Atrophy/Degeneration affecting the central nervous system

0007367

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Case	Control
10027	450167

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr19:45422946	rs4420638	-	A>G	4512	177999	94.32	2.681e-22	1.179
chr19:45410002	rs769449	APOE	G>A	3004	114916	88.3	5.616e-21	1.206
chr19:45395619	rs2075650	TOMM40	A>G	3439	136972	58.34	2.203e-14	1.155
chr19:45395714	rs157581	TOMM40	T>C	5096	210451	47.2	6.4e-12	1.118
chr19:45414451	rs439401	-	C>T	7360	347408	24.67	6.787e-07	0.9301
chr8:139302266	rs78340141	FAM135B	G>A	641	23876	22.95	1.666e-06	1.215
chr13:46447104	rs759960	-	A>G	1585	79998	22.85	1.755e-06	0.8816
chr5:101155096	rs72770602	-	C>T	6915	325883	22.53	2.072e-06	0.9321
chr21:37579120	rs77335750	DOP1B	C>T	636	23749	22.07	2.622e-06	1.211
chr18:13399272	rs79328727	LDLRAD4	A>G	233	14229	21.87	2.91e-06	0.7339
chr1:112129736	rs17028048	RAP1A	T>C	2118	86478	21.5	3.53e-06	1.113
chr6:145518570	rs62437750	-	G>A	1701	68693	20.65	5.525e-06	1.123
chr5:133887641	rs41298956	JADE2	A>G	496	27324	20.59	5.695e-06	0.8125
chr7:28210660	rs520161	JAZF1	C>T	6587	282573	20.56	5.789e-06	1.07
chr7:28185091	rs849141	JAZF1	G>A	6277	268909	20.36	6.429e-06	1.071
chr23:39833745	rs5917908	-	T>G	3027	153322	20.32	6.567e-06	0.912
chr6:33552202	rs549888	-	A>G	8310	388232	19.78	8.698e-06	0.9387
chr21:45180380	Affx-18113854	PDXK	A>G	5188	220937	19.64	9.368e-06	1.074
chr20:12226412	rs78479182	-	G>A	415	23219	19.57	9.694e-06	0.8018
chr21:19050937	rs112926469	-	C>A	640	24202	19.51	9.999e-06	1.196
chr19:45422946	rs4420638	-	A>G	4285	169311	84.65	3.568e-20	1.174
chr19:45410002	rs769449	APOE	G>A	2911	111769	79.79	4.165e-19	1.199
chr19:45395619	rs2075650	TOMM40	A>G	3274	130493	53.01	3.317e-13	1.151
chr19:45395714	rs157581	TOMM40	T>C	4714	193713	46.21	1.064e-11	1.121
chr9:125548202	rs11793583	-	C>T	2105	85012	25.72	3.941e-07	1.126
chr21:37579120	rs77335750	DOP1B	C>T	630	23488	21.73	3.135e-06	1.21
chr19:45414451	rs439401	-	C>T	6945	326374	21.04	4.5e-06	0.9335
chr8:139302266	rs78340141	FAM135B	G>A	628	23540	20.49	5.994e-06	1.204
chr14:67128346	rs7150227	GPHN	A>G	218	7229	19.74	8.857e-06	1.358
chr8:75155388	rs12216776	JPH1	T>G	256	8743	18.88	1.393e-05	1.318
chr5:101155096	rs72770602	-	C>T	6589	308817	18.69	1.541e-05	0.9364
chr3:184303349	rs61545883	-	T>C	3507	147240	18.66	1.558e-05	1.085
chr23:39833745	rs5917908	-	T>G	2905	146833	18.53	1.676e-05	0.914
chr6:145518570	rs62437750	-	G>A	1669	67574	18.51	1.69e-05	1.118
chr9:26153585	rs16910205	-	T>C	1437	71984	18.5	1.696e-05	0.8879
chr4:74358308	rs77466464	AFM	G>C	371	20805	18.45	1.743e-05	0.7972
chr21:19050937	rs112926469	-	C>A	613	23162	18.42	1.776e-05	1.195
chr2:176745775	rs34155645	-	T>C	1787	88349	18.16	2.035e-05	0.8988
chr7:16566645	rs2301968	SOSTDC1	C>G	2256	92886	18.15	2.037e-05	1.101
chr13:27471503	rs61946191	-	T>C	1221	48669	18.03	2.17e-05	1.135

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr19:45422946	rs4420638	-	A>G	4285	44336	80.92	2.351e-19	1.176
chr19:45410002	rs769449	APOE	G>A	2911	29347	72.83	1.414e-17	1.196
chr19:45395619	rs2075650	TOMM40	A>G	3274	34213	49.54	1.942e-12	1.151
chr19:45395714	rs157581	TOMM40	T>C	4714	50544	48.0	4.263e-12	1.128
chr9:125548202	rs11793583	-	C>T	2105	22186	26.1	3.234e-07	1.131
chr21:37579120	rs77335750	DOP1B	C>T	630	6093	22.58	2.013e-06	1.223
chr14:67128346	rs7150227	GPHN	A>G	218	1832	22.5	2.101e-06	1.405
chr14:67609692	rs28410937	GPHN	C>T	214	1817	20.72	5.314e-06	1.39
chr8:75155388	rs12216776	JPH1	T>G	256	2237	20.68	5.424e-06	1.351
chr13:27471503	rs61946191	-	T>C	1221	12604	20.52	5.914e-06	1.15
chr19:45414451	rs439401	-	C>T	6945	85594	20.3	6.627e-06	0.9327
chr14:67724778	rs10151131	MPP5	T>C	261	2304	19.73	8.928e-06	1.338
chr1:63261652	rs12122434	ATG4C	A>G	797	7982	19.7	9.071e-06	1.183
chr5:165043610	rs80167075	-	G>A	3723	40943	19.33	1.098e-05	1.087
chr3:184303349	rs61545883	-	T>C	3507	38474	19.21	1.17e-05	1.089
chr21:19050937	rs112926469	-	C>A	613	6017	18.98	1.323e-05	1.206
chr7:16566645	rs2301968	SOSTDC1	C>G	2256	24242	18.89	1.382e-05	1.107
chr5:101155096	rs72770602	-	C>T	6589	81037	18.53	1.673e-05	0.9349
chr1:247125355	rs11579381	ZNF670-ZNF695	C>T	6539	80480	18.07	2.127e-05	0.9353
chr11:115783437	rs61899166	-	T>C	540	7644	17.74	2.529e-05	0.827

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: F009	Dementia in Alzheimer's disease, unspecified	5/20
ICD: F067	Mild cognitive disorder	1/20
ICD: G309	Alzheimer's disease, unspecified	5/20
ICD: G318	Other specified degenerative diseases of nervous system	1/20
ICD: G319	Degenerative disease of nervous system, unspecified	1/20

ID	Name	Top Correlation
ICD-10: A498	Other bacterial infections of unspecified site	0/20
ICD-10: A499	Bacterial infection, unspecified	0/20
ICD-10: C676	Ureteric orifice	0/20
ICD-10: C711	Frontal lobe	0/20
ICD-10: C712	Temporal lobe	0/20
ICD-10: C713	Parietal lobe	0/20
ICD-10: E854	Organ-limited amyloidosis	0/20
ICD-10: F023	Dementia in Parkinson's disease	0/20
ICD-10: F801	Expressive language disorder	0/20
ICD-10: G122	Motor neuron disease	0/20
ICD-10: G373	Acute transverse myelitis in demyelinating disease of central nervous system	0/20
ICD-10: G379	Demyelinating disease of central nervous system, unspecified	0/20
ICD-10: G930	Cerebral cysts	0/20
ICD-10: G939	Disorder of brain, unspecified	0/20
ICD-10: H530	Amblyopia ex anopsia	0/20
ICD-10: H538	Other visual disturbances	0/20
ICD-10: H539	Visual disturbance, unspecified	0/20
ICD-10: H549	Unspecified visual impairment (binocular)	0/20
ICD-10: H903	Sensorineural hearing loss, bilateral	0/20
ICD-10: J180	Bronchopneumonia, unspecified	0/20
ICD-10: N429	Disorder of prostate, unspecified	0/20
ICD-10: O140	Moderate preeclampsia	0/20
ICD-10: R470	Dysphasia and aphasia	0/20
ICD-10: T435	Other and unspecified antipsychotics and neuroleptics	0/20

Atrophy/Degeneration affecting the central nervous system

0007367

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ