Statistics
| Case | Control |
|---|---|
| 47581 | 412613 |
Phenotype Definition
A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 8362 | 58696 | 288.1 | 1.297e-64 | 1.229 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 7115 | 49877 | 246.1 | 1.857e-55 | 1.228 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 10603 | 79505 | 163.6 | 1.853e-37 | 1.15 |
| chr2:66725070 | rs12995572 | MEIS1 | G>C | 3476 | 23675 | 153.7 | 2.724e-35 | 1.257 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 5064 | 35916 | 151.9 | 6.625e-35 | 1.208 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 5077 | 36070 | 149.6 | 2.071e-34 | 1.206 |
| chr11:61095368 | rs7397033 | DDB1 | T>C | 1993 | 12933 | 128.5 | 8.878e-30 | 1.316 |
| chr16:28995057 | rs11859822 | SPNS1 | T>C | 3680 | 25756 | 125.1 | 4.874e-29 | 1.222 |
| chr16:28954860 | rs7203982 | - | T>C | 3668 | 25714 | 122.6 | 1.678e-28 | 1.22 |
| chr6:100241479 | rs9495569 | - | A>G | 2890 | 19813 | 119.8 | 7.119e-28 | 1.247 |
| chr23:19215613 | rs5955734 | - | C>G | 3701 | 26324 | 119.7 | 7.476e-28 | 1.217 |
| chr23:102191083 | rs5987498 | - | G>T | 1998 | 13276 | 116.7 | 3.3e-27 | 1.299 |
| chr23:102201216 | rs725570 | - | A>G | 2425 | 16545 | 114.3 | 1.137e-26 | 1.266 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 2789 | 19154 | 113.9 | 1.387e-26 | 1.245 |
| chr1:31907102 | rs7417775 | SERINC2 | G>A | 4762 | 34477 | 112.4 | 2.888e-26 | 1.182 |
| chr23:64367019 | rs7064929 | - | G>A | 2255 | 15311 | 111.1 | 5.763e-26 | 1.272 |
| chr9:129562274 | rs78594581 | - | C>T | 1834 | 12045 | 108.4 | 2.195e-25 | 1.3 |
| chr5:100990247 | rs6883027 | - | G>A | 2951 | 20535 | 106.0 | 7.205e-25 | 1.228 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 2519 | 17432 | 105.0 | 1.249e-24 | 1.248 |
| chr16:129223 | rs710079 | MPG | C>T | 3468 | 24574 | 104.2 | 1.861e-24 | 1.207 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 21393 | 177522 | 45.5 | 1.527e-11 | 1.057 |
| chr1:216079027 | rs11590241 | USH2A | A>C | 6670 | 53390 | 40.65 | 1.825e-10 | 1.09 |
| chr1:216070254 | rs79692866 | USH2A | G>A | 9703 | 79038 | 37.98 | 7.135e-10 | 1.072 |
| chr6:421281 | rs62389423 | - | G>A | 17413 | 144452 | 37.45 | 9.367e-10 | 1.056 |
| chr8:3265590 | rs10088378 | CSMD1 | T>C | 32825 | 276826 | 34.67 | 3.903e-09 | 1.043 |
| chr17:27909352 | rs894606 | GIT1 | C>T | 39126 | 346717 | 28.9 | 7.625e-08 | 0.9633 |
| chr7:2078981 | rs56226325 | MAD1L1 | C>T | 14189 | 128500 | 28.54 | 9.171e-08 | 0.95 |
| chr7:2028968 | rs34809719 | MAD1L1 | G>T | 17018 | 153345 | 27.66 | 1.443e-07 | 0.9542 |
| chr4:38202641 | rs7671119 | - | C>T | 35255 | 312931 | 27.02 | 2.013e-07 | 0.9638 |
| chr17:28074563 | rs1038088 | SSH2 | G>T | 44814 | 395877 | 26.72 | 2.347e-07 | 0.9651 |
| chr18:77563334 | rs11665567 | - | G>A | 20518 | 171988 | 26.66 | 2.424e-07 | 1.044 |
| chr17:28076217 | rs2617866 | SSH2 | G>A | 44814 | 395751 | 26.31 | 2.913e-07 | 0.9654 |
| chr15:97950113 | rs12903357 | - | A>G | 29514 | 262639 | 26.13 | 3.195e-07 | 0.9628 |
| chr15:97963559 | rs7177625 | - | G>A | 29051 | 258577 | 26.06 | 3.309e-07 | 0.9627 |
| chr17:27924878 | rs62068577 | ANKRD13B | T>G | 37223 | 329742 | 25.56 | 4.295e-07 | 0.9647 |
| chr6:161010118 | rs10455872 | LPA | A>G | 7918 | 64832 | 25.18 | 5.213e-07 | 1.064 |
| chr16:82902451 | rs11150506 | CDH13 | A>C | 11290 | 93476 | 24.67 | 6.806e-07 | 1.054 |
| chr6:160608804 | rs16891156 | SLC22A2 | A>C | 2136 | 16563 | 24.43 | 7.723e-07 | 1.122 |
| chr1:201884952 | rs2819348 | LMOD1 | T>C | 34250 | 290258 | 24.4 | 7.823e-07 | 1.036 |
| chr12:133423662 | rs2306536 | CHFR | C>T | 16793 | 151046 | 24.25 | 8.441e-07 | 0.9567 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:111718067 | rs6843082 | - | A>G | 18890 | 14638 | 89.01 | 3.937e-21 | 0.8897 |
| chr4:111710169 | rs2200733 | - | C>T | 10166 | 8196 | 88.53 | 5.015e-21 | 0.8621 |
| chr4:111708287 | rs17042171 | - | C>A | 10117 | 8127 | 83.67 | 5.84e-20 | 0.8652 |
| chr4:111665917 | rs1906610 | - | G>A | 9262 | 7456 | 77.39 | 1.402e-18 | 0.8648 |
| chr4:111653211 | rs17042081 | - | G>T | 10352 | 8257 | 75.96 | 2.892e-18 | 0.8722 |
| chr4:111641053 | rs1448817 | - | A>G | 23627 | 17870 | 62.79 | 2.304e-15 | 0.9128 |
| chr4:111728614 | rs13141190 | - | G>A | 33874 | 25113 | 52.08 | 5.33e-13 | 0.9273 |
| chr4:111608485 | rs2723298 | - | C>T | 26604 | 19758 | 39.62 | 3.078e-10 | 0.9323 |
| chr25:2661556 | rs73188900 | - | A>C | 1803 | 1565 | 37.3 | 1.015e-09 | 0.8081 |
| chr4:111719685 | rs11931959 | - | A>G | 25629 | 19011 | 34.29 | 4.737e-09 | 0.9362 |
| chr4:111625464 | rs1375302 | - | T>C | 28386 | 20975 | 34.21 | 4.945e-09 | 0.938 |
| chr25:155104608 | rs5940618 | - | G>A | 19286 | 14420 | 32.67 | 1.091e-08 | 0.9315 |
| chr16:73051620 | rs2106261 | ZFHX3 | C>T | 16029 | 12047 | 31.43 | 2.072e-08 | 0.9283 |
| chr1:216070254 | rs79692866 | USH2A | G>A | 9703 | 6298 | 31.12 | 2.421e-08 | 1.1 |
| chr16:73068678 | rs879324 | ZFHX3 | G>A | 16137 | 12105 | 29.91 | 4.52e-08 | 0.9301 |
| chr1:216079027 | rs11590241 | USH2A | A>C | 6670 | 4262 | 28.38 | 9.988e-08 | 1.114 |
| chr1:154840287 | rs10908444 | KCNN3 | G>A | 40107 | 27479 | 28.2 | 1.096e-07 | 1.056 |
| chr4:111761487 | rs3853445 | - | T>C | 23943 | 16191 | 27.81 | 1.335e-07 | 1.064 |
| chr25:154999134 | rs6642320 | - | G>A | 33667 | 22955 | 26.32 | 2.899e-07 | 1.057 |
| chr1:154919080 | rs2061690 | PBXIP1 | C>T | 40415 | 27718 | 25.35 | 4.791e-07 | 1.053 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: R002 | Palpitations | 2/20 |
| ICD: R072 | Precordial pain | 2/20 |
| ICD: R073 | Other chest pain | 5/20 |
| ICD: R074 | Chest pain, unspecified | 15/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: N952 | Postmenopausal atrophic vaginitis | 0/20 |
| ICD-10: R071 | Chest pain on breathing | 0/20 |
| ICD-10: R42 | Dizziness and giddiness | 0/20 |