Statistics
| Case | Control |
|---|---|
| 15407 | 444787 |
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1621 | 65437 | 167.3 | 2.948e-38 | 0.7173 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 1384 | 55608 | 137.1 | 1.15e-31 | 0.7229 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 561 | 26965 | 136.7 | 1.399e-31 | 0.6077 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 14626 | 461477 | 120.0 | 6.177e-28 | 0.8823 |
| chr15:48392165 | rs1834640 | - | A>G | 699 | 30925 | 117.1 | 2.784e-27 | 0.66 |
| chr16:28995057 | rs11859822 | SPNS1 | T>C | 665 | 28771 | 98.91 | 2.644e-23 | 0.6759 |
| chr16:29035406 | rs74014848 | - | A>G | 448 | 21033 | 98.14 | 3.893e-23 | 0.6237 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 999 | 39981 | 94.74 | 2.172e-22 | 0.7294 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 396 | 18981 | 94.6 | 2.334e-22 | 0.6114 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 1005 | 40142 | 94.08 | 3.038e-22 | 0.7309 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 2463 | 87645 | 93.08 | 5.032e-22 | 0.8147 |
| chr16:28954860 | rs7203982 | - | T>C | 673 | 28709 | 92.81 | 5.753e-22 | 0.6856 |
| chr15:45491394 | rs1648299 | SHF | T>C | 341 | 16818 | 91.41 | 1.166e-21 | 0.5945 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 332 | 16408 | 89.89 | 2.524e-21 | 0.5931 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 10380 | 283317 | 88.48 | 5.13e-21 | 1.121 |
| chr2:66725070 | rs12995572 | MEIS1 | G>C | 618 | 26533 | 88.04 | 6.409e-21 | 0.6816 |
| chr6:3185712 | rs7754077 | - | C>T | 386 | 18286 | 87.6 | 7.995e-21 | 0.6189 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 11329 | 311319 | 87.17 | 9.951e-21 | 1.118 |
| chr8:10557760 | rs57041981 | RP1L1 | A>G | 333 | 16315 | 86.99 | 1.088e-20 | 0.5984 |
| chr3:149925742 | rs7629443 | - | T>C | 435 | 19947 | 85.71 | 2.085e-20 | 0.6388 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 13868 | 424810 | 89.64 | 2.852e-21 | 0.8954 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 10007 | 268136 | 76.43 | 2.28e-18 | 1.114 |
| chr11:111165009 | rs7103178 | - | T>C | 10020 | 268773 | 73.88 | 8.295e-18 | 1.112 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 6287 | 164935 | 68.33 | 1.38e-16 | 1.126 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 11051 | 300129 | 61.78 | 3.85e-15 | 1.1 |
| chr8:128413305 | rs6983267 | POU5F1B | G>T | 14187 | 428574 | 55.0 | 1.207e-13 | 0.9174 |
| chr8:128407443 | rs10505477 | POU5F1B | A>G | 14476 | 436556 | 52.57 | 4.145e-13 | 0.9192 |
| chr15:32994756 | rs4779584 | - | C>T | 6305 | 167870 | 48.97 | 2.604e-12 | 1.106 |
| chr8:117640315 | rs11986063 | - | C>T | 3021 | 77365 | 45.93 | 1.225e-11 | 1.141 |
| chr18:46453754 | rs35352860 | SMAD7 | C>T | 7717 | 237806 | 44.48 | 2.575e-11 | 0.9147 |
| chr8:117630683 | rs16892766 | - | A>C | 2748 | 70364 | 41.32 | 1.295e-10 | 1.14 |
| chr20:60968596 | rs1570027 | CABLES2 | A>G | 6493 | 201263 | 40.96 | 1.553e-10 | 0.9131 |
| chr20:60920700 | rs6143035 | LAMA5 | T>C | 7121 | 219454 | 39.22 | 3.795e-10 | 0.9176 |
| chr10:8701219 | rs10795668 | - | G>A | 9522 | 289952 | 38.45 | 5.61e-10 | 0.9252 |
| chr20:60921044 | rs4925386 | LAMA5 | C>T | 9224 | 280845 | 37.79 | 7.876e-10 | 0.9252 |
| chr20:60958651 | rs11699160 | - | T>C | 10450 | 317168 | 37.69 | 8.305e-10 | 0.9275 |
| chr15:32992658 | rs28399071 | - | G>A | 3173 | 82918 | 33.22 | 8.251e-09 | 1.116 |
| chr11:111179054 | rs3087587 | COLCA2 | G>A | 13022 | 390539 | 32.94 | 9.506e-09 | 0.9349 |
| chr11:111181120 | rs7947952 | - | T>C | 13551 | 405538 | 31.88 | 1.643e-08 | 0.9361 |
| chr8:117643773 | rs9650068 | - | A>G | 5069 | 157430 | 31.79 | 1.718e-08 | 0.9157 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr14:34772972 | rs17520953 | EGLN3 | T>C | 2605 | 2835 | 24.43 | 7.688e-07 | 0.8689 |
| chr8:12973575 | rs2410025 | DLC1 | A>C | 5498 | 4829 | 22.95 | 1.662e-06 | 1.109 |
| chr16:11621325 | rs4781120 | - | T>C | 10401 | 9419 | 22.93 | 1.676e-06 | 1.087 |
| chr15:32515100 | rs77997955 | - | T>C | 1828 | 1499 | 20.98 | 4.63e-06 | 1.178 |
| chr10:126279034 | rs56079813 | LHPP | A>G | 487 | 607 | 19.34 | 1.096e-05 | 0.764 |
| chr5:85015445 | rs7718884 | - | C>T | 9545 | 9634 | 18.97 | 1.33e-05 | 0.9266 |
| chr10:44297019 | rs74394503 | - | C>T | 2386 | 2012 | 18.97 | 1.329e-05 | 1.147 |
| chr10:98950477 | rs7474809 | ARHGAP19-SLIT1 | C>T | 8581 | 8689 | 18.92 | 1.362e-05 | 0.9246 |
| chr23:9766019 | rs5934685 | SHROOM2 | C>T | 4718 | 4227 | 18.92 | 1.362e-05 | 1.109 |
| chr22:45322792 | rs136684 | PHF21B | T>C | 416 | 528 | 18.87 | 1.396e-05 | 0.7512 |
| chr15:30579273 | rs73377207 | - | T>G | 2708 | 2308 | 18.7 | 1.53e-05 | 1.136 |
| chr8:138567034 | rs55833606 | - | G>T | 4556 | 4732 | 18.46 | 1.732e-05 | 0.9076 |
| chr8:138490692 | rs79472906 | - | G>T | 4583 | 4763 | 18.41 | 1.78e-05 | 0.9079 |
| chr10:114386739 | rs76124550 | VTI1A | C>T | 808 | 947 | 18.41 | 1.783e-05 | 0.8121 |
| chr3:169465212 | rs76242544 | - | G>A | 426 | 536 | 18.14 | 2.053e-05 | 0.7574 |
| chr8:62281866 | rs78190006 | CLVS1 | A>G | 1117 | 887 | 18.06 | 2.138e-05 | 1.214 |
| chr3:43174229 | rs7648947 | - | G>A | 14471 | 14371 | 18.02 | 2.183e-05 | 0.9331 |
| chr5:171842167 | rs883989 | SH3PXD2B | C>T | 11918 | 11911 | 17.86 | 2.375e-05 | 0.9319 |
| chr5:116665877 | rs58110127 | - | G>T | 3349 | 2904 | 17.7 | 2.589e-05 | 1.119 |
| chr2:79782293 | rs2685161 | CTNNA2 | C>A | 771 | 590 | 17.28 | 3.221e-05 | 1.258 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: C187 | Sigmoid colon | 1/20 |
| ICD: C787 | Secondary malignant neoplasm of liver | 5/20 |
| ICD: D125 | Sigmoid colon | 12/20 |
| ICD: D126 | Colon, unspecified | 8/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: C189 | Colon, unspecified | 0/20 |
| ICD-10: C19 | Malignant neoplasm of rectosigmoid junction | 0/20 |
| ICD-10: D374 | Colon | 0/20 |