Statistics
| Case | Control |
|---|---|
| 14257 | 445937 |
Phenotype Definition
An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:45556163 | rs8023604 | SLC28A2 | T>C | 627 | 12284 | 123.9 | 8.756e-29 | 1.578 |
| chr15:45695612 | rs1346265 | SPATA5L1 | C>T | 570 | 11100 | 115.2 | 6.971e-27 | 1.586 |
| chr15:45694768 | rs1834686 | SPATA5L1 | G>T | 506 | 9713 | 108.8 | 1.791e-25 | 1.608 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 814 | 17331 | 106.7 | 5.132e-25 | 1.452 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 853 | 18524 | 100.5 | 1.193e-23 | 1.425 |
| chr8:116631902 | rs7823278 | TRPS1 | C>A | 538 | 10821 | 94.0 | 3.153e-22 | 1.535 |
| chr4:177863637 | rs2728145 | - | C>T | 1176 | 27176 | 93.84 | 3.418e-22 | 1.341 |
| chr5:35790252 | rs6875303 | SPEF2 | A>G | 509 | 10141 | 92.86 | 5.611e-22 | 1.549 |
| chr6:37328215 | Affx-28571852 | RNF8 | C>CT | 841 | 18475 | 92.54 | 6.6e-22 | 1.408 |
| chr23:64367019 | rs7064929 | - | G>A | 728 | 16838 | 91.87 | 9.233e-22 | 1.443 |
| chr9:5114722 | rs12342708 | JAK2 | A>G | 572 | 11724 | 91.13 | 1.345e-21 | 1.506 |
| chr18:9536315 | rs14336 | RALBP1 | A>C | 594 | 12273 | 91.08 | 1.381e-21 | 1.495 |
| chr23:42913158 | rs5991558 | - | C>T | 658 | 14973 | 90.59 | 1.764e-21 | 1.466 |
| chr4:177862976 | rs2728147 | - | G>T | 1148 | 26599 | 90.02 | 2.361e-21 | 1.337 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 487 | 10539 | 86.03 | 1.772e-20 | 1.539 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 909 | 20461 | 86.01 | 1.788e-20 | 1.374 |
| chr17:29350769 | rs8073072 | - | T>G | 1068 | 24638 | 85.91 | 1.885e-20 | 1.341 |
| chr17:40957849 | rs61995868 | CNTD1 | G>A | 503 | 10179 | 85.21 | 2.681e-20 | 1.525 |
| chr4:177863886 | rs2574926 | - | T>C | 1160 | 27169 | 84.4 | 4.041e-20 | 1.323 |
| chr16:17200685 | rs8046024 | XYLT1 | C>T | 846 | 18931 | 83.02 | 8.129e-20 | 1.382 |
| chr6:32626272 | rs9273363 | - | C>A | 9260 | 267345 | 82.27 | 1.186e-19 | 1.124 |
| chr6:32626302 | rs9273364 | - | T>G | 9018 | 260484 | 80.38 | 3.093e-19 | 1.124 |
| chr6:32654714 | rs9275184 | - | T>C | 3322 | 90294 | 69.4 | 8.038e-17 | 1.169 |
| chr6:32667850 | rs9275356 | - | C>G | 3342 | 91271 | 66.26 | 3.949e-16 | 1.165 |
| chr6:32681483 | rs7454108 | - | T>C | 3339 | 91198 | 65.88 | 4.799e-16 | 1.164 |
| chr6:32682019 | rs3998159 | - | A>C | 3352 | 91671 | 65.23 | 6.678e-16 | 1.163 |
| chr6:32681530 | rs3957146 | - | T>C | 3334 | 91193 | 64.49 | 9.678e-16 | 1.162 |
| chr6:32667107 | rs9275334 | - | T>C | 3249 | 88526 | 63.73 | 1.428e-15 | 1.164 |
| chr6:32682137 | Affx-28502500 | - | A>G | 3349 | 91943 | 61.95 | 3.525e-15 | 1.159 |
| chr6:32675634 | rs9275532 | - | C>G | 3307 | 90790 | 60.95 | 5.851e-15 | 1.158 |
| chr6:32682429 | rs9275599 | - | C>T | 3168 | 86712 | 60.66 | 6.776e-15 | 1.161 |
| chr6:32573760 | rs146733600 | - | C>T | 629 | 14388 | 60.53 | 7.255e-15 | 1.376 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 6690 | 192225 | 54.5 | 1.558e-13 | 1.111 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 3900 | 109460 | 50.5 | 1.192e-12 | 1.133 |
| chr6:32667343 | rs9275338 | - | A>T | 3927 | 110254 | 50.37 | 1.272e-12 | 1.132 |
| chr6:32665728 | rs9275312 | - | A>G | 4033 | 113725 | 48.56 | 3.197e-12 | 1.128 |
| chr6:32685550 | rs3916765 | - | G>A | 3516 | 99043 | 42.16 | 8.429e-11 | 1.126 |
| chr6:32684257 | rs9275614 | - | A>G | 3511 | 99084 | 40.37 | 2.106e-10 | 1.123 |
| chr10:114758349 | rs7903146 | TCF7L2 | C>T | 8590 | 253562 | 36.61 | 1.444e-09 | 1.083 |
| chr6:32583357 | rs6931277 | - | A>T | 5683 | 165273 | 36.35 | 1.645e-09 | 1.095 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32573760 | rs146733600 | - | C>T | 629 | 3208 | 44.93 | 2.043e-11 | 1.342 |
| chr6:32654714 | rs9275184 | - | T>C | 3322 | 20167 | 41.0 | 1.523e-10 | 1.136 |
| chr6:32667850 | rs9275356 | - | C>G | 3342 | 20382 | 38.9 | 4.46e-10 | 1.132 |
| chr6:32681483 | rs7454108 | - | T>C | 3339 | 20377 | 38.33 | 5.959e-10 | 1.131 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 6690 | 42256 | 38.15 | 6.55e-10 | 1.097 |
| chr6:32682019 | rs3998159 | - | A>C | 3352 | 20471 | 38.14 | 6.575e-10 | 1.13 |
| chr6:32667107 | rs9275334 | - | T>C | 3249 | 19766 | 37.79 | 7.87e-10 | 1.132 |
| chr6:32681530 | rs3957146 | - | T>C | 3334 | 20380 | 37.25 | 1.039e-09 | 1.129 |
| chr6:32682137 | Affx-28502500 | - | A>G | 3349 | 20505 | 36.55 | 1.49e-09 | 1.127 |
| chr6:32675634 | rs9275532 | - | C>G | 3307 | 20253 | 35.76 | 2.235e-09 | 1.127 |
| chr6:32682429 | rs9275599 | - | C>T | 3168 | 19373 | 35.14 | 3.064e-09 | 1.128 |
| chr24:14902414 | rs20321 | USP9Y | G>A | 453 | 1940 | 29.88 | 4.592e-08 | 1.34 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 3900 | 24322 | 29.66 | 5.161e-08 | 1.106 |
| chr6:32626272 | rs9273363 | - | C>A | 9260 | 59955 | 29.33 | 6.09e-08 | 1.076 |
| chr6:32665728 | rs9275312 | - | A>G | 4033 | 25246 | 28.59 | 8.966e-08 | 1.103 |
| chr6:32667343 | rs9275338 | - | A>T | 3927 | 24541 | 28.5 | 9.378e-08 | 1.104 |
| chr4:39403731 | rs33968162 | - | T>C | 12299 | 87051 | 28.43 | 9.696e-08 | 0.9339 |
| chr6:32626302 | rs9273364 | - | T>G | 9018 | 58505 | 27.48 | 1.588e-07 | 1.075 |
| chr2:100161578 | rs111715478 | - | G>A | 455 | 2380 | 27.08 | 1.955e-07 | 1.307 |
| chr4:39425248 | rs13146907 | KLB | A>G | 10205 | 72547 | 26.6 | 2.503e-07 | 0.934 |