Case | Control |
---|---|
13197 | 446997 |
An anomaly that is characterized progressive airflow obstruction that is only partly reversible, inflammation in the airways, and systemic effects or comorbities. [PMID:25943942]
COPD is usually conceptualized as a disease entity. It is heterogeneous histologically and pathogenically, and conventionally includes emphysema and chronic bronchitis, It is included as a phenotype term as COPD is often annotated as a feature of other diseases.
Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
---|---|---|---|---|---|---|---|---|
chr15:48426484 | rs1426654 | SLC24A5 | A>G | 440 | 27086 | 154.0 | 2.282e-35 | 0.5528 |
chr15:48392165 | rs1834640 | - | A>G | 555 | 31069 | 135.0 | 3.381e-31 | 0.608 |
chr1:159174683 | rs2814778 | ACKR1 | T>C | 314 | 19063 | 103.6 | 2.509e-24 | 0.563 |
chr5:33958959 | rs28777 | SLC45A2 | A>C | 1222 | 55770 | 100.4 | 1.267e-23 | 0.7443 |
chr23:71628912 | rs3012642 | AL133500.1 | A>G | 369 | 22355 | 100.0 | 1.524e-23 | 0.5923 |
chr5:147863034 | rs9325101 | HTR4 | A>G | 263 | 16477 | 96.74 | 7.921e-23 | 0.5461 |
chr6:136480972 | rs9483910 | PDE7B | C>T | 368 | 21002 | 96.0 | 1.15e-22 | 0.5986 |
chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1485 | 65573 | 95.96 | 1.17e-22 | 0.7683 |
chr6:170242949 | rs9396958 | - | T>C | 253 | 15861 | 92.94 | 5.404e-22 | 0.5463 |
chr6:3665772 | rs9502040 | - | G>A | 290 | 17305 | 90.8 | 1.59e-21 | 0.5712 |
chr5:147671850 | rs7724380 | - | G>A | 348 | 19835 | 90.22 | 2.134e-21 | 0.5997 |
chr2:171380643 | rs34020565 | MYO3B | T>G | 456 | 24403 | 89.84 | 2.578e-21 | 0.6389 |
chr5:54280007 | rs1508890 | ESM1 | C>A | 309 | 18107 | 89.69 | 2.786e-21 | 0.5828 |
chr9:127267689 | rs3814134 | NR5A1 | A>G | 563 | 28643 | 87.27 | 9.457e-21 | 0.6709 |
chr2:226686177 | rs7581591 | - | T>C | 344 | 19491 | 86.39 | 1.479e-20 | 0.6044 |
chr6:3185712 | rs7754077 | - | C>T | 318 | 18354 | 86.31 | 1.538e-20 | 0.593 |
chr17:29298304 | rs7225888 | RNF135 | C>G | 347 | 19588 | 86.13 | 1.683e-20 | 0.6062 |
chr6:144665357 | rs6917261 | UTRN | T>C | 195 | 12920 | 85.98 | 1.815e-20 | 0.5171 |
chr17:29290106 | rs55861543 | - | C>T | 366 | 20393 | 85.98 | 1.821e-20 | 0.6142 |
chr14:33956209 | rs1012023 | NPAS3 | C>A | 659 | 32401 | 84.98 | 3.012e-20 | 0.6941 |
chr15:78898723 | rs12914385 | CHRNA3 | C>T | 10685 | 340168 | 64.39 | 1.02e-15 | 1.108 |
chr15:78911181 | rs8040868 | CHRNA3 | T>C | 10941 | 349805 | 57.77 | 2.952e-14 | 1.101 |
chr15:78878541 | rs951266 | CHRNA5 | G>A | 9262 | 293810 | 57.36 | 3.62e-14 | 1.104 |
chr15:78873993 | rs7180002 | CHRNA5 | A>T | 9260 | 293725 | 57.2 | 3.939e-14 | 1.104 |
chr15:78882925 | rs16969968 | CHRNA5 | G>A | 9279 | 294665 | 56.11 | 6.847e-14 | 1.103 |
chr15:78911672 | rs4243084 | CHRNA3 | G>C | 9414 | 299459 | 55.33 | 1.021e-13 | 1.102 |
chr15:78894339 | rs1051730 | CHRNA3 | G>A | 9265 | 294315 | 55.31 | 1.028e-13 | 1.102 |
chr15:78867482 | rs17486278 | CHRNA5 | A>C | 9278 | 294943 | 54.48 | 1.568e-13 | 1.101 |
chr15:78802869 | rs9788721 | HYKK | T>C | 9522 | 303055 | 54.38 | 1.656e-13 | 1.101 |
chr15:78806023 | rs8034191 | HYKK | T>C | 9377 | 298152 | 54.11 | 1.897e-13 | 1.101 |
chr15:78868636 | rs72740964 | CHRNA5 | G>A | 9148 | 290718 | 53.98 | 2.025e-13 | 1.101 |
chr6:396321 | rs12203592 | IRF4 | C>T | 6199 | 192716 | 53.4 | 2.715e-13 | 1.114 |
chr15:78814046 | rs10519203 | HYKK | A>G | 9409 | 299539 | 52.43 | 4.452e-13 | 1.099 |
chr15:78754000 | rs1964678 | IREB2 | G>A | 9515 | 341938 | 52.32 | 4.718e-13 | 0.9102 |
chr15:78789488 | rs13180 | IREB2 | T>C | 9568 | 343692 | 52.31 | 4.749e-13 | 0.9103 |
chr15:78774271 | rs8042238 | IREB2 | T>C | 9565 | 343596 | 52.17 | 5.102e-13 | 0.9104 |
chr15:78857939 | rs55853698 | CHRNA5 | T>G | 9360 | 298083 | 51.78 | 6.196e-13 | 1.099 |
chr15:78826180 | rs931794 | HYKK | A>G | 9389 | 299300 | 51.49 | 7.178e-13 | 1.098 |
chr15:78896129 | rs1317286 | CHRNA3 | A>G | 9325 | 296958 | 51.34 | 7.767e-13 | 1.098 |
chr15:78857986 | rs55781567 | CHRNA5 | C>G | 9352 | 298023 | 51.33 | 7.811e-13 | 1.098 |
Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
---|---|---|---|---|---|---|---|---|
chr16:60361691 | rs80027631 | - | G>A | 299 | 15 | 28.36 | 1.008e-07 | 0.2628 |
chr6:32377053 | rs116835963 | - | C>T | 410 | 18 | 27.2 | 1.836e-07 | 0.2977 |
chr9:84242375 | rs79955842 | TLE1 | A>G | 279 | 14 | 26.91 | 2.131e-07 | 0.2606 |
chr7:8979628 | rs74502274 | - | T>C | 1314 | 39 | 26.75 | 2.317e-07 | 0.4219 |
chr14:55834585 | rs45470002 | ATG14 | A>G | 1638 | 46 | 26.26 | 2.978e-07 | 0.4506 |
chr22:47973949 | rs115118 | - | G>A | 949 | 31 | 26.0 | 3.419e-07 | 0.3917 |
chr12:131036199 | rs75714868 | RIMBP2 | G>A | 286 | 14 | 25.55 | 4.31e-07 | 0.2688 |
chr6:4044942 | rs115419839 | PRPF4B | A>G | 1371 | 40 | 25.19 | 5.2e-07 | 0.4369 |
chr6:32384527 | rs9268541 | - | T>C | 1578 | 44 | 24.72 | 6.637e-07 | 0.4546 |
chr17:41592920 | rs72833132 | DHX8 | C>T | 522 | 20 | 23.29 | 1.396e-06 | 0.3405 |
chr13:20622817 | rs116904224 | ZMYM2 | A>G | 412 | 17 | 23.03 | 1.591e-06 | 0.3161 |
chr6:32637867 | rs35788076 | - | G>A | 597 | 22 | 22.83 | 1.773e-06 | 0.3592 |
chr6:32679690 | rs3129727 | - | C>T | 613 | 22 | 22.32 | 2.311e-06 | 0.3632 |
chr6:163915611 | rs117765914 | QKI | C>T | 314 | 14 | 21.85 | 2.946e-06 | 0.2941 |
chr7:131887841 | rs73155278 | PLXNA4 | C>T | 1256 | 36 | 21.85 | 2.951e-06 | 0.4453 |
chr4:141879334 | rs116356465 | RNF150 | C>T | 501 | 19 | 21.65 | 3.279e-06 | 0.3447 |
chr1:63159531 | rs78994645 | - | A>G | 295 | 13 | 21.49 | 3.552e-06 | 0.2851 |
chr9:111373144 | rs117272108 | - | A>G | 464 | 18 | 21.38 | 3.775e-06 | 0.3381 |
chr11:33606545 | rs117542557 | KIAA1549L | C>G | 426 | 17 | 21.34 | 3.838e-06 | 0.3291 |
chr5:178890302 | rs4701162 | - | A>G | 3564 | 78 | 20.83 | 5.011e-06 | 0.5599 |
chr6:32384527 | rs9268541 | - | T>C | 1414 | 44 | 30.5 | 3.34e-08 | 0.4179 |
chr16:60361691 | rs80027631 | - | G>A | 290 | 15 | 28.3 | 1.038e-07 | 0.2628 |
chr6:32377053 | rs116835963 | - | C>T | 398 | 18 | 27.11 | 1.921e-07 | 0.2979 |
chr6:32637867 | rs35788076 | - | G>A | 542 | 22 | 26.09 | 3.263e-07 | 0.336 |
chr9:84242375 | rs79955842 | TLE1 | A>G | 276 | 14 | 25.98 | 3.447e-07 | 0.2659 |
chr12:131036199 | rs75714868 | RIMBP2 | G>A | 277 | 14 | 25.56 | 4.282e-07 | 0.2684 |
chr6:32679690 | rs3129727 | - | C>T | 560 | 22 | 25.27 | 4.985e-07 | 0.3416 |
chr5:178890302 | rs4701162 | - | A>G | 3313 | 78 | 24.59 | 7.094e-07 | 0.5326 |
chr22:47973949 | rs115118 | - | G>A | 907 | 30 | 24.05 | 9.401e-07 | 0.3997 |
chr6:4044942 | rs115419839 | PRPF4B | A>G | 1354 | 40 | 23.96 | 9.812e-07 | 0.4452 |
chr6:32236054 | rs3132933 | - | G>T | 1219 | 37 | 23.92 | 1.005e-06 | 0.4336 |
chr6:32283394 | rs493136 | TSBP1 | A>G | 1223 | 37 | 23.84 | 1.048e-06 | 0.4341 |
chr14:55834585 | rs45470002 | ATG14 | A>G | 1603 | 45 | 23.49 | 1.253e-06 | 0.4661 |
chr13:20622817 | rs116904224 | ZMYM2 | A>G | 399 | 17 | 23.09 | 1.549e-06 | 0.3155 |
chr6:32597110 | rs116106319 | HLA-DQA1 | G>T | 549 | 21 | 22.94 | 1.674e-06 | 0.3507 |
chr7:8979628 | rs74502274 | - | T>C | 1258 | 37 | 22.8 | 1.802e-06 | 0.4412 |
chr6:32233814 | rs3115562 | - | C>T | 1255 | 37 | 22.16 | 2.507e-06 | 0.4468 |
chr6:163915611 | rs117765914 | QKI | C>T | 306 | 14 | 21.64 | 3.296e-06 | 0.2955 |
chr6:32286761 | rs498422 | TSBP1 | T>G | 1508 | 42 | 21.54 | 3.472e-06 | 0.4709 |
chr1:63159531 | rs78994645 | - | A>G | 285 | 13 | 21.44 | 3.659e-06 | 0.2852 |
ID | Name | Top Correlation |
---|---|---|
ICD: J441 | Chronic obstructive pulmonary disease with acute exacerbation, unspecified | 1/20 |
ICD: J449 | Chronic obstructive pulmonary disease, unspecified | 14/20 |