Statistics
| Case | Control |
|---|---|
| 332 | 459862 |
Phenotype Definition
Very rapid breathing. [HPO:probinson]
Phenotype Comment
In adults, a beathing rate of between 12-20 breaths per minute is normal and tachypnea is present with a ventilatory rate greater than 20 breaths per minute.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:27082821 | rs2370920 | - | G>A | 30 | 16833 | 28.76 | 8.207e-08 | 2.626 |
| chr3:164001826 | rs80186955 | - | A>C | 51 | 34275 | 28.01 | 1.208e-07 | 2.121 |
| chr3:164166643 | rs78830223 | - | A>G | 48 | 31450 | 27.91 | 1.27e-07 | 2.163 |
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 80 | 63213 | 26.74 | 2.325e-07 | 1.831 |
| chr7:17632452 | rs73080733 | - | A>C | 23 | 11526 | 25.63 | 4.13e-07 | 2.796 |
| chr10:28697041 | rs61845766 | - | G>A | 46 | 31392 | 24.05 | 9.386e-07 | 2.079 |
| chr12:26228118 | rs117334962 | RASSF8 | A>G | 32 | 19509 | 23.12 | 1.523e-06 | 2.329 |
| chr2:52029283 | rs116676140 | - | G>A | 44 | 30559 | 22.02 | 2.703e-06 | 2.045 |
| chr1:244486658 | rs12021788 | - | A>G | 32 | 19851 | 21.65 | 3.268e-06 | 2.269 |
| chr7:147748359 | rs78016531 | CNTNAP2 | T>C | 24 | 13264 | 21.52 | 3.504e-06 | 2.535 |
| chr10:8192172 | rs80089822 | - | C>T | 39 | 106303 | 21.38 | 3.766e-06 | 0.475 |
| chr16:7047105 | rs72776236 | RBFOX1 | A>G | 67 | 53423 | 21.37 | 3.778e-06 | 1.796 |
| chr1:97316509 | rs11584120 | - | G>A | 60 | 46384 | 21.29 | 3.958e-06 | 1.846 |
| chr9:74379485 | rs10869058 | CEMIP2 | T>C | 250 | 427599 | 20.91 | 4.811e-06 | 0.699 |
| chr11:84521369 | rs74610635 | DLG2 | A>G | 34 | 22267 | 20.27 | 6.737e-06 | 2.165 |
| chr7:5797436 | rs4720641 | RNF216 | T>G | 103 | 92269 | 19.94 | 8.005e-06 | 1.604 |
| chr2:125092113 | rs11694014 | CNTNAP5 | C>A | 68 | 55776 | 19.69 | 9.099e-06 | 1.749 |
| chr11:15298730 | rs78644894 | - | T>C | 34 | 22663 | 19.26 | 1.141e-05 | 2.126 |
| chr14:42312609 | rs78126980 | LRFN5 | A>G | 27 | 16425 | 19.1 | 1.241e-05 | 2.302 |
| chr10:5639560 | rs72781981 | - | C>T | 48 | 35850 | 18.82 | 1.435e-05 | 1.894 |
| chr3:164166643 | rs78830223 | - | A>G | 44 | 28525 | 26.96 | 2.082e-07 | 2.204 |
| chr18:4157690 | rs6506185 | DLGAP1 | T>C | 7 | 1764 | 25.67 | 4.046e-07 | 5.541 |
| chr3:164001826 | rs80186955 | - | A>C | 46 | 31177 | 25.18 | 5.214e-07 | 2.117 |
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 75 | 60527 | 23.87 | 1.028e-06 | 1.805 |
| chr3:27082821 | rs2370920 | - | G>A | 23 | 12616 | 23.82 | 1.06e-06 | 2.71 |
| chr7:17632452 | rs73080733 | - | A>C | 22 | 11328 | 23.52 | 1.234e-06 | 2.743 |
| chr12:26228118 | rs117334962 | RASSF8 | A>G | 31 | 18833 | 23.1 | 1.538e-06 | 2.359 |
| chr3:3127656 | rs74517922 | IL5RA | T>C | 29 | 17057 | 22.91 | 1.694e-06 | 2.413 |
| chr10:28697041 | rs61845766 | - | G>A | 44 | 30716 | 22.03 | 2.683e-06 | 2.049 |
| chr10:8192172 | rs80089822 | - | C>T | 36 | 101944 | 21.64 | 3.295e-06 | 0.4595 |
| chr11:84521369 | rs74610635 | DLG2 | A>G | 34 | 21901 | 21.55 | 3.441e-06 | 2.219 |
| chr1:24775094 | rs72652576 | NIPAL3 | A>G | 48 | 35845 | 19.99 | 7.779e-06 | 1.932 |
| chr21:36597454 | rs78464335 | RUNX1 | C>T | 14 | 6247 | 19.9 | 8.17e-06 | 3.136 |
| chr2:52029283 | rs116676140 | - | G>A | 42 | 30079 | 19.62 | 9.453e-06 | 1.999 |
| chr18:6834925 | rs118113497 | ARHGAP28 | C>T | 21 | 11589 | 19.44 | 1.04e-05 | 2.569 |
| chr11:18689653 | rs12295403 | - | C>A | 278 | 311083 | 19.41 | 1.056e-05 | 1.412 |
| chr2:69887601 | rs76371146 | AAK1 | A>G | 26 | 15712 | 19.18 | 1.187e-05 | 2.342 |
| chr13:97359151 | rs9634493 | HS6ST3 | C>T | 17 | 8581 | 19.05 | 1.271e-05 | 2.795 |
| chr10:5639560 | rs72781981 | - | C>T | 47 | 35301 | 18.45 | 1.744e-05 | 1.896 |
| chr13:106240785 | rs71432857 | - | A>G | 26 | 15992 | 18.36 | 1.833e-05 | 2.301 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr18:4157690 | rs6506185 | DLGAP1 | T>C | 7 | 74 | 33.06 | 8.943e-09 | 7.083 |
| chr11:84521369 | rs74610635 | DLG2 | A>G | 34 | 1094 | 25.14 | 5.332e-07 | 2.384 |
| chr3:164166643 | rs78830223 | - | A>G | 44 | 1571 | 24.42 | 7.742e-07 | 2.145 |
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 75 | 3215 | 24.2 | 8.69e-07 | 1.824 |
| chr3:27082821 | rs2370920 | - | G>A | 23 | 677 | 23.14 | 1.507e-06 | 2.713 |
| chr3:164001826 | rs80186955 | - | A>C | 46 | 1708 | 23.06 | 1.569e-06 | 2.07 |
| chr10:28697041 | rs61845766 | - | G>A | 44 | 1623 | 22.43 | 2.182e-06 | 2.08 |
| chr10:8192172 | rs80089822 | - | C>T | 36 | 5527 | 22.23 | 2.425e-06 | 0.4537 |
| chr12:26228118 | rs117334962 | RASSF8 | A>G | 31 | 1020 | 21.89 | 2.888e-06 | 2.335 |
| chr11:18689653 | rs12295403 | - | C>A | 278 | 16502 | 20.98 | 4.63e-06 | 1.435 |
| chr7:17632452 | rs73080733 | - | A>C | 22 | 633 | 20.78 | 5.163e-06 | 2.63 |
| chr2:52029283 | rs116676140 | - | G>A | 42 | 1575 | 20.58 | 5.728e-06 | 2.049 |
| chr3:3127656 | rs74517922 | IL5RA | T>C | 29 | 945 | 20.51 | 5.935e-06 | 2.333 |
| chr25:2669401 | rs146821057 | - | A>G | 120 | 6059 | 20.44 | 6.143e-06 | 1.579 |
| chr9:89512998 | rs62570812 | - | T>C | 51 | 2076 | 19.31 | 1.113e-05 | 1.891 |
| chr2:69887601 | rs76371146 | AAK1 | A>G | 26 | 832 | 19.22 | 1.163e-05 | 2.372 |
| chr1:24775094 | rs72652576 | NIPAL3 | A>G | 48 | 1935 | 19.12 | 1.229e-05 | 1.919 |
| chr21:36597454 | rs78464335 | RUNX1 | C>T | 14 | 336 | 19.06 | 1.269e-05 | 3.129 |
| chr3:147879043 | rs113017146 | - | T>C | 43 | 1705 | 18.74 | 1.497e-05 | 1.975 |
| chr7:137032473 | rs117865485 | - | G>A | 29 | 984 | 18.47 | 1.726e-05 | 2.239 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: K821 | Hydrops of gallbladder | 1/20 |
| ICD: O120 | Gestational oedema | 2/20 |
| ID | Name | Top Correlation |
|---|