Statistics
| Case | Control |
|---|---|
| 8211 | 451983 |
Phenotype Definition
Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:15052947 | rs10516283 | CPEB2 | G>T | 8753 | 459325 | 25.42 | 4.608e-07 | 1.08 |
| chr5:78202968 | rs11747224 | ARSB | C>T | 1727 | 83495 | 24.61 | 7.017e-07 | 1.136 |
| chr17:53386117 | rs9892195 | HLF | A>C | 624 | 28014 | 23.46 | 1.279e-06 | 1.221 |
| chr3:61648251 | rs2365935 | PTPRG | G>A | 2426 | 120697 | 22.77 | 1.821e-06 | 1.111 |
| chr2:23794857 | rs115993808 | KLHL29 | G>A | 255 | 10356 | 22.04 | 2.671e-06 | 1.348 |
| chr6:164583566 | rs807916 | - | T>C | 3376 | 197977 | 21.93 | 2.832e-06 | 0.9135 |
| chr6:107241055 | rs9480707 | - | T>C | 541 | 24175 | 21.53 | 3.486e-06 | 1.227 |
| chr5:34769122 | rs114927146 | RAI14 | C>G | 235 | 17279 | 21.39 | 3.756e-06 | 0.7374 |
| chr6:31631531 | rs114733011 | GPANK1 | G>A | 542 | 24248 | 21.31 | 3.914e-06 | 1.225 |
| chr11:23997178 | rs16911969 | - | T>C | 1659 | 81089 | 20.86 | 4.928e-06 | 1.126 |
| chr4:39355501 | rs13142220 | RFC1 | G>A | 1791 | 88090 | 20.5 | 5.973e-06 | 1.121 |
| chr9:7802916 | rs17547673 | DMAC1 | T>C | 2733 | 137330 | 20.47 | 6.049e-06 | 1.1 |
| chr10:10321179 | rs7899465 | - | C>G | 1260 | 60706 | 20.31 | 6.584e-06 | 1.143 |
| chr16:73976130 | rs4402595 | - | A>G | 5416 | 311223 | 20.28 | 6.691e-06 | 0.9283 |
| chr6:138961124 | rs12528696 | NHSL1 | G>A | 3703 | 189155 | 20.19 | 7.026e-06 | 1.088 |
| chr3:143032574 | rs73868774 | SLC9A9 | T>C | 1168 | 56035 | 20.11 | 7.299e-06 | 1.147 |
| chr16:12536294 | rs7185322 | SNX29 | G>A | 6109 | 348755 | 19.84 | 8.406e-06 | 0.9313 |
| chr14:90813429 | rs2149652 | - | C>T | 8328 | 438247 | 19.76 | 8.765e-06 | 1.072 |
| chr11:111105024 | rs11820603 | - | C>A | 7202 | 408260 | 19.6 | 9.537e-06 | 0.9337 |
| chr15:78930510 | rs1316971 | CHRNB4 | G>A | 3492 | 203752 | 19.51 | 1.003e-05 | 0.9192 |
| chr3:143032574 | rs73868774 | SLC9A9 | T>C | 1049 | 49322 | 27.3 | 1.739e-07 | 1.183 |
| chr15:78930510 | rs1316971 | CHRNB4 | G>A | 2931 | 175635 | 25.24 | 5.059e-07 | 0.9019 |
| chr2:23794857 | rs115993808 | KLHL29 | G>A | 252 | 10215 | 23.46 | 1.273e-06 | 1.363 |
| chr3:61648251 | rs2365935 | PTPRG | G>A | 2315 | 115987 | 22.98 | 1.634e-06 | 1.115 |
| chr6:31631531 | rs114733011 | GPANK1 | G>A | 528 | 23648 | 22.57 | 2.026e-06 | 1.236 |
| chr15:79033489 | rs7176070 | - | C>T | 3696 | 217784 | 22.18 | 2.488e-06 | 0.9151 |
| chr4:39355501 | rs13142220 | RFC1 | G>A | 1739 | 85998 | 21.6 | 3.363e-06 | 1.126 |
| chr6:31862876 | rs115062572 | EHMT2 | C>T | 524 | 23637 | 20.97 | 4.672e-06 | 1.228 |
| chr4:15052947 | rs10516283 | CPEB2 | G>T | 8032 | 426287 | 20.71 | 5.354e-06 | 1.075 |
| chr3:127523282 | rs116020442 | MGLL | C>A | 311 | 13255 | 20.26 | 6.759e-06 | 1.297 |
| chr5:78202968 | rs11747224 | ARSB | C>T | 1489 | 72874 | 20.26 | 6.755e-06 | 1.132 |
| chr15:79045857 | rs11072800 | - | G>A | 3737 | 219181 | 20.13 | 7.246e-06 | 0.9192 |
| chr12:92999920 | rs920116 | - | A>G | 7043 | 403652 | 19.89 | 8.192e-06 | 0.9314 |
| chr5:62945522 | rs34030062 | - | C>T | 321 | 13800 | 19.75 | 8.818e-06 | 1.288 |
| chr16:847743 | rs2294451 | CHTF18 | C>T | 3665 | 189049 | 19.71 | 8.99e-06 | 1.088 |
| chr6:164583566 | rs807916 | - | T>C | 3219 | 190151 | 19.68 | 9.161e-06 | 0.9158 |
| chr20:12640401 | rs6041522 | - | T>C | 2210 | 132844 | 19.42 | 1.05e-05 | 0.9034 |
| chr9:7802916 | rs17547673 | DMAC1 | T>C | 2632 | 133680 | 19.27 | 1.136e-05 | 1.099 |
| chr15:79021140 | rs1814880 | - | C>T | 3675 | 215688 | 19.26 | 1.138e-05 | 0.9204 |
| chr3:82923002 | rs115819236 | - | G>A | 1283 | 62694 | 19.23 | 1.16e-05 | 1.137 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32625869 | Affx-28496566 | - | C>T | 6220 | 26211 | 65.12 | 7.047e-16 | 1.156 |
| chr6:32612430 | Affx-37072023 | HLA-DQA1 | C>T | 6761 | 28686 | 63.92 | 1.296e-15 | 1.151 |
| chr6:32612488 | rs9273088 | HLA-DQA1 | C>A | 6432 | 27302 | 60.36 | 7.893e-15 | 1.147 |
| chr6:32620399 | rs17843606 | - | T>G | 6297 | 26664 | 60.14 | 8.829e-15 | 1.148 |
| chr6:32634838 | rs9274552 | HLA-DQB1 | C>A | 6357 | 26989 | 59.93 | 9.832e-15 | 1.148 |
| chr6:32627714 | rs1063355 | HLA-DQB1 | G>T | 6455 | 27412 | 58.75 | 1.792e-14 | 1.145 |
| chr6:32635809 | rs3828790 | HLA-DQB1 | C>T | 6314 | 26795 | 58.69 | 1.844e-14 | 1.146 |
| chr6:32613712 | rs9273215 | HLA-DQA1 | A>G | 6449 | 27394 | 58.65 | 1.886e-14 | 1.145 |
| chr6:32620775 | rs17843619 | - | A>C | 6432 | 27309 | 58.52 | 2.012e-14 | 1.145 |
| chr6:32615458 | rs17612576 | - | A>G | 6421 | 27271 | 58.44 | 2.091e-14 | 1.145 |
| chr6:32623430 | rs9273339 | - | A>G | 6454 | 27437 | 56.33 | 6.131e-14 | 1.142 |
| chr6:32636866 | rs3134996 | - | T>A | 5876 | 24953 | 52.08 | 5.34e-13 | 1.139 |
| chr6:32428115 | rs9268835 | - | G>A | 5142 | 25934 | 49.89 | 1.628e-12 | 0.8776 |
| chr6:32428062 | rs9268833 | - | C>T | 5152 | 25953 | 48.68 | 3.018e-12 | 0.8791 |
| chr6:32546557 | rs34839759 | HLA-DRB1 | C>G | 5610 | 27998 | 45.56 | 1.478e-11 | 0.8849 |
| chr6:32560934 | rs28366302 | - | G>C | 5653 | 28230 | 44.41 | 2.663e-11 | 0.8866 |
| chr6:32492866 | rs111834747 | HLA-DRB5 | C>T | 5547 | 27687 | 44.34 | 2.759e-11 | 0.8858 |
| chr6:32433167 | rs2395185 | - | G>T | 5674 | 28353 | 44.18 | 2.993e-11 | 0.8867 |
| chr6:32546696 | rs3208409 | HLA-DRB1 | G>A | 5637 | 28143 | 43.4 | 4.464e-11 | 0.8877 |
| chr6:32546879 | Affx-28486470 | HLA-DRB1 | A>G | 5653 | 28207 | 43.3 | 4.688e-11 | 0.8879 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: R05 | Cough | 1/20 |