Statistics
| Case | Control |
|---|---|
| 1094 | 459100 |
Phenotype Definition
An increased susceptibility to meningitis as manifested by a medical history of recurrent episodes of meningitis. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:1166662 | rs116239321 | CNTN6 | G>A | 62 | 12902 | 31.91 | 1.619e-08 | 2.041 |
| chr2:223025055 | rs116254882 | - | G>T | 148 | 40037 | 29.79 | 4.818e-08 | 1.585 |
| chr14:79711359 | rs140653417 | NRXN3 | T>G | 67 | 15546 | 24.29 | 8.275e-07 | 1.828 |
| chr18:25207864 | rs117613818 | - | A>G | 90 | 23307 | 21.58 | 3.389e-06 | 1.641 |
| chr3:64546459 | rs7615657 | ADAMTS9 | C>T | 1260 | 480179 | 21.44 | 3.656e-06 | 1.213 |
| chr3:7387768 | rs6775292 | GRM7 | T>G | 815 | 387314 | 21.37 | 3.782e-06 | 0.8179 |
| chr5:145202363 | rs11950450 | PRELID2 | T>C | 23 | 24093 | 21.19 | 4.162e-06 | 0.3941 |
| chr4:99716929 | rs62323692 | - | A>G | 152 | 44334 | 21.08 | 4.405e-06 | 1.467 |
| chr12:95962921 | rs117804583 | - | A>G | 116 | 32019 | 21.05 | 4.474e-06 | 1.544 |
| chr13:93778485 | rs184385 | - | C>A | 920 | 430132 | 20.72 | 5.304e-06 | 0.8245 |
| chr5:2776401 | rs11741201 | - | T>C | 72 | 17826 | 20.54 | 5.841e-06 | 1.711 |
| chr6:22020195 | rs78328425 | - | C>T | 70 | 17312 | 20.23 | 6.859e-06 | 1.717 |
| chr2:219803902 | rs11694036 | - | C>T | 121 | 34114 | 19.97 | 7.884e-06 | 1.514 |
| chr11:20244114 | rs12283523 | - | T>C | 407 | 138444 | 19.46 | 1.028e-05 | 1.273 |
| chr17:31761562 | rs116288490 | ASIC2 | A>C | 64 | 15613 | 19.42 | 1.051e-05 | 1.738 |
| chr15:75772586 | rs117968432 | PTPN9 | C>G | 82 | 21320 | 19.39 | 1.067e-05 | 1.634 |
| chr17:74327442 | rs57032897 | PRPSAP1 | C>T | 97 | 26301 | 19.1 | 1.242e-05 | 1.569 |
| chr12:95953790 | rs76360007 | - | C>T | 150 | 44427 | 18.99 | 1.316e-05 | 1.443 |
| chr13:32454539 | rs354 | FRY | A>C | 184 | 56251 | 18.9 | 1.376e-05 | 1.396 |
| chr16:78302656 | rs182797506 | WWOX | C>A | 50 | 11455 | 18.85 | 1.416e-05 | 1.845 |
| chr2:223025055 | rs116254882 | - | G>T | 146 | 39534 | 29.58 | 5.353e-08 | 1.588 |
| chr3:1166662 | rs116239321 | CNTN6 | G>A | 60 | 12705 | 29.52 | 5.548e-08 | 2.011 |
| chr14:79711359 | rs140653417 | NRXN3 | T>G | 66 | 15117 | 25.2 | 5.159e-07 | 1.857 |
| chr12:95953790 | rs76360007 | - | C>T | 143 | 40561 | 23.17 | 1.48e-06 | 1.513 |
| chr18:25207864 | rs117613818 | - | A>G | 89 | 22931 | 22.02 | 2.693e-06 | 1.655 |
| chr12:95962921 | rs117804583 | - | A>G | 112 | 30662 | 21.36 | 3.805e-06 | 1.561 |
| chr3:64546459 | rs7615657 | ADAMTS9 | C>T | 1197 | 456281 | 21.32 | 3.883e-06 | 1.219 |
| chr5:2776401 | rs11741201 | - | T>C | 69 | 17020 | 20.13 | 7.233e-06 | 1.722 |
| chr6:22020195 | rs78328425 | - | C>T | 69 | 17069 | 20.12 | 7.277e-06 | 1.721 |
| chr2:219803902 | rs11694036 | - | C>T | 119 | 33657 | 19.56 | 9.766e-06 | 1.514 |
| chr20:34018121 | rs73093063 | - | C>T | 71 | 17712 | 19.55 | 9.793e-06 | 1.697 |
| chr23:38928417 | rs147441967 | - | G>A | 129 | 38300 | 19.38 | 1.073e-05 | 1.494 |
| chr5:145202363 | rs11950450 | PRELID2 | T>C | 23 | 23210 | 19.37 | 1.076e-05 | 0.4094 |
| chr2:61832519 | rs34536416 | - | A>G | 141 | 41231 | 19.33 | 1.102e-05 | 1.464 |
| chr3:7387768 | rs6775292 | GRM7 | T>G | 769 | 365070 | 19.13 | 1.224e-05 | 0.822 |
| chr25:2491479 | rs35603448 | - | T>C | 1176 | 450601 | 18.99 | 1.311e-05 | 1.206 |
| chr9:101457739 | rs76071271 | GABBR2 | A>G | 295 | 97747 | 18.97 | 1.326e-05 | 1.313 |
| chr13:93778485 | rs184385 | - | C>A | 874 | 408448 | 18.95 | 1.341e-05 | 0.827 |
| chr3:22311979 | rs74881280 | ZNF385D | C>G | 174 | 53228 | 18.9 | 1.38e-05 | 1.409 |
| chr15:75772586 | rs117968432 | PTPN9 | C>G | 80 | 20868 | 18.83 | 1.427e-05 | 1.633 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:1166662 | rs116239321 | CNTN6 | G>A | 60 | 74 | 32.11 | 1.458e-08 | 2.609 |
| chr2:223025055 | rs116254882 | - | G>T | 146 | 278 | 26.26 | 2.979e-07 | 1.706 |
| chr2:46192092 | rs59298278 | PRKCE | A>G | 90 | 156 | 21.89 | 2.886e-06 | 1.861 |
| chr5:133829010 | rs59486588 | - | A>G | 172 | 362 | 20.62 | 5.59e-06 | 1.542 |
| chr25:2491479 | rs35603448 | - | T>C | 1176 | 3325 | 20.5 | 5.955e-06 | 1.249 |
| chr11:12169610 | rs2403572 | MICAL2 | G>A | 946 | 3377 | 20.34 | 6.493e-06 | 0.8001 |
| chr5:145202363 | rs11950450 | PRELID2 | T>C | 23 | 187 | 20.13 | 7.225e-06 | 0.3824 |
| chr9:79669904 | rs118056706 | - | G>A | 95 | 172 | 19.9 | 8.154e-06 | 1.775 |
| chr16:9744095 | rs17550532 | - | A>G | 366 | 1454 | 19.32 | 1.106e-05 | 0.7538 |
| chr5:117378598 | rs72771497 | - | T>C | 67 | 110 | 18.91 | 1.373e-05 | 1.955 |
| chr7:51806112 | rs17152331 | - | T>G | 187 | 409 | 18.72 | 1.514e-05 | 1.485 |
| chr5:17437742 | rs6893246 | - | C>T | 662 | 2443 | 18.62 | 1.599e-05 | 0.796 |
| chr8:10715493 | rs116985826 | - | C>A | 43 | 59 | 18.58 | 1.632e-05 | 2.331 |
| chr15:47449728 | rs117002055 | - | C>T | 40 | 53 | 18.51 | 1.686e-05 | 2.41 |
| chr23:12632568 | rs62590580 | FRMPD4 | A>G | 694 | 1916 | 18.51 | 1.693e-05 | 1.286 |
| chr23:87713824 | rs6617649 | - | T>C | 536 | 1437 | 18.5 | 1.699e-05 | 1.3 |
| chr17:13836209 | rs11078212 | - | G>A | 699 | 2554 | 18.4 | 1.786e-05 | 0.7995 |
| chr8:8938897 | rs77067339 | ERI1 | C>T | 60 | 96 | 18.13 | 2.058e-05 | 2.004 |
| chr3:64546459 | rs7615657 | ADAMTS9 | C>T | 1197 | 3419 | 17.81 | 2.445e-05 | 1.231 |
| chr15:75772586 | rs117968432 | PTPN9 | C>G | 80 | 143 | 17.6 | 2.728e-05 | 1.799 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: H71 | Cholesteatoma of middle ear | 1/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: G039 | Meningitis, unspecified | 0/20 |
| ICD-10: G960 | Cerebrospinal fluid leak | 0/20 |