Obstructive lung disease

0006536

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Sex Split

Interactive Plot

Statistics

Case	Control
13610	446584

Phenotype Definition

Obstruction of conducting airways of the lung. [HPO:probinson]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr15:48426484	rs1426654	SLC24A5	A>G	450	27076	162.2	3.654e-37	0.5481
chr15:48392165	rs1834640	-	A>G	573	31051	138.6	5.463e-32	0.6087
chr5:33958959	rs28777	SLC45A2	A>C	1248	55744	109.8	1.083e-25	0.7367
chr1:159174683	rs2814778	ACKR1	T>C	323	19054	107.5	3.469e-25	0.5615
chr5:33951693	rs16891982	SLC45A2	G>C	1519	65539	104.7	1.397e-24	0.7617
chr23:71628912	rs3012642	AL133500.1	A>G	378	22346	103.7	2.307e-24	0.5903
chr5:147863034	rs9325101	HTR4	A>G	269	16471	101.8	6.213e-24	0.5415
chr6:136480972	rs9483910	PDE7B	C>T	378	20992	100.2	1.357e-23	0.5961
chr6:170242949	rs9396958	-	T>C	261	15853	95.7	1.336e-22	0.5465
chr2:171380643	rs34020565	MYO3B	T>G	467	24392	94.98	1.919e-22	0.6343
chr5:54280007	rs1508890	ESM1	C>A	318	18098	93.06	5.074e-22	0.5815
chr5:147671850	rs7724380	-	G>A	359	19824	92.85	5.636e-22	0.5999
chr9:127267689	rs3814134	NR5A1	A>G	579	28627	91.0	1.437e-21	0.669
chr6:3665772	rs9502040	-	G>A	302	17293	90.91	1.505e-21	0.5772
chr6:144665357	rs6917261	UTRN	T>C	201	12914	88.76	4.465e-21	0.5168
chr6:3185712	rs7754077	-	C>T	329	18343	88.1	6.212e-21	0.5949
chr15:45491394	rs1648299	SHF	T>C	294	16865	87.94	6.761e-21	0.5783
chr14:33956209	rs1012023	NPAS3	C>A	680	32380	87.31	9.278e-21	0.6945
chr1:173579034	rs12065033	AL139142.2	C>T	253	15088	87.29	9.392e-21	0.5562
chr11:68817229	rs4930259	TPCN2	T>C	303	17180	86.47	1.416e-20	0.5854
chr15:78898723	rs12914385	CHRNA3	C>T	11000	339853	62.59	2.552e-15	1.104
chr15:78911181	rs8040868	CHRNA3	T>C	11265	349481	55.95	7.429e-14	1.098
chr15:78878541	rs951266	CHRNA5	G>A	9528	293544	54.5	1.552e-13	1.1
chr15:78873993	rs7180002	CHRNA5	A>T	9527	293458	54.45	1.594e-13	1.1
chr15:78882925	rs16969968	CHRNA5	G>A	9549	294395	53.87	2.146e-13	1.099
chr6:396321	rs12203592	IRF4	C>T	6386	192529	53.45	2.648e-13	1.112
chr15:78911672	rs4243084	CHRNA3	G>C	9687	299186	53.05	3.245e-13	1.098
chr15:78754000	rs1964678	IREB2	G>A	9820	341633	52.75	3.789e-13	0.9112
chr15:78894339	rs1051730	CHRNA3	G>A	9530	294050	52.54	4.214e-13	1.098
chr15:78867482	rs17486278	CHRNA5	A>C	9548	294673	52.38	4.571e-13	1.098
chr15:78789488	rs13180	IREB2	T>C	9877	343383	52.18	5.052e-13	0.9117
chr15:78774271	rs8042238	IREB2	T>C	9873	343288	52.06	5.378e-13	0.9118
chr15:78802869	rs9788721	HYKK	T>C	9797	302780	51.76	6.258e-13	1.097
chr15:78806023	rs8034191	HYKK	T>C	9646	297883	51.17	8.48e-13	1.096
chr15:78868636	rs72740964	CHRNA5	G>A	9410	290456	51.09	8.813e-13	1.097
chr15:78814046	rs10519203	HYKK	A>G	9681	299267	50.19	1.395e-12	1.095
chr6:421281	rs62389423	-	G>A	5222	156643	49.72	1.773e-12	1.117
chr15:78896129	rs1317286	CHRNA3	A>G	9598	296685	49.55	1.937e-12	1.095
chr15:78857939	rs55853698	CHRNA5	T>G	9630	297813	49.08	2.454e-12	1.094
chr15:78857986	rs55781567	CHRNA5	C>G	9624	297751	49.0	2.562e-12	1.094

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr15:78898723	rs12914385	CHRNA3	C>T	11000	81257	53.03	3.282e-13	1.1
chr15:78911181	rs8040868	CHRNA3	T>C	11265	83620	46.03	1.162e-11	1.093
chr15:78873993	rs7180002	CHRNA5	A>T	9527	70255	44.87	2.11e-11	1.095
chr15:78878541	rs951266	CHRNA5	G>A	9528	70291	44.46	2.601e-11	1.094
chr15:78882925	rs16969968	CHRNA5	G>A	9549	70465	44.34	2.758e-11	1.094
chr4:145480780	rs1828591	AC098588.2	A>G	10179	84083	43.34	4.591e-11	0.9162
chr4:145479761	rs6537293	AC098588.2	A>G	10161	83950	43.28	4.75e-11	0.9162
chr15:78867482	rs17486278	CHRNA5	A>C	9548	70523	43.13	5.122e-11	1.093
chr15:78894339	rs1051730	CHRNA3	G>A	9530	70389	43.03	5.382e-11	1.093
chr15:78911672	rs4243084	CHRNA3	G>C	9687	71648	42.9	5.75e-11	1.092
chr4:145474473	rs1489759	AC098588.2	A>G	10148	83816	42.52	6.997e-11	0.9168
chr15:78774271	rs8042238	IREB2	T>C	9873	81617	41.61	1.112e-10	0.9173
chr15:78754000	rs1964678	IREB2	G>A	9820	81176	41.57	1.14e-10	0.9173
chr15:78868636	rs72740964	CHRNA5	G>A	9410	69564	41.3	1.307e-10	1.091
chr4:145506456	rs13141641	AC098588.2	T>C	10146	83734	41.26	1.33e-10	0.9181
chr15:78789488	rs13180	IREB2	T>C	9877	81597	41.26	1.333e-10	0.9177
chr4:145486389	rs13118928	AC098588.2	A>G	10161	83889	41.18	1.392e-10	0.9182
chr4:145485738	rs1980057	AC098588.2	C>T	10123	83494	41.03	1.502e-10	0.9183
chr4:145436324	rs12504628	AC098588.2	T>C	10091	83352	40.93	1.576e-10	0.9183
chr4:145460230	rs13147758	AC098588.2	A>G	10145	83685	40.76	1.721e-10	0.9186

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: J441	Chronic obstructive pulmonary disease with acute exacerbation, unspecified	2/20
ICD: J449	Chronic obstructive pulmonary disease, unspecified	12/20
ICD: J61	Pneumoconiosis due to asbestos and other mineral fibres	2/20

ID	Name	Top Correlation
ICD-10: J069	Acute upper respiratory infection, unspecified	0/20
ICD-10: J42	Unspecified chronic bronchitis	0/20
ICD-10: J448	Other specified chronic obstructive pulmonary disease	0/20
ICD-10: J958	Other postprocedural respiratory disorders	0/20
ICD-10: J989	Respiratory disorder, unspecified	0/20
ICD-10: T598	Other specified gases, fumes and vapours	0/20

Obstructive lung disease

0006536

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ