Statistics
| Case | Control |
|---|---|
| 6374 | 453820 |
Phenotype Definition
Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr19:45163671 | rs754340 | PVR | T>C | 1272 | 78345 | 25.96 | 3.488e-07 | 1.163 |
| chr16:78546566 | rs16947866 | WWOX | T>C | 1082 | 65871 | 25.58 | 4.251e-07 | 1.175 |
| chr19:808586 | rs13169 | PTBP1 | C>G | 2095 | 134002 | 24.3 | 8.259e-07 | 1.125 |
| chr1:208739034 | rs10779485 | - | G>A | 524 | 30114 | 23.06 | 1.568e-06 | 1.24 |
| chr20:34644985 | rs17093325 | - | A>G | 2824 | 184096 | 22.64 | 1.954e-06 | 1.107 |
| chr10:79073350 | rs71475647 | KCNMA1 | G>C | 537 | 31040 | 22.21 | 2.444e-06 | 1.232 |
| chr3:28862496 | rs12498054 | AC098650.1 | A>G | 291 | 15639 | 22.11 | 2.579e-06 | 1.323 |
| chr3:181903629 | rs6791870 | - | T>C | 663 | 39276 | 21.58 | 3.397e-06 | 1.205 |
| chr1:77072458 | rs2647389 | ST6GALNAC3 | T>C | 2171 | 140261 | 20.9 | 4.833e-06 | 1.114 |
| chr16:65762809 | rs4436778 | - | T>C | 424 | 24058 | 20.76 | 5.213e-06 | 1.254 |
| chr5:177484841 | rs4246820 | - | C>T | 2321 | 178718 | 20.51 | 5.941e-06 | 0.9014 |
| chr14:99988724 | rs2400681 | CCNK | G>A | 471 | 27029 | 20.42 | 6.226e-06 | 1.238 |
| chr14:88784398 | rs12884581 | KCNK10 | G>T | 6411 | 471042 | 20.26 | 6.769e-06 | 0.9247 |
| chr3:28871098 | rs76942027 | AC098650.1 | T>C | 230 | 12095 | 20.22 | 6.904e-06 | 1.351 |
| chr19:795816 | rs8113356 | - | G>A | 2076 | 133952 | 20.06 | 7.518e-06 | 1.114 |
| chr15:101423806 | rs76489532 | ALDH1A3 | C>T | 393 | 22240 | 19.64 | 9.359e-06 | 1.256 |
| chr23:37799036 | rs5964258 | AF241726.2 | G>A | 363 | 19995 | 19.51 | 1.003e-05 | 1.268 |
| chr23:42913158 | rs5991558 | - | C>T | 287 | 15344 | 19.49 | 1.012e-05 | 1.304 |
| chr6:129720298 | rs114501367 | LAMA2 | C>T | 226 | 11936 | 19.22 | 1.165e-05 | 1.344 |
| chr2:31122801 | rs73921185 | - | A>G | 621 | 52051 | 18.93 | 1.353e-05 | 0.8356 |
| chr10:79073350 | rs71475647 | KCNMA1 | G>C | 527 | 30341 | 24.26 | 8.431e-07 | 1.247 |
| chr19:808586 | rs13169 | PTBP1 | C>G | 1945 | 125148 | 22.93 | 1.679e-06 | 1.126 |
| chr14:88784398 | rs12884581 | KCNK10 | G>T | 5997 | 445267 | 22.54 | 2.057e-06 | 0.9182 |
| chr3:181903629 | rs6791870 | - | T>C | 650 | 38563 | 22.51 | 2.092e-06 | 1.212 |
| chr16:81600901 | rs62043778 | CMIP | A>G | 2516 | 194236 | 20.84 | 4.999e-06 | 0.9028 |
| chr8:126289605 | rs7816350 | NSMCE2 | A>G | 1407 | 112077 | 20.14 | 7.203e-06 | 0.8802 |
| chr19:795816 | rs8113356 | - | G>A | 1919 | 124169 | 20.14 | 7.194e-06 | 1.118 |
| chr20:34644985 | rs17093325 | - | A>G | 2534 | 166331 | 20.14 | 7.183e-06 | 1.106 |
| chr2:115368825 | rs17782936 | DPP10 | T>C | 1278 | 102396 | 19.81 | 8.547e-06 | 0.8763 |
| chr16:78546566 | rs16947866 | WWOX | T>C | 967 | 59937 | 19.38 | 1.07e-05 | 1.16 |
| chr2:193042235 | rs79243004 | TMEFF2 | T>C | 295 | 16298 | 18.83 | 1.431e-05 | 1.293 |
| chr5:146141748 | rs36115021 | PPP2R2B | G>C | 383 | 33904 | 18.8 | 1.449e-05 | 0.7979 |
| chr6:129720298 | rs114501367 | LAMA2 | C>T | 206 | 10851 | 18.67 | 1.555e-05 | 1.357 |
| chr10:18685891 | rs1570939 | CACNB2 | G>A | 4280 | 321129 | 18.64 | 1.581e-05 | 0.9217 |
| chr2:31122801 | rs73921185 | - | A>G | 549 | 46711 | 18.34 | 1.851e-05 | 0.8289 |
| chr2:200619835 | rs34210468 | - | A>G | 658 | 39766 | 18.17 | 2.022e-05 | 1.187 |
| chr1:77072458 | rs2647389 | ST6GALNAC3 | T>C | 2005 | 130799 | 18.03 | 2.175e-05 | 1.11 |
| chr7:146023023 | rs17170038 | CNTNAP2 | G>A | 720 | 59730 | 17.91 | 2.319e-05 | 0.8494 |
| chr16:78585747 | rs117792755 | WWOX | C>G | 785 | 48326 | 17.66 | 2.638e-05 | 1.169 |
| chr1:175526374 | rs10913000 | TNR | G>A | 5644 | 418866 | 17.22 | 3.335e-05 | 0.9281 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr8:10143553 | rs2952176 | MSRA | A>G | 3011 | 1482 | 23.04 | 1.584e-06 | 0.8362 |
| chr10:126038055 | rs72835536 | - | G>A | 558 | 329 | 20.17 | 7.067e-06 | 0.7263 |
| chr21:46814879 | rs75271368 | - | C>T | 267 | 63 | 20.08 | 7.412e-06 | 1.863 |
| chr15:97079333 | rs2083117 | - | G>A | 638 | 196 | 19.35 | 1.089e-05 | 1.44 |
| chr17:4191295 | rs72829375 | UBE2G1 | T>C | 457 | 276 | 19.29 | 1.122e-05 | 0.711 |
| chr2:43713400 | rs113925878 | THADA | T>C | 657 | 204 | 18.92 | 1.364e-05 | 1.425 |
| chr15:65287336 | rs117904709 | - | C>G | 280 | 69 | 18.86 | 1.406e-05 | 1.786 |
| chr10:32821436 | rs78620612 | CCDC7 | G>A | 481 | 287 | 18.78 | 1.466e-05 | 0.7191 |
| chr10:90877896 | rs79411806 | - | G>A | 279 | 182 | 18.75 | 1.488e-05 | 0.6598 |
| chr6:103269058 | rs11156223 | - | T>C | 332 | 87 | 18.73 | 1.506e-05 | 1.683 |
| chr6:103270874 | rs7754418 | - | G>A | 315 | 81 | 18.61 | 1.605e-05 | 1.709 |
| chr18:5850612 | rs77231600 | - | G>A | 383 | 105 | 18.6 | 1.61e-05 | 1.61 |
| chr22:50112347 | rs111369962 | - | G>A | 1029 | 347 | 18.47 | 1.725e-05 | 1.317 |
| chr4:182791365 | Affx-24047955 | - | A>C | 415 | 252 | 18.37 | 1.816e-05 | 0.7061 |
| chr4:28010426 | rs115966571 | - | C>T | 187 | 131 | 18.24 | 1.952e-05 | 0.6143 |
| chr14:51206145 | rs12717411 | NIN | A>T | 434 | 124 | 18.01 | 2.192e-05 | 1.544 |
| chr23:23772435 | rs149531197 | ACOT9 | G>A | 837 | 252 | 17.85 | 2.388e-05 | 1.368 |
| chr1:43223412 | rs12127559 | P3H1 | G>A | 164 | 118 | 17.82 | 2.424e-05 | 0.6011 |
| chr4:28449159 | rs112073802 | - | G>A | 256 | 168 | 17.79 | 2.465e-05 | 0.6561 |
| chr2:3964932 | rs12463896 | - | T>C | 1237 | 652 | 17.6 | 2.732e-05 | 0.8066 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: R208 | Other and unspecified disturbances of skin sensation | 1/20 |
| ICD: R521 | Chronic intractable pain | 1/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: G500 | Trigeminal neuralgia | 0/20 |
| ICD-10: G571 | Meralgia paraesthetica | 0/20 |
| ICD-10: M755 | Bursitis of shoulder | 0/20 |
| ICD-10: R202 | Paraesthesia of skin | 0/20 |