Statistics
| Case | Control |
|---|---|
| 9566 | 450628 |
Phenotype Definition
The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin. [HPO:curators]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 6601 | 287096 | 87.36 | 9.034e-21 | 1.153 |
| chr11:111165009 | rs7103178 | - | T>C | 6612 | 288271 | 82.37 | 1.13e-19 | 1.148 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 7154 | 315494 | 74.98 | 4.752e-18 | 1.138 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 9132 | 466971 | 72.48 | 1.685e-17 | 0.8848 |
| chr8:117630683 | rs16892766 | - | A>C | 1887 | 76810 | 53.63 | 2.421e-13 | 1.196 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 929 | 56063 | 51.71 | 6.42e-13 | 0.7842 |
| chr15:48392165 | rs1834640 | - | A>G | 469 | 31155 | 51.2 | 8.333e-13 | 0.7151 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 397 | 27129 | 51.18 | 8.415e-13 | 0.6953 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1118 | 65940 | 51.02 | 9.159e-13 | 0.8015 |
| chr11:111213944 | rs12365324 | - | G>A | 8313 | 375288 | 48.83 | 2.797e-12 | 1.107 |
| chr12:51213765 | rs11169571 | ATF1 | T>C | 8449 | 382434 | 45.35 | 1.652e-11 | 1.102 |
| chr12:51171090 | rs12372718 | ATF1 | A>G | 8435 | 381717 | 44.99 | 1.983e-11 | 1.102 |
| chr8:117640315 | rs11986063 | - | C>T | 2066 | 86459 | 41.47 | 1.2e-10 | 1.163 |
| chr11:111202486 | rs1893990 | - | C>T | 9468 | 432190 | 40.83 | 1.662e-10 | 1.096 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 272 | 19105 | 40.35 | 2.124e-10 | 0.6783 |
| chr2:242813574 | rs4075286 | RTP5 | T>C | 447 | 28765 | 40.0 | 2.545e-10 | 0.738 |
| chr1:64273591 | rs659592 | ROR1 | A>G | 513 | 32404 | 39.89 | 2.683e-10 | 0.7529 |
| chr12:51203371 | rs1129406 | ATF1 | C>T | 8494 | 386092 | 39.06 | 4.103e-10 | 1.095 |
| chr18:46459032 | rs4464148 | SMAD7 | T>C | 6233 | 279306 | 39.06 | 4.099e-10 | 1.101 |
| chr8:47297510 | rs11136176 | - | T>C | 1079 | 62167 | 38.69 | 4.968e-10 | 0.8219 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 6332 | 271811 | 76.6 | 2.095e-18 | 1.146 |
| chr11:111165009 | rs7103178 | - | T>C | 6337 | 272456 | 73.0 | 1.295e-17 | 1.142 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6957 | 304223 | 58.87 | 1.683e-14 | 1.124 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 8597 | 430081 | 58.15 | 2.432e-14 | 0.8939 |
| chr8:117630683 | rs16892766 | - | A>C | 1801 | 71311 | 57.58 | 3.244e-14 | 1.209 |
| chr8:117640315 | rs11986063 | - | C>T | 1943 | 78443 | 50.1 | 1.462e-12 | 1.187 |
| chr12:51213765 | rs11169571 | ATF1 | T>C | 8148 | 362632 | 43.06 | 5.316e-11 | 1.102 |
| chr12:51171090 | rs12372718 | ATF1 | A>G | 8145 | 362995 | 40.6 | 1.87e-10 | 1.099 |
| chr12:51203371 | rs1129406 | ATF1 | C>T | 8151 | 363427 | 40.38 | 2.094e-10 | 1.098 |
| chr10:8701219 | rs10795668 | - | G>A | 5821 | 293653 | 38.8 | 4.702e-10 | 0.9058 |
| chr12:51032415 | rs12818741 | DIP2B | A>G | 7143 | 317972 | 35.36 | 2.742e-09 | 1.094 |
| chr11:111213944 | rs12365324 | - | G>A | 8152 | 365327 | 33.89 | 5.824e-09 | 1.09 |
| chr8:128413305 | rs6983267 | POU5F1B | G>T | 8811 | 433950 | 33.18 | 8.401e-09 | 0.919 |
| chr12:50934931 | rs11169484 | DIP2B | G>A | 7102 | 317068 | 32.07 | 1.489e-08 | 1.09 |
| chr18:46453754 | rs35352860 | SMAD7 | C>T | 4766 | 240757 | 31.21 | 2.32e-08 | 0.91 |
| chr15:32992658 | rs28399071 | - | G>A | 2010 | 84081 | 30.33 | 3.639e-08 | 1.14 |
| chr8:128407443 | rs10505477 | POU5F1B | A>G | 9003 | 442029 | 29.96 | 4.409e-08 | 0.923 |
| chr11:111202486 | rs1893990 | - | C>T | 9213 | 416354 | 29.15 | 6.686e-08 | 1.082 |
| chr18:46459032 | rs4464148 | SMAD7 | T>C | 6093 | 270686 | 29.1 | 6.868e-08 | 1.088 |
| chr7:46866208 | rs9791388 | - | C>T | 5875 | 261093 | 27.63 | 1.467e-07 | 1.087 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 6332 | 35550 | 50.15 | 1.427e-12 | 1.125 |
| chr11:111165009 | rs7103178 | - | T>C | 6337 | 35669 | 46.49 | 9.231e-12 | 1.12 |
| chr8:117630683 | rs16892766 | - | A>C | 1801 | 9292 | 44.62 | 2.396e-11 | 1.198 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6957 | 39663 | 39.37 | 3.498e-10 | 1.107 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 8597 | 55145 | 39.21 | 3.8e-10 | 0.9064 |
| chr8:117640315 | rs11986063 | - | C>T | 1943 | 10243 | 37.39 | 9.655e-10 | 1.173 |
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 1246 | 8935 | 32.3 | 1.319e-08 | 0.8372 |
| chr11:111213944 | rs12365324 | - | G>A | 8152 | 47084 | 32.27 | 1.339e-08 | 1.094 |
| chr4:151207127 | rs3749574 | LRBA | C>T | 5832 | 37884 | 31.34 | 2.165e-08 | 0.9097 |
| chr12:51213765 | rs11169571 | ATF1 | T>C | 8148 | 47071 | 30.95 | 2.653e-08 | 1.092 |
| chr4:151206319 | rs6817154 | LRBA | T>C | 5845 | 37869 | 29.51 | 5.559e-08 | 0.9123 |
| chr12:51171090 | rs12372718 | ATF1 | A>G | 8145 | 47125 | 29.25 | 6.359e-08 | 1.089 |
| chr4:151148930 | rs28405622 | DCLK2 | C>T | 5606 | 36323 | 28.43 | 9.717e-08 | 0.9128 |
| chr12:51203371 | rs1129406 | ATF1 | C>T | 8151 | 47220 | 28.09 | 1.158e-07 | 1.087 |
| chr2:44065090 | Affx-20089987 | ABCG5 | G>A | 1194 | 8506 | 28.07 | 1.168e-07 | 0.8445 |
| chr10:8701219 | rs10795668 | - | G>A | 5821 | 37651 | 27.08 | 1.947e-07 | 0.9157 |
| chr11:111202486 | rs1893990 | - | C>T | 9213 | 53723 | 26.69 | 2.393e-07 | 1.084 |
| chr4:151172930 | rs59435073 | DCLK2 | G>A | 5445 | 35256 | 26.57 | 2.542e-07 | 0.9149 |
| chr4:151199080 | rs2290846 | LRBA | G>A | 5316 | 34441 | 26.4 | 2.774e-07 | 0.9146 |
| chr18:46453754 | rs35352860 | SMAD7 | C>T | 4766 | 31039 | 26.1 | 3.241e-07 | 0.9122 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: C187 | Sigmoid colon | 4/20 |
| ICD: D125 | Sigmoid colon | 10/20 |