Statistics
| Case | Control |
|---|---|
| 9389 | 450805 |
Phenotype Definition
Abnormally increased cuvature (anterior concavity) of the lumbar or cervical spine. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr23:64367019 | rs7064929 | - | G>A | 563 | 17003 | 98.95 | 2.593e-23 | 1.538 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 592 | 18785 | 93.77 | 3.543e-22 | 1.503 |
| chr12:132549300 | rs7136109 | EP400 | A>G | 353 | 10277 | 82.3 | 1.167e-19 | 1.633 |
| chr23:142717383 | rs73577386 | SLITRK4 | A>G | 274 | 7348 | 78.66 | 7.375e-19 | 1.723 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 544 | 17601 | 78.05 | 1.005e-18 | 1.473 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 368 | 10658 | 77.93 | 1.066e-18 | 1.599 |
| chr23:53347028 | rs1547218 | IQSEC2 | T>C | 1082 | 38171 | 77.45 | 1.364e-18 | 1.323 |
| chr23:63410110 | rs61730681 | AMER1 | T>C | 706 | 23427 | 74.85 | 5.073e-18 | 1.4 |
| chr23:63423664 | rs5964740 | AMER1 | C>T | 703 | 23397 | 73.34 | 1.09e-17 | 1.396 |
| chr15:45491394 | rs1648299 | SHF | T>C | 514 | 16645 | 73.02 | 1.284e-17 | 1.47 |
| chr16:17200685 | rs8046024 | XYLT1 | C>T | 579 | 19198 | 72.43 | 1.73e-17 | 1.437 |
| chr16:17200759 | rs8044934 | XYLT1 | G>A | 572 | 18923 | 72.4 | 1.759e-17 | 1.439 |
| chr19:39575987 | rs544041 | ACP7 | G>A | 340 | 10157 | 71.11 | 3.378e-17 | 1.591 |
| chr15:45694768 | rs1834686 | SPATA5L1 | G>T | 332 | 9887 | 70.22 | 5.304e-17 | 1.595 |
| chr6:144665357 | rs6917261 | UTRN | T>C | 407 | 12708 | 69.32 | 8.365e-17 | 1.523 |
| chr9:117110112 | Affx-52344420 | AKNA | T>TG | 444 | 14135 | 68.9 | 1.035e-16 | 1.495 |
| chr23:110685534 | rs16986503 | - | C>T | 398 | 12085 | 67.82 | 1.792e-16 | 1.525 |
| chr15:45695612 | rs1346265 | SPATA5L1 | C>T | 368 | 11302 | 67.69 | 1.917e-16 | 1.547 |
| chr18:9536315 | rs14336 | RALBP1 | A>C | 399 | 12468 | 67.63 | 1.97e-16 | 1.521 |
| chr9:129984107 | rs3739553 | RALGPS1 | G>A | 463 | 14950 | 66.52 | 3.469e-16 | 1.472 |
| chr17:1978484 | rs9901671 | SMG6 | C>T | 7127 | 357808 | 22.42 | 2.187e-06 | 0.9305 |
| chr2:69407720 | rs10173269 | ANTXR1 | T>G | 8973 | 415323 | 21.66 | 3.256e-06 | 1.071 |
| chr1:207233675 | rs12135736 | PFKFB2 | A>C | 2227 | 97350 | 21.56 | 3.429e-06 | 1.112 |
| chr3:173127641 | rs114467752 | NLGN1 | A>G | 306 | 11251 | 21.11 | 4.337e-06 | 1.307 |
| chr1:93953301 | rs11164939 | FNBP1L | A>G | 1991 | 86667 | 21.01 | 4.558e-06 | 1.116 |
| chr17:1990959 | rs3744274 | SMG6 | A>C | 6183 | 311265 | 20.68 | 5.427e-06 | 0.9311 |
| chr1:229339176 | rs16849566 | - | T>G | 2966 | 131788 | 20.31 | 6.584e-06 | 1.095 |
| chr20:30581522 | rs12481016 | XKR7 | G>A | 1477 | 63250 | 20.26 | 6.769e-06 | 1.131 |
| chr4:15824742 | rs71601500 | CD38 | C>T | 1200 | 50732 | 20.2 | 6.979e-06 | 1.145 |
| chr20:30584710 | rs61750849 | XKR7 | C>T | 1532 | 65941 | 19.45 | 1.03e-05 | 1.126 |
| chr16:25258450 | rs61746579 | ZKSCAN2 | T>C | 413 | 15957 | 19.43 | 1.044e-05 | 1.248 |
| chr15:67367706 | rs1498507 | SMAD3 | A>C | 8368 | 416315 | 19.05 | 1.274e-05 | 0.9372 |
| chr15:75763377 | rs80163632 | PTPN9 | A>G | 5248 | 239093 | 19.01 | 1.303e-05 | 1.074 |
| chr15:75781554 | rs77716675 | PTPN9 | A>G | 5218 | 237983 | 18.93 | 1.358e-05 | 1.074 |
| chr15:75738292 | rs78428611 | SIN3A | C>A | 5231 | 238404 | 18.68 | 1.545e-05 | 1.074 |
| chr15:75775476 | rs76063558 | PTPN9 | G>A | 5228 | 238340 | 18.59 | 1.617e-05 | 1.074 |
| chr14:99791285 | rs80343998 | - | G>A | 913 | 38060 | 18.5 | 1.699e-05 | 1.159 |
| chr18:22808876 | rs75935553 | ZNF521 | T>C | 1000 | 41995 | 18.43 | 1.762e-05 | 1.151 |
| chr6:34546560 | rs2814982 | - | C>T | 2091 | 91761 | 18.41 | 1.78e-05 | 1.106 |
| chr7:93163467 | rs73221772 | CALCR | A>G | 595 | 23973 | 18.34 | 1.85e-05 | 1.198 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 592 | 416 | 84.87 | 3.185e-20 | 1.8 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 724 | 565 | 73.36 | 1.078e-17 | 1.622 |
| chr23:64367019 | rs7064929 | - | G>A | 563 | 415 | 69.79 | 6.61e-17 | 1.719 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 544 | 405 | 65.09 | 7.161e-16 | 1.698 |
| chr15:48392165 | rs1834640 | - | A>G | 811 | 673 | 64.36 | 1.039e-15 | 1.526 |
| chr8:10557760 | rs57041981 | RP1L1 | A>G | 482 | 351 | 61.48 | 4.48e-15 | 1.731 |
| chr15:45491394 | rs1648299 | SHF | T>C | 514 | 384 | 60.41 | 7.686e-15 | 1.688 |
| chr3:188327555 | rs7645635 | LPP | T>C | 433 | 308 | 59.56 | 1.186e-14 | 1.773 |
| chr12:132549300 | rs7136109 | EP400 | A>G | 353 | 234 | 59.17 | 1.444e-14 | 1.9 |
| chr23:71628912 | rs3012642 | AL133500.1 | A>G | 636 | 509 | 58.81 | 1.733e-14 | 1.584 |
| chr10:117649124 | rs7904803 | ATRNL1 | C>A | 529 | 404 | 58.09 | 2.504e-14 | 1.655 |
| chr17:3553526 | rs161350 | CTNS | G>A | 327 | 213 | 57.32 | 3.705e-14 | 1.933 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 368 | 251 | 57.3 | 3.735e-14 | 1.851 |
| chr21:17639822 | rs183564 | - | C>T | 712 | 591 | 56.27 | 6.314e-14 | 1.523 |
| chr1:1233941 | rs1739855 | ACAP3 | T>C | 2283 | 2317 | 55.8 | 8.018e-14 | 1.261 |
| chr13:72441665 | rs3759505 | - | C>T | 467 | 350 | 54.29 | 1.731e-13 | 1.682 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 455 | 341 | 52.73 | 3.827e-13 | 1.681 |
| chr23:63410110 | rs61730681 | AMER1 | T>C | 706 | 596 | 51.89 | 5.863e-13 | 1.5 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 474 | 363 | 51.31 | 7.883e-13 | 1.648 |
| chr15:45694768 | rs1834686 | SPATA5L1 | G>T | 332 | 227 | 51.03 | 9.108e-13 | 1.84 |
| chr5:81572150 | rs112359833 | ATG10 | G>T | 307 | 555 | 24.62 | 6.987e-07 | 0.7015 |
| chr3:37783896 | rs77147659 | ITGA9 | C>T | 895 | 914 | 23.47 | 1.267e-06 | 1.262 |
| chr6:31348987 | rs115999992 | - | T>A | 763 | 1213 | 23.44 | 1.292e-06 | 0.7958 |
| chr1:207233675 | rs12135736 | PFKFB2 | A>C | 2227 | 2494 | 22.83 | 1.769e-06 | 1.159 |
| chr3:69400627 | rs74488326 | FRMD4B | A>G | 452 | 759 | 22.3 | 2.326e-06 | 0.7531 |
| chr6:31351090 | rs3997984 | - | G>A | 814 | 1272 | 21.38 | 3.766e-06 | 0.8087 |
| chr6:31370984 | rs116135464 | MICA | C>T | 821 | 1279 | 21.15 | 4.257e-06 | 0.8103 |
| chr6:31344916 | rs116488202 | - | C>T | 820 | 1276 | 20.47 | 6.071e-06 | 0.8129 |
| chr6:31327034 | rs116666910 | - | C>A | 820 | 1272 | 19.92 | 8.061e-06 | 0.815 |
| chr6:31365787 | rs4349859 | - | G>A | 812 | 1256 | 19.39 | 1.063e-05 | 0.8164 |
| chr6:31389923 | rs17200400 | - | G>A | 876 | 1346 | 19.36 | 1.085e-05 | 0.8222 |
| chr23:39741002 | rs7885790 | - | C>A | 709 | 723 | 19.23 | 1.16e-05 | 1.267 |
| chr1:38104456 | rs55967339 | - | A>G | 4271 | 5023 | 19.1 | 1.239e-05 | 1.109 |
| chr4:64022007 | rs77839870 | - | C>T | 391 | 365 | 19.05 | 1.272e-05 | 1.376 |
| chr1:229339176 | rs16849566 | - | T>G | 2966 | 3424 | 18.78 | 1.468e-05 | 1.125 |
| chr6:31409802 | rs115660274 | - | A>T | 878 | 1346 | 18.71 | 1.523e-05 | 0.825 |
| chr17:34869992 | rs12452009 | MYO19 | A>G | 570 | 913 | 18.58 | 1.628e-05 | 0.7917 |
| chr6:31388386 | rs115681000 | - | A>G | 880 | 1347 | 18.48 | 1.72e-05 | 0.8262 |
| chr4:48829545 | rs75060373 | OCIAD1 | C>T | 413 | 391 | 18.31 | 1.881e-05 | 1.355 |
| chr6:31417995 | rs116447526 | - | T>C | 873 | 1335 | 18.12 | 2.074e-05 | 0.8271 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M549 | Dorsalgia, unspecified | 15/20 |