Thickened skin

0001072

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
17016	443178

Phenotype Definition

Laminar thickening of skin. [HPO:sdoelken]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:31316699	rs28732138	HLA-B	G>A	3817	83840	138.9	4.581e-32	1.229
chr6:31289714	rs28894993	HLA-B	G>T	3856	84712	138.2	6.731e-32	1.227
chr6:31251924	rs12189871	HLA-B	C>T	3821	84070	134.9	3.421e-31	1.225
chr6:31242731	rs12199223	HLA-B	T>A	3685	80917	132.1	1.436e-30	1.227
chr6:31221698	rs1793891	-	C>T	10201	245397	116.4	3.905e-27	1.138
chr6:31233510	Affx-28446136	-	T>C	10092	242983	113.2	1.912e-26	1.136
chr6:31206979	rs2394895	-	T>C	10329	249023	112.8	2.395e-26	1.135
chr6:31210866	rs3134762	-	T>C	10317	248796	112.0	3.627e-26	1.134
chr6:31218239	rs3130424	-	A>C	10337	249246	111.6	4.466e-26	1.134
chr6:31206920	rs2394894	-	T>C	10319	249017	111.1	5.683e-26	1.134
chr6:31176226	rs3132506	-	T>C	10424	251847	110.7	7.029e-26	1.133
chr6:31196671	rs3130944	-	C>G	10655	258056	105.5	9.486e-25	1.129
chr6:31125978	rs3130455	CCHCR1	A>T	9218	221569	104.3	1.727e-24	1.134
chr6:31143652	rs887465	POU5F1	C>G	9717	234150	104.1	1.906e-24	1.132
chr15:48426484	rs1426654	SLC24A5	A>G	692	26834	103.8	2.275e-24	0.6746
chr6:31205617	rs3130713	-	G>T	10739	260666	103.1	3.122e-24	1.127
chr6:31177503	rs3132505	-	G>T	10435	252641	102.6	4.015e-24	1.128
chr6:31199208	rs3130473	-	C>T	10765	261298	102.5	4.261e-24	1.127
chr6:31147194	rs3130457	POU5F1	T>C	9739	234931	101.5	7.212e-24	1.13
chr6:31001143	rs13210132	MUC22	A>G	2483	53677	101.4	7.665e-24	1.238
chr6:31289714	rs28894993	HLA-B	G>T	3668	79556	129.6	5.104e-30	1.225
chr6:31316699	rs28732138	HLA-B	G>A	3628	78720	129.4	5.595e-30	1.226
chr6:31251924	rs12189871	HLA-B	C>T	3635	78970	126.4	2.56e-29	1.223
chr6:31242731	rs12199223	HLA-B	T>A	3505	75918	124.9	5.406e-29	1.226
chr6:31176226	rs3132506	-	T>C	10061	240210	102.7	3.828e-24	1.131
chr6:31206979	rs2394895	-	T>C	10029	239552	99.17	2.318e-23	1.128
chr6:31210866	rs3134762	-	T>C	10019	239343	98.75	2.859e-23	1.128
chr6:31221698	rs1793891	-	C>T	9881	235929	98.11	3.965e-23	1.128
chr6:31218239	rs3130424	-	A>C	10037	239772	98.05	4.089e-23	1.128
chr6:31196671	rs3130944	-	C>G	10323	247047	97.65	4.997e-23	1.126
chr6:31206920	rs2394894	-	T>C	10019	239555	97.4	5.659e-23	1.127
chr6:31199208	rs3130473	-	C>T	10410	249592	95.56	1.435e-22	1.124
chr6:31205617	rs3130713	-	G>T	10385	249100	95.29	1.644e-22	1.124
chr6:31233510	Affx-28446136	-	T>C	9780	233775	94.93	1.974e-22	1.126
chr6:31197293	rs3130942	-	C>T	10378	248885	94.55	2.388e-22	1.124
chr6:31177503	rs3132505	-	G>T	10071	240980	94.45	2.519e-22	1.125
chr6:31244082	rs13203895	HLA-B	C>T	4705	107182	92.1	8.255e-22	1.166
chr6:31143652	rs887465	POU5F1	C>G	9397	224288	91.24	1.271e-21	1.125
chr6:31001143	rs13210132	MUC22	A>G	2372	50862	91.07	1.386e-21	1.23
chr15:50785016	rs148783236	USP8	A>G	4703	107192	90.75	1.631e-21	1.165

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:31316699	rs28732138	HLA-B	G>A	3817	31141	134.4	4.369e-31	1.234
chr6:31289714	rs28894993	HLA-B	G>T	3856	31535	131.0	2.484e-30	1.229
chr6:31251924	rs12189871	HLA-B	C>T	3821	31281	128.5	8.555e-30	1.228
chr6:31242731	rs12199223	HLA-B	T>A	3685	30076	126.7	2.213e-29	1.23
chr6:31221698	rs1793891	-	C>T	10201	91908	99.36	2.104e-23	1.131
chr6:31233510	Affx-28446136	-	T>C	10092	91012	96.01	1.14e-22	1.129
chr6:31244082	rs13203895	HLA-B	C>T	4973	42692	95.9	1.211e-22	1.171
chr6:31240771	rs13203722	HLA-B	T>C	5220	45028	95.32	1.62e-22	1.167
chr15:50785016	rs148783236	USP8	A>G	4957	42541	95.3	1.638e-22	1.171
chr6:31001143	rs13210132	MUC22	A>G	2483	20001	94.95	1.952e-22	1.239
chr6:31245534	rs10456057	HLA-B	A>G	4933	42379	94.32	2.688e-22	1.17
chr6:31274555	rs10484554	HLA-B	C>T	4950	42541	94.32	2.69e-22	1.17
chr6:31206979	rs2394895	-	T>C	10329	93340	94.18	2.88e-22	1.127
chr6:31001177	rs28732080	MUC22	T>C	2480	19991	94.08	3.028e-22	1.238
chr6:31240932	rs13218306	HLA-B	C>A	5223	45098	94.07	3.04e-22	1.166
chr6:31252925	rs12191877	HLA-B	C>T	4871	41848	93.52	4.02e-22	1.17
chr6:31210866	rs3134762	-	T>C	10317	93267	93.12	4.922e-22	1.126
chr6:31218239	rs3130424	-	A>C	10337	93442	92.63	6.311e-22	1.125
chr6:31206920	rs2394894	-	T>C	10319	93347	92.3	7.436e-22	1.125
chr6:31176226	rs3132506	-	T>C	10424	94413	91.71	1.006e-21	1.125
chr6:31316699	rs28732138	HLA-B	G>A	3628	29282	126.9	1.987e-29	1.233
chr6:31289714	rs28894993	HLA-B	G>T	3668	29666	124.2	7.653e-29	1.229
chr6:31251924	rs12189871	HLA-B	C>T	3635	29437	121.6	2.856e-28	1.227
chr6:31242731	rs12199223	HLA-B	T>A	3505	28266	121.2	3.536e-28	1.231
chr6:31240771	rs13203722	HLA-B	T>C	4899	41594	95.24	1.682e-22	1.172
chr6:31244082	rs13203895	HLA-B	C>T	4705	39802	94.99	1.909e-22	1.175
chr6:31240932	rs13218306	HLA-B	C>A	4903	41666	94.17	2.891e-22	1.171
chr15:50785016	rs148783236	USP8	A>G	4703	39805	93.6	3.868e-22	1.174
chr6:31274555	rs10484554	HLA-B	C>T	4699	39822	92.88	5.57e-22	1.173
chr6:31245534	rs10456057	HLA-B	A>G	4679	39662	92.13	8.135e-22	1.173
chr6:31252925	rs12191877	HLA-B	C>T	4627	39210	91.73	9.928e-22	1.173
chr6:31087060	rs13201757	PSORS1C1	C>T	3951	33050	90.2	2.154e-21	1.185
chr6:31263297	rs28732109	HLA-B	G>A	4744	40322	90.02	2.359e-21	1.17
chr6:31090078	rs6913137	PSORS1C1	T>G	4007	33588	89.59	2.924e-21	1.183
chr6:31093190	rs6909321	PSORS1C1	G>A	3788	31622	88.94	4.076e-21	1.187
chr6:31267618	rs9380238	HLA-B	A>G	4939	42140	88.91	4.142e-21	1.165
chr6:31094803	rs17196961	PSORS1C1	G>T	3790	31666	87.9	6.897e-21	1.186
chr6:31095003	rs6931921	PSORS1C1	G>C	3708	30922	87.69	7.647e-21	1.188
chr6:31221698	rs1793891	-	C>T	9881	88407	87.59	8.056e-21	1.125
chr6:31001143	rs13210132	MUC22	A>G	2372	18966	87.07	1.047e-20	1.234

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: L400	Psoriasis vulgaris	4/20
ICD: L409	Psoriasis, unspecified	5/20
ICD: L570	Actinic keratosis	1/20
ICD: L858	Other specified epidermal thickening	1/20

ID	Name	Top Correlation
ICD-10: A630	Anogenital (venereal) warts	0/20
ICD-10: B351	Tinea unguium	0/20
ICD-10: C500	Nipple and areola	0/20
ICD-10: D130	Oesophagus	0/20
ICD-10: D377	Other digestive organs	0/20
ICD-10: G978	Other postprocedural disorders of nervous system	0/20
ICD-10: I730	Raynaud's syndrome	0/20
ICD-10: J383	Other diseases of vocal cords	0/20
ICD-10: K108	Other specified diseases of jaws	0/20
ICD-10: K224	Dyskinesia of oesophagus	0/20
ICD-10: L280	Lichen simplex chronicus	0/20
ICD-10: L439	Lichen planus, unspecified	0/20
ICD-10: L578	Other skin changes due to chronic exposure to nonionising radiation	0/20
ICD-10: L608	Other nail disorders	0/20
ICD-10: L739	Follicular disorder, unspecified	0/20
ICD-10: L814	Other melanin hyperpigmentation	0/20
ICD-10: L83	Acanthosis nigricans	0/20
ICD-10: L859	Epidermal thickening, unspecified	0/20
ICD-10: L900	Lichen sclerosus et atrophicus	0/20
ICD-10: L930	Discoid lupus erythematosus	0/20
ICD-10: M349	Systemic sclerosis, unspecified	0/20
ICD-10: M359	Systemic involvement of connective tissue, unspecified	0/20
ICD-10: M790	Rheumatism, unspecified	0/20
ICD-10: N085	Glomerular disorders in systemic connective tissue disorders	0/20
ICD-10: N904	Leukoplakia of vulva	0/20
ICD-10: R238	Other and unspecified skin changes	0/20
ICD-10: Y450	Opioids and related analgesics	0/20

Thickened skin

0001072

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ