Normal Case/Contol

GWAS of 0003304

Sibling Case/Control

No sibling GWAS available 0003304


Case Control
16863 443331

Phenotype Definition

Spondylolysis is an osseous defect of the pars interarticularis, thought to be a developmental or acquired stress fracture secondary to chronic low-grade trauma. [HPO:probinson, PMID:20440613]

Phenotype Comment

The pars interarticularis is one of the bony bridges that connect the upper with the lower facet joints of the vertebra. Lumbar spondylolysis is a common cause of lower back pain. The vast majority of cases of spondylolysis occur at the L5 or L4 levels, and is usually diagnosed radiographically. Over half of patients affected by spondylolysis have associated spondylolisthesis.

Top SNP Information

Associated Diseases

ID Name Top Correlation
ICD: M545 Low back pain 12/20
ICD: M549 Dorsalgia, unspecified 14/20