Upper motor neuron dysfunction


Normal Case/Contol

GWAS of 0002493

Sibling Case/Control

No sibling GWAS available 0002493


Case Control
22505 437689

Phenotype Definition

A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs. [HPO:probinson]

Phenotype Comment

A functional deficit of the tract that conveys nervous impulses from the motor cortex of the brain to the spinal cord. The corticospinal tract mediates discrete voluntary skilled movements. Clinical features of corticospinal tract dysfunction may include spasticity and weakness, particularly affecting the lower limbs, as well as hyperreflexia, clonus at the ankles and knees, and extensor plantar responses (Babinski response).

Top SNP Information

Associated Diseases

ID Name Top Correlation
ICD: M479 Spondylosis, unspecified 1/20