Statistics
| Case | Control |
|---|---|
| 12803 | 447391 |
Phenotype Definition
An abnormality of the spleen. [HPO:probinson]
Phenotype Comment
The spleen is an abdominal organ that functions as a member of the hematopoietic system and of the immune system.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:396321 | rs12203592 | IRF4 | C>T | 5950 | 195255 | 25.43 | 4.578e-07 | 1.078 |
| chr4:31762304 | rs35051162 | - | A>C | 3300 | 106073 | 23.93 | 1.001e-06 | 1.097 |
| chr2:60031166 | rs72814366 | - | A>G | 438 | 12134 | 22.91 | 1.698e-06 | 1.264 |
| chr2:60096269 | rs72816332 | - | G>T | 442 | 12336 | 21.6 | 3.361e-06 | 1.254 |
| chr24:14850341 | rs2032598 | USP9Y | T>C | 50 | 2762 | 20.63 | 5.57e-06 | 0.5276 |
| chr15:69732736 | rs937724 | KIF23 | T>C | 836 | 34096 | 20.6 | 5.648e-06 | 0.8511 |
| chr20:6773370 | rs12624364 | - | G>A | 891 | 36149 | 20.6 | 5.66e-06 | 0.8553 |
| chr15:92246643 | rs117527651 | - | G>A | 2397 | 76378 | 20.34 | 6.471e-06 | 1.103 |
| chr7:80402554 | rs13222151 | SEMA3C | G>A | 589 | 24698 | 20.0 | 7.736e-06 | 0.8284 |
| chr12:108654248 | rs114871330 | - | C>T | 675 | 19822 | 19.81 | 8.556e-06 | 1.193 |
| chr18:77755460 | rs57083541 | TXNL4A | T>C | 450 | 19318 | 19.42 | 1.05e-05 | 0.8094 |
| chr1:120273909 | rs12094392 | PHGDH | T>C | 697 | 20593 | 19.26 | 1.139e-05 | 1.187 |
| chr15:69728949 | rs3825858 | KIF23 | G>A | 821 | 33327 | 19.21 | 1.173e-05 | 0.8546 |
| chr1:171224087 | rs10798294 | FMO1 | C>G | 8689 | 291598 | 18.59 | 1.623e-05 | 1.059 |
| chr9:9919631 | rs28545236 | PTPRD | C>T | 2165 | 82507 | 18.21 | 1.98e-05 | 0.9077 |
| chr3:73861164 | rs13081760 | - | G>A | 2165 | 82519 | 18.12 | 2.078e-05 | 0.9079 |
| chr18:13585010 | rs1284402 | LDLRAD4 | T>C | 2668 | 85920 | 18.09 | 2.112e-05 | 1.092 |
| chr2:5600812 | rs792068 | - | T>C | 8860 | 320778 | 18.05 | 2.15e-05 | 0.9458 |
| chr9:118701934 | rs10983022 | - | G>A | 731 | 21756 | 18.04 | 2.158e-05 | 1.176 |
| chr18:58523947 | rs55980020 | - | A>G | 393 | 11046 | 18.04 | 2.158e-05 | 1.245 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 5876 | 193039 | 25.69 | 4.019e-07 | 1.08 |
| chr2:60031166 | rs72814366 | - | A>G | 424 | 11809 | 21.49 | 3.559e-06 | 1.259 |
| chr2:60096269 | rs72816332 | - | G>T | 429 | 11965 | 21.41 | 3.699e-06 | 1.257 |
| chr5:30137225 | rs4391181 | - | G>A | 7065 | 258440 | 20.29 | 6.644e-06 | 0.9381 |
| chr4:31762304 | rs35051162 | - | A>C | 3192 | 103319 | 20.27 | 6.718e-06 | 1.09 |
| chr15:92246643 | rs117527651 | - | G>A | 2335 | 74518 | 20.01 | 7.696e-06 | 1.104 |
| chr2:5600812 | rs792068 | - | T>C | 8191 | 298054 | 19.92 | 8.086e-06 | 0.9411 |
| chr18:58523947 | rs55980020 | - | A>G | 390 | 10874 | 19.59 | 9.604e-06 | 1.258 |
| chr18:13585010 | rs1284402 | LDLRAD4 | T>C | 2553 | 81971 | 19.41 | 1.056e-05 | 1.098 |
| chr15:78774271 | rs8042238 | IREB2 | T>C | 9491 | 343670 | 19.06 | 1.266e-05 | 0.9443 |
| chr7:32518614 | rs76226443 | - | G>T | 1174 | 36148 | 18.98 | 1.322e-05 | 1.141 |
| chr9:118701934 | rs10983022 | - | G>A | 719 | 21348 | 18.73 | 1.505e-05 | 1.181 |
| chr7:80402554 | rs13222151 | SEMA3C | G>A | 583 | 24357 | 18.63 | 1.584e-05 | 0.833 |
| chr16:16232976 | rs45455291 | ABCC1 | C>T | 786 | 23546 | 18.49 | 1.704e-05 | 1.171 |
| chr4:120850031 | rs77841345 | - | C>T | 4596 | 169705 | 18.41 | 1.78e-05 | 0.9315 |
| chr1:120273909 | rs12094392 | PHGDH | T>C | 592 | 17345 | 18.34 | 1.85e-05 | 1.198 |
| chr16:62677117 | rs117155835 | - | C>T | 641 | 18896 | 18.34 | 1.852e-05 | 1.19 |
| chr16:716273 | rs11866949 | WDR90 | T>C | 3392 | 110622 | 18.05 | 2.15e-05 | 1.083 |
| chr15:78789488 | rs13180 | IREB2 | T>C | 9501 | 343759 | 17.84 | 2.408e-05 | 0.9461 |
| chr17:36764491 | rs41379647 | - | A>G | 1256 | 38985 | 17.81 | 2.436e-05 | 1.132 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:60096269 | rs72816332 | - | G>T | 429 | 7126 | 24.98 | 5.791e-07 | 1.284 |
| chr2:60031166 | rs72814366 | - | A>G | 424 | 7047 | 24.65 | 6.886e-07 | 1.284 |
| chr5:30137225 | rs4391181 | - | G>A | 7065 | 157263 | 20.46 | 6.091e-06 | 0.9374 |
| chr18:58523947 | rs55980020 | - | A>G | 390 | 6575 | 20.14 | 7.19e-06 | 1.265 |
| chr15:92246643 | rs117527651 | - | G>A | 2335 | 45314 | 19.64 | 9.335e-06 | 1.104 |
| chr15:78774271 | rs8042238 | IREB2 | T>C | 9491 | 209119 | 19.4 | 1.058e-05 | 0.9433 |
| chr16:16232976 | rs45455291 | ABCC1 | C>T | 786 | 14269 | 18.93 | 1.357e-05 | 1.176 |
| chr16:716273 | rs11866949 | WDR90 | T>C | 3392 | 67174 | 18.46 | 1.737e-05 | 1.085 |
| chr6:89301303 | rs4707495 | - | A>C | 1875 | 36118 | 18.43 | 1.76e-05 | 1.111 |
| chr7:32518614 | rs76226443 | - | G>T | 1174 | 22007 | 18.28 | 1.907e-05 | 1.14 |
| chr5:29859644 | rs116168305 | - | G>A | 315 | 8533 | 18.2 | 1.987e-05 | 0.7822 |
| chr1:180219242 | rs7538567 | LHX4 | A>G | 943 | 17423 | 18.1 | 2.1e-05 | 1.156 |
| chr15:78789488 | rs13180 | IREB2 | T>C | 9501 | 209143 | 18.08 | 2.122e-05 | 0.9453 |
| chr9:118701934 | rs10983022 | - | G>A | 719 | 13000 | 18.02 | 2.189e-05 | 1.179 |
| chr16:62677117 | rs117155835 | - | C>T | 641 | 11490 | 17.98 | 2.228e-05 | 1.19 |
| chr1:120273909 | rs12094392 | PHGDH | T>C | 592 | 10547 | 17.95 | 2.272e-05 | 1.198 |
| chr9:79891789 | rs71511421 | VPS13A | T>C | 1124 | 21049 | 17.83 | 2.418e-05 | 1.141 |
| chr10:21211699 | rs186454254 | NEBL | T>G | 700 | 12664 | 17.71 | 2.567e-05 | 1.18 |
| chr1:206771341 | rs113616691 | EIF2D | G>A | 558 | 14197 | 17.66 | 2.639e-05 | 0.8326 |
| chr7:80402554 | rs13222151 | SEMA3C | G>A | 583 | 14760 | 17.66 | 2.642e-05 | 0.8359 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|