Statistics
| Case | Control |
|---|---|
| 695 | 459499 |
Phenotype Definition
The presence of circulating autoantibodies to phospholipids. [HPO:probinson]
Phenotype Comment
This group of autoantibodies comprises anticardiolipin, antiphosphatidylinositol, atiphosphatidylglycerol, and antiphosphatidylserine antibodies.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 104 | 18041 | 186.7 | 1.678e-42 | 3.657 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 130 | 27396 | 162.0 | 4.186e-37 | 3.032 |
| chr9:117110112 | Affx-52344420 | AKNA | T>TG | 85 | 14494 | 157.5 | 4.015e-36 | 3.697 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 100 | 19277 | 147.7 | 5.445e-34 | 3.278 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 86 | 15331 | 147.4 | 6.408e-34 | 3.539 |
| chr10:1411012 | rs12762472 | ADARB2 | G>C | 65 | 9824 | 147.0 | 7.807e-34 | 4.13 |
| chr19:44740602 | rs3810137 | ZNF227 | G>A | 80 | 13766 | 145.2 | 1.923e-33 | 3.647 |
| chr23:64367019 | rs7064929 | - | G>A | 106 | 17460 | 144.2 | 3.158e-33 | 3.155 |
| chr12:56722060 | rs1918496 | PAN2 | G>T | 71 | 11546 | 142.1 | 9.404e-33 | 3.846 |
| chr17:58506748 | rs57928695 | C17orf64 | C>T | 64 | 9783 | 142.1 | 9.172e-33 | 4.083 |
| chr4:190837589 | rs6822336 | - | C>T | 69 | 11077 | 141.3 | 1.418e-32 | 3.895 |
| chr12:13065709 | rs1640874 | GPRC5A | A>G | 71 | 11648 | 141.3 | 1.405e-32 | 3.835 |
| chr19:44680489 | rs2178342 | ZNF226 | G>A | 79 | 13705 | 141.1 | 1.522e-32 | 3.612 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 105 | 21265 | 140.8 | 1.747e-32 | 3.122 |
| chr3:188327555 | rs7645635 | LPP | T>C | 81 | 14295 | 140.7 | 1.878e-32 | 3.558 |
| chr6:137344363 | rs1744080 | IL20RA | G>A | 89 | 16521 | 140.7 | 1.907e-32 | 3.387 |
| chr5:147671850 | rs7724380 | - | G>A | 101 | 20082 | 139.9 | 2.757e-32 | 3.17 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 106 | 21837 | 138.7 | 5.019e-32 | 3.084 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 114 | 19837 | 138.7 | 5.192e-32 | 2.988 |
| chr7:137347299 | rs7797609 | DGKI | T>C | 102 | 20636 | 137.1 | 1.141e-31 | 3.122 |
| chr6:31434621 | rs3131618 | - | A>G | 284 | 129051 | 46.73 | 8.132e-12 | 1.571 |
| chr6:31172151 | rs3132510 | - | T>C | 276 | 124529 | 46.64 | 8.511e-12 | 1.577 |
| chr6:31306420 | rs1625792 | HLA-B | G>A | 284 | 129360 | 45.76 | 1.34e-11 | 1.564 |
| chr6:31434366 | rs3094013 | - | G>A | 283 | 129683 | 45.04 | 1.935e-11 | 1.559 |
| chr6:31430694 | rs3094605 | - | G>C | 283 | 129647 | 44.57 | 2.454e-11 | 1.555 |
| chr6:31312326 | rs3134792 | HLA-B | T>G | 287 | 132305 | 43.8 | 3.64e-11 | 1.546 |
| chr6:31058340 | rs3130544 | - | C>A | 298 | 138749 | 43.57 | 4.09e-11 | 1.535 |
| chr6:31353171 | rs2844531 | - | A>G | 280 | 129782 | 42.75 | 6.232e-11 | 1.545 |
| chr6:31514247 | rs9267488 | ATP6V1G2-DDX39B | A>G | 276 | 127030 | 42.06 | 8.863e-11 | 1.542 |
| chr6:31892484 | rs497309 | C2 | A>C | 263 | 120024 | 41.79 | 1.017e-10 | 1.552 |
| chr6:31442782 | rs3131643 | - | G>A | 309 | 145909 | 41.74 | 1.045e-10 | 1.513 |
| chr6:32080191 | rs1269852 | TNXB | G>C | 261 | 118932 | 41.61 | 1.115e-10 | 1.553 |
| chr6:32064726 | rs1150752 | TNXB | T>C | 262 | 119562 | 41.59 | 1.124e-10 | 1.551 |
| chr6:31094703 | rs3130557 | PSORS1C1 | C>T | 295 | 138865 | 41.59 | 1.126e-10 | 1.523 |
| chr6:31129310 | rs7750641 | TCF19 | C>T | 298 | 140260 | 41.06 | 1.476e-10 | 1.516 |
| chr6:31085356 | rs3130985 | PSORS1C1 | C>T | 298 | 140162 | 41.03 | 1.501e-10 | 1.516 |
| chr6:31244789 | rs2524069 | HLA-B | A>T | 327 | 156804 | 40.8 | 1.687e-10 | 1.494 |
| chr6:32059867 | rs1150753 | TNXB | A>G | 261 | 119641 | 40.73 | 1.746e-10 | 1.546 |
| chr6:31870326 | rs558702 | C2 | G>A | 262 | 120090 | 40.62 | 1.847e-10 | 1.544 |
| chr6:31725230 | rs3117574 | MSH5 | G>A | 263 | 121063 | 40.56 | 1.908e-10 | 1.542 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32590953 | rs9271588 | - | T>C | 613 | 17084 | 47.2 | 6.415e-12 | 0.6859 |
| chr6:32413459 | rs2227139 | - | A>G | 650 | 12064 | 46.69 | 8.319e-12 | 1.454 |
| chr6:32427789 | rs9268832 | - | C>T | 650 | 12083 | 46.05 | 1.15e-11 | 1.45 |
| chr6:32412539 | rs7195 | HLA-DRA | G>A | 634 | 11836 | 45.5 | 1.525e-11 | 1.452 |
| chr6:32412480 | rs7194 | HLA-DRA | A>G | 647 | 12064 | 45.43 | 1.586e-11 | 1.448 |
| chr6:32413830 | rs3763327 | - | C>G | 647 | 12053 | 45.1 | 1.871e-11 | 1.445 |
| chr6:32448129 | rs4410767 | - | T>C | 572 | 16100 | 44.55 | 2.484e-11 | 0.6907 |
| chr6:32413094 | rs2213586 | - | G>A | 648 | 12059 | 44.35 | 2.745e-11 | 1.44 |
| chr6:32411646 | rs7192 | HLA-DRA | G>T | 646 | 12051 | 44.16 | 3.033e-11 | 1.439 |
| chr6:32678999 | rs9275572 | - | G>A | 685 | 12877 | 44.1 | 3.128e-11 | 1.437 |
| chr6:32675109 | rs9275524 | - | C>T | 684 | 12877 | 43.71 | 3.799e-11 | 1.435 |
| chr6:32428772 | rs9268839 | - | A>G | 576 | 16152 | 43.57 | 4.084e-11 | 0.6939 |
| chr6:32664458 | rs2647012 | - | C>T | 654 | 12262 | 42.85 | 5.913e-11 | 1.431 |
| chr6:32664880 | rs2647003 | - | G>T | 650 | 12160 | 42.66 | 6.501e-11 | 1.431 |
| chr6:32670308 | rs2856717 | - | G>A | 653 | 12217 | 42.66 | 6.527e-11 | 1.43 |
| chr6:32670464 | rs2858305 | - | T>G | 645 | 12023 | 42.51 | 7.045e-11 | 1.43 |
| chr6:32669018 | rs1612904 | - | A>C | 619 | 11547 | 42.4 | 7.456e-11 | 1.432 |
| chr6:32660375 | rs2858324 | - | G>A | 652 | 12224 | 42.3 | 7.823e-11 | 1.429 |
| chr6:32447341 | rs29001568 | - | G>A | 556 | 15615 | 41.61 | 1.116e-10 | 0.6967 |
| chr6:32668336 | rs2647046 | - | C>A | 652 | 12232 | 41.37 | 1.258e-10 | 1.422 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M329 | Systemic lupus erythematosus, unspecified | 15/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: O120 | Gestational oedema | 0/20 |