.8153 |
| chr9:136455785 | rs112151537 | FAM163B | C>T | 2682 | 2125 | 21.77 | 3.073e-06 | 0.8697 |
| chr13:106344524 | rs117721540 | - | A>G | 2034 | 1198 | 21.75 | 3.108e-06 | 1.189 |
| chr9:136473053 | rs113864525 | FAM163B | C>A | 5520 | 4195 | 21.49 | 3.559e-06 | 0.9038 |
| chr2:47565795 | rs10865224 | - | T>G | 22340 | 14955 | 21.3 | 3.917e-06 | 1.068 |
| chr11:134507482 | rs949112 | - | A>G | 18543 | 12352 | 20.99 | 4.611e-06 | 1.069 |
| chr25:2691012 | rs142162416 | - | A>G | 2248 | 1340 | 20.64 | 5.546e-06 | 1.174 |
| chr6:123122385 | rs9372718 | SMPDL3A | A>C | 8864 | 5747 | 20.55 | 5.811e-06 | 1.088 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: F32 | Depressive episode | 10/20 |
| ICD: F419 | Anxiety disorder, unspecified | 6/20 |