Statistics
| Female Case | Female Control | % Female |
|---|---|---|
| 15345 | 234512 | 63% |
| Male Case | Male Control | % Male |
|---|---|---|
| 9068 | 201269 | 37% |
Phenotype Definition
A type of anxiety disorder characterized by avoidance of public places, especially where crowds gather. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:109513601 | rs3827760 | - | A>G | 210 | 5439 | 57.62 | 3.176e-14 | 0.5889 |
| chr2:150445102 | rs4618014 | - | A>G | 395 | 8495 | 44.81 | 2.173e-11 | 0.7082 |
| chr2:26113913 | rs78404020 | - | A>G | 349 | 7665 | 44.47 | 2.586e-11 | 0.6942 |
| chr19:7694662 | rs3760675 | - | T>C | 375 | 7968 | 39.37 | 3.504e-10 | 0.7175 |
| chr23:73544041 | rs17312507 | - | T>C | 224 | 5205 | 38.34 | 5.938e-10 | 0.6564 |
| chr1:169087494 | rs3766033 | ATP1B1 | G>C | 500 | 10012 | 35.14 | 3.067e-09 | 0.7611 |
| chr19:7710854 | Affx-16268850 | STXBP2 | T>C | 464 | 9378 | 34.8 | 3.659e-09 | 0.7545 |
| chr1:169190606 | rs6675220 | NME7 | G>A | 514 | 10198 | 33.6 | 6.753e-09 | 0.7684 |
| chr7:5494487 | rs72577283 | FBXL18 | T>C | 324 | 6817 | 31.87 | 1.652e-08 | 0.7252 |
| chr23:2843818 | rs2302077 | ARSD | A>G | 714 | 13489 | 30.93 | 2.676e-08 | 0.8061 |
| chr23:113179454 | rs72619782 | - | T>G | 448 | 8954 | 30.91 | 2.696e-08 | 0.7632 |
| chr2:3316021 | rs56240155 | EIPR1 | G>A | 2935 | 49683 | 30.78 | 2.892e-08 | 0.8954 |
| chr14:35857405 | rs61988300 | - | A>G | 6484 | 93311 | 30.09 | 4.118e-08 | 1.082 |
| chr7:78169182 | rs10243724 | MAGI2 | G>C | 459 | 9084 | 29.56 | 5.424e-08 | 0.7701 |
| chr6:93667780 | rs9363020 | - | G>A | 308 | 6447 | 29.28 | 6.262e-08 | 0.7292 |
| chr15:29223282 | rs8026324 | APBA2 | T>A | 1217 | 21791 | 29.25 | 6.377e-08 | 0.8503 |
| chr1:169345868 | rs1028180 | BLZF1 | A>G | 562 | 10840 | 29.18 | 6.593e-08 | 0.7904 |
| chr2:3313043 | rs73133173 | EIPR1 | A>C | 391 | 7893 | 29.03 | 7.131e-08 | 0.7558 |
| chr7:22797207 | rs73276345 | - | A>G | 1714 | 29864 | 28.82 | 7.952e-08 | 0.872 |
| chr20:9033714 | rs6086745 | - | A>G | 2346 | 40063 | 28.76 | 8.173e-08 | 0.8885 |
| chr14:35857405 | rs61988300 | - | A>G | 6271 | 90263 | 27.36 | 1.693e-07 | 1.08 |
| chr13:82899537 | Affx-9852717 | - | C>T | 7182 | 104117 | 24.06 | 9.359e-07 | 1.071 |
| chr14:35809244 | rs17103212 | - | C>T | 7711 | 112055 | 23.54 | 1.224e-06 | 1.068 |
| chr13:104973086 | rs7323636 | - | A>G | 11834 | 186534 | 22.99 | 1.625e-06 | 0.9427 |
| chr8:21591717 | rs34534358 | GFRA2 | A>G | 333 | 6604 | 21.95 | 2.803e-06 | 0.7681 |
| chr23:150890713 | rs56766712 | FATE1 | A>G | 4470 | 72999 | 21.83 | 2.973e-06 | 0.925 |
| chr6:62235412 | rs62424573 | - | C>A | 1927 | 26487 | 21.52 | 3.502e-06 | 1.12 |
| chr12:100482866 | rs17851246 | UHRF1BP1L | G>A | 2117 | 29279 | 20.78 | 5.158e-06 | 1.112 |
| chr3:43688012 | rs9856765 | ANO10 | G>A | 2036 | 28121 | 20.64 | 5.546e-06 | 1.114 |
| chr12:100585559 | rs11110282 | - | G>A | 2107 | 29159 | 20.6 | 5.666e-06 | 1.112 |
| chr8:23225745 | rs2294133 | LOXL2 | C>T | 1876 | 31809 | 20.51 | 5.932e-06 | 0.8949 |
| chr3:43618280 | rs56389778 | ANO10 | T>C | 2024 | 27985 | 20.09 | 7.404e-06 | 1.113 |
| chr3:75073052 | rs62258879 | - | G>A | 5368 | 86810 | 19.85 | 8.378e-06 | 0.9333 |
| chr17:72177159 | rs75443985 | - | A>G | 4065 | 58118 | 19.64 | 9.368e-06 | 1.08 |
| chr2:10338185 | rs72788358 | RRM2 | C>T | 9831 | 144608 | 19.52 | 9.958e-06 | 1.057 |
| chr12:100516793 | rs11110249 | UHRF1BP1L | T>A | 2041 | 28284 | 19.46 | 1.029e-05 | 1.11 |
| chr3:43591327 | rs17409162 | ANO10 | G>A | 2029 | 28119 | 19.45 | 1.035e-05 | 1.111 |
| chr12:104251424 | rs12368164 | - | G>A | 8856 | 140889 | 19.38 | 1.07e-05 | 0.9444 |
| chr14:21509929 | rs1243468 | NDRG2 | G>C | 4960 | 71426 | 19.17 | 1.194e-05 | 1.073 |
| chr4:134453158 | rs36022501 | - | G>A | 13705 | 203315 | 19.02 | 1.29e-05 | 1.053 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 228 | 7497 | 34.88 | 3.498e-09 | 0.6724 |
| chr15:45491394 | rs1648299 | SHF | T>C | 216 | 7090 | 32.53 | 1.172e-08 | 0.6746 |
| chr8:116837897 | rs7842594 | - | G>A | 431 | 12584 | 32.16 | 1.421e-08 | 0.7557 |
| chr20:2315543 | rs6132532 | AL121899.2 | A>G | 775 | 21074 | 31.59 | 1.905e-08 | 0.811 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 375 | 11107 | 30.68 | 3.047e-08 | 0.7463 |
| chr1:864757 | rs2340588 | SAMD11 | A>G | 241 | 7665 | 30.61 | 3.149e-08 | 0.696 |
| chr19:6391219 | rs8102597 | GTF2F1 | A>G | 1491 | 38154 | 30.51 | 3.326e-08 | 0.8592 |
| chr8:27324429 | rs3824103 | CHRNA2 | T>C | 546 | 15340 | 29.91 | 4.521e-08 | 0.7858 |
| chr5:83128858 | rs7709612 | - | A>G | 128 | 4603 | 29.56 | 5.411e-08 | 0.6162 |
| chr11:20065779 | rs3802800 | NAV2 | G>C | 266 | 8230 | 28.77 | 8.161e-08 | 0.7154 |
| chr9:140957557 | rs11137360 | CACNA1B | A>G | 285 | 8720 | 28.71 | 8.406e-08 | 0.7236 |
| chr5:39249206 | rs835194 | FYB1 | G>A | 386 | 11284 | 28.66 | 8.647e-08 | 0.7565 |
| chr7:137319214 | rs11982810 | DGKI | C>T | 256 | 7958 | 28.41 | 9.793e-08 | 0.7124 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 295 | 8934 | 28.15 | 1.125e-07 | 0.7297 |
| chr6:168550581 | rs6455491 | - | G>A | 362 | 10627 | 27.69 | 1.422e-07 | 0.7535 |
| chr7:146955688 | rs17170378 | CNTNAP2 | C>T | 1754 | 44053 | 27.28 | 1.76e-07 | 0.8751 |
| chr1:236085940 | rs12038310 | - | C>T | 203 | 6522 | 27.27 | 1.774e-07 | 0.6893 |
| chr5:64447660 | rs6879867 | ADAMTS6 | G>A | 146 | 4994 | 26.87 | 2.172e-07 | 0.6482 |
| chr1:173579034 | rs12065033 | AL139142.2 | C>T | 195 | 6292 | 26.77 | 2.296e-07 | 0.6866 |
| chr10:77126174 | rs1891678 | - | G>A | 362 | 10570 | 26.67 | 2.414e-07 | 0.7574 |
| chr2:58137755 | rs2678904 | VRK2 | T>G | 6885 | 161046 | 30.67 | 3.066e-08 | 0.9169 |
| chr2:58164435 | rs2678890 | VRK2 | T>C | 6818 | 159492 | 29.48 | 5.659e-08 | 0.9184 |
| chr2:58445910 | rs72618694 | FANCL | T>C | 5816 | 136600 | 26.85 | 2.199e-07 | 0.9192 |
| chr2:32510072 | rs390480 | YIPF4 | T>G | 6431 | 135426 | 26.4 | 2.771e-07 | 1.085 |
| chr2:58094873 | rs2717068 | - | C>A | 6720 | 156849 | 26.39 | 2.789e-07 | 0.9224 |
| chr2:58222928 | rs2312147 | VRK2 | C>T | 6587 | 153663 | 25.63 | 4.146e-07 | 0.9232 |
| chr2:231795066 | Affx-36450019 | GPR55 | C>T | 994 | 18802 | 25.38 | 4.697e-07 | 1.183 |
| chr2:32849207 | rs6723226 | - | A>G | 6639 | 140019 | 24.99 | 5.772e-07 | 1.082 |
| chr2:32718849 | rs6543658 | BIRC6 | A>G | 6600 | 139199 | 24.86 | 6.157e-07 | 1.082 |
| chr2:58311684 | rs12620940 | VRK2 | C>T | 5746 | 134609 | 24.26 | 8.425e-07 | 0.9227 |
| chr2:58014831 | rs13026830 | - | T>C | 6361 | 148213 | 23.61 | 1.178e-06 | 0.9253 |
| chr18:50346689 | rs1431731 | DCC | G>A | 1585 | 39595 | 23.44 | 1.29e-06 | 0.8783 |
| chr2:32620888 | rs10172510 | BIRC6 | G>A | 8143 | 173458 | 22.73 | 1.864e-06 | 1.076 |
| chr2:32661543 | rs12992095 | BIRC6 | C>A | 4057 | 84229 | 21.82 | 2.994e-06 | 1.089 |
| chr1:108589487 | rs76785680 | - | C>T | 968 | 18550 | 21.1 | 4.37e-06 | 1.168 |
| chr7:23543444 | rs12333686 | - | C>T | 6997 | 148246 | 21.02 | 4.538e-06 | 1.074 |
| chr5:60731458 | rs7709645 | ZSWIM6 | C>G | 8856 | 203570 | 20.91 | 4.805e-06 | 0.9328 |
| chr22:23941213 | rs112352859 | - | G>C | 815 | 15439 | 20.47 | 6.068e-06 | 1.181 |
| chr2:169570414 | rs114093421 | CERS6 | A>G | 458 | 8216 | 20.16 | 7.119e-06 | 1.243 |
| chr12:121682051 | rs2686340 | CAMKK2 | C>T | 3819 | 79309 | 20.06 | 7.524e-06 | 1.087 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: F32 | Depressive episode | 10/20 |
| ICD: F419 | Anxiety disorder, unspecified | 6/20 |