Statistics
| Case | Control |
|---|---|
| 4496 | 455698 |
Phenotype Definition
Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:235130071 | rs10177096 | - | A>G | 127 | 21123 | 31.32 | 2.191e-08 | 0.6087 |
| chr13:72463541 | rs1460465 | - | A>G | 91 | 16033 | 27.95 | 1.243e-07 | 0.5761 |
| chr15:69650053 | rs11072089 | PAQR5 | T>C | 352 | 47209 | 27.45 | 1.611e-07 | 0.7522 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 184 | 27342 | 26.78 | 2.276e-07 | 0.681 |
| chr21:19052087 | rs8128554 | - | T>G | 206 | 29596 | 24.6 | 7.045e-07 | 0.7055 |
| chr6:170242949 | rs9396958 | - | T>C | 96 | 16018 | 23.9 | 1.017e-06 | 0.6079 |
| chr8:57803673 | rs10958508 | - | A>C | 4660 | 452165 | 23.89 | 1.019e-06 | 1.108 |
| chr1:29752525 | rs9426345 | - | A>G | 101 | 16598 | 23.48 | 1.265e-06 | 0.6178 |
| chr6:90715964 | rs16882347 | BACH2 | C>T | 1161 | 135326 | 23.39 | 1.322e-06 | 0.8589 |
| chr20:648431 | rs6053807 | AL121758.1 | T>G | 133 | 20525 | 23.35 | 1.349e-06 | 0.6569 |
| chr8:31815829 | rs327399 | NRG1 | T>C | 117 | 18505 | 23.12 | 1.519e-06 | 0.6408 |
| chr8:30280833 | rs2979489 | RBPMS | A>G | 2624 | 247332 | 22.82 | 1.781e-06 | 1.117 |
| chr16:67357900 | rs79656987 | KCTD19 | G>T | 270 | 20693 | 22.81 | 1.793e-06 | 1.344 |
| chr12:10480508 | rs4102739 | KLRD1 | G>A | 2779 | 305841 | 22.66 | 1.934e-06 | 0.8974 |
| chr2:135303704 | rs58713275 | TMEM163 | A>G | 264 | 35937 | 22.65 | 1.943e-06 | 0.743 |
| chr11:69627762 | rs10908229 | FGF3 | G>A | 2015 | 187042 | 22.54 | 2.059e-06 | 1.127 |
| chr9:127267689 | rs3814134 | NR5A1 | A>G | 205 | 29001 | 22.42 | 2.191e-06 | 0.7161 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 124 | 19253 | 22.35 | 2.273e-06 | 0.6534 |
| chr2:23751828 | rs13015374 | KLHL29 | A>G | 550 | 68311 | 22.15 | 2.522e-06 | 0.8128 |
| chr4:156539639 | rs7679296 | - | C>T | 423 | 53947 | 22.06 | 2.642e-06 | 0.7913 |
| chr16:67357900 | rs79656987 | KCTD19 | G>T | 268 | 20387 | 22.63 | 1.963e-06 | 1.344 |
| chr3:111771157 | rs11927988 | TMPRSS7 | A>G | 2937 | 277517 | 20.81 | 5.059e-06 | 1.109 |
| chr5:121182996 | rs2116427 | - | G>A | 2374 | 221642 | 20.73 | 5.285e-06 | 1.116 |
| chr2:43974805 | rs76744729 | PLEKHH2 | C>A | 102 | 16031 | 20.2 | 6.991e-06 | 0.6407 |
| chr12:121926320 | rs12818602 | KDM2B | T>C | 142 | 20872 | 20.1 | 7.368e-06 | 0.6851 |
| chr11:69627762 | rs10908229 | FGF3 | G>A | 1973 | 182713 | 19.91 | 8.127e-06 | 1.121 |
| chr7:11981028 | rs77801298 | - | C>T | 245 | 18763 | 19.55 | 9.815e-06 | 1.333 |
| chr8:57803673 | rs10958508 | - | A>C | 4454 | 430781 | 19.51 | 1.002e-05 | 1.1 |
| chr20:42953115 | rs6073410 | - | C>T | 1063 | 122060 | 18.99 | 1.317e-05 | 0.8669 |
| chr12:10480508 | rs4102739 | KLRD1 | G>A | 2623 | 285175 | 18.97 | 1.331e-05 | 0.9032 |
| chr8:29513975 | rs73232593 | - | A>C | 144 | 10182 | 18.85 | 1.414e-05 | 1.441 |
| chr12:4137217 | rs2532549 | - | A>C | 164 | 11879 | 18.69 | 1.535e-05 | 1.407 |
| chr8:57826568 | rs12681817 | - | C>T | 3929 | 377026 | 18.63 | 1.586e-05 | 1.097 |
| chr11:112101559 | rs111330439 | PTS | C>T | 322 | 25753 | 18.44 | 1.755e-05 | 1.277 |
| chr2:69976661 | rs115809993 | ANXA4 | T>C | 365 | 29628 | 18.43 | 1.767e-05 | 1.259 |
| chr1:171154959 | rs2020870 | FMO2 | A>G | 520 | 63158 | 18.24 | 1.949e-05 | 0.8241 |
| chr3:12306778 | rs73019497 | - | G>A | 770 | 67257 | 18.19 | 1.998e-05 | 1.175 |
| chr18:55432311 | rs11663334 | ATP8B1 | T>C | 248 | 19212 | 18.19 | 1.996e-05 | 1.317 |
| chr6:93392046 | rs117969642 | - | T>G | 229 | 30569 | 18.13 | 2.06e-05 | 0.7519 |
| chr19:31929293 | rs10221471 | - | T>C | 1351 | 122952 | 17.86 | 2.374e-05 | 1.134 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:170403308 | rs79664434 | NEK1 | C>T | 740 | 918 | 24.9 | 6.034e-07 | 0.7729 |
| chr2:38642220 | rs959051 | - | G>C | 1057 | 1255 | 23.1 | 1.535e-06 | 0.8072 |
| chr2:23751828 | rs13015374 | KLHL29 | A>G | 550 | 704 | 23.08 | 1.552e-06 | 0.7541 |
| chr15:67034674 | rs117090955 | SMAD6 | G>A | 302 | 194 | 22.34 | 2.281e-06 | 1.549 |
| chr12:78665642 | rs795941 | - | C>T | 577 | 429 | 20.48 | 6.039e-06 | 1.344 |
| chr4:6647324 | rs10804983 | - | G>T | 1652 | 1862 | 20.3 | 6.61e-06 | 0.8447 |
| chr18:76703479 | rs73971164 | - | C>T | 316 | 429 | 20.19 | 7.026e-06 | 0.713 |
| chr9:105868318 | rs12686544 | - | G>A | 312 | 208 | 19.85 | 8.391e-06 | 1.494 |
| chr7:147938567 | rs11772596 | CNTNAP2 | C>A | 818 | 642 | 19.68 | 9.163e-06 | 1.275 |
| chr17:77152124 | rs9903870 | RBFOX3 | G>A | 267 | 371 | 19.61 | 9.494e-06 | 0.6979 |
| chr4:170521730 | rs62334509 | NEK1 | G>A | 859 | 1028 | 19.48 | 1.016e-05 | 0.8058 |
| chr15:75714310 | rs76005098 | SIN3A | T>C | 748 | 902 | 18.98 | 1.323e-05 | 0.7984 |
| chr5:121182996 | rs2116427 | - | G>A | 2586 | 2282 | 18.51 | 1.686e-05 | 1.154 |
| chr9:101778265 | rs2297603 | COL15A1 | G>T | 1068 | 874 | 18.0 | 2.213e-05 | 1.226 |
| chr1:78604013 | rs72687149 | GIPC2 | T>G | 359 | 251 | 17.95 | 2.267e-05 | 1.423 |
| chr9:92859610 | rs12552603 | - | G>A | 1435 | 1620 | 17.79 | 2.467e-05 | 0.8462 |
| chr16:86770016 | rs8051549 | - | G>C | 4361 | 4575 | 17.74 | 2.531e-05 | 0.8839 |
| chr2:196309295 | rs6761003 | - | T>C | 335 | 232 | 17.69 | 2.6e-05 | 1.438 |
| chr22:31575749 | rs79419741 | RNF185 | G>A | 138 | 212 | 17.36 | 3.087e-05 | 0.6337 |
| chr20:9904213 | rs6057026 | - | A>G | 2413 | 2119 | 17.32 | 3.164e-05 | 1.153 |
| chr4:170403308 | rs79664434 | NEK1 | C>T | 726 | 910 | 25.8 | 3.792e-07 | 0.7676 |
| chr15:67034674 | rs117090955 | SMAD6 | G>A | 300 | 193 | 22.64 | 1.953e-06 | 1.555 |
| chr4:170521730 | rs62334509 | NEK1 | G>A | 843 | 1022 | 20.86 | 4.953e-06 | 0.7983 |
| chr4:6647324 | rs10804983 | - | G>T | 1482 | 1695 | 20.72 | 5.324e-06 | 0.8367 |
| chr5:121182996 | rs2116427 | - | G>A | 2374 | 2081 | 20.62 | 5.6e-06 | 1.17 |
| chr15:75714310 | rs76005098 | SIN3A | T>C | 734 | 897 | 20.38 | 6.341e-06 | 0.7904 |
| chr2:23751828 | rs13015374 | KLHL29 | A>G | 499 | 638 | 19.82 | 8.492e-06 | 0.7602 |
| chr9:105868318 | rs12686544 | - | G>A | 295 | 196 | 19.56 | 9.768e-06 | 1.507 |
| chr1:78604013 | rs72687149 | GIPC2 | T>G | 356 | 248 | 18.73 | 1.505e-05 | 1.436 |
| chr2:43974805 | rs76744729 | PLEKHH2 | C>A | 102 | 171 | 18.62 | 1.595e-05 | 0.5842 |
| chr9:101778265 | rs2297603 | COL15A1 | G>T | 1040 | 853 | 18.21 | 1.978e-05 | 1.231 |
| chr1:204181317 | rs72749759 | GOLT1A | A>C | 369 | 485 | 18.12 | 2.071e-05 | 0.7406 |
| chr12:52265382 | rs697626 | - | G>T | 2506 | 2730 | 17.93 | 2.293e-05 | 0.8699 |
| chr2:38642220 | rs959051 | - | G>C | 974 | 1146 | 17.9 | 2.324e-05 | 0.8217 |
| chr8:58080486 | rs7015686 | - | A>G | 262 | 362 | 17.82 | 2.431e-05 | 0.7069 |
| chr19:51251956 | rs73044684 | - | G>C | 1371 | 1564 | 17.73 | 2.542e-05 | 0.8434 |
| chr1:78245642 | rs72683701 | MIGA1 | G>T | 381 | 272 | 17.66 | 2.639e-05 | 1.403 |
| chr12:6454297 | rs7297961 | - | A>G | 70 | 127 | 17.46 | 2.932e-05 | 0.5402 |
| chr6:78176870 | rs1213366 | - | A>G | 3760 | 3989 | 17.4 | 3.033e-05 | 0.8802 |
| chr5:4959331 | rs72737774 | - | C>T | 131 | 71 | 17.23 | 3.306e-05 | 1.833 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|