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ICD-10
HPO
Compare GWAS

Super Class
Abnormality of the optic nerve
Morphological central nervous system abnormality
Sub Class
Nonarteritic anterior ischemic optic neuropathy

Optic neuropathy

0001138

Normal Case/Contol ^ⓘ

GWAS of 0001138

Sibling Case/Control ^ⓘ

No sibling GWAS available 0001138

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Interactive Plot

Statistics

Case	Control
965	459229

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr8:19805708	rs1801177	LPL	G>A	70	17177	32.47	1.211e-08	1.976
chr6:28754817	rs9257182	-	C>A	501	194837	25.88	3.627e-07	1.299
chr6:28792477	rs209181	-	G>A	427	162613	25.69	4.014e-07	1.317
chr6:28769671	rs2765220	-	T>C	449	173138	24.59	7.087e-07	1.303
chr3:45155614	rs112097437	CDCP1	C>T	117	35896	24.38	7.899e-07	1.595
chr4:165777992	rs72695868	-	C>T	88	25252	23.81	1.062e-06	1.693
chr6:29337500	rs6934993	OR5V1	A>G	624	252652	22.6	1.992e-06	1.256
chr7:64404296	rs12539512	-	C>T	116	83347	22.3	2.333e-06	0.638
chr6:28325201	rs6921919	ZKSCAN3	C>G	584	235147	21.62	3.328e-06	1.255
chr18:22100922	rs79385303	-	C>T	92	27311	21.51	3.511e-06	1.634
chr2:222016671	rs114548519	-	T>C	95	28434	21.4	3.728e-06	1.62
chr6:28325308	rs6922111	ZKSCAN3	C>T	582	235157	21.32	3.882e-06	1.254
chr6:29335661	rs9257794	OR5V1	C>T	616	251314	20.97	4.675e-06	1.247
chr16:47991323	rs72802536	-	C>T	85	24882	20.8	5.108e-06	1.65
chr1:97961878	rs115346130	DPYD	C>T	48	12063	20.49	5.983e-06	1.917
chr1:20883503	rs7545658	-	A>G	546	219086	20.25	6.807e-06	1.254
chr10:113529438	rs35349035	-	G>C	113	35600	20.17	7.086e-06	1.54
chr6:29821896	rs2734980	-	G>A	623	254168	19.91	8.111e-06	1.239
chr18:42619378	rs4890506	SETBP1	T>G	414	161508	19.81	8.541e-06	1.277
chr8:19762732	rs6586879	LPL	C>T	85	25285	19.73	8.922e-06	1.629
chr8:19762732	rs6586879	LPL	C>T	67	16645	29.68	5.107e-08	1.947
chr8:19805708	rs1801177	LPL	G>A	64	15783	29.05	7.042e-08	1.962
chr6:28325201	rs6921919	ZKSCAN3	C>G	556	221216	23.15	1.5e-06	1.273
chr4:165777992	rs72695868	-	C>T	82	23299	22.91	1.695e-06	1.707
chr6:28325308	rs6922111	ZKSCAN3	C>T	554	221229	22.83	1.77e-06	1.272
chr18:22100922	rs79385303	-	C>T	84	24097	22.44	2.165e-06	1.688
chr7:64404296	rs12539512	-	C>T	106	77509	22.31	2.324e-06	0.6254
chr1:97961878	rs115346130	DPYD	C>T	48	11900	21.29	3.942e-06	1.942
chr3:45155614	rs112097437	CDCP1	C>T	111	34612	21.23	4.069e-06	1.565
chr9:17293779	rs645117	CNTLN	G>A	581	319411	21.18	4.19e-06	0.7921
chr18:42619378	rs4890506	SETBP1	T>G	384	147552	20.81	5.077e-06	1.297
chr6:28792477	rs209181	-	G>A	403	155834	20.74	5.266e-06	1.29
chr10:113529438	rs35349035	-	G>C	112	35041	20.53	5.868e-06	1.55
chr6:28769671	rs2765220	-	T>C	424	166044	19.67	9.19e-06	1.276
chr6:28754817	rs9257182	-	C>A	469	185954	19.53	9.928e-06	1.264
chr1:20883503	rs7545658	-	A>G	500	198805	19.52	9.981e-06	1.259
chr6:29337500	rs6934993	OR5V1	A>G	591	240504	19.48	1.015e-05	1.243
chr2:222016671	rs114548519	-	T>C	92	27942	19.28	1.126e-05	1.593
chr1:120169137	rs4659222	ZNF697	C>A	856	362458	19.15	1.207e-05	1.223
chr6:26598004	rs4634439	ABT1	A>G	318	120369	19.13	1.218e-05	1.307

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr8:19762732	rs6586879	LPL	C>T	67	4689	28.93	7.511e-08	1.938
chr8:19805708	rs1801177	LPL	G>A	64	4484	27.58	1.504e-07	1.935
chr3:45155614	rs112097437	CDCP1	C>T	111	9552	22.68	1.918e-06	1.591
chr4:165777992	rs72695868	-	C>T	82	6585	21.98	2.754e-06	1.693
chr18:22100922	rs79385303	-	C>T	84	6780	21.93	2.822e-06	1.682
chr7:64404296	rs12539512	-	C>T	106	21453	20.86	4.948e-06	0.6345
chr1:97961878	rs115346130	DPYD	C>T	48	3353	20.74	5.262e-06	1.932
chr9:17293779	rs645117	CNTLN	G>A	581	89514	20.7	5.382e-06	0.7937
chr6:28325201	rs6921919	ZKSCAN3	C>G	556	62637	20.59	5.675e-06	1.257
chr6:28325308	rs6922111	ZKSCAN3	C>T	554	62609	20.39	6.318e-06	1.256
chr18:42619378	rs4890506	SETBP1	T>G	384	41448	20.31	6.572e-06	1.294
chr1:120169137	rs4659222	ZNF697	C>A	856	101308	19.82	8.511e-06	1.228
chr10:113529438	rs35349035	-	G>C	112	9918	19.45	1.031e-05	1.535
chr9:132150995	rs11789821	-	T>C	614	70580	19.22	1.165e-05	1.24
chr1:20883503	rs7545658	-	A>G	500	55923	18.82	1.439e-05	1.255
chr19:2705763	rs59593034	-	G>A	98	8515	18.71	1.519e-05	1.564
chr10:34468587	rs12254714	PARD3	C>A	123	11211	18.65	1.569e-05	1.495
chr2:222016671	rs114548519	-	T>C	92	7888	18.53	1.675e-05	1.582
chr23:31747144	rs17330048	DMD	T>C	87	7244	18.38	1.809e-05	1.603
chr5:155418126	rs79375969	SGCD	G>A	85	7198	18.14	2.054e-05	1.601

Associated Diseases ^ⓘ

ID	Name	Top Correlation

ID	Name	Top Correlation
ICD-10: H050	Acute inflammation of orbit	0/20
ICD-10: H46	Optic neuritis	0/20
ICD-10: H473	Other disorders of optic disk	0/20
ICD-10: H547	Unspecified visual loss	0/20