Neurodegeneration

0002180

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Sex Split

Interactive Plot

Statistics

Case	Control
6581	453613

Phenotype Definition

Progressive loss of neural cells and tissue. [HPO:probinson]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr19:45422946	rs4420638	-	A>G	3074	179437	106.3	6.186e-25	1.236
chr19:45410002	rs769449	APOE	G>A	2063	115857	99.37	2.09e-23	1.27
chr19:45395619	rs2075650	TOMM40	A>G	2341	138070	67.54	2.067e-16	1.206
chr19:45395714	rs157581	TOMM40	T>C	3420	212127	50.31	1.316e-12	1.151
chr18:13399272	rs79328727	LDLRAD4	A>G	132	14330	27.61	1.485e-07	0.6328
chr19:45324138	rs28399637	BCAM	G>A	4532	294610	24.14	8.961e-07	1.094
chr6:149664131	rs71568272	TAB2	A>G	1164	70080	23.3	1.384e-06	1.161
chr9:125548202	rs11793583	-	C>T	1480	90768	23.03	1.592e-06	1.142
chr7:75211414	rs237238	HIP1	A>G	842	68187	22.61	1.984e-06	0.8437
chr19:45414451	rs439401	-	C>T	4800	349968	20.51	5.929e-06	0.9219
chr2:136825272	rs932206	-	T>C	5053	367272	20.24	6.846e-06	0.923
chr19:5772950	rs61180947	CATSPERD	G>A	3160	233997	20.06	7.513e-06	0.9128
chr2:131508894	rs77116938	-	C>T	531	30332	19.56	9.757e-06	1.218
chr5:101155096	rs72770602	-	C>T	4505	328293	19.44	1.039e-05	0.9227
chr1:71047239	rs12135820	-	G>A	1083	65727	19.33	1.099e-05	1.15
chr2:19735627	rs12620079	-	A>G	243	22214	19.32	1.108e-05	0.752
chr1:212430756	rs12728266	-	A>G	2675	199297	19.12	1.228e-05	0.9097
chr4:176122493	rs13134743	-	T>C	5637	406621	18.97	1.328e-05	0.9271
chr4:143339095	rs17715398	INPP4B	T>C	133	13355	18.95	1.343e-05	0.6846
chr23:8550121	rs141578003	ANOS1	C>T	998	61418	18.84	1.422e-05	1.157
chr19:45422946	rs4420638	-	A>G	2915	170681	94.59	2.341e-22	1.228
chr19:45410002	rs769449	APOE	G>A	1997	112683	90.17	2.186e-21	1.261
chr19:45395619	rs2075650	TOMM40	A>G	2221	131546	59.0	1.578e-14	1.197
chr19:45395714	rs157581	TOMM40	T>C	3165	195262	48.89	2.713e-12	1.154
chr9:125548202	rs11793583	-	C>T	1432	85685	31.38	2.118e-08	1.171
chr6:149664131	rs71568272	TAB2	A>G	1148	68989	22.9	1.706e-06	1.161
chr19:45324138	rs28399637	BCAM	G>A	4388	285561	21.03	4.513e-06	1.089
chr19:5772950	rs61180947	CATSPERD	G>A	3035	224672	20.66	5.477e-06	0.9096
chr3:184303349	rs61545883	-	T>C	2346	148401	20.48	6.013e-06	1.109
chr19:45326664	rs10405693	-	C>T	4458	291779	18.87	1.402e-05	1.084
chr1:61624740	rs75783946	NFIA	A>C	311	16768	18.86	1.406e-05	1.285
chr4:143339095	rs17715398	INPP4B	T>C	130	13055	18.78	1.467e-05	0.6828
chr19:45414451	rs439401	-	C>T	4523	328796	18.78	1.466e-05	0.923
chr9:90101452	rs75268734	-	G>A	471	26649	18.64	1.579e-05	1.226
chr5:165043610	rs80167075	-	G>A	2496	159130	18.58	1.63e-05	1.101
chr10:120496670	rs6585505	CACUL1	C>T	2553	189912	18.53	1.672e-05	0.9088
chr19:3251219	rs17764205	CELF5	T>G	2162	136836	18.48	1.719e-05	1.107
chr1:71047239	rs12135820	-	G>A	1064	64653	17.97	2.242e-05	1.146
chr7:75211414	rs237238	HIP1	A>G	777	61969	17.58	2.755e-05	0.8557
chr5:100178754	rs116202507	ST8SIA4	G>A	483	27580	17.49	2.889e-05	1.216

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr4:64625952	rs77802160	-	A>G	402	301	23.0	1.622e-06	0.6902
chr5:147104275	rs7713010	JAKMIP2	C>T	2316	1029	22.93	1.677e-06	1.216
chr14:51491648	rs11844215	TRIM9	A>G	1678	1042	21.31	3.897e-06	0.8216
chr9:12481047	rs56305323	-	G>T	365	120	20.34	6.471e-06	1.608
chr4:176069166	rs17061161	-	C>A	4774	2718	19.44	1.036e-05	0.8736
chr2:238085547	rs67502140	-	C>A	830	329	19.14	1.215e-05	1.339
chr3:25223036	rs321524	RARB	G>A	2445	1110	19.13	1.222e-05	1.19
chr15:50146582	rs7165202	-	T>C	564	389	19.06	1.265e-05	0.7447
chr14:59665714	rs1152565	DAAM1	T>C	333	109	18.99	1.311e-05	1.618
chr14:80140401	rs74394317	NRXN3	C>T	330	247	18.82	1.438e-05	0.6915
chr4:143339095	rs17715398	INPP4B	T>C	130	117	18.81	1.442e-05	0.577
chr11:49075533	rs72904501	TRIM64C	C>T	211	171	18.68	1.544e-05	0.6402
chr4:185803073	rs56382498	-	A>C	1808	1100	18.36	1.828e-05	0.8371
chr14:85795572	rs117514109	-	G>A	331	247	18.34	1.851e-05	0.6949
chr2:238092122	rs7355390	-	C>T	1011	418	17.84	2.402e-05	1.289
chr11:50589087	rs72905285	-	C>T	234	184	17.74	2.528e-05	0.659
chr5:111668712	rs12517378	EPB41L4A	T>C	203	164	17.73	2.547e-05	0.642
chr10:18277652	rs72778339	SLC39A12	G>A	284	215	17.32	3.15e-05	0.6843
chr12:128654964	rs1877894	-	A>G	4700	2252	17.07	3.605e-05	1.14
chr22:45203246	rs116978125	PRR5-ARHGAP8	G>A	421	299	17.04	3.665e-05	0.7282

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: G309	Alzheimer's disease, unspecified	6/20
ICD: G318	Other specified degenerative diseases of nervous system	1/20
ICD: G319	Degenerative disease of nervous system, unspecified	1/20

ID	Name	Top Correlation
ICD-10: C713	Parietal lobe	0/20
ICD-10: F023	Dementia in Parkinson's disease	0/20
ICD-10: G930	Cerebral cysts	0/20
ICD-10: G939	Disorder of brain, unspecified	0/20
ICD-10: H530	Amblyopia ex anopsia	0/20
ICD-10: H538	Other visual disturbances	0/20
ICD-10: H539	Visual disturbance, unspecified	0/20
ICD-10: H549	Unspecified visual impairment (binocular)	0/20
ICD-10: H903	Sensorineural hearing loss, bilateral	0/20
ICD-10: O140	Moderate preeclampsia	0/20
ICD-10: R470	Dysphasia and aphasia	0/20
ICD-10: T435	Other and unspecified antipsychotics and neuroleptics	0/20

Neurodegeneration

0002180

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ