Statistics
| Case | Control |
|---|---|
| 192 | 460002 |
Phenotype Definition
A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:165395592 | rs75288102 | RXRG | G>A | 23 | 18485 | 30.12 | 4.061e-08 | 3.062 |
| chr15:56831661 | rs74419080 | - | C>T | 18 | 13320 | 28.31 | 1.035e-07 | 3.351 |
| chr5:59850224 | rs79394740 | - | A>G | 40 | 44133 | 25.18 | 5.214e-07 | 2.254 |
| chr7:64323552 | rs41474947 | - | C>T | 15 | 10656 | 24.71 | 6.675e-07 | 3.419 |
| chr20:258785 | rs78944940 | C20orf96 | G>T | 38 | 42261 | 23.73 | 1.109e-06 | 2.243 |
| chr8:37734755 | rs61746628 | RAB11FIP1 | G>A | 15 | 11029 | 23.19 | 1.467e-06 | 3.304 |
| chr1:109283654 | rs72697127 | FNDC7 | A>G | 21 | 18443 | 22.76 | 1.831e-06 | 2.784 |
| chr2:240430761 | rs74002813 | - | C>T | 23 | 21626 | 21.51 | 3.512e-06 | 2.608 |
| chr8:121818242 | rs117582647 | SNTB1 | C>T | 39 | 45565 | 21.26 | 4.02e-06 | 2.134 |
| chr11:44843134 | rs11038167 | TSPAN18 | A>C | 14 | 10435 | 21.25 | 4.025e-06 | 3.268 |
| chr7:64361241 | rs78670515 | ZNF273 | A>G | 29 | 30207 | 21.2 | 4.147e-06 | 2.365 |
| chr23:27430654 | rs144084329 | - | T>C | 31 | 35552 | 21.0 | 4.584e-06 | 2.327 |
| chr5:173015152 | rs72822174 | - | C>A | 28 | 28983 | 20.74 | 5.252e-06 | 2.374 |
| chr2:129857028 | rs114033225 | - | G>A | 17 | 14209 | 20.42 | 6.209e-06 | 2.911 |
| chr11:111128963 | rs75651722 | C11orf53 | G>A | 14 | 10653 | 20.42 | 6.219e-06 | 3.2 |
| chr7:51774342 | rs12718533 | - | T>C | 193 | 352415 | 20.34 | 6.485e-06 | 1.555 |
| chr11:16372007 | rs72869994 | SOX6 | A>G | 20 | 18069 | 20.26 | 6.776e-06 | 2.694 |
| chr17:74972170 | rs61641128 | - | A>G | 47 | 59613 | 19.97 | 7.883e-06 | 1.973 |
| chr8:139537588 | rs72725686 | - | G>T | 56 | 75377 | 19.82 | 8.488e-06 | 1.877 |
| chr7:152746240 | rs7790868 | - | A>C | 206 | 383471 | 19.7 | 9.043e-06 | 1.545 |
| chr7:64323552 | rs41474947 | - | C>T | 15 | 9745 | 29.6 | 5.32e-08 | 3.793 |
| chr1:165395592 | rs75288102 | RXRG | G>A | 22 | 18027 | 28.35 | 1.01e-07 | 3.04 |
| chr17:74972170 | rs61641128 | - | A>G | 46 | 53990 | 25.7 | 3.987e-07 | 2.176 |
| chr8:37734755 | rs61746628 | RAB11FIP1 | G>A | 15 | 10811 | 24.6 | 7.057e-07 | 3.416 |
| chr16:847936 | rs117923274 | CHTF18 | C>T | 18 | 14924 | 24.51 | 7.409e-07 | 3.117 |
| chr10:100123612 | rs11814584 | - | T>C | 48 | 58331 | 24.4 | 7.843e-07 | 2.107 |
| chr11:111128963 | rs75651722 | C11orf53 | G>A | 14 | 9962 | 23.68 | 1.135e-06 | 3.47 |
| chr5:59850224 | rs79394740 | - | A>G | 37 | 41085 | 23.59 | 1.193e-06 | 2.265 |
| chr7:64361241 | rs78670515 | ZNF273 | A>G | 29 | 29694 | 22.86 | 1.745e-06 | 2.446 |
| chr5:93746810 | rs58184555 | KIAA0825 | T>C | 57 | 75836 | 22.35 | 2.278e-06 | 1.948 |
| chr23:27430654 | rs144084329 | - | T>C | 31 | 35107 | 22.17 | 2.5e-06 | 2.386 |
| chr1:109283654 | rs72697127 | FNDC7 | A>G | 20 | 17783 | 21.63 | 3.3e-06 | 2.783 |
| chr11:16372007 | rs72869994 | SOX6 | A>G | 20 | 17763 | 21.58 | 3.394e-06 | 2.78 |
| chr16:79811120 | rs112017732 | - | G>T | 36 | 41172 | 21.38 | 3.765e-06 | 2.202 |
| chr7:51774342 | rs12718533 | - | T>C | 183 | 333594 | 21.31 | 3.902e-06 | 1.596 |
| chr16:845819 | rs2294446 | CHTF18 | A>G | 19 | 16891 | 21.17 | 4.212e-06 | 2.822 |
| chr8:121818242 | rs117582647 | SNTB1 | C>T | 38 | 44622 | 21.13 | 4.298e-06 | 2.153 |
| chr5:67238839 | rs12658630 | - | C>T | 99 | 155770 | 21.12 | 4.312e-06 | 1.699 |
| chr3:122339936 | rs73192177 | PARP15 | C>T | 24 | 23705 | 20.78 | 5.16e-06 | 2.529 |
| chr9:91444149 | rs117615916 | - | T>A | 16 | 13101 | 20.63 | 5.577e-06 | 3.016 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:6343063 | rs157300 | - | G>A | 1 | 3 | 71.23 | 3.184e-17 | 0.007833 |
| chr17:77435148 | rs60236734 | RBFOX3 | G>A | 1 | 3 | 70.85 | 3.85e-17 | 0.007874 |
| chr9:109297345 | rs5899707 | - | A>AG | 0 | 2 | 64.32 | 1.055e-15 | 0.0 |
| chr12:45430105 | rs11182802 | DBX2 | G>C | 0 | 2 | 64.32 | 1.055e-15 | 0.0 |
| chr12:45467602 | rs73280803 | - | T>C | 0 | 2 | 64.32 | 1.055e-15 | 0.0 |
| chr17:25485020 | rs79786666 | - | G>T | 7 | 5 | 62.87 | 2.213e-15 | 0.02599 |
| chr17:25352832 | rs116996972 | - | T>C | 7 | 5 | 62.87 | 2.213e-15 | 0.02599 |
| chr17:22145506 | rs11150730 | - | C>T | 7 | 5 | 62.52 | 2.64e-15 | 0.02613 |
| chr17:22183129 | rs118171966 | - | C>T | 4 | 4 | 61.3 | 4.899e-15 | 0.02105 |
| chr17:25567080 | rs12602978 | - | C>T | 8 | 5 | 57.42 | 3.514e-14 | 0.02979 |
| chr3:142171595 | rs11717703 | ATR | G>A | 2 | 3 | 55.93 | 7.505e-14 | 0.01571 |
| chr22:36863491 | rs8141619 | TXN2 | G>A | 2 | 3 | 55.93 | 7.505e-14 | 0.01571 |
| chr2:236033076 | rs115504974 | - | G>T | 5 | 4 | 53.75 | 2.274e-13 | 0.02639 |
| chr3:172045902 | rs79337583 | FNDC3B | G>A | 5 | 4 | 53.75 | 2.274e-13 | 0.02639 |
| chr4:744067 | rs17721689 | PCGF3 | G>C | 2 | 3 | 53.53 | 2.546e-13 | 0.01639 |
| chr8:72944617 | rs78574213 | TRPA1 | G>A | 9 | 5 | 52.76 | 3.768e-13 | 0.0336 |
| chr5:75216636 | rs115354848 | - | G>A | 10 | 5 | 48.44 | 3.401e-12 | 0.03763 |
| chr19:24264524 | rs56195414 | ZNF254 | G>A | 1 | 2 | 47.86 | 4.583e-12 | 0.01096 |
| chr4:145453103 | rs75595362 | AC098588.2 | G>A | 6 | 4 | 47.72 | 4.923e-12 | 0.03175 |
| chr14:59413010 | rs61975146 | - | T>G | 3 | 3 | 45.74 | 1.35e-11 | 0.02362 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: F801 | Expressive language disorder | 3/20 |
| ID | Name | Top Correlation |
|---|