Chronic bronchitis

0004469

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
15204	444990

Phenotype Definition

Chronic inflammation of the bronchi. [HPO:probinson]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr15:48426484	rs1426654	SLC24A5	A>G	509	27017	175.8	4.006e-40	0.5546
chr15:48392165	rs1834640	-	A>G	650	30974	147.2	7.095e-34	0.618
chr5:33958959	rs28777	SLC45A2	A>C	1390	55602	124.9	5.451e-29	0.7341
chr5:33951693	rs16891982	SLC45A2	G>C	1682	65376	124.4	6.857e-29	0.7541
chr23:71628912	rs3012642	AL133500.1	A>G	427	22297	113.1	2.065e-26	0.5953
chr6:136480972	rs9483910	PDE7B	C>T	432	20938	104.3	1.757e-24	0.6097
chr6:170242949	rs9396958	-	T>C	295	15819	103.9	2.129e-24	0.5526
chr5:147863034	rs9325101	HTR4	A>G	313	16427	102.5	4.383e-24	0.564
chr1:159174683	rs2814778	ACKR1	T>C	384	18993	100.4	1.236e-23	0.5981
chr2:3313043	rs73133173	EIPR1	A>C	258	14205	99.67	1.8e-23	0.538
chr2:171380643	rs34020565	MYO3B	T>G	532	24327	98.73	2.896e-23	0.6468
chr9:127267689	rs3814134	NR5A1	A>G	659	28547	93.68	3.706e-22	0.6817
chr10:49805216	rs11101394	ARHGAP22	C>T	367	17990	93.56	3.945e-22	0.6019
chr6:3185712	rs7754077	-	C>T	376	18296	91.68	1.021e-21	0.6085
chr6:3665772	rs9502040	-	G>A	349	17246	91.44	1.15e-21	0.5979
chr17:29298304	rs7225888	RNF135	C>G	412	19523	89.71	2.758e-21	0.6248
chr14:33956209	rs1012023	NPAS3	C>A	773	32287	89.42	3.201e-21	0.707
chr5:54280007	rs1508890	ESM1	C>A	374	18042	88.66	4.688e-21	0.6126
chr8:145639681	rs1871534	SLC39A4	G>C	367	17778	88.0	6.551e-21	0.611
chr11:68851414	rs2376558	TPCN2	C>T	273	14255	87.63	7.875e-21	0.5673
chr15:78898723	rs12914385	CHRNA3	C>T	12227	338626	58.32	2.229e-14	1.095
chr15:78754000	rs1964678	IREB2	G>A	10977	340476	57.5	3.384e-14	0.9121
chr4:145474473	rs1489759	AC098588.2	A>G	11315	350209	57.21	3.91e-14	0.9127
chr4:145480780	rs1828591	AC098588.2	A>G	11356	351427	56.79	4.842e-14	0.9131
chr15:78789488	rs13180	IREB2	T>C	11046	342214	56.51	5.578e-14	0.9129
chr15:78774271	rs8042238	IREB2	T>C	11042	342119	55.74	8.267e-14	0.9135
chr4:145479761	rs6537293	AC098588.2	A>G	11341	350728	55.69	8.49e-14	0.9139
chr4:145506456	rs13141641	AC098588.2	T>C	11312	349996	55.4	9.852e-14	0.9141
chr4:145486389	rs13118928	AC098588.2	A>G	11334	350598	54.37	1.661e-13	0.9149
chr4:145485738	rs1980057	AC098588.2	C>T	11296	348991	53.52	2.553e-13	0.9155
chr15:78911181	rs8040868	CHRNA3	T>C	12531	348215	53.51	2.578e-13	1.091
chr4:145460230	rs13147758	AC098588.2	A>G	11318	349664	53.5	2.581e-13	0.9155
chr4:145436324	rs12504628	AC098588.2	T>C	11261	348226	52.93	3.449e-13	0.9158
chr15:78802869	rs9788721	HYKK	T>C	10912	301665	52.34	4.677e-13	1.092
chr15:78873993	rs7180002	CHRNA5	A>T	10590	292395	51.05	8.987e-13	1.092
chr15:78878541	rs951266	CHRNA5	G>A	10591	292481	50.8	1.023e-12	1.091
chr15:78806023	rs8034191	HYKK	T>C	10738	296791	50.44	1.226e-12	1.091
chr15:78882925	rs16969968	CHRNA5	G>A	10611	293333	50.14	1.428e-12	1.091
chr15:78911672	rs4243084	CHRNA3	G>C	10769	298104	49.86	1.652e-12	1.09
chr15:78814046	rs10519203	HYKK	A>G	10776	298172	49.52	1.963e-12	1.09

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr4:145474473	rs1489759	AC098588.2	A>G	11315	16104	37.09	1.126e-09	0.9092
chr4:145480780	rs1828591	AC098588.2	A>G	11356	16138	35.51	2.535e-09	0.9112
chr4:145479761	rs6537293	AC098588.2	A>G	11341	16127	35.05	3.213e-09	0.9118
chr4:145436324	rs12504628	AC098588.2	T>C	11261	16002	34.81	3.63e-09	0.9119
chr4:145486389	rs13118928	AC098588.2	A>G	11334	16115	34.64	3.965e-09	0.9123
chr4:145485738	rs1980057	AC098588.2	C>T	11296	16039	34.43	4.423e-09	0.9124
chr4:145506456	rs13141641	AC098588.2	T>C	11312	16071	34.3	4.724e-09	0.9126
chr4:145460230	rs13147758	AC098588.2	A>G	11318	16057	33.15	8.531e-09	0.914
chr4:145257681	rs2202507	AC098588.2	T>G	14355	20070	27.5	1.572e-07	0.9234
chr4:145374760	rs6828795	AC098588.2	C>T	8858	12618	26.1	3.237e-07	0.9189
chr4:145371436	rs13142439	AC098588.2	A>G	8848	12605	25.7	3.982e-07	0.9195
chr4:145321822	rs12500355	AC098588.2	T>C	8811	12558	25.15	5.312e-07	0.9202
chr4:145451913	rs4835639	AC098588.2	T>G	14319	18554	21.09	4.382e-06	1.073
chr3:131664194	rs1381077	CPNE4	A>G	4070	4994	20.78	5.144e-06	1.109
chr2:230012602	rs115135904	PID1	C>A	476	478	20.56	5.768e-06	1.343
chr4:145440288	rs6829956	AC098588.2	T>C	14627	18933	20.14	7.193e-06	1.071
chr7:153487944	rs2098112	-	G>A	14862	19253	20.1	7.333e-06	1.07
chr3:62601366	rs1231831	CADPS	T>C	11802	16522	19.99	7.804e-06	0.933
chr6:108808298	rs72938697	AFG1L	G>A	1181	1328	19.99	7.783e-06	1.2
chr15:78898723	rs12914385	CHRNA3	C>T	12227	15741	19.75	8.84e-06	1.071

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: J439	Emphysema, unspecified	1/20
ICD: J449	Chronic obstructive pulmonary disease, unspecified	12/20
ICD: J61	Pneumoconiosis due to asbestos and other mineral fibres	2/20

ID	Name	Top Correlation
ICD-10: J069	Acute upper respiratory infection, unspecified	0/20
ICD-10: J209	Acute bronchitis, unspecified	0/20
ICD-10: J40	Bronchitis, not specified as acute or chronic	0/20
ICD-10: J42	Unspecified chronic bronchitis	0/20
ICD-10: J448	Other specified chronic obstructive pulmonary disease	0/20
ICD-10: J958	Other postprocedural respiratory disorders	0/20
ICD-10: J989	Respiratory disorder, unspecified	0/20
ICD-10: T598	Other specified gases, fumes and vapours	0/20

Chronic bronchitis

0004469

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ