Statistics
| Case | Control |
|---|---|
| 53220 | 406974 |
Phenotype Definition
Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 23926 | 166337 | 206.0 | 1.007e-46 | 1.118 |
| chr6:32620399 | rs17843606 | - | T>G | 41593 | 334286 | 199.3 | 2.912e-45 | 0.9113 |
| chr6:32634838 | rs9274552 | HLA-DQB1 | C>A | 42035 | 337305 | 198.6 | 4.169e-45 | 0.9118 |
| chr6:32620775 | rs17843619 | - | A>C | 42575 | 341723 | 198.2 | 5.115e-45 | 0.9123 |
| chr6:32613712 | rs9273215 | HLA-DQA1 | A>G | 42702 | 342783 | 196.9 | 9.963e-45 | 0.9127 |
| chr6:32627714 | rs1063355 | HLA-DQB1 | G>T | 42733 | 342758 | 194.3 | 3.741e-44 | 0.9133 |
| chr6:32615458 | rs17612576 | - | A>G | 42517 | 340974 | 193.5 | 5.409e-44 | 0.9133 |
| chr6:32612488 | rs9273088 | HLA-DQA1 | C>A | 42599 | 341539 | 191.5 | 1.516e-43 | 0.9138 |
| chr6:32623430 | rs9273339 | - | A>G | 42775 | 343061 | 191.5 | 1.461e-43 | 0.9138 |
| chr6:32582650 | rs3104413 | - | C>G | 22543 | 156526 | 191.4 | 1.535e-43 | 1.116 |
| chr6:32625869 | Affx-28496566 | - | C>T | 40824 | 327138 | 189.2 | 4.662e-43 | 0.9126 |
| chr6:32577973 | rs532965 | - | T>G | 22703 | 157834 | 188.2 | 7.928e-43 | 1.115 |
| chr6:32612430 | Affx-37072023 | HLA-DQA1 | C>T | 45005 | 359815 | 187.6 | 1.047e-42 | 0.9154 |
| chr6:32583357 | rs6931277 | - | A>T | 22214 | 154478 | 183.4 | 8.624e-42 | 1.115 |
| chr6:32636866 | rs3134996 | - | T>A | 38032 | 306073 | 181.7 | 2.084e-41 | 0.9138 |
| chr6:32635809 | rs3828790 | HLA-DQB1 | C>T | 41783 | 334432 | 181.0 | 2.862e-41 | 0.9156 |
| chr6:32577380 | rs660895 | - | A>G | 25413 | 178234 | 174.4 | 7.911e-40 | 1.106 |
| chr6:32581973 | rs521539 | - | G>A | 25418 | 178379 | 173.6 | 1.195e-39 | 1.105 |
| chr6:32428062 | rs9268833 | - | C>T | 37505 | 268292 | 165.2 | 8.317e-38 | 1.09 |
| chr6:32428115 | rs9268835 | - | G>A | 37467 | 268247 | 163.7 | 1.733e-37 | 1.09 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 23038 | 160252 | 233.2 | 1.202e-52 | 1.129 |
| chr6:32582650 | rs3104413 | - | C>G | 21797 | 151397 | 218.2 | 2.217e-49 | 1.127 |
| chr6:32634838 | rs9274552 | HLA-DQB1 | C>A | 38739 | 314808 | 215.2 | 9.914e-49 | 0.9052 |
| chr6:32620399 | rs17843606 | - | T>G | 38332 | 312008 | 215.0 | 1.098e-48 | 0.9049 |
| chr6:32620775 | rs17843619 | - | A>C | 39238 | 318914 | 214.1 | 1.752e-48 | 0.9059 |
| chr6:32577973 | rs532965 | - | T>G | 21951 | 152716 | 213.3 | 2.629e-48 | 1.125 |
| chr6:32613712 | rs9273215 | HLA-DQA1 | A>G | 39365 | 319903 | 211.9 | 5.344e-48 | 0.9065 |
| chr6:32627714 | rs1063355 | HLA-DQB1 | G>T | 39391 | 319882 | 209.3 | 1.97e-47 | 0.9071 |
| chr6:32615458 | rs17612576 | - | A>G | 39196 | 318258 | 208.5 | 2.972e-47 | 0.9071 |
| chr6:32583357 | rs6931277 | - | A>T | 21482 | 149474 | 208.4 | 3.088e-47 | 1.125 |
| chr6:32612488 | rs9273088 | HLA-DQA1 | C>A | 39264 | 318724 | 206.6 | 7.461e-47 | 0.9075 |
| chr6:32612430 | Affx-37072023 | HLA-DQA1 | C>T | 41320 | 334648 | 206.5 | 8.044e-47 | 0.9084 |
| chr6:32623430 | rs9273339 | - | A>G | 39426 | 320109 | 206.1 | 9.657e-47 | 0.9077 |
| chr6:32625869 | Affx-28496566 | - | C>T | 37640 | 305276 | 203.7 | 3.305e-46 | 0.9065 |
| chr6:32577380 | rs660895 | - | A>G | 24319 | 170648 | 200.3 | 1.821e-45 | 1.117 |
| chr6:32581973 | rs521539 | - | G>A | 24326 | 170769 | 199.8 | 2.349e-45 | 1.116 |
| chr6:32635809 | rs3828790 | HLA-DQB1 | C>T | 38512 | 312122 | 196.6 | 1.126e-44 | 0.9091 |
| chr6:32636866 | rs3134996 | - | T>A | 35813 | 291023 | 183.0 | 1.079e-41 | 0.9109 |
| chr6:32428062 | rs9268833 | - | C>T | 35722 | 256393 | 182.9 | 1.136e-41 | 1.098 |
| chr6:32428115 | rs9268835 | - | G>A | 35685 | 256349 | 181.2 | 2.599e-41 | 1.098 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32626249 | rs6928482 | - | T>C | 51146 | 70472 | 165.6 | 6.771e-38 | 1.108 |
| chr6:32657543 | rs4642516 | - | G>T | 52397 | 72323 | 165.1 | 8.837e-38 | 1.108 |
| chr6:32637016 | rs9274697 | - | A>G | 52437 | 72386 | 164.1 | 1.469e-37 | 1.108 |
| chr6:32664332 | rs7745040 | - | T>C | 39955 | 54490 | 152.4 | 5.082e-35 | 1.108 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 23038 | 30572 | 145.7 | 1.54e-33 | 1.126 |
| chr6:32582650 | rs3104413 | - | C>G | 21797 | 28839 | 137.4 | 9.68e-32 | 1.125 |
| chr6:32577973 | rs532965 | - | T>G | 21951 | 29094 | 136.4 | 1.642e-31 | 1.124 |
| chr6:32581973 | rs521539 | - | G>A | 24326 | 32477 | 133.8 | 5.987e-31 | 1.118 |
| chr6:32427748 | rs9268831 | - | C>T | 52604 | 72994 | 133.1 | 8.611e-31 | 1.096 |
| chr6:32577380 | rs660895 | - | A>G | 24319 | 32483 | 131.1 | 2.359e-30 | 1.116 |
| chr6:32583357 | rs6931277 | - | A>T | 21482 | 28516 | 130.8 | 2.735e-30 | 1.122 |
| chr6:32409305 | rs6926374 | HLA-DRA | A>G | 49169 | 68108 | 128.5 | 8.917e-30 | 1.095 |
| chr6:32402889 | rs9268615 | - | G>A | 40399 | 55480 | 125.0 | 5e-29 | 1.097 |
| chr6:32411523 | rs2239804 | HLA-DRA | T>C | 49166 | 68154 | 124.4 | 7.053e-29 | 1.093 |
| chr6:32398675 | rs7756262 | - | T>A | 38973 | 53453 | 124.4 | 7.026e-29 | 1.098 |
| chr6:32428062 | rs9268833 | - | C>T | 35722 | 48758 | 124.2 | 7.528e-29 | 1.099 |
| chr6:32408527 | rs9268645 | HLA-DRA | C>G | 39904 | 54766 | 124.0 | 8.315e-29 | 1.097 |
| chr6:32428115 | rs9268835 | - | G>A | 35685 | 48755 | 123.7 | 9.955e-29 | 1.099 |
| chr6:32398202 | rs9268589 | - | G>A | 39985 | 54895 | 123.6 | 1.04e-28 | 1.096 |
| chr6:32409787 | rs6911419 | HLA-DRA | T>C | 49135 | 68107 | 122.6 | 1.733e-28 | 1.093 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: J330 | Polyp of nasal cavity | 6/20 |
| ICD: J339 | Nasal polyp, unspecified | 6/20 |
| ICD: J459 | Asthma, unspecified | 18/20 |