Statistics
| Female Case | Female Control | % Female |
|---|---|---|
| 6758 | 243099 | 44% |
| Male Case | Male Control | % Male |
|---|---|---|
| 8649 | 201688 | 56% |
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 753 | 35454 | 50.07 | 1.485e-12 | 0.7656 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 5031 | 170441 | 46.22 | 1.055e-11 | 1.129 |
| chr15:48392165 | rs1834640 | - | A>G | 342 | 17815 | 43.48 | 4.291e-11 | 0.696 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 294 | 15750 | 43.33 | 4.629e-11 | 0.6776 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 4602 | 155342 | 43.18 | 5.005e-11 | 1.127 |
| chr11:111165009 | rs7103178 | - | T>C | 4610 | 155971 | 40.59 | 1.877e-10 | 1.123 |
| chr5:40265904 | rs1348612 | - | A>G | 4268 | 143831 | 39.63 | 3.075e-10 | 1.124 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 648 | 30192 | 39.11 | 4.008e-10 | 0.776 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 6493 | 251457 | 37.56 | 8.872e-10 | 0.9001 |
| chr11:111181120 | rs7947952 | - | T>C | 6247 | 241600 | 34.71 | 3.836e-09 | 0.9036 |
| chr15:45491394 | rs1648299 | SHF | T>C | 169 | 9684 | 34.39 | 4.499e-09 | 0.6351 |
| chr2:30982883 | rs13399585 | CAPN13 | G>A | 475 | 22670 | 34.36 | 4.585e-09 | 0.7591 |
| chr11:111179054 | rs3087587 | COLCA2 | G>A | 6023 | 233377 | 33.39 | 7.547e-09 | 0.905 |
| chr16:28995057 | rs11859822 | SPNS1 | T>C | 315 | 15927 | 33.22 | 8.249e-09 | 0.7188 |
| chr20:15550306 | rs1233751 | MACROD2 | G>T | 551 | 25679 | 32.83 | 1.006e-08 | 0.778 |
| chr23:102201216 | rs725570 | - | A>G | 255 | 13304 | 32.33 | 1.298e-08 | 0.6971 |
| chr8:42306813 | rs7832529 | SLC20A2 | T>C | 661 | 29981 | 31.74 | 1.766e-08 | 0.7973 |
| chr10:98742605 | rs3814163 | LCOR | C>T | 289 | 14669 | 31.26 | 2.26e-08 | 0.716 |
| chr1:64273591 | rs659592 | ROR1 | A>G | 365 | 17834 | 30.78 | 2.897e-08 | 0.7437 |
| chr4:113868183 | rs77023571 | ANK2 | A>C | 92 | 5958 | 30.49 | 3.352e-08 | 0.5632 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 4427 | 146924 | 40.0 | 2.539e-10 | 1.125 |
| chr11:111165009 | rs7103178 | - | T>C | 4433 | 147274 | 38.68 | 4.988e-10 | 1.123 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 4912 | 164440 | 38.24 | 6.258e-10 | 1.119 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 2786 | 90666 | 33.5 | 7.144e-09 | 1.133 |
| chr5:40265904 | rs1348612 | - | A>G | 4197 | 139853 | 32.84 | 1.003e-08 | 1.114 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 6128 | 231900 | 29.07 | 6.997e-08 | 0.9097 |
| chr11:111181120 | rs7947952 | - | T>C | 5861 | 221732 | 27.77 | 1.365e-07 | 0.9114 |
| chr8:61662038 | rs7816126 | CHD7 | T>C | 3100 | 121893 | 27.04 | 1.996e-07 | 0.8971 |
| chr11:111179054 | rs3087587 | COLCA2 | G>A | 5642 | 213549 | 25.49 | 4.439e-07 | 0.9146 |
| chr15:32994756 | rs4779584 | - | C>T | 2785 | 92138 | 23.11 | 1.532e-06 | 1.109 |
| chr5:40228560 | rs353366 | - | T>C | 5963 | 205240 | 22.32 | 2.308e-06 | 1.087 |
| chr10:29101651 | rs787334 | - | C>A | 3337 | 111051 | 22.12 | 2.556e-06 | 1.101 |
| chr11:111154350 | rs10891243 | C11orf53 | T>C | 3596 | 138287 | 21.99 | 2.744e-06 | 0.9117 |
| chr8:61679374 | rs11991467 | CHD7 | G>T | 2997 | 116256 | 21.85 | 2.947e-06 | 0.9066 |
| chr8:61713126 | rs112021443 | CHD7 | ATGGACT>A | 3047 | 117804 | 21.17 | 4.195e-06 | 0.9085 |
| chr10:94824424 | rs117507138 | CYP26C1 | G>T | 102 | 5765 | 21.07 | 4.424e-06 | 0.6336 |
| chr2:30982883 | rs13399585 | CAPN13 | G>A | 371 | 16840 | 20.57 | 5.763e-06 | 0.786 |
| chr7:46873024 | rs6463349 | - | T>C | 5257 | 198419 | 20.48 | 6.014e-06 | 0.9219 |
| chr12:112072424 | rs11065987 | - | A>G | 5375 | 202782 | 20.12 | 7.277e-06 | 0.9232 |
| chr8:26193394 | rs78097851 | PPP2R2A | C>T | 588 | 25297 | 19.73 | 8.917e-06 | 0.8276 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 868 | 29983 | 122.8 | 1.519e-28 | 0.6778 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 736 | 25416 | 103.0 | 3.431e-24 | 0.6803 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 267 | 11215 | 86.74 | 1.235e-20 | 0.5636 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 8133 | 210020 | 85.98 | 1.815e-20 | 0.8675 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 180 | 8160 | 75.53 | 3.599e-18 | 0.5236 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 1338 | 40091 | 73.28 | 1.126e-17 | 0.7813 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 536 | 18452 | 72.33 | 1.823e-17 | 0.6864 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 542 | 18531 | 70.55 | 4.49e-17 | 0.691 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 168 | 7557 | 68.88 | 1.045e-16 | 0.5275 |
| chr16:29035406 | rs74014848 | - | A>G | 224 | 9265 | 68.44 | 1.306e-16 | 0.5736 |
| chr15:48392165 | rs1834640 | - | A>G | 357 | 13110 | 66.53 | 3.444e-16 | 0.645 |
| chr16:28995057 | rs11859822 | SPNS1 | T>C | 350 | 12844 | 65.06 | 7.265e-16 | 0.6454 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 229 | 9295 | 64.99 | 7.522e-16 | 0.5849 |
| chr16:28954860 | rs7203982 | - | T>C | 353 | 12880 | 63.75 | 1.415e-15 | 0.6494 |
| chr3:149925742 | rs7629443 | - | T>C | 215 | 8821 | 63.68 | 1.467e-15 | 0.5785 |
| chr5:147671850 | rs7724380 | - | G>A | 198 | 8287 | 62.95 | 2.119e-15 | 0.5677 |
| chr3:191924614 | rs7624178 | FGF12 | A>C | 342 | 12478 | 61.72 | 3.95e-15 | 0.6495 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 158 | 6998 | 61.38 | 4.71e-15 | 0.5363 |
| chr16:13922331 | rs7193298 | - | T>G | 469 | 16069 | 61.37 | 4.731e-15 | 0.6908 |
| chr5:147666044 | rs7707813 | - | T>C | 180 | 7674 | 61.11 | 5.397e-15 | 0.5576 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 7740 | 192910 | 62.63 | 2.494e-15 | 0.8836 |
| chr8:128407443 | rs10505477 | POU5F1B | A>G | 7982 | 197810 | 56.19 | 6.578e-14 | 0.8898 |
| chr8:128413305 | rs6983267 | POU5F1B | G>T | 7829 | 194215 | 56.17 | 6.654e-14 | 0.8897 |
| chr18:46453754 | rs35352860 | SMAD7 | C>T | 4265 | 108149 | 39.72 | 2.938e-10 | 0.8928 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 5580 | 121212 | 38.02 | 7.003e-10 | 1.108 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 3501 | 74269 | 36.79 | 1.317e-09 | 1.125 |
| chr11:111165009 | rs7103178 | - | T>C | 5587 | 121499 | 36.76 | 1.339e-09 | 1.106 |
| chr11:74414919 | rs11607100 | CHRDL2 | C>T | 569 | 16919 | 34.18 | 5.016e-09 | 0.7766 |
| chr8:117630683 | rs16892766 | - | A>C | 1569 | 31817 | 31.68 | 1.818e-08 | 1.165 |
| chr11:74413843 | rs34695217 | CHRDL2 | T>C | 583 | 17134 | 31.58 | 1.918e-08 | 0.7865 |
| chr8:128428638 | Affx-31548678 | POU5F1B | G>A | 6689 | 164384 | 30.47 | 3.391e-08 | 0.9155 |
| chr8:117640315 | rs11986063 | - | C>T | 1701 | 35019 | 28.03 | 1.193e-07 | 1.148 |
| chr15:32994756 | rs4779584 | - | C>T | 3520 | 75732 | 27.04 | 1.995e-07 | 1.106 |
| chr20:60920700 | rs6143035 | LAMA5 | T>C | 3984 | 99842 | 26.48 | 2.669e-07 | 0.9096 |
| chr20:60968596 | rs1570027 | CABLES2 | A>G | 3646 | 91783 | 26.47 | 2.674e-07 | 0.9068 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6139 | 135689 | 26.22 | 3.047e-07 | 1.087 |
| chr20:60921044 | rs4925386 | LAMA5 | C>T | 5156 | 127590 | 25.93 | 3.547e-07 | 0.9172 |
| chr23:9766019 | rs5934685 | SHROOM2 | C>T | 1935 | 40696 | 24.9 | 6.04e-07 | 1.141 |
| chr20:60958651 | rs11699160 | - | T>C | 5858 | 144107 | 24.56 | 7.21e-07 | 0.9218 |
| chr1:175839509 | rs12034224 | - | C>T | 4982 | 109237 | 24.34 | 8.089e-07 | 1.088 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: C187 | Sigmoid colon | 1/20 |
| ICD: C787 | Secondary malignant neoplasm of liver | 5/20 |
| ICD: D125 | Sigmoid colon | 12/20 |
| ICD: D126 | Colon, unspecified | 8/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: C189 | Colon, unspecified | 0/20 |
| ICD-10: C19 | Malignant neoplasm of rectosigmoid junction | 0/20 |
| ICD-10: D374 | Colon | 0/20 |