Statistics
| Case | Control |
|---|---|
| 2409 | 457785 |
Phenotype Definition
A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias. [NCIT:C7539]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:134210598 | rs61729591 | TCF21 | C>G | 90 | 10252 | 24.48 | 7.507e-07 | 1.686 |
| chr3:59076794 | rs115559198 | - | C>T | 177 | 23438 | 23.82 | 1.06e-06 | 1.452 |
| chr20:16513342 | rs6044081 | KIF16B | G>A | 1067 | 230539 | 22.69 | 1.907e-06 | 0.8486 |
| chr3:169492101 | rs10936599 | MYNN | C>T | 1089 | 235173 | 22.59 | 2.01e-06 | 0.8499 |
| chr3:169497585 | rs1317082 | MYNN | A>G | 1090 | 234925 | 22.06 | 2.639e-06 | 0.8516 |
| chr6:21822656 | rs56233915 | - | A>C | 216 | 30218 | 21.11 | 4.337e-06 | 1.376 |
| chr12:96498151 | rs11108416 | - | A>C | 144 | 18802 | 21.02 | 4.548e-06 | 1.472 |
| chr2:202023160 | rs2041765 | CFLAR | A>G | 2638 | 471455 | 20.83 | 5.013e-06 | 1.137 |
| chr15:46132930 | rs34876148 | - | G>A | 249 | 62654 | 20.76 | 5.21e-06 | 0.7441 |
| chr8:8277522 | rs117287823 | - | A>G | 217 | 30487 | 20.73 | 5.293e-06 | 1.371 |
| chr10:55963315 | rs16905760 | PCDH15 | T>C | 421 | 64613 | 20.71 | 5.338e-06 | 1.261 |
| chr2:202111380 | rs3769825 | CASP8 | G>A | 2416 | 429626 | 20.57 | 5.741e-06 | 1.136 |
| chr5:1282319 | rs7726159 | TERT | C>A | 1813 | 316868 | 20.43 | 6.179e-06 | 1.142 |
| chr10:56192417 | rs61853575 | PCDH15 | T>C | 431 | 66637 | 20.28 | 6.689e-06 | 1.255 |
| chr15:86640869 | rs78624668 | AGBL1 | T>C | 121 | 15407 | 20.03 | 7.616e-06 | 1.508 |
| chr2:231175549 | rs200258126 | SP140 | T>C | 1578 | 273413 | 19.72 | 8.954e-06 | 1.144 |
| chr1:197782332 | rs116332466 | - | A>G | 111 | 13956 | 19.61 | 9.505e-06 | 1.527 |
| chr19:3266172 | rs78754690 | CELF5 | G>A | 184 | 25478 | 19.36 | 1.083e-05 | 1.391 |
| chr10:98862817 | rs17112405 | SLIT1 | C>A | 561 | 127114 | 19.27 | 1.137e-05 | 0.8215 |
| chr18:72979984 | rs35281515 | TSHZ1 | C>T | 576 | 92286 | 19.25 | 1.149e-05 | 1.215 |
| chr5:1282319 | rs7726159 | TERT | C>A | 1732 | 298804 | 24.48 | 7.51e-07 | 1.161 |
| chr6:134210598 | rs61729591 | TCF21 | C>G | 88 | 10076 | 23.21 | 1.449e-06 | 1.674 |
| chr2:202111380 | rs3769825 | CASP8 | G>A | 2232 | 393136 | 22.48 | 2.126e-06 | 1.147 |
| chr3:169492101 | rs10936599 | MYNN | C>T | 1035 | 223104 | 21.81 | 3.009e-06 | 0.8487 |
| chr20:16513342 | rs6044081 | KIF16B | G>A | 1030 | 221765 | 21.73 | 3.131e-06 | 0.8487 |
| chr3:169497585 | rs1317082 | MYNN | A>G | 1036 | 223086 | 21.62 | 3.325e-06 | 0.8493 |
| chr3:59076794 | rs115559198 | - | C>T | 171 | 22973 | 20.99 | 4.621e-06 | 1.428 |
| chr10:55963315 | rs16905760 | PCDH15 | T>C | 407 | 61974 | 20.95 | 4.709e-06 | 1.268 |
| chr8:8277522 | rs117287823 | - | A>G | 215 | 30044 | 20.93 | 4.775e-06 | 1.376 |
| chr15:86640869 | rs78624668 | AGBL1 | T>C | 119 | 15025 | 20.29 | 6.659e-06 | 1.517 |
| chr10:56192417 | rs61853575 | PCDH15 | T>C | 411 | 63074 | 20.2 | 6.983e-06 | 1.261 |
| chr16:7730342 | rs11077211 | RBFOX1 | G>C | 484 | 111238 | 19.97 | 7.849e-06 | 0.8071 |
| chr6:21822656 | rs56233915 | - | A>C | 211 | 29617 | 19.85 | 8.355e-06 | 1.368 |
| chr14:57189352 | rs198245 | - | G>A | 84 | 9872 | 19.77 | 8.722e-06 | 1.627 |
| chr3:175831874 | rs12497666 | - | G>A | 609 | 97734 | 19.58 | 9.624e-06 | 1.212 |
| chr9:23440188 | rs74816034 | - | T>C | 257 | 37312 | 19.51 | 1.003e-05 | 1.327 |
| chr2:202023160 | rs2041765 | CFLAR | A>G | 2458 | 437872 | 19.26 | 1.138e-05 | 1.135 |
| chr1:117856355 | rs35583396 | - | C>T | 206 | 28992 | 19.24 | 1.15e-05 | 1.366 |
| chr12:96498151 | rs11108416 | - | A>C | 139 | 18323 | 19.0 | 1.308e-05 | 1.454 |
| chr19:3266172 | rs78754690 | CELF5 | G>A | 181 | 25021 | 19.0 | 1.305e-05 | 1.391 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:202111380 | rs3769825 | CASP8 | G>A | 2232 | 20132 | 26.43 | 2.739e-07 | 1.169 |
| chr6:21822656 | rs56233915 | - | A>C | 211 | 1465 | 23.26 | 1.413e-06 | 1.435 |
| chr15:86640869 | rs78624668 | AGBL1 | T>C | 119 | 737 | 22.62 | 1.977e-06 | 1.602 |
| chr6:111149764 | rs117314611 | - | A>G | 153 | 1005 | 22.59 | 2.009e-06 | 1.516 |
| chr10:55963315 | rs16905760 | PCDH15 | T>C | 407 | 3152 | 21.82 | 2.99e-06 | 1.292 |
| chr10:56192417 | rs61853575 | PCDH15 | T>C | 411 | 3199 | 21.69 | 3.21e-06 | 1.29 |
| chr11:65293463 | rs55662663 | SCYL1 | G>A | 198 | 1378 | 21.64 | 3.294e-06 | 1.432 |
| chr3:59076794 | rs115559198 | - | C>T | 171 | 1160 | 21.54 | 3.457e-06 | 1.469 |
| chr6:134210598 | rs61729591 | TCF21 | C>G | 88 | 512 | 21.53 | 3.492e-06 | 1.705 |
| chr7:1645843 | rs13245145 | - | C>T | 2009 | 18172 | 21.05 | 4.476e-06 | 1.151 |
| chr7:1648737 | rs4725257 | - | T>G | 2040 | 18472 | 20.58 | 5.731e-06 | 1.149 |
| chr16:7730342 | rs11077211 | RBFOX1 | G>C | 484 | 5816 | 20.54 | 5.846e-06 | 0.7978 |
| chr10:112587774 | rs17831429 | RBM20 | A>G | 183 | 1271 | 20.09 | 7.369e-06 | 1.432 |
| chr2:202082459 | rs13006529 | CASP10 | T>A | 2222 | 23492 | 19.78 | 8.696e-06 | 0.8734 |
| chr11:64824621 | rs76915260 | NAALADL1 | C>T | 162 | 1105 | 19.59 | 9.586e-06 | 1.457 |
| chr13:77531179 | rs116855637 | ACOD1 | A>G | 79 | 457 | 19.58 | 9.638e-06 | 1.711 |
| chr2:202048123 | rs11674246 | CASP10 | C>T | 2235 | 23538 | 19.55 | 9.79e-06 | 0.8745 |
| chr3:188647903 | rs79322149 | - | G>A | 116 | 741 | 19.31 | 1.109e-05 | 1.554 |
| chr21:19624679 | rs9808639 | CHODL | A>G | 650 | 5412 | 19.0 | 1.306e-05 | 1.214 |
| chr6:15769538 | rs220896 | - | A>G | 2197 | 20074 | 18.96 | 1.333e-05 | 1.142 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: C911 | Chronic lymphocytic leukaemia | 1/20 |