Recurrent gram-negative bacterial infections

0005420

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
1321	458873

Phenotype Definition

Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents. [HPO:probinson]

Phenotype Comment

Gram-negative bacteria have a unique outer membrane, a thinner layer of peptidoglycan compared to gram-positive bacteria, and a periplasmic space between the cell wall and the membrane.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr22:48834199	rs5768620	-	G>A	98	20551	24.69	6.731e-07	1.66
chr3:187054392	rs7652396	-	A>G	89	18266	24.56	7.186e-07	1.697
chr4:27125152	rs10027736	-	C>T	69	13391	23.42	1.299e-06	1.792
chr1:110830871	rs4839303	-	T>C	830	246946	22.76	1.838e-06	1.218
chr1:110815957	rs58155611	KCNC4	G>T	828	246090	22.72	1.874e-06	1.218
chr2:131904064	rs76214160	PLEKHB2	A>G	54	9825	22.6	1.991e-06	1.904
chr10:23987536	rs16923668	KIAA1217	A>G	236	61134	20.14	7.189e-06	1.356
chr10:23975876	rs74122362	-	T>A	149	35765	20.07	7.471e-06	1.457
chr1:244872820	rs6693775	-	T>C	89	48248	20.0	7.753e-06	0.6199
chr11:87290372	rs1880116	-	A>G	681	200684	19.87	8.301e-06	1.217
chr23:111155233	rs7050529	TRPC5	G>A	184	48918	19.83	8.48e-06	1.409
chr10:23898189	rs74122350	-	G>C	66	13253	19.58	9.641e-06	1.726
chr8:21558132	rs56395481	GFRA2	T>C	205	52206	19.5	1.009e-05	1.376
chr18:8342478	Affx-15459317	PTPRM	G>A	1139	352939	18.94	1.35e-05	1.182
chr16:5693358	rs118097235	RBFOX1	G>A	54	10374	18.77	1.476e-05	1.801
chr14:71602338	rs74060596	-	C>T	87	18908	18.73	1.505e-05	1.597
chr12:12068495	rs11610877	-	C>T	98	21958	18.69	1.542e-05	1.556
chr9:137872847	rs11793918	-	A>G	96	21278	18.64	1.581e-05	1.561
chr4:25686546	rs17838935	-	C>T	59	11661	18.61	1.607e-05	1.753
chr5:78437914	rs79274518	DMGDH	A>G	58	11445	18.33	1.857e-05	1.754
chr1:110815957	rs58155611	KCNC4	G>T	758	227130	21.71	3.171e-06	1.222
chr1:110830871	rs4839303	-	T>C	758	227458	21.58	3.39e-06	1.221
chr23:30334971	rs73205867	-	T>C	267	76139	20.16	7.11e-06	1.344
chr12:12068495	rs11610877	-	C>T	96	21350	20.04	7.594e-06	1.588
chr13:84210456	rs76319052	-	A>G	122	28612	19.77	8.719e-06	1.507
chr11:122678728	rs12793476	UBASH3B	A>G	447	128018	19.34	1.091e-05	1.256
chr13:84417741	rs74442376	-	T>C	132	31649	19.18	1.189e-05	1.476
chr6:94103626	rs2052636	EPHA7	G>A	334	92459	19.11	1.234e-05	1.291
chr16:10089296	rs78466681	GRIN2A	G>A	146	35667	19.11	1.233e-05	1.449
chr23:111155233	rs7050529	TRPC5	G>A	163	43359	18.94	1.349e-05	1.426
chr16:5693358	rs118097235	RBFOX1	G>A	53	10234	18.87	1.396e-05	1.814
chr4:32640652	rs9995527	-	C>T	36	6193	18.48	1.714e-05	2.031
chr3:126270319	rs116172093	C3orf22	G>A	65	13350	18.46	1.734e-05	1.707
chr8:21558132	rs56395481	GFRA2	T>C	168	42254	18.38	1.807e-05	1.406
chr3:192203763	rs73195324	FGF12	C>T	54	10625	17.93	2.298e-05	1.778
chr4:149283684	rs72729952	NR3C2	G>C	114	26917	17.59	2.734e-05	1.492
chr9:137872847	rs11793918	-	A>G	88	19612	17.58	2.758e-05	1.571
chr4:25686546	rs17838935	-	C>T	51	9974	17.38	3.052e-05	1.791
chr9:138061252	rs76982791	-	T>C	56	11280	17.29	3.21e-05	1.743
chr3:173183709	rs17319099	NLGN1	T>G	497	145584	17.23	3.306e-05	1.23

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr16:5693358	rs118097235	RBFOX1	G>A	53	121	21.26	4.006e-06	2.115
chr1:244872820	rs6693775	-	T>C	86	669	20.06	7.512e-06	0.596
chr6:71360155	rs16869446	-	C>T	190	638	19.97	7.862e-06	1.463
chr3:59347880	rs75423863	-	T>C	149	1031	19.56	9.754e-06	0.6721
chr2:87108211	rs6709175	-	T>C	523	2054	19.55	9.803e-06	1.272
chr10:126395144	rs76495587	AC068896.3	C>T	84	232	19.41	1.054e-05	1.754
chr3:192203763	rs73195324	FGF12	C>T	54	129	19.23	1.16e-05	2.02
chr10:132693122	rs1655127	-	A>C	639	2578	19.21	1.174e-05	1.248
chr1:110830871	rs4839303	-	T>C	758	3111	18.98	1.323e-05	1.231
chr9:33745844	rs10971674	-	T>C	1090	4660	18.42	1.769e-05	1.206
chr1:110815957	rs58155611	KCNC4	G>T	758	3116	18.29	1.898e-05	1.226
chr7:120171210	rs79671838	KCND2	T>G	60	152	18.13	2.068e-05	1.906
chr16:23375921	rs238551	SCNN1B	A>G	995	4213	18.03	2.17e-05	1.207
chr3:16372251	rs76802013	OXNAD1	T>C	83	235	17.78	2.478e-05	1.716
chr4:84950019	rs1882393	-	T>G	90	678	17.66	2.648e-05	0.6213
chr23:138798494	rs2805899	-	T>C	207	777	17.5	2.873e-05	1.41
chr15:70649109	rs74488675	-	G>A	125	396	17.33	3.143e-05	1.543
chr7:115976160	rs16869914	CAV2	A>C	287	1054	17.3	3.192e-05	1.339
chr8:96029817	rs17666409	NDUFAF6	G>T	187	640	17.28	3.229e-05	1.428
chr5:107563468	rs2922426	FBXL17	A>G	1172	6170	17.27	3.242e-05	0.8362

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: A499	Bacterial infection, unspecified	1/20
ICD: B964	Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters	1/20

ID	Name	Top Correlation
ICD-10: A498	Other bacterial infections of unspecified site	0/20
ICD-10: R845	Abnormal microbiological findings	0/20