Statistics
| Case | Control |
|---|---|
| 19186 | 441008 |
Phenotype Definition
An anomaly of a toe. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 812 | 26714 | 100.2 | 1.398e-23 | 0.6989 |
| chr15:48392165 | rs1834640 | - | A>G | 1006 | 30618 | 75.13 | 4.416e-18 | 0.7555 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 532 | 17613 | 67.6 | 2.001e-16 | 0.6961 |
| chr23:71628912 | rs3012642 | AL133500.1 | A>G | 782 | 21942 | 63.23 | 1.84e-15 | 0.7469 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 496 | 16244 | 58.87 | 1.683e-14 | 0.7046 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 680 | 19271 | 58.57 | 1.962e-14 | 0.7404 |
| chr9:90684844 | rs4480216 | - | C>T | 839 | 25238 | 56.79 | 4.859e-14 | 0.7661 |
| chr16:87836531 | rs28380303 | - | C>T | 776 | 23489 | 55.04 | 1.182e-13 | 0.7615 |
| chr17:58786625 | rs2643103 | BCAS3 | G>A | 596 | 18662 | 53.45 | 2.658e-13 | 0.7369 |
| chr20:2315543 | rs6132532 | AL121899.2 | A>G | 1734 | 47800 | 52.96 | 3.409e-13 | 0.8339 |
| chr13:72441665 | rs3759505 | - | C>T | 506 | 16209 | 52.67 | 3.938e-13 | 0.7202 |
| chr16:29035406 | rs74014848 | - | A>G | 681 | 20800 | 51.54 | 6.999e-13 | 0.755 |
| chr1:36106253 | rs584598 | PSMB2 | A>G | 1503 | 41839 | 50.88 | 9.801e-13 | 0.8265 |
| chr4:56082270 | rs10014689 | - | C>T | 1143 | 32577 | 48.74 | 2.916e-12 | 0.8083 |
| chr16:88321213 | rs7184400 | - | A>G | 388 | 12821 | 48.33 | 3.61e-12 | 0.699 |
| chr6:170242949 | rs9396958 | - | T>C | 492 | 15622 | 48.19 | 3.873e-12 | 0.7272 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 612 | 18765 | 47.53 | 5.421e-12 | 0.7524 |
| chr2:211717706 | rs12995612 | - | C>G | 507 | 15965 | 47.32 | 6.022e-12 | 0.7327 |
| chr1:216641894 | rs7533687 | - | A>G | 564 | 17485 | 47.24 | 6.296e-12 | 0.7445 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 2431 | 64627 | 47.14 | 6.615e-12 | 0.864 |
| chr25:2691012 | rs142162416 | - | A>G | 1919 | 38521 | 35.25 | 2.901e-09 | 1.153 |
| chr25:154986418 | rs142918084 | - | C>G | 1472 | 29229 | 31.31 | 2.196e-08 | 1.165 |
| chr25:155058865 | rs73234550 | - | G>A | 1069 | 28942 | 29.18 | 6.588e-08 | 0.8432 |
| chr1:115437986 | rs6661511 | SYCP1 | G>A | 8395 | 183195 | 27.34 | 1.703e-07 | 1.068 |
| chr6:31429927 | rs3094228 | - | T>C | 7231 | 175168 | 23.98 | 9.739e-07 | 0.9368 |
| chr4:103188709 | rs13107325 | SLC39A8 | C>T | 3117 | 65747 | 23.93 | 9.998e-07 | 1.098 |
| chr17:69323448 | rs76965506 | - | A>G | 7471 | 163086 | 23.21 | 1.45e-06 | 1.066 |
| chr25:2645366 | rs311083 | - | C>G | 13589 | 322967 | 22.28 | 2.353e-06 | 0.9497 |
| chr4:96070525 | rs1970801 | BMPR1B | T>G | 15069 | 356800 | 21.96 | 2.781e-06 | 0.9511 |
| chr6:31434198 | rs3128987 | - | T>C | 6906 | 167128 | 21.87 | 2.925e-06 | 0.9385 |
| chr6:32582354 | rs5004277 | - | C>T | 15250 | 360364 | 21.65 | 3.266e-06 | 0.9514 |
| chr6:3262190 | rs72847872 | PSMG4 | C>T | 1024 | 27177 | 21.18 | 4.184e-06 | 0.8621 |
| chr3:36003776 | rs2054856 | - | G>A | 9378 | 206629 | 20.82 | 5.046e-06 | 1.057 |
| chr17:44326845 | rs2696624 | - | A>G | 8205 | 180190 | 20.76 | 5.198e-06 | 1.06 |
| chr17:17726965 | rs12936927 | SREBF1 | T>C | 12796 | 304049 | 20.42 | 6.203e-06 | 0.9512 |
| chr1:112277597 | rs1000947 | INKA2 | T>C | 13113 | 311139 | 20.18 | 7.04e-06 | 0.9518 |
| chr22:49574509 | rs2318943 | - | C>T | 11903 | 264113 | 20.17 | 7.095e-06 | 1.052 |
| chr1:115876618 | rs10776800 | NGF | T>G | 18612 | 438042 | 20.02 | 7.676e-06 | 0.9544 |
| chr1:66996088 | rs17129043 | - | G>A | 6020 | 146069 | 19.97 | 7.861e-06 | 0.938 |
| chr11:134247842 | rs10894804 | GLB1L2 | A>T | 18001 | 403621 | 19.94 | 7.974e-06 | 1.048 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:31851234 | rs652888 | EHMT2 | A>G | 8661 | 33806 | 41.69 | 1.068e-10 | 0.9152 |
| chr25:2691012 | rs142162416 | - | A>G | 1919 | 5966 | 39.21 | 3.814e-10 | 1.183 |
| chr6:32335347 | rs2143461 | TSBP1 | G>A | 7153 | 28115 | 39.14 | 3.94e-10 | 0.9121 |
| chr6:32333299 | rs3129924 | TSBP1 | C>T | 7157 | 28082 | 38.13 | 6.635e-10 | 0.9132 |
| chr6:32336766 | rs3129939 | TSBP1 | A>G | 7162 | 28127 | 38.03 | 6.952e-10 | 0.9133 |
| chr6:32336364 | rs3129937 | TSBP1 | C>A | 7167 | 28134 | 37.99 | 7.098e-10 | 0.9134 |
| chr6:32307532 | rs1033499 | TSBP1 | G>A | 7026 | 27592 | 37.89 | 7.492e-10 | 0.9129 |
| chr6:32333480 | rs3129926 | TSBP1 | T>C | 7174 | 28160 | 37.81 | 7.81e-10 | 0.9136 |
| chr6:32284340 | rs9268220 | TSBP1 | C>T | 6986 | 27451 | 37.79 | 7.884e-10 | 0.9128 |
| chr6:32289358 | rs7756177 | TSBP1 | G>A | 7391 | 28980 | 37.45 | 9.401e-10 | 0.9149 |
| chr25:154986418 | rs142918084 | - | C>G | 1472 | 4487 | 36.94 | 1.218e-09 | 1.205 |
| chr6:32335204 | rs2143462 | TSBP1 | G>A | 7203 | 28231 | 36.65 | 1.412e-09 | 0.915 |
| chr6:32148031 | rs1062070 | RNF5 | A>G | 7298 | 28592 | 36.64 | 1.42e-09 | 0.9154 |
| chr6:32277211 | rs9268192 | TSBP1 | C>T | 7750 | 30261 | 35.97 | 2.007e-09 | 0.9172 |
| chr6:32147696 | rs3130349 | RNF5 | G>A | 7378 | 28854 | 35.71 | 2.294e-09 | 0.9168 |
| chr6:32151934 | rs3131300 | AGER | A>G | 7343 | 28705 | 35.44 | 2.634e-09 | 0.9169 |
| chr6:32263458 | rs6910668 | TSBP1 | T>G | 7046 | 27608 | 35.37 | 2.725e-09 | 0.9157 |
| chr6:32264179 | rs9268153 | TSBP1 | C>T | 6988 | 27371 | 35.21 | 2.954e-09 | 0.9157 |
| chr6:32287754 | rs9268231 | TSBP1 | T>C | 6838 | 26758 | 34.83 | 3.602e-09 | 0.9152 |
| chr6:31434198 | rs3128987 | - | T>C | 6906 | 27064 | 34.82 | 3.615e-09 | 0.9158 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: J342 | Deviated nasal septum | 6/20 |
| ICD: M202 | Hallux rigidus | 6/20 |
| ICD: M204 | Other hammer toe(s) (acquired) | 6/20 |
| ICD: M205 | Other deformities of toe(s) (acquired) | 5/20 |