Statistics
| Case | Control |
|---|---|
| 16358 | 443836 |
Phenotype Definition
An impairment of the electrical continuity between the atria and ventricles. [PMID:15372490]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr9:22124477 | rs10757278 | - | A>G | 17581 | 448519 | 121.2 | 3.471e-28 | 1.128 |
| chr9:22125503 | rs1333049 | - | G>C | 17590 | 448848 | 118.1 | 1.685e-27 | 1.126 |
| chr9:22098574 | rs4977574 | - | A>G | 17704 | 452717 | 114.7 | 9.076e-27 | 1.124 |
| chr9:22088260 | rs10757272 | - | C>T | 17752 | 453996 | 113.8 | 1.423e-26 | 1.124 |
| chr9:22096055 | rs10757274 | - | A>G | 17771 | 454781 | 112.1 | 3.341e-26 | 1.123 |
| chr9:22125347 | rs1333048 | - | A>C | 18152 | 465505 | 108.8 | 1.81e-25 | 1.121 |
| chr6:161010118 | rs10455872 | LPA | A>G | 3124 | 70575 | 108.4 | 2.153e-25 | 1.22 |
| chr6:160997118 | rs74617384 | LPA | A>T | 3045 | 68782 | 106.6 | 5.476e-25 | 1.221 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 417 | 17728 | 85.34 | 2.509e-20 | 0.6335 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 461 | 18916 | 79.92 | 3.904e-19 | 0.6563 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 710 | 26816 | 78.92 | 6.459e-19 | 0.712 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 350 | 15067 | 75.34 | 3.962e-18 | 0.6266 |
| chr6:12903957 | rs9349379 | PHACTR1 | A>G | 14723 | 377475 | 75.2 | 4.246e-18 | 1.101 |
| chr9:22083404 | rs1333040 | - | T>C | 13513 | 388103 | 73.47 | 1.021e-17 | 0.9084 |
| chr9:22115959 | rs2383207 | - | G>A | 15658 | 446381 | 70.62 | 4.341e-17 | 0.9118 |
| chr16:29790864 | rs235636 | ZG16 | A>G | 282 | 12539 | 69.69 | 6.944e-17 | 0.6068 |
| chr5:147671850 | rs7724380 | - | G>A | 501 | 19682 | 69.16 | 9.1e-17 | 0.6861 |
| chr5:147666044 | rs7707813 | - | T>C | 461 | 18302 | 67.33 | 2.302e-16 | 0.679 |
| chr9:22081850 | rs6475606 | - | C>T | 17957 | 466312 | 66.17 | 4.135e-16 | 1.093 |
| chr6:12873775 | rs9381462 | PHACTR1 | G>A | 16311 | 463305 | 65.93 | 4.681e-16 | 0.9149 |
| chr6:161010118 | rs10455872 | LPA | A>G | 3083 | 69667 | 107.6 | 3.369e-25 | 1.222 |
| chr6:160997118 | rs74617384 | LPA | A>T | 3004 | 67884 | 105.7 | 8.768e-25 | 1.222 |
| chr9:22125503 | rs1333049 | - | G>C | 16667 | 427251 | 97.76 | 4.731e-23 | 1.118 |
| chr9:22124477 | rs10757278 | - | A>G | 16660 | 427446 | 97.37 | 5.749e-23 | 1.118 |
| chr9:22088260 | rs10757272 | - | C>T | 16739 | 430467 | 89.92 | 2.484e-21 | 1.113 |
| chr9:22125347 | rs1333048 | - | A>C | 17159 | 441982 | 89.73 | 2.736e-21 | 1.113 |
| chr9:22098574 | rs4977574 | - | A>G | 16781 | 431945 | 88.72 | 4.557e-21 | 1.112 |
| chr9:22096055 | rs10757274 | - | A>G | 16833 | 433320 | 88.27 | 5.711e-21 | 1.112 |
| chr9:22115959 | rs2383207 | - | G>A | 15037 | 430984 | 84.21 | 4.449e-20 | 0.9015 |
| chr9:22081850 | rs6475606 | - | C>T | 16599 | 428163 | 80.62 | 2.734e-19 | 1.106 |
| chr9:22083404 | rs1333040 | - | T>C | 12791 | 367767 | 71.5 | 2.769e-17 | 0.9071 |
| chr6:12903957 | rs9349379 | PHACTR1 | A>G | 13911 | 359057 | 56.52 | 5.575e-14 | 1.089 |
| chr6:12873775 | rs9381462 | PHACTR1 | G>A | 15487 | 438614 | 53.81 | 2.204e-13 | 0.9206 |
| chr6:12889004 | rs1332844 | PHACTR1 | T>C | 11165 | 320165 | 51.0 | 9.252e-13 | 0.9187 |
| chr9:21974218 | rs3731239 | AL359922.1 | A>G | 11332 | 324375 | 49.44 | 2.042e-12 | 0.9202 |
| chr6:12901441 | rs9369640 | PHACTR1 | A>C | 11275 | 322465 | 48.71 | 2.967e-12 | 0.9207 |
| chr9:22033366 | rs2157719 | - | T>C | 13549 | 384673 | 46.19 | 1.072e-11 | 0.9252 |
| chr25:2661556 | rs73188900 | - | A>C | 812 | 17302 | 46.04 | 1.161e-11 | 1.279 |
| chr9:22068652 | rs4977756 | - | A>G | 12514 | 356126 | 45.91 | 1.24e-11 | 0.9245 |
| chr6:160922870 | rs117733303 | - | A>G | 765 | 16219 | 45.54 | 1.497e-11 | 1.287 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:21682336 | rs78487864 | - | G>A | 1321 | 1098 | 24.92 | 5.984e-07 | 0.8118 |
| chr4:88898941 | rs11728697 | SPP1 | T>C | 13878 | 9032 | 21.07 | 4.422e-06 | 1.085 |
| chr6:12889004 | rs1332844 | PHACTR1 | T>C | 11165 | 8036 | 20.95 | 4.705e-06 | 0.9201 |
| chr6:12927544 | rs12526453 | PHACTR1 | C>G | 10335 | 7461 | 20.92 | 4.78e-06 | 0.9188 |
| chr1:6552600 | rs79794148 | PLEKHG5 | G>C | 1926 | 1526 | 20.83 | 5.028e-06 | 0.8508 |
| chr4:88896421 | rs11730582 | - | T>C | 15525 | 11026 | 20.6 | 5.666e-06 | 0.9241 |
| chr3:38561079 | rs17037809 | EXOG | G>A | 1733 | 993 | 19.96 | 7.902e-06 | 1.2 |
| chr6:12901441 | rs9369640 | PHACTR1 | A>C | 11275 | 8093 | 19.94 | 7.971e-06 | 0.9221 |
| chr7:10887687 | rs17163688 | - | G>A | 228 | 234 | 19.78 | 8.697e-06 | 0.6618 |
| chr21:24298015 | rs61214835 | - | C>T | 1674 | 1336 | 19.71 | 8.998e-06 | 0.8458 |
| chr6:12873775 | rs9381462 | PHACTR1 | G>A | 15487 | 10980 | 19.29 | 1.125e-05 | 0.9265 |
| chr11:109866912 | rs10891044 | RDX | G>A | 15394 | 10086 | 19.17 | 1.195e-05 | 1.079 |
| chr1:178154474 | rs77413844 | RASAL2 | C>T | 1484 | 844 | 19.05 | 1.275e-05 | 1.212 |
| chr8:108148941 | rs72670417 | - | G>A | 2988 | 2285 | 19.02 | 1.292e-05 | 0.8803 |
| chr15:56453138 | rs75391484 | RFX7 | T>C | 745 | 640 | 19.02 | 1.295e-05 | 0.7885 |
| chr12:83240687 | rs74552277 | TMTC2 | T>C | 1034 | 858 | 18.87 | 1.401e-05 | 0.8155 |
| chr13:55611462 | rs116983952 | - | G>T | 2356 | 1395 | 18.87 | 1.402e-05 | 1.164 |
| chr5:104136270 | rs77848771 | - | C>T | 534 | 477 | 18.86 | 1.403e-05 | 0.7592 |
| chr11:112709499 | rs74801481 | - | C>T | 455 | 414 | 18.5 | 1.699e-05 | 0.7456 |
| chr10:117866641 | rs2694794 | GFRA1 | T>C | 5919 | 3719 | 18.36 | 1.83e-05 | 1.104 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I252 | Old myocardial infarction | 15/20 |