Statistics
| Case | Control |
|---|---|
| 26108 | 434086 |
Phenotype Definition
A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [HPO:probinson, NCIT:C3161]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:91469768 | rs12204116 | - | T>C | 12353 | 215898 | 38.35 | 5.914e-10 | 0.937 |
| chr5:167170953 | rs13436693 | TENM2 | A>C | 6034 | 92844 | 37.73 | 8.125e-10 | 1.09 |
| chr13:114585454 | rs7490083 | - | G>A | 17775 | 306261 | 32.89 | 9.766e-09 | 0.9477 |
| chr2:227446101 | rs75800364 | - | A>G | 4399 | 67217 | 31.23 | 2.293e-08 | 1.095 |
| chr13:96744951 | rs74372804 | HS6ST3 | G>A | 1153 | 16214 | 30.76 | 2.923e-08 | 1.186 |
| chr9:138959289 | rs10114701 | NACC2 | T>C | 2817 | 42268 | 29.08 | 6.93e-08 | 1.114 |
| chr25:2609031 | rs149548031 | - | C>T | 465 | 9948 | 28.69 | 8.477e-08 | 0.7753 |
| chr4:140949671 | rs11725252 | MAML3 | A>G | 24308 | 414610 | 28.16 | 1.12e-07 | 0.9543 |
| chr5:167140568 | rs10475523 | TENM2 | C>G | 3103 | 46887 | 28.16 | 1.115e-07 | 1.107 |
| chr7:89690199 | rs1990160 | - | T>C | 1492 | 28467 | 27.85 | 1.314e-07 | 0.8676 |
| chr2:227411359 | rs962171 | - | C>A | 2260 | 41918 | 26.94 | 2.103e-07 | 0.8919 |
| chr23:109671384 | rs768312 | AMMECR1 | T>C | 1032 | 14607 | 26.58 | 2.528e-07 | 1.183 |
| chr8:101943393 | rs6996921 | YWHAZ | C>A | 2465 | 36912 | 26.26 | 2.989e-07 | 1.115 |
| chr23:129686502 | rs3007758 | - | T>G | 1764 | 26021 | 26.03 | 3.36e-07 | 1.137 |
| chr10:134108692 | rs7074272 | STK32C | C>T | 21272 | 343674 | 25.83 | 3.722e-07 | 1.047 |
| chr2:150445102 | rs4618014 | - | A>G | 752 | 15087 | 25.77 | 3.844e-07 | 0.8264 |
| chr3:134533302 | rs6793917 | EPHB1 | C>A | 16955 | 272461 | 25.76 | 3.865e-07 | 1.049 |
| chr22:42448761 | rs5758563 | WBP2NL | G>T | 676 | 13700 | 25.74 | 3.904e-07 | 0.8181 |
| chr23:64367019 | rs7064929 | - | G>A | 1144 | 16422 | 24.84 | 6.229e-07 | 1.167 |
| chr14:90601236 | rs4453396 | KCNK13 | A>G | 5128 | 79602 | 24.83 | 6.251e-07 | 1.078 |
| chr5:167170953 | rs13436693 | TENM2 | A>C | 5520 | 85235 | 31.44 | 2.053e-08 | 1.086 |
| chr6:91469768 | rs12204116 | - | T>C | 11565 | 201292 | 29.83 | 4.711e-08 | 0.9425 |
| chr7:53212225 | rs4947784 | - | C>T | 11279 | 196397 | 28.92 | 7.544e-08 | 0.9429 |
| chr2:227446101 | rs75800364 | - | A>G | 4310 | 66105 | 28.11 | 1.147e-07 | 1.091 |
| chr13:114585454 | rs7490083 | - | G>A | 16780 | 288548 | 27.38 | 1.668e-07 | 0.9508 |
| chr7:53181639 | rs6969640 | - | C>T | 11412 | 197836 | 24.6 | 7.037e-07 | 0.9474 |
| chr2:227432257 | rs74316167 | - | G>A | 2336 | 35002 | 24.59 | 7.076e-07 | 1.114 |
| chr8:124807111 | rs72715041 | FAM91A1 | A>G | 1189 | 17086 | 24.24 | 8.499e-07 | 1.161 |
| chr3:187899989 | rs17350636 | LPP | T>C | 3741 | 57410 | 24.21 | 8.655e-07 | 1.09 |
| chr14:90601236 | rs4453396 | KCNK13 | A>G | 4896 | 75977 | 24.18 | 8.76e-07 | 1.079 |
| chr5:167140568 | rs10475523 | TENM2 | C>G | 2855 | 43302 | 24.08 | 9.24e-07 | 1.102 |
| chr14:90604999 | rs17799172 | KCNK13 | A>G | 8067 | 127353 | 23.72 | 1.112e-06 | 1.063 |
| chr6:32418848 | rs28895095 | - | G>A | 8427 | 133178 | 23.53 | 1.229e-06 | 1.061 |
| chr4:38798648 | rs5743618 | TLR1 | C>A | 11241 | 180139 | 23.5 | 1.248e-06 | 1.055 |
| chr3:100619865 | rs79373562 | ABI3BP | G>A | 1408 | 20533 | 22.7 | 1.892e-06 | 1.142 |
| chr6:32659878 | rs9275224 | - | A>G | 25622 | 416736 | 22.29 | 2.348e-06 | 1.044 |
| chr8:64708707 | rs17288962 | - | C>A | 5961 | 93151 | 21.93 | 2.83e-06 | 1.069 |
| chr6:32419782 | rs28895107 | - | T>C | 8598 | 136312 | 21.88 | 2.895e-06 | 1.059 |
| chr5:85867680 | rs62376302 | - | G>A | 2718 | 49393 | 21.67 | 3.241e-06 | 0.9101 |
| chr6:50965520 | rs78943356 | - | G>A | 770 | 10782 | 21.58 | 3.397e-06 | 1.19 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:396321 | rs12203592 | IRF4 | C>T | 11184 | 24836 | 72.13 | 2.016e-17 | 0.8961 |
| chr6:421281 | rs62389423 | - | G>A | 9053 | 20209 | 62.16 | 3.172e-15 | 0.8958 |
| chr6:31916400 | rs537160 | AL645922.1 | G>A | 18288 | 39082 | 43.13 | 5.114e-11 | 0.9292 |
| chr6:31922254 | rs630379 | NELFE | C>A | 16265 | 34889 | 41.21 | 1.366e-10 | 0.9289 |
| chr6:31919578 | rs2072633 | AL645922.1 | G>A | 24096 | 50944 | 39.53 | 3.237e-10 | 0.9348 |
| chr6:31929014 | rs437179 | SKIV2L | C>A | 16521 | 35339 | 38.18 | 6.446e-10 | 0.9317 |
| chr6:31947460 | rs389883 | STK19 | T>G | 16493 | 35295 | 37.42 | 9.545e-10 | 0.9324 |
| chr6:31927342 | rs440454 | SKIV2L | G>A | 16542 | 35381 | 37.14 | 1.098e-09 | 0.9326 |
| chr6:31936668 | rs410851 | SKIV2L | C>T | 16474 | 35239 | 36.52 | 1.514e-09 | 0.9331 |
| chr6:31928799 | rs419788 | SKIV2L | C>T | 16557 | 35371 | 35.99 | 1.988e-09 | 0.9337 |
| chr6:31143511 | rs887466 | POU5F1 | G>A | 19254 | 37673 | 34.39 | 4.516e-09 | 1.067 |
| chr6:31883957 | rs644045 | C2 | G>A | 19528 | 41444 | 34.05 | 5.382e-09 | 0.9377 |
| chr6:31327400 | rs2523587 | - | C>T | 18136 | 38567 | 33.86 | 5.919e-09 | 0.9368 |
| chr6:32670464 | rs2858305 | - | T>G | 20246 | 42929 | 32.91 | 9.633e-09 | 0.939 |
| chr6:32660375 | rs2858324 | - | G>A | 20608 | 43647 | 32.41 | 1.25e-08 | 0.9397 |
| chr6:32413830 | rs3763327 | - | C>G | 20236 | 42898 | 32.18 | 1.404e-08 | 0.9398 |
| chr6:31188397 | rs9263980 | - | G>A | 23520 | 49560 | 31.9 | 1.626e-08 | 0.9411 |
| chr6:32664458 | rs2647012 | - | C>T | 20672 | 43774 | 31.63 | 1.861e-08 | 0.9405 |
| chr6:31178233 | rs9263927 | - | T>C | 23556 | 49666 | 31.57 | 1.923e-08 | 0.9415 |
| chr6:32413459 | rs2227139 | - | A>G | 20242 | 42863 | 31.52 | 1.979e-08 | 0.9404 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: R69 | Unknown and unspecified causes of morbidity | 5/20 |