Obstructive lung disease

0006536

Female ^ⓘ

Male ^ⓘ

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Statistics

Female Case	Female Control	% Female
6292	243565	46%

Male Case	Male Control	% Male
7318	203019	54%

Phenotype Definition

Obstruction of conducting airways of the lung. [HPO:probinson]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr15:48426484	rs1426654	SLC24A5	A>G	226	15818	77.59	1.269e-18	0.556
chr15:48392165	rs1834640	-	A>G	283	17874	65.16	6.916e-16	0.6161
chr23:71628912	rs3012642	AL133500.1	A>G	251	16257	63.91	1.305e-15	0.6017
chr6:170242949	rs9396958	-	T>C	115	9209	60.18	8.643e-15	0.4888
chr15:78882925	rs16969968	CHRNA5	G>A	4579	165205	53.05	3.25e-13	1.145
chr9:16918076	rs10125606	-	T>G	68	6248	51.73	6.365e-13	0.426
chr15:78878541	rs951266	CHRNA5	G>A	4580	165377	51.45	7.333e-13	1.142
chr15:78857939	rs55853698	CHRNA5	T>G	4631	167362	51.15	8.568e-13	1.142
chr15:78894339	rs1051730	CHRNA3	G>A	4585	165606	51.0	9.215e-13	1.142
chr15:78873993	rs7180002	CHRNA5	A>T	4575	165309	50.13	1.441e-12	1.141
chr15:78868636	rs72740964	CHRNA5	G>A	4505	163009	48.93	2.659e-12	1.14
chr1:65860660	rs12077111	DNAJC6	T>C	241	14755	48.12	4.002e-12	0.637
chr5:33958959	rs28777	SLC45A2	A>C	580	30260	47.42	5.74e-12	0.7451
chr9:127267689	rs3814134	NR5A1	A>G	272	16192	47.42	5.72e-12	0.6555
chr5:33951693	rs16891982	SLC45A2	G>C	699	35508	47.34	5.97e-12	0.7639
chr23:128718936	rs2362937	OCRL	T>C	234	14382	47.27	6.195e-12	0.6355
chr1:65858151	rs11208644	DNAJC6	C>T	241	14689	46.75	8.083e-12	0.6411
chr3:50336292	rs72932959	-	A>G	57	5399	46.56	8.867e-12	0.414
chr15:78857986	rs55781567	CHRNA5	C>G	4665	169603	46.32	1.004e-11	1.134
chr3:50352200	rs11130248	-	A>G	57	5345	46.04	1.157e-11	0.4159
chr15:78878541	rs951266	CHRNA5	G>A	4468	160218	37.75	8.031e-10	1.123
chr15:78857986	rs55781567	CHRNA5	C>G	4525	162524	37.56	8.87e-10	1.122
chr15:78882925	rs16969968	CHRNA5	G>A	4476	160667	37.44	9.409e-10	1.122
chr15:78898723	rs12914385	CHRNA3	C>T	5129	185541	37.36	9.824e-10	1.119
chr15:78894339	rs1051730	CHRNA3	G>A	4472	160418	37.18	1.08e-09	1.122
chr15:78873993	rs7180002	CHRNA5	A>T	4464	160150	36.97	1.201e-09	1.122
chr15:78857939	rs55853698	CHRNA5	T>G	4524	162574	36.31	1.685e-09	1.12
chr15:78867482	rs17486278	CHRNA5	A>C	4473	160802	35.85	2.126e-09	1.12
chr15:78911672	rs4243084	CHRNA3	G>C	4531	163251	34.82	3.621e-09	1.117
chr15:78868636	rs72740964	CHRNA5	G>A	4403	158479	34.4	4.479e-09	1.118
chr15:78814046	rs10519203	HYKK	A>G	4538	163508	34.38	4.529e-09	1.117
chr15:78806023	rs8034191	HYKK	T>C	4519	162741	34.29	4.757e-09	1.117
chr15:78802869	rs9788721	HYKK	T>C	4584	165354	34.13	5.164e-09	1.116
chr15:78911181	rs8040868	CHRNA3	T>C	5257	190754	34.08	5.295e-09	1.113
chr15:78896129	rs1317286	CHRNA3	A>G	4495	161904	33.82	6.035e-09	1.116
chr15:78826180	rs931794	HYKK	A>G	4521	163360	32.41	1.247e-08	1.113
chr4:145474473	rs1489759	AC098588.2	A>G	4646	191892	32.23	1.369e-08	0.8991
chr4:145479761	rs6537293	AC098588.2	A>G	4658	192215	30.82	2.834e-08	0.9014
chr4:145480780	rs1828591	AC098588.2	A>G	4664	192578	30.66	3.069e-08	0.9016
chr4:145506456	rs13141641	AC098588.2	T>C	4649	191745	30.48	3.379e-08	0.9019

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr15:48426484	rs1426654	SLC24A5	A>G	224	11258	77.07	1.652e-18	0.5552
chr2:171380643	rs34020565	MYO3B	T>G	221	10949	71.87	2.298e-17	0.5641
chr1:159174683	rs2814778	ACKR1	T>C	147	8193	70.62	4.328e-17	0.502
chr15:48392165	rs1834640	-	A>G	290	13177	67.3	2.328e-16	0.6145
chr5:147863034	rs9325101	HTR4	A>G	120	7036	66.79	3.017e-16	0.4778
chr5:33958959	rs28777	SLC45A2	A>C	668	25484	62.9	2.177e-15	0.7286
chr15:45491394	rs1648299	SHF	T>C	128	7178	62.52	2.64e-15	0.4995
chr6:136480972	rs9483910	PDE7B	C>T	180	9049	61.82	3.765e-15	0.556
chr2:66725070	rs12995572	MEIS1	G>C	259	11729	58.86	1.697e-14	0.6179
chr5:33951693	rs16891982	SLC45A2	G>C	820	30031	58.16	2.414e-14	0.7583
chr8:145639681	rs1871534	SLC39A4	G>C	145	7580	56.65	5.203e-14	0.5358
chr15:45556163	rs8023604	SLC28A2	T>C	91	5487	54.62	1.466e-13	0.4654
chr9:140957557	rs11137360	CACNA1B	A>G	182	8823	54.29	1.727e-13	0.5779
chr6:3185712	rs7754077	-	C>T	159	7930	52.6	4.082e-13	0.5621
chr15:45695612	rs1346265	SPATA5L1	C>T	80	4967	52.04	5.451e-13	0.452
chr6:37328215	Affx-28571852	RNF8	C>CT	166	8161	52.02	5.488e-13	0.5705
chr3:188327555	rs7645635	LPP	T>C	110	6080	51.11	8.73e-13	0.508
chr10:49801412	rs73302224	ARHGAP22	T>C	164	8014	50.49	1.197e-12	0.5732
chr2:116743703	rs10173690	-	T>C	362	14782	50.01	1.531e-12	0.6849
chr10:49805216	rs11101394	ARHGAP22	C>T	159	7804	49.98	1.552e-12	0.57
chr6:396321	rs12203592	IRF4	C>T	3458	87577	34.5	4.256e-09	1.124
chr15:78789488	rs13180	IREB2	T>C	5287	156269	33.62	6.694e-09	0.9035
chr15:78754000	rs1964678	IREB2	G>A	5260	155471	33.51	7.103e-09	0.9035
chr15:78774271	rs8042238	IREB2	T>C	5290	156237	32.84	1.002e-08	0.9046
chr6:421281	rs62389423	-	G>A	2837	71287	32.57	1.148e-08	1.129
chr6:475489	rs12210050	-	C>T	3212	81651	29.62	5.251e-08	1.117
chr8:81304576	rs4739739	-	A>G	6372	168113	26.58	2.533e-07	1.092
chr15:78898723	rs12914385	CHRNA3	C>T	5871	154312	26.57	2.542e-07	1.093
chr15:78873119	rs569207	CHRNA5	C>T	3086	92871	26.08	3.279e-07	0.9002
chr7:23603071	rs227943	-	T>C	1155	37023	25.92	3.55e-07	0.8535
chr15:78863472	rs667282	CHRNA5	T>C	3083	92715	25.41	4.629e-07	0.9013
chr15:78907656	rs6495308	CHRNA3	T>C	3103	93160	24.13	8.984e-07	0.9039
chr8:81315490	rs28661389	-	A>G	5950	156930	24.02	9.522e-07	1.088
chr15:78896547	rs938682	CHRNA3	A>G	3105	93132	23.97	9.776e-07	0.9043
chr20:62002451	rs62206958	CHRNA4	C>T	1221	29575	23.36	1.341e-06	1.159
chr15:78911181	rs8040868	CHRNA3	T>C	6008	158727	23.15	1.501e-06	1.086
chr15:78891627	rs12910984	CHRNA3	A>G	3108	93064	22.67	1.923e-06	0.9068
chr15:78741384	rs2656074	IREB2	C>T	2936	88230	22.59	2.002e-06	0.905
chr8:81295224	rs1543857	-	A>G	5940	156905	22.52	2.081e-06	1.085
chr24:14902414	rs20321	USP9Y	G>A	397	8757	21.96	2.782e-06	1.28

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: J441	Chronic obstructive pulmonary disease with acute exacerbation, unspecified	2/20
ICD: J449	Chronic obstructive pulmonary disease, unspecified	12/20
ICD: J61	Pneumoconiosis due to asbestos and other mineral fibres	2/20

ID	Name	Top Correlation
ICD-10: J069	Acute upper respiratory infection, unspecified	0/20
ICD-10: J42	Unspecified chronic bronchitis	0/20
ICD-10: J448	Other specified chronic obstructive pulmonary disease	0/20
ICD-10: J958	Other postprocedural respiratory disorders	0/20
ICD-10: J989	Respiratory disorder, unspecified	0/20
ICD-10: T598	Other specified gases, fumes and vapours	0/20

Obstructive lung disease

0006536

Female ⓘ

Male ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Female Show Male

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Female ^ⓘ

Male ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ