Statistics
| Case | Control |
|---|---|
| 17370 | 442824 |
Phenotype Definition
An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:103224594 | rs116595123 | SLC39A8 | T>C | 815 | 25077 | 28.84 | 7.878e-08 | 0.8245 |
| chr2:3313043 | rs73133173 | EIPR1 | A>C | 437 | 14026 | 22.94 | 1.674e-06 | 0.7917 |
| chr2:77379840 | rs72807284 | LRRTM4 | T>C | 661 | 20284 | 22.48 | 2.123e-06 | 0.8279 |
| chr9:44234927 | rs55755621 | - | G>A | 2671 | 74486 | 22.45 | 2.156e-06 | 0.9077 |
| chr1:230278488 | rs78428815 | GALNT2 | T>G | 397 | 12845 | 22.33 | 2.298e-06 | 0.7854 |
| chr7:146533276 | rs78695584 | CNTNAP2 | T>G | 1073 | 23673 | 22.24 | 2.403e-06 | 1.161 |
| chr4:179452868 | rs75768508 | - | A>G | 947 | 28141 | 22.23 | 2.417e-06 | 0.8541 |
| chr1:236085940 | rs12038310 | - | C>T | 467 | 14809 | 22.08 | 2.621e-06 | 0.8011 |
| chr13:27967085 | rs76657723 | - | T>G | 301 | 10051 | 21.69 | 3.204e-06 | 0.7613 |
| chr2:237222746 | rs60984264 | - | G>A | 613 | 18869 | 21.54 | 3.46e-06 | 0.8255 |
| chr12:68707287 | rs2306392 | MDM1 | G>A | 11651 | 286517 | 21.3 | 3.929e-06 | 1.054 |
| chr4:179424283 | rs17066229 | - | A>G | 920 | 27303 | 21.24 | 4.055e-06 | 0.8553 |
| chr23:132561910 | rs17000449 | - | T>G | 5801 | 152384 | 21.07 | 4.417e-06 | 1.072 |
| chr12:68742411 | rs4913438 | - | A>G | 11396 | 280011 | 21.06 | 4.46e-06 | 1.054 |
| chr6:31800868 | rs2471980 | - | G>C | 11814 | 311590 | 20.55 | 5.806e-06 | 0.9497 |
| chr6:31327334 | rs2523589 | - | T>G | 17872 | 466961 | 20.4 | 6.285e-06 | 0.9531 |
| chr10:22403894 | rs118081660 | - | G>C | 1255 | 28178 | 20.17 | 7.083e-06 | 1.141 |
| chr11:35404934 | rs4756226 | SLC1A2 | A>G | 5726 | 137993 | 20.08 | 7.433e-06 | 1.068 |
| chr12:133090939 | rs117170626 | FBRSL1 | G>A | 1257 | 28239 | 19.85 | 8.372e-06 | 1.14 |
| chr2:57213612 | rs13427160 | - | A>C | 443 | 13962 | 19.83 | 8.45e-06 | 0.8059 |
| chr4:103224594 | rs116595123 | SLC39A8 | T>C | 785 | 24463 | 31.64 | 1.858e-08 | 0.8139 |
| chr23:132561910 | rs17000449 | - | T>G | 5205 | 135528 | 24.99 | 5.759e-07 | 1.083 |
| chr7:146533276 | rs78695584 | CNTNAP2 | T>G | 1055 | 23236 | 22.36 | 2.255e-06 | 1.163 |
| chr6:31327334 | rs2523589 | - | T>G | 17085 | 447026 | 21.84 | 2.96e-06 | 0.9501 |
| chr6:26582327 | rs9393735 | - | A>G | 4591 | 124836 | 21.49 | 3.548e-06 | 0.9279 |
| chr12:133090939 | rs117170626 | FBRSL1 | G>A | 1238 | 27703 | 20.85 | 4.963e-06 | 1.145 |
| chr6:31334945 | rs2844575 | - | T>C | 16461 | 408602 | 20.4 | 6.279e-06 | 1.051 |
| chr6:26639613 | rs1027204 | ZNF322 | T>C | 15230 | 377687 | 20.23 | 6.875e-06 | 1.051 |
| chr12:68707287 | rs2306392 | MDM1 | G>A | 11089 | 272976 | 19.38 | 1.071e-05 | 1.053 |
| chr9:44234927 | rs55755621 | - | G>A | 2474 | 68794 | 19.35 | 1.088e-05 | 0.9108 |
| chr1:208036829 | rs1891422 | - | A>G | 2875 | 67670 | 19.15 | 1.207e-05 | 1.091 |
| chr2:33745336 | rs2305575 | RASGRP3 | C>T | 7216 | 192746 | 19.13 | 1.219e-05 | 0.9427 |
| chr1:48196251 | rs11211596 | - | G>A | 8873 | 235625 | 19.04 | 1.277e-05 | 0.9468 |
| chr6:26622734 | rs2101582 | - | C>T | 15251 | 378305 | 19.03 | 1.289e-05 | 1.049 |
| chr6:127617243 | rs11154391 | ECHDC1 | T>C | 5803 | 155962 | 19.0 | 1.306e-05 | 0.9381 |
| chr15:66556450 | rs17257440 | - | T>C | 3149 | 74412 | 18.85 | 1.414e-05 | 1.086 |
| chr10:29448724 | rs545294 | - | A>G | 15408 | 402990 | 18.74 | 1.502e-05 | 0.9534 |
| chr6:26629404 | rs2451741 | - | A>G | 15236 | 378063 | 18.69 | 1.536e-05 | 1.049 |
| chr2:23584565 | rs875077 | - | C>T | 11523 | 283928 | 18.66 | 1.565e-05 | 1.052 |
| chr12:33533374 | rs10732554 | SYT10 | T>C | 14229 | 373273 | 18.58 | 1.631e-05 | 0.9531 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 2247 | 13519 | 29.05 | 7.048e-08 | 0.8808 |
| chr4:103224594 | rs116595123 | SLC39A8 | T>C | 785 | 5109 | 27.13 | 1.906e-07 | 0.8173 |
| chr2:44065090 | Affx-20089987 | ABCG5 | G>A | 2151 | 12894 | 25.72 | 3.946e-07 | 0.8852 |
| chr12:33533374 | rs10732554 | SYT10 | T>C | 14229 | 78805 | 25.18 | 5.231e-07 | 0.942 |
| chr7:146533276 | rs78695584 | CNTNAP2 | T>G | 1055 | 4784 | 23.99 | 9.69e-07 | 1.184 |
| chr2:44073656 | rs41360247 | ABCG8 | T>C | 2174 | 12904 | 21.6 | 3.35e-06 | 0.8947 |
| chr13:39100824 | rs79450803 | - | T>C | 1584 | 7520 | 19.29 | 1.121e-05 | 1.132 |
| chr22:27242642 | rs136516 | - | A>G | 14093 | 77703 | 19.19 | 1.181e-05 | 0.9492 |
| chr1:48196251 | rs11211596 | - | G>A | 8873 | 49540 | 19.04 | 1.277e-05 | 0.9433 |
| chr8:16982443 | rs2904649 | - | A>G | 6821 | 34664 | 19.01 | 1.298e-05 | 1.067 |
| chr2:169015118 | rs2218701 | STK39 | C>T | 16491 | 90468 | 18.52 | 1.677e-05 | 0.9507 |
| chr7:38835035 | rs11984145 | VPS41 | C>T | 2553 | 12474 | 18.49 | 1.711e-05 | 1.102 |
| chr12:33479246 | rs11611627 | - | C>A | 10363 | 53323 | 18.32 | 1.868e-05 | 1.056 |
| chr2:77684774 | rs13030949 | LRRTM4 | C>T | 8644 | 44236 | 18.31 | 1.873e-05 | 1.06 |
| chr3:149135059 | rs111404472 | - | G>A | 2196 | 10646 | 18.25 | 1.934e-05 | 1.109 |
| chr4:146697205 | rs4835257 | ZNF827 | C>A | 16545 | 86138 | 18.15 | 2.043e-05 | 1.051 |
| chr17:75831416 | rs117915028 | - | T>C | 790 | 3580 | 18.05 | 2.153e-05 | 1.184 |
| chr7:98247288 | rs73143702 | NPTX2 | C>T | 595 | 2628 | 17.99 | 2.225e-05 | 1.214 |
| chr7:98378474 | rs73159468 | - | A>G | 639 | 2842 | 17.96 | 2.253e-05 | 1.206 |
| chr23:132561910 | rs17000449 | - | T>G | 5205 | 28827 | 17.93 | 2.288e-05 | 1.074 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: N320 | Bladder-neck obstruction | 1/20 |