Statistics
| Case | Control |
|---|---|
| 16428 | 443766 |
Phenotype Definition
Presence of multiple adenomatous polyps in the colon. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 15890 | 460213 | 103.7 | 2.408e-24 | 0.8939 |
| chr20:60968596 | rs1570027 | CABLES2 | A>G | 7005 | 213166 | 101.8 | 6.238e-24 | 0.8718 |
| chr20:60921044 | rs4925386 | LAMA5 | C>T | 10456 | 307775 | 84.79 | 3.323e-20 | 0.8961 |
| chr20:60920700 | rs6143035 | LAMA5 | T>C | 7798 | 232598 | 78.15 | 9.543e-19 | 0.8907 |
| chr20:60898244 | rs57627107 | LAMA5 | A>G | 7247 | 215785 | 67.58 | 2.026e-16 | 0.8953 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1989 | 65069 | 67.34 | 2.286e-16 | 0.8252 |
| chr20:60899182 | rs11698080 | LAMA5 | C>T | 6960 | 207103 | 66.43 | 3.633e-16 | 0.8943 |
| chr20:60958651 | rs11699160 | - | T>C | 11981 | 347710 | 65.65 | 5.392e-16 | 0.9108 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 1674 | 55318 | 62.6 | 2.527e-15 | 0.818 |
| chr5:147671850 | rs7724380 | - | G>A | 509 | 19674 | 61.42 | 4.616e-15 | 0.7028 |
| chr8:117630683 | rs16892766 | - | A>C | 3160 | 75537 | 58.61 | 1.924e-14 | 1.157 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 372 | 15045 | 57.51 | 3.368e-14 | 0.6719 |
| chr5:147666044 | rs7707813 | - | T>C | 473 | 18290 | 57.31 | 3.725e-14 | 0.7024 |
| chr15:48392165 | rs1834640 | - | A>G | 873 | 30751 | 57.12 | 4.1e-14 | 0.7695 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 494 | 18883 | 55.99 | 7.299e-14 | 0.7104 |
| chr7:46919215 | rs6463354 | - | G>A | 13879 | 360690 | 54.14 | 1.869e-13 | 1.086 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 751 | 26775 | 53.58 | 2.485e-13 | 0.7611 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 6962 | 175524 | 53.58 | 2.48e-13 | 1.105 |
| chr14:99587529 | rs10145157 | - | T>C | 417 | 16264 | 52.99 | 3.361e-13 | 0.6968 |
| chr17:58506748 | rs57928695 | C17orf64 | C>T | 216 | 9631 | 52.27 | 4.843e-13 | 0.6102 |
| chr20:60968596 | rs1570027 | CABLES2 | A>G | 6662 | 201094 | 102.2 | 5.025e-24 | 0.8685 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 14845 | 423833 | 84.79 | 3.315e-20 | 0.9011 |
| chr20:60920700 | rs6143035 | LAMA5 | T>C | 7412 | 219163 | 78.38 | 8.485e-19 | 0.8879 |
| chr20:60898244 | rs57627107 | LAMA5 | A>G | 6900 | 203735 | 68.85 | 1.06e-16 | 0.8918 |
| chr20:60899182 | rs11698080 | LAMA5 | C>T | 6619 | 195481 | 68.52 | 1.255e-16 | 0.8902 |
| chr20:60921044 | rs4925386 | LAMA5 | C>T | 9691 | 280378 | 65.2 | 6.759e-16 | 0.9054 |
| chr8:117630683 | rs16892766 | - | A>C | 2990 | 70122 | 62.08 | 3.297e-15 | 1.167 |
| chr15:32994756 | rs4779584 | - | C>T | 6742 | 167433 | 56.74 | 4.963e-14 | 1.111 |
| chr20:60986019 | rs2236200 | RBBP8NL | A>C | 7938 | 230367 | 53.37 | 2.763e-13 | 0.9087 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 6606 | 164616 | 51.27 | 8.031e-13 | 1.106 |
| chr18:46453754 | rs35352860 | SMAD7 | C>T | 8211 | 237312 | 50.05 | 1.496e-12 | 0.9123 |
| chr20:60958651 | rs11699160 | - | T>C | 11090 | 316528 | 48.88 | 2.721e-12 | 0.9202 |
| chr15:32992658 | rs28399071 | - | G>A | 3430 | 82661 | 46.89 | 7.525e-12 | 1.134 |
| chr7:46919215 | rs6463354 | - | G>A | 13357 | 344245 | 46.51 | 9.119e-12 | 1.081 |
| chr8:117640315 | rs11986063 | - | C>T | 3202 | 77184 | 44.06 | 3.186e-11 | 1.134 |
| chr15:33066195 | rs75798403 | FMN1 | C>A | 4670 | 115099 | 43.69 | 3.842e-11 | 1.112 |
| chr7:46866208 | rs9791388 | - | C>T | 10062 | 256906 | 42.73 | 6.284e-11 | 1.083 |
| chr7:46826056 | rs1525231 | - | T>C | 9027 | 229640 | 42.03 | 9.011e-11 | 1.085 |
| chr6:55708497 | rs2023523 | BMP5 | A>G | 12621 | 356392 | 41.26 | 1.332e-10 | 0.9285 |
| chr20:6377965 | rs432266 | - | C>T | 11254 | 289240 | 39.63 | 3.066e-10 | 1.077 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr11:128741739 | rs7116606 | - | C>T | 9571 | 13428 | 24.35 | 8.035e-07 | 0.9241 |
| chr6:97954709 | rs1339970 | - | T>C | 1118 | 1771 | 22.09 | 2.598e-06 | 0.833 |
| chr17:77325299 | rs62061499 | RBFOX3 | A>G | 1821 | 2762 | 20.6 | 5.646e-06 | 0.8684 |
| chr8:12973575 | rs2410025 | DLC1 | A>C | 5420 | 7740 | 20.44 | 6.157e-06 | 0.9158 |
| chr9:113911287 | rs117335559 | - | C>T | 1008 | 1102 | 20.41 | 6.254e-06 | 1.221 |
| chr9:136149399 | rs507666 | ABO | G>A | 5836 | 8305 | 20.24 | 6.819e-06 | 0.9185 |
| chr12:128911483 | rs10847617 | TMEM132C | T>C | 5110 | 6274 | 20.16 | 7.129e-06 | 1.096 |
| chr9:136153875 | rs651007 | - | C>T | 6614 | 9345 | 18.99 | 1.313e-05 | 0.9244 |
| chr14:73475161 | rs112369954 | ZFYVE1 | T>C | 2917 | 4278 | 18.9 | 1.377e-05 | 0.8962 |
| chr5:78787853 | rs115455827 | HOMER1 | A>G | 1168 | 1819 | 18.76 | 1.48e-05 | 0.8475 |
| chr9:136155000 | rs635634 | - | C>T | 5799 | 8217 | 18.5 | 1.701e-05 | 0.9217 |
| chr10:119290267 | rs79811690 | - | C>T | 528 | 540 | 18.48 | 1.718e-05 | 1.302 |
| chr9:136154168 | rs579459 | - | T>C | 6624 | 9345 | 18.13 | 2.064e-05 | 0.9261 |
| chr2:233823993 | rs34559264 | NGEF | CT>C | 6382 | 7945 | 17.98 | 2.229e-05 | 1.082 |
| chr20:5169466 | rs6053187 | CDS2 | A>G | 286 | 518 | 17.96 | 2.251e-05 | 0.7316 |
| chr9:136154867 | rs495828 | - | G>T | 6620 | 9329 | 17.95 | 2.269e-05 | 0.9264 |
| chr11:2606621 | rs56413900 | KCNQ1 | C>T | 482 | 489 | 17.95 | 2.27e-05 | 1.314 |
| chr14:73631092 | rs362350 | PSEN1 | A>G | 2939 | 4298 | 17.94 | 2.285e-05 | 0.8991 |
| chr3:996315 | rs7629228 | - | A>G | 1769 | 2058 | 17.92 | 2.301e-05 | 1.151 |
| chr15:47148996 | rs34537802 | - | G>A | 4103 | 5009 | 17.89 | 2.34e-05 | 1.1 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: K635 | Polyp of colon | 20/20 |
| ID | Name | Top Correlation |
|---|