Hernia of the abdominal wall

0004299

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
32248	427946

Phenotype Definition

The presence of a hernia in the abdominal wall. [HPO:probinson]

Phenotype Comment

A hernia refers to a sac formed by the lining of the abdominal cavity (peritoneum). The sac can protrude through a hole or weak area in the abdominal fascia.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr2:56096892	rs3791679	EFEMP1	A>G	13636	208342	262.8	4.222e-59	0.8517
chr2:56111309	rs3791675	EFEMP1	C>T	14127	214845	252.5	7.291e-57	0.8562
chr15:48426484	rs1426654	SLC24A5	A>G	1308	26218	205.0	1.732e-46	0.6657
chr2:56189500	rs74938797	-	T>C	23613	342664	193.4	5.795e-44	0.8901
chr11:32473807	rs3858455	-	T>C	26780	385678	192.2	1.065e-43	0.8931
chr2:56095104	rs11125608	EFEMP1	T>G	25174	363780	190.4	2.646e-43	0.8925
chr1:219734960	rs2820441	-	A>C	22424	279389	185.9	2.5e-42	1.123
chr1:219750717	rs4846567	-	G>T	21162	262694	184.9	4.17e-42	1.124
chr2:56199556	rs55805406	-	G>A	24588	355095	179.6	5.9e-41	0.8949
chr2:56053095	rs7572523	-	A>G	28581	408621	171.8	2.988e-39	0.8996
chr2:56055869	rs1960050	-	T>C	28577	408739	167.2	3.053e-38	0.9007
chr1:219722104	rs4846565	-	G>A	24007	301639	165.5	7.17e-38	1.113
chr15:48392165	rs1834640	-	A>G	1622	30002	160.9	7.214e-37	0.7218
chr5:33951693	rs16891982	SLC45A2	G>C	3843	63215	155.3	1.229e-35	0.8083
chr2:56053353	rs6708796	-	T>C	26943	385102	153.7	2.642e-35	0.9039
chr5:33958959	rs28777	SLC45A2	A>C	3230	53762	144.9	2.233e-33	0.8
chr1:219700519	rs2785980	-	T>C	23911	301610	144.2	3.193e-33	1.106
chr25:154999134	rs6642320	-	G>A	22535	322480	130.3	3.527e-30	0.9067
chr13:72463541	rs1460465	-	A>G	756	15368	125.3	4.346e-29	0.6594
chr1:219644224	rs2605100	-	G>A	21885	276355	123.8	9.169e-29	1.1
chr2:56096892	rs3791679	EFEMP1	A>G	13048	195349	231.7	2.602e-52	0.8571
chr2:56111309	rs3791675	EFEMP1	C>T	13529	201877	227.3	2.32e-51	0.8601
chr2:56189500	rs74938797	-	T>C	22641	322897	176.5	2.86e-40	0.8925
chr2:56199556	rs55805406	-	G>A	23532	333757	158.4	2.559e-36	0.8988
chr1:219750717	rs4846567	-	G>T	20552	253093	149.7	1.987e-34	1.113
chr1:219734960	rs2820441	-	A>C	21784	269332	148.3	4.033e-34	1.111
chr2:56095104	rs11125608	EFEMP1	T>G	23514	331790	134.9	3.445e-31	0.9062
chr25:154999134	rs6642320	-	G>A	21384	301979	128.2	1.007e-29	0.9052
chr1:219722104	rs4846565	-	G>A	23329	291035	126.7	2.193e-29	1.101
chr25:2692710	rs2259750	-	A>G	12872	155730	126.2	2.722e-29	1.123
chr2:56053095	rs7572523	-	A>G	26639	372325	119.7	7.264e-28	0.9133
chr11:32473807	rs3858455	-	T>C	24932	349425	118.0	1.737e-27	0.913
chr2:56055869	rs1960050	-	T>C	26625	372239	115.7	5.455e-27	0.9146
chr1:219700519	rs2785980	-	T>C	23175	289813	113.4	1.805e-26	1.095
chr2:56053353	rs6708796	-	T>C	25221	352485	109.1	1.54e-25	0.9163
chr25:2661556	rs73188900	-	A>C	1621	16493	107.5	3.447e-25	1.314
chr25:154986418	rs142918084	-	C>G	1705	28996	100.7	1.096e-23	0.7763
chr25:155013081	rs146997510	-	T>A	2239	23910	100.1	1.47e-23	1.252
chr2:56040099	rs10199082	-	T>C	9500	114249	98.37	3.467e-23	1.121
chr25:2679949	rs311121	-	G>T	8327	122461	97.35	5.797e-23	0.8871

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr2:56096892	rs3791679	EFEMP1	A>G	13636	36404	168.1	1.917e-38	0.8638
chr2:56111309	rs3791675	EFEMP1	C>T	14127	37598	166.4	4.413e-38	0.8661
chr25:2692710	rs2259750	-	A>G	13691	28952	161.6	5.029e-37	1.159
chr25:154999134	rs6642320	-	G>A	22535	57902	157.1	4.95e-36	0.884
chr25:2661556	rs73188900	-	A>C	1635	2659	152.3	5.507e-35	1.477
chr1:219750717	rs4846567	-	G>T	21162	46475	132.0	1.478e-30	1.121
chr25:155013081	rs146997510	-	T>A	2266	4022	129.4	5.455e-30	1.353
chr1:219734960	rs2820441	-	A>C	22424	49478	129.2	6.216e-30	1.118
chr2:56189500	rs74938797	-	T>C	23613	60187	126.2	2.85e-29	0.8978
chr25:2679949	rs311121	-	G>T	8785	23780	126.1	2.968e-29	0.8601
chr25:154986418	rs142918084	-	C>G	1832	5861	125.4	4.239e-29	0.7381
chr25:154974730	rs144759332	-	C>G	1442	4702	113.6	1.598e-26	0.7237
chr2:56095104	rs11125608	EFEMP1	T>G	25174	63717	112.6	2.633e-26	0.9045
chr25:154935282	rs112437556	-	C>T	1655	5270	112.5	2.757e-26	0.7393
chr2:56199556	rs55805406	-	G>A	24588	62305	112.0	3.486e-26	0.9043
chr1:219722104	rs4846565	-	G>A	24007	53511	109.1	1.531e-25	1.106
chr2:56053095	rs7572523	-	A>G	28581	71669	101.2	8.262e-24	0.9109
chr25:155104608	rs5940618	-	G>A	14969	32710	100.0	1.486e-23	1.118
chr1:219700519	rs2785980	-	T>C	23911	53404	99.48	1.978e-23	1.101
chr2:56055869	rs1960050	-	T>C	28577	71713	99.21	2.273e-23	0.9117
chr25:154999134	rs6642320	-	G>A	21384	54594	150.2	1.581e-34	0.8837
chr2:56111309	rs3791675	EFEMP1	C>T	13529	35552	144.9	2.238e-33	0.8717
chr25:2661556	rs73188900	-	A>C	1621	2638	144.7	2.441e-33	1.465
chr2:56096892	rs3791679	EFEMP1	A>G	13048	34366	144.4	2.884e-33	0.8703
chr25:2692710	rs2259750	-	A>G	12872	27105	140.9	1.662e-32	1.153
chr25:154986418	rs142918084	-	C>G	1705	5559	139.6	3.209e-32	0.7181
chr25:2679949	rs311121	-	G>T	8327	22462	127.4	1.549e-29	0.856
chr25:155013081	rs146997510	-	T>A	2239	3965	123.1	1.336e-28	1.346
chr25:155104608	rs5940618	-	G>A	13956	29857	121.5	2.936e-28	1.136
chr1:219750717	rs4846567	-	G>T	20552	44940	118.6	1.305e-27	1.117
chr1:219734960	rs2820441	-	A>C	21784	47844	116.3	3.986e-27	1.114
chr25:154935282	rs112437556	-	C>T	1635	5198	116.2	4.315e-27	0.7342
chr2:56189500	rs74938797	-	T>C	22641	57110	111.6	4.448e-26	0.9014
chr25:2644302	rs1136470	-	C>T	8094	21571	101.4	7.418e-24	0.8687
chr2:56199556	rs55805406	-	G>A	23532	59016	97.96	4.261e-23	0.9082
chr1:219722104	rs4846565	-	G>A	23329	51764	97.17	6.366e-23	1.102
chr25:2691012	rs142162416	-	A>G	2395	7067	93.36	4.359e-22	0.7924
chr2:56095104	rs11125608	EFEMP1	T>G	23514	58855	92.14	8.071e-22	0.9108
chr1:219700519	rs2785980	-	T>C	23175	51477	90.37	1.98e-21	1.098
chr2:56053095	rs7572523	-	A>G	26639	66180	86.33	1.522e-20	0.9153

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: K402	Bilateral inguinal hernia, without obstruction or gangrene	4/20
ICD: K409	Unilateral or unspecified inguinal hernia, without obstruction or gangrene	10/20
ICD: K419	Unilateral or unspecified femoral hernia, without obstruction or gangrene	7/20
ICD: K429	Umbilical hernia without obstruction or gangrene	5/20
ICD: K43	Ventral hernia	6/20

ID	Name	Top Correlation
ICD-10: C181	Appendix	0/20
ICD-10: K351	Acute appendicitis with peritoneal abscess	0/20
ICD-10: K358	Acute appendicitis, other and unspecified	0/20
ICD-10: K359	Acute appendicitis, unspecified	0/20
ICD-10: K36	Other appendicitis	0/20
ICD-10: K37	Unspecified appendicitis	0/20
ICD-10: K403	Unilateral or unspecified inguinal hernia, with obstruction, without gangrene	0/20
ICD-10: K413	Unilateral or unspecified femoral hernia, with obstruction, without gangrene	0/20
ICD-10: K420	Umbilical hernia with obstruction, without gangrene	0/20
ICD-10: K458	Other specified abdominal hernia without obstruction or gangrene	0/20
ICD-10: K469	Unspecified abdominal hernia without obstruction or gangrene	0/20
ICD-10: K559	Vascular disorder of intestine, unspecified	0/20
ICD-10: K632	Fistula of intestine	0/20
ICD-10: M707	Other bursitis of hip	0/20