Statistics
| Case | Control |
|---|---|
| 3063 | 457131 |
Phenotype Definition
An increased erythrocyte sedimentation rate (ESR). The ESR a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. [PMID:10524488]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32577973 | rs532965 | - | T>G | 1621 | 178916 | 192.2 | 1.065e-43 | 1.488 |
| chr6:32583357 | rs6931277 | - | A>T | 1596 | 175096 | 191.8 | 1.312e-43 | 1.492 |
| chr6:32582650 | rs3104413 | - | C>G | 1606 | 177463 | 186.5 | 1.843e-42 | 1.482 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 1659 | 188604 | 168.5 | 1.561e-38 | 1.448 |
| chr6:32379295 | rs9268515 | - | G>C | 1588 | 178782 | 163.4 | 2.045e-37 | 1.446 |
| chr6:32577380 | rs660895 | - | A>G | 1760 | 201887 | 163.0 | 2.507e-37 | 1.428 |
| chr6:32581973 | rs521539 | - | G>A | 1762 | 202035 | 162.8 | 2.814e-37 | 1.428 |
| chr6:32303848 | rs28361060 | TSBP1 | G>A | 1804 | 212056 | 140.9 | 1.724e-32 | 1.39 |
| chr6:32333341 | rs9268362 | TSBP1 | A>G | 1807 | 212604 | 139.8 | 2.887e-32 | 1.388 |
| chr6:32681483 | rs7454108 | - | T>C | 932 | 97329 | 138.2 | 6.446e-32 | 1.515 |
| chr6:32681530 | rs3957146 | - | T>C | 932 | 97318 | 138.1 | 7.05e-32 | 1.514 |
| chr6:32282854 | rs6910071 | TSBP1 | A>G | 1797 | 211803 | 137.5 | 9.428e-32 | 1.385 |
| chr6:32257284 | rs9268145 | TSBP1 | T>G | 1798 | 211830 | 137.5 | 9.516e-32 | 1.385 |
| chr6:32682019 | rs3998159 | - | A>C | 934 | 97927 | 136.8 | 1.367e-31 | 1.511 |
| chr6:32654714 | rs9275184 | - | T>C | 921 | 96335 | 136.7 | 1.382e-31 | 1.515 |
| chr6:32667850 | rs9275356 | - | C>G | 930 | 97406 | 135.8 | 2.25e-31 | 1.51 |
| chr6:32682429 | rs9275599 | - | C>T | 892 | 92868 | 134.5 | 4.286e-31 | 1.518 |
| chr6:32675634 | rs9275532 | - | C>G | 925 | 96878 | 133.8 | 6.08e-31 | 1.507 |
| chr6:32682137 | Affx-28502500 | - | A>G | 933 | 98782 | 129.3 | 5.886e-30 | 1.494 |
| chr6:32387809 | rs2395163 | - | T>C | 1775 | 211008 | 126.7 | 2.132e-29 | 1.369 |
| chr6:32577973 | rs532965 | - | T>G | 1587 | 173080 | 194.3 | 3.631e-44 | 1.5 |
| chr6:32583357 | rs6931277 | - | A>T | 1562 | 169394 | 193.0 | 7.183e-44 | 1.504 |
| chr6:32582650 | rs3104413 | - | C>G | 1573 | 171621 | 189.8 | 3.586e-43 | 1.496 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 1622 | 181668 | 174.1 | 9.594e-40 | 1.466 |
| chr6:32577380 | rs660895 | - | A>G | 1711 | 193256 | 167.7 | 2.309e-38 | 1.445 |
| chr6:32581973 | rs521539 | - | G>A | 1711 | 193384 | 166.4 | 4.562e-38 | 1.443 |
| chr6:32379295 | rs9268515 | - | G>C | 1568 | 174618 | 166.0 | 5.669e-38 | 1.457 |
| chr6:32681483 | rs7454108 | - | T>C | 909 | 93628 | 139.5 | 3.442e-32 | 1.527 |
| chr6:32681530 | rs3957146 | - | T>C | 909 | 93618 | 139.3 | 3.791e-32 | 1.527 |
| chr6:32303848 | rs28361060 | TSBP1 | G>A | 1776 | 207461 | 138.3 | 6.327e-32 | 1.392 |
| chr6:32682019 | rs3998159 | - | A>C | 910 | 94113 | 137.6 | 8.845e-32 | 1.523 |
| chr6:32333341 | rs9268362 | TSBP1 | A>G | 1779 | 208003 | 137.3 | 1.03e-31 | 1.391 |
| chr6:32654714 | rs9275184 | - | T>C | 898 | 92718 | 137.1 | 1.148e-31 | 1.526 |
| chr6:32667850 | rs9275356 | - | C>G | 907 | 93706 | 136.9 | 1.237e-31 | 1.522 |
| chr6:32675634 | rs9275532 | - | C>G | 902 | 93195 | 134.9 | 3.48e-31 | 1.519 |
| chr6:32282854 | rs6910071 | TSBP1 | A>G | 1769 | 207211 | 134.5 | 4.291e-31 | 1.387 |
| chr6:32257284 | rs9268145 | TSBP1 | T>G | 1769 | 207226 | 134.3 | 4.714e-31 | 1.386 |
| chr6:32387809 | rs2395163 | - | T>C | 1730 | 202099 | 134.0 | 5.47e-31 | 1.389 |
| chr6:32682429 | rs9275599 | - | C>T | 864 | 89016 | 132.3 | 1.306e-30 | 1.524 |
| chr6:32371915 | rs3793127 | BTNL2 | C>T | 1735 | 202919 | 131.6 | 1.861e-30 | 1.384 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:31256026 | rs17198734 | HLA-B | C>G | 155 | 71 | 34.27 | 4.79e-09 | 0.4336 |
| chr6:31256058 | rs17192386 | HLA-B | G>T | 162 | 73 | 33.98 | 5.559e-09 | 0.4404 |
| chr6:32553626 | rs113647600 | HLA-DRB1 | C>A | 739 | 221 | 28.5 | 9.391e-08 | 0.6423 |
| chr6:32581889 | rs4530903 | - | C>T | 725 | 216 | 26.93 | 2.106e-07 | 0.6477 |
| chr6:32504136 | rs66525318 | - | C>A | 813 | 237 | 26.6 | 2.499e-07 | 0.6602 |
| chr6:32548469 | rs3830133 | HLA-DRB1 | A>G | 743 | 219 | 25.76 | 3.863e-07 | 0.6557 |
| chr6:100568615 | rs2397789 | - | A>G | 2666 | 448 | 25.53 | 4.355e-07 | 1.376 |
| chr6:32590844 | rs17533167 | - | G>C | 733 | 216 | 25.28 | 4.946e-07 | 0.6567 |
| chr6:32549638 | rs72850244 | HLA-DRB1 | G>A | 737 | 217 | 25.22 | 5.108e-07 | 0.6576 |
| chr6:32542638 | rs34451186 | - | T>C | 739 | 217 | 24.99 | 5.756e-07 | 0.6589 |
| chr6:32527079 | rs28530648 | - | A>C | 786 | 228 | 24.94 | 5.906e-07 | 0.6648 |
| chr6:31248568 | rs9380234 | HLA-B | G>A | 193 | 76 | 24.92 | 5.965e-07 | 0.5059 |
| chr6:32583188 | rs113979555 | - | G>A | 737 | 216 | 24.74 | 6.568e-07 | 0.6598 |
| chr6:29910549 | rs45585732 | HLA-A | G>A | 200 | 78 | 24.62 | 6.965e-07 | 0.5121 |
| chr6:31245080 | rs9391714 | HLA-B | G>A | 198 | 77 | 24.44 | 7.666e-07 | 0.5117 |
| chr6:31344916 | rs116488202 | - | C>T | 282 | 100 | 23.92 | 1.004e-06 | 0.5587 |
| chr6:32453194 | rs72849247 | - | T>C | 714 | 209 | 23.79 | 1.072e-06 | 0.6614 |
| chr6:31240096 | rs9366775 | HLA-B | G>A | 200 | 77 | 23.77 | 1.084e-06 | 0.5167 |
| chr6:31327034 | rs116666910 | - | C>A | 280 | 99 | 23.75 | 1.095e-06 | 0.5584 |
| chr6:31240479 | rs9357121 | HLA-B | T>G | 200 | 77 | 23.7 | 1.124e-06 | 0.5172 |
| chr6:31256058 | rs17192386 | HLA-B | G>T | 151 | 71 | 36.85 | 1.277e-09 | 0.4192 |
| chr6:31256026 | rs17198734 | HLA-B | C>G | 152 | 70 | 34.53 | 4.192e-09 | 0.4292 |
| chr6:32553626 | rs113647600 | HLA-DRB1 | C>A | 722 | 216 | 28.52 | 9.254e-08 | 0.638 |
| chr6:31248568 | rs9380234 | HLA-B | G>A | 179 | 74 | 28.04 | 1.191e-07 | 0.4791 |
| chr6:29910549 | rs45585732 | HLA-A | G>A | 186 | 76 | 27.81 | 1.339e-07 | 0.4851 |
| chr6:32581889 | rs4530903 | - | C>T | 708 | 212 | 27.71 | 1.409e-07 | 0.6401 |
| chr6:31245080 | rs9391714 | HLA-B | G>A | 184 | 75 | 27.46 | 1.605e-07 | 0.4855 |
| chr6:31240096 | rs9366775 | HLA-B | G>A | 185 | 75 | 27.19 | 1.845e-07 | 0.4873 |
| chr6:31240479 | rs9357121 | HLA-B | T>G | 186 | 75 | 26.64 | 2.454e-07 | 0.4911 |
| chr6:32548469 | rs3830133 | HLA-DRB1 | A>G | 725 | 214 | 25.92 | 3.559e-07 | 0.6508 |
| chr6:100568615 | rs2397789 | - | A>G | 2557 | 426 | 25.81 | 3.762e-07 | 1.39 |
| chr6:31322367 | rs3819299 | HLA-B | T>G | 333 | 115 | 25.78 | 3.819e-07 | 0.5673 |
| chr6:32590844 | rs17533167 | - | G>C | 716 | 211 | 25.29 | 4.928e-07 | 0.6526 |
| chr6:32549638 | rs72850244 | HLA-DRB1 | G>A | 720 | 212 | 25.18 | 5.214e-07 | 0.6538 |
| chr6:32542638 | rs34451186 | - | T>C | 722 | 212 | 25.0 | 5.739e-07 | 0.6549 |
| chr6:32504136 | rs66525318 | - | C>A | 776 | 225 | 24.99 | 5.772e-07 | 0.6617 |
| chr6:31344916 | rs116488202 | - | C>T | 276 | 99 | 24.97 | 5.834e-07 | 0.5493 |
| chr6:32583188 | rs113979555 | - | G>A | 720 | 211 | 24.7 | 6.702e-07 | 0.656 |
| chr6:31365787 | rs4349859 | - | G>A | 272 | 97 | 24.25 | 8.475e-07 | 0.5511 |
| chr6:31327034 | rs116666910 | - | C>A | 276 | 98 | 24.24 | 8.503e-07 | 0.5529 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M316 | Other giant cell arteritis | 12/20 |
| ICD: M353 | Polymyalgia rheumatica | 19/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: R071 | Chest pain on breathing | 0/20 |
| ICD-10: R700 | Elevated erythrocyte sedimentation rate | 0/20 |