Statistics
| Case | Control |
|---|---|
| 7642 | 452552 |
Phenotype Definition
Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr16:57183274 | rs78751841 | - | A>G | 575 | 26421 | 35.2 | 2.978e-09 | 1.289 |
| chr10:116071128 | rs76313352 | AFAP1L2 | T>C | 381 | 17389 | 24.32 | 8.15e-07 | 1.294 |
| chr19:54562619 | rs73060626 | VSTM1 | A>G | 434 | 20194 | 23.81 | 1.065e-06 | 1.27 |
| chr3:7686957 | rs9850541 | GRM7 | T>C | 1061 | 53987 | 23.24 | 1.428e-06 | 1.167 |
| chr4:111516322 | rs113989538 | - | T>A | 286 | 12649 | 22.97 | 1.649e-06 | 1.334 |
| chr3:193979362 | rs73075694 | - | C>A | 1423 | 74049 | 22.21 | 2.447e-06 | 1.141 |
| chr11:47538102 | rs117784947 | CELF1 | T>C | 1026 | 52239 | 22.01 | 2.715e-06 | 1.165 |
| chr11:47746962 | rs11039358 | FNBP4 | A>G | 1092 | 55934 | 21.52 | 3.509e-06 | 1.158 |
| chr11:86103702 | rs10501615 | CCDC81 | A>G | 227 | 9807 | 21.41 | 3.702e-06 | 1.366 |
| chr20:40985566 | rs79159352 | PTPRT | C>A | 726 | 36017 | 21.14 | 4.261e-06 | 1.193 |
| chr2:119892556 | rs17798163 | - | G>A | 936 | 47497 | 20.85 | 4.957e-06 | 1.168 |
| chr8:15952841 | rs117033280 | - | A>G | 152 | 12891 | 20.7 | 5.374e-06 | 0.6902 |
| chr18:9536315 | rs14336 | RALBP1 | A>C | 281 | 12586 | 20.69 | 5.41e-06 | 1.318 |
| chr1:156558843 | rs10796962 | - | A>C | 3543 | 222972 | 20.56 | 5.791e-06 | 0.9168 |
| chr18:46222367 | rs16949816 | CTIF | G>A | 355 | 16400 | 20.55 | 5.818e-06 | 1.278 |
| chr6:108602696 | rs9486843 | - | C>T | 305 | 13812 | 20.42 | 6.202e-06 | 1.301 |
| chr1:156565834 | rs12024215 | GPATCH4 | G>C | 3564 | 223805 | 20.37 | 6.398e-06 | 0.9174 |
| chr8:107941373 | rs74876892 | - | A>G | 225 | 9803 | 20.29 | 6.665e-06 | 1.356 |
| chr4:149283684 | rs72729952 | NR3C2 | G>C | 552 | 26814 | 20.21 | 6.956e-06 | 1.217 |
| chr1:182429995 | rs10911080 | RGSL1 | C>A | 2793 | 177241 | 20.15 | 7.164e-06 | 0.9103 |
| chr16:57183274 | rs78751841 | - | A>G | 561 | 25768 | 36.68 | 1.389e-09 | 1.3 |
| chr19:54562619 | rs73060626 | VSTM1 | A>G | 420 | 19793 | 22.09 | 2.608e-06 | 1.264 |
| chr1:156565834 | rs12024215 | GPATCH4 | G>C | 3244 | 206506 | 21.92 | 2.847e-06 | 0.9109 |
| chr1:156558843 | rs10796962 | - | A>C | 3235 | 206282 | 21.82 | 3.002e-06 | 0.9109 |
| chr8:23148940 | rs2272761 | R3HCC1 | A>G | 5605 | 348025 | 20.51 | 5.93e-06 | 0.9239 |
| chr3:117238369 | rs6792959 | - | T>C | 2274 | 146931 | 20.34 | 6.471e-06 | 0.9019 |
| chr8:31880140 | rs116076530 | NRG1 | A>C | 384 | 18087 | 20.34 | 6.491e-06 | 1.265 |
| chr1:182429995 | rs10911080 | RGSL1 | C>A | 2636 | 168953 | 20.22 | 6.885e-06 | 0.9075 |
| chr4:149283684 | rs72729952 | NR3C2 | G>C | 542 | 26489 | 20.17 | 7.075e-06 | 1.219 |
| chr19:8929561 | rs118128745 | ZNF558 | T>C | 269 | 12126 | 20.12 | 7.268e-06 | 1.321 |
| chr8:31921896 | rs116841098 | NRG1 | G>A | 546 | 26714 | 20.11 | 7.304e-06 | 1.218 |
| chr8:15952841 | rs117033280 | - | A>G | 149 | 12687 | 19.89 | 8.208e-06 | 0.6926 |
| chr18:9255718 | Affx-15483831 | ANKRD12 | G>A | 273 | 12465 | 19.78 | 8.678e-06 | 1.315 |
| chr2:119892556 | rs17798163 | - | G>A | 894 | 45785 | 19.53 | 9.893e-06 | 1.166 |
| chr6:18542918 | rs74527361 | - | G>A | 263 | 11878 | 19.19 | 1.184e-05 | 1.316 |
| chr8:23150878 | rs13530 | R3HCC1 | G>T | 6332 | 390992 | 19.18 | 1.189e-05 | 0.93 |
| chr22:19675944 | rs1123657 | - | G>T | 4043 | 253732 | 19.01 | 1.297e-05 | 0.9225 |
| chr11:47538102 | rs117784947 | CELF1 | T>C | 988 | 51084 | 18.96 | 1.338e-05 | 1.155 |
| chr10:114736614 | rs11196175 | TCF7L2 | T>C | 4053 | 254412 | 18.6 | 1.611e-05 | 0.9234 |
| chr1:223211594 | rs61838985 | - | G>C | 3538 | 196552 | 18.55 | 1.655e-05 | 1.087 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr16:57183274 | rs78751841 | - | A>G | 561 | 5922 | 39.13 | 3.96e-10 | 1.324 |
| chr19:54562619 | rs73060626 | VSTM1 | A>G | 420 | 4555 | 23.69 | 1.132e-06 | 1.285 |
| chr8:15952841 | rs117033280 | - | A>G | 149 | 3059 | 22.61 | 1.988e-06 | 0.6715 |
| chr1:182429995 | rs10911080 | RGSL1 | C>A | 2636 | 39703 | 21.75 | 3.099e-06 | 0.902 |
| chr1:156558843 | rs10796962 | - | A>C | 3235 | 48241 | 20.96 | 4.697e-06 | 0.9105 |
| chr1:75825794 | rs35898530 | SLC44A5 | C>T | 265 | 2744 | 20.83 | 5.011e-06 | 1.343 |
| chr1:156565834 | rs12024215 | GPATCH4 | G>C | 3244 | 48283 | 20.69 | 5.388e-06 | 0.9112 |
| chr5:117272458 | rs75499501 | - | T>G | 310 | 3308 | 19.69 | 9.089e-06 | 1.304 |
| chr4:149283684 | rs72729952 | NR3C2 | G>C | 542 | 6171 | 19.68 | 9.159e-06 | 1.224 |
| chr19:8929561 | rs118128745 | ZNF558 | T>C | 269 | 2824 | 19.33 | 1.102e-05 | 1.326 |
| chr11:86103702 | rs10501615 | CCDC81 | A>G | 164 | 1591 | 19.19 | 1.18e-05 | 1.432 |
| chr10:114736614 | rs11196175 | TCF7L2 | T>C | 4053 | 59629 | 19.16 | 1.202e-05 | 0.9204 |
| chr8:3003625 | rs1380768 | CSMD1 | T>C | 7735 | 103069 | 19.15 | 1.209e-05 | 1.076 |
| chr5:14039647 | rs6889677 | - | C>T | 2170 | 32820 | 19.08 | 1.256e-05 | 0.9007 |
| chr8:31921896 | rs116841098 | NRG1 | G>A | 546 | 6240 | 19.08 | 1.257e-05 | 1.219 |
| chr5:179021982 | rs28685239 | RUFY1 | A>G | 4147 | 60885 | 18.69 | 1.535e-05 | 0.9219 |
| chr6:13836495 | rs73723776 | - | C>T | 1824 | 22882 | 18.45 | 1.743e-05 | 1.118 |
| chr1:182446356 | rs267899 | RGSL1 | G>A | 4948 | 72113 | 18.37 | 1.822e-05 | 0.9262 |
| chr1:10710255 | rs284298 | CASZ1 | G>A | 2800 | 35936 | 18.34 | 1.846e-05 | 1.097 |
| chr8:23148940 | rs2272761 | R3HCC1 | A>G | 5605 | 81586 | 18.31 | 1.878e-05 | 0.9261 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|