Statistics
| Case | Control |
|---|---|
| 6662 | 453532 |
Phenotype Definition
Conduction block in the posterior division of the left bundle branch of the bundle of His. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 273 | 27253 | 40.58 | 1.883e-10 | 0.6778 |
| chr15:72053984 | rs922917 | THSD4 | C>T | 501 | 44604 | 36.87 | 1.262e-09 | 0.7581 |
| chr5:147671850 | rs7724380 | - | G>A | 192 | 19991 | 34.92 | 3.432e-09 | 0.6517 |
| chr15:48392165 | rs1834640 | - | A>G | 333 | 31291 | 34.79 | 3.675e-09 | 0.7208 |
| chr15:72054830 | rs7402101 | THSD4 | C>T | 518 | 45555 | 34.45 | 4.365e-09 | 0.7683 |
| chr18:9536315 | rs14336 | RALBP1 | A>C | 108 | 12759 | 33.43 | 7.375e-09 | 0.5748 |
| chr9:129979758 | rs3780318 | RALGPS1 | G>A | 150 | 16091 | 31.31 | 2.205e-08 | 0.6329 |
| chr9:140957557 | rs11137360 | CACNA1B | A>G | 208 | 20798 | 30.95 | 2.648e-08 | 0.6783 |
| chr13:113979972 | Affx-80297025 | GRTP1 | A>ACACT | 110 | 12597 | 30.16 | 3.987e-08 | 0.5933 |
| chr20:30135990 | rs1115713 | HM13 | A>G | 1580 | 122832 | 30.16 | 3.97e-08 | 0.8629 |
| chr5:147666044 | rs7707813 | - | T>C | 182 | 18581 | 30.1 | 4.093e-08 | 0.6646 |
| chr9:129984107 | rs3739553 | RALGPS1 | G>A | 142 | 15271 | 30.04 | 4.224e-08 | 0.631 |
| chr18:42439886 | rs991014 | SETBP1 | C>T | 5969 | 385854 | 29.98 | 4.367e-08 | 1.099 |
| chr18:42456653 | rs663651 | SETBP1 | A>G | 5784 | 417347 | 29.81 | 4.769e-08 | 0.9098 |
| chr5:110303365 | rs10043173 | - | T>C | 1001 | 80431 | 28.59 | 8.956e-08 | 0.8384 |
| chr5:179322514 | rs270330 | TBC1D9B | T>C | 98 | 11400 | 28.57 | 9.056e-08 | 0.5841 |
| chr4:23818884 | rs2932971 | PPARGC1A | C>T | 3714 | 235211 | 28.16 | 1.115e-07 | 1.108 |
| chr2:185043361 | rs1997132 | - | T>C | 89 | 10539 | 27.67 | 1.44e-07 | 0.5743 |
| chr13:113979968 | rs200506581 | GRTP1 | C>CCACA | 114 | 12612 | 27.16 | 1.875e-07 | 0.6142 |
| chr4:190837589 | rs6822336 | - | C>T | 96 | 11050 | 26.85 | 2.197e-07 | 0.5904 |
| chr18:42456653 | rs663651 | SETBP1 | A>G | 5405 | 390143 | 31.99 | 1.548e-08 | 0.9041 |
| chr18:42439886 | rs991014 | SETBP1 | C>T | 5747 | 370208 | 29.46 | 5.704e-08 | 1.1 |
| chr18:42456670 | rs3085861 | SETBP1 | CTCTT>C | 5525 | 396797 | 28.98 | 7.309e-08 | 0.9091 |
| chr4:23818884 | rs2932971 | PPARGC1A | C>T | 3548 | 223440 | 28.68 | 8.546e-08 | 1.112 |
| chr14:58536728 | rs10129164 | ARMH4 | T>C | 5719 | 369232 | 27.01 | 2.028e-07 | 1.096 |
| chr4:23851538 | rs76327932 | PPARGC1A | C>T | 3804 | 241213 | 25.94 | 3.521e-07 | 1.104 |
| chr6:166087403 | rs35511241 | PDE10A | C>T | 6515 | 423179 | 25.36 | 4.752e-07 | 1.092 |
| chr2:36673555 | rs7562790 | CRIM1 | T>G | 5650 | 366287 | 23.14 | 1.504e-06 | 1.089 |
| chr2:73615717 | rs78377455 | ALMS1 | A>G | 314 | 16387 | 22.91 | 1.7e-06 | 1.317 |
| chr16:85982521 | rs305086 | - | G>A | 2336 | 145140 | 22.73 | 1.865e-06 | 1.116 |
| chr18:42456664 | rs202066186 | SETBP1 | TTC>T | 5350 | 379822 | 22.01 | 2.715e-06 | 0.9196 |
| chr8:123279212 | rs10216766 | - | T>C | 638 | 36359 | 20.81 | 5.082e-06 | 1.205 |
| chr8:720794 | rs11784310 | DLGAP2 | A>G | 4172 | 301149 | 20.73 | 5.279e-06 | 0.9178 |
| chr18:59598753 | rs12967946 | PIGN | A>C | 696 | 55853 | 19.91 | 8.134e-06 | 0.8398 |
| chr5:111984370 | rs114344673 | - | A>G | 374 | 20277 | 19.71 | 9.036e-06 | 1.264 |
| chr12:117068974 | rs4766799 | - | A>G | 5371 | 383038 | 19.34 | 1.091e-05 | 0.9247 |
| chr2:187865727 | rs62173501 | - | C>T | 437 | 36544 | 19.24 | 1.152e-05 | 0.8072 |
| chr11:7262789 | rs16923778 | SYT9 | C>T | 89 | 9599 | 19.2 | 1.18e-05 | 0.6288 |
| chr17:53407592 | rs11657291 | - | A>G | 3941 | 284340 | 19.01 | 1.299e-05 | 0.9199 |
| chr2:42281312 | rs34372645 | PKDCC | G>A | 121 | 12191 | 18.68 | 1.55e-05 | 0.6742 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr12:61994640 | rs11174093 | - | A>C | 156 | 64 | 23.18 | 1.472e-06 | 0.4928 |
| chr7:37226702 | rs117402485 | ELMO1 | G>A | 198 | 76 | 23.02 | 1.6e-06 | 0.5248 |
| chr12:124516911 | rs12829378 | RFLNA | G>A | 1549 | 406 | 22.7 | 1.894e-06 | 0.7512 |
| chr3:38767315 | rs6801957 | SCN10A | C>T | 5483 | 1250 | 21.54 | 3.464e-06 | 0.8217 |
| chr3:38774832 | rs6800541 | SCN10A | T>C | 5496 | 1253 | 21.35 | 3.834e-06 | 0.8226 |
| chr3:38766675 | rs6795970 | SCN10A | G>A | 5387 | 1228 | 20.78 | 5.145e-06 | 0.824 |
| chr17:71402939 | rs11654556 | SDK2 | C>G | 4689 | 838 | 19.41 | 1.052e-05 | 1.221 |
| chr19:37842735 | rs10417503 | ZNF875 | T>C | 2156 | 351 | 18.92 | 1.367e-05 | 1.308 |
| chr7:72214844 | rs4717678 | TYW1B | T>C | 3103 | 530 | 18.86 | 1.403e-05 | 1.256 |
| chr14:23964351 | rs72686266 | NGDN | T>C | 1389 | 362 | 18.85 | 1.412e-05 | 0.7606 |
| chr14:31090143 | rs17091497 | - | T>C | 926 | 129 | 18.31 | 1.877e-05 | 1.507 |
| chr5:95773631 | rs155438 | - | C>G | 5457 | 1238 | 18.3 | 1.883e-05 | 0.8344 |
| chr6:68464375 | rs116419865 | - | A>G | 815 | 227 | 18.14 | 2.053e-05 | 0.7177 |
| chr7:72193868 | rs2960999 | TYW1B | G>A | 3110 | 533 | 18.08 | 2.118e-05 | 1.25 |
| chr19:37854235 | rs3745765 | ZNF875 | G>T | 2200 | 361 | 18.05 | 2.156e-05 | 1.296 |
| chr16:19361972 | rs2213281 | - | C>T | 460 | 140 | 18.03 | 2.176e-05 | 0.6589 |
| chr2:117727045 | rs4848429 | - | A>C | 4883 | 1116 | 18.01 | 2.199e-05 | 0.8334 |
| chr5:44297010 | rs79238287 | - | A>G | 581 | 71 | 17.95 | 2.268e-05 | 1.706 |
| chr16:85399430 | rs8057928 | GSE1 | C>T | 4909 | 886 | 17.88 | 2.348e-05 | 1.208 |
| chr19:37945274 | rs1015848 | ZNF569 | A>C | 2153 | 353 | 17.78 | 2.486e-05 | 1.296 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I447 | Left bundle-branch block, unspecified | 5/20 |
| ICD: I451 | Other and unspecified right bundle-branch block | 3/20 |