Statistics
| Case | Control |
|---|---|
| 2486 | 457708 |
Phenotype Definition
Increased susceptibility to staphylococcal infections, as manifested by recurrent episodes of staphylococcal infections. [ORCID:0000-0001-7941-2961]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:27804465 | rs112950344 | - | G>C | 333 | 47540 | 23.62 | 1.171e-06 | 1.317 |
| chr5:63108045 | rs165495 | - | G>A | 90 | 10064 | 23.54 | 1.222e-06 | 1.67 |
| chr12:99233282 | rs201401 | ANKS1B | T>C | 2321 | 399027 | 22.11 | 2.577e-06 | 1.14 |
| chr23:98580572 | rs141164384 | - | A>G | 124 | 16513 | 21.21 | 4.11e-06 | 1.521 |
| chr7:42906093 | rs77148183 | - | C>A | 106 | 12675 | 20.89 | 4.873e-06 | 1.563 |
| chr13:50263874 | rs77656974 | EBPL | C>A | 88 | 26249 | 20.88 | 4.892e-06 | 0.6143 |
| chr6:145354556 | rs62437682 | - | G>A | 796 | 127003 | 20.21 | 6.927e-06 | 1.189 |
| chr2:229484949 | rs79457218 | - | C>T | 115 | 32102 | 20.06 | 7.497e-06 | 0.657 |
| chr6:165740697 | rs73026299 | - | G>A | 155 | 20224 | 19.38 | 1.069e-05 | 1.431 |
| chr13:36231455 | rs78481779 | NBEA | T>C | 373 | 55512 | 19.06 | 1.268e-05 | 1.265 |
| chr14:24250588 | rs61977195 | - | C>T | 193 | 48531 | 19.02 | 1.293e-05 | 0.7267 |
| chr2:46194334 | rs7607360 | PRKCE | A>G | 1598 | 323651 | 18.9 | 1.377e-05 | 0.8774 |
| chr2:36511050 | rs10182603 | - | A>G | 107 | 13096 | 18.71 | 1.519e-05 | 1.524 |
| chr4:70587288 | rs72648417 | SULT1B1 | C>T | 84 | 9776 | 18.48 | 1.714e-05 | 1.601 |
| chr2:218775108 | rs10172987 | TNS1 | A>G | 630 | 99676 | 18.35 | 1.838e-05 | 1.2 |
| chr9:2705784 | rs117525403 | - | A>G | 131 | 16790 | 18.15 | 2.044e-05 | 1.457 |
| chr4:55956836 | rs7671745 | KDR | G>A | 1967 | 337037 | 17.97 | 2.242e-05 | 1.129 |
| chr18:77522573 | rs72978132 | - | T>C | 1119 | 184957 | 17.87 | 2.37e-05 | 1.154 |
| chr3:35314489 | rs192038327 | - | T>C | 123 | 15650 | 17.73 | 2.545e-05 | 1.467 |
| chr5:137419989 | rs2040862 | WNT8A | C>T | 1020 | 167774 | 17.28 | 3.223e-05 | 1.156 |
| chr5:63108045 | rs165495 | - | G>A | 90 | 9930 | 24.27 | 8.371e-07 | 1.683 |
| chr3:27804465 | rs112950344 | - | G>C | 329 | 47013 | 22.17 | 2.494e-06 | 1.308 |
| chr7:42906093 | rs77148183 | - | C>A | 103 | 12020 | 22.03 | 2.684e-06 | 1.592 |
| chr12:99233282 | rs201401 | ANKS1B | T>C | 2203 | 376277 | 21.37 | 3.783e-06 | 1.142 |
| chr23:98580572 | rs141164384 | - | A>G | 122 | 16231 | 20.54 | 5.846e-06 | 1.516 |
| chr15:48213547 | rs2934177 | - | T>C | 107 | 12770 | 20.44 | 6.162e-06 | 1.553 |
| chr18:658170 | rs28602966 | TYMS | G>T | 142 | 37714 | 20.01 | 7.709e-06 | 0.6843 |
| chr5:2491585 | Affx-26346040 | - | C>A | 348 | 50944 | 19.3 | 1.12e-05 | 1.277 |
| chr14:24250588 | rs61977195 | - | C>T | 190 | 47551 | 18.91 | 1.368e-05 | 0.7254 |
| chr21:43734984 | rs225361 | TFF3 | A>G | 2050 | 405747 | 18.7 | 1.532e-05 | 0.8807 |
| chr13:36231455 | rs78481779 | NBEA | T>C | 368 | 54705 | 18.06 | 2.142e-05 | 1.259 |
| chr6:145354556 | rs62437682 | - | G>A | 758 | 120826 | 18.03 | 2.176e-05 | 1.183 |
| chr19:44049881 | rs25476 | XRCC1 | G>T | 194 | 48027 | 17.97 | 2.248e-05 | 0.7336 |
| chr6:165740697 | rs73026299 | - | G>A | 151 | 19799 | 17.73 | 2.547e-05 | 1.416 |
| chr4:13860234 | rs10939518 | - | A>G | 1098 | 180546 | 17.63 | 2.684e-05 | 1.155 |
| chr5:113605294 | rs114967957 | KCNN2 | A>G | 382 | 57107 | 17.63 | 2.678e-05 | 1.251 |
| chr3:35314489 | rs192038327 | - | T>C | 122 | 15466 | 17.45 | 2.954e-05 | 1.465 |
| chr8:56451339 | rs17364795 | XKR4 | G>T | 393 | 88290 | 17.38 | 3.066e-05 | 0.8032 |
| chr5:113617360 | rs1457758 | KCNN2 | C>G | 381 | 57185 | 17.17 | 3.421e-05 | 1.248 |
| chr14:98128744 | rs2101101 | - | A>G | 154 | 20419 | 16.98 | 3.783e-05 | 1.401 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr11:36108497 | rs2030834 | LDLRAD3 | A>G | 1727 | 3159 | 24.85 | 6.191e-07 | 1.2 |
| chr6:66888913 | rs114080299 | - | A>G | 88 | 94 | 20.88 | 4.882e-06 | 1.955 |
| chr19:46949730 | rs9304659 | - | A>G | 134 | 431 | 20.87 | 4.904e-06 | 0.6342 |
| chr1:35065885 | rs56133319 | - | A>G | 492 | 1276 | 20.49 | 5.995e-06 | 0.776 |
| chr19:46955064 | rs2163838 | - | T>C | 134 | 429 | 20.48 | 6.036e-06 | 0.6368 |
| chr17:14114280 | rs7211577 | COX10 | A>G | 2405 | 5371 | 19.74 | 8.859e-06 | 0.8574 |
| chr18:658170 | rs28602966 | TYMS | G>T | 142 | 445 | 19.45 | 1.031e-05 | 0.6511 |
| chr2:82799016 | rs79840079 | - | T>C | 246 | 357 | 19.42 | 1.051e-05 | 1.45 |
| chr8:56451339 | rs17364795 | XKR4 | G>T | 393 | 1041 | 19.3 | 1.118e-05 | 0.7624 |
| chr5:85042123 | rs79070981 | - | G>A | 75 | 78 | 19.2 | 1.175e-05 | 2.012 |
| chr2:55355402 | rs56336934 | - | A>G | 531 | 874 | 19.17 | 1.194e-05 | 1.288 |
| chr5:80875563 | rs6880224 | SSBP2 | C>T | 416 | 1093 | 18.77 | 1.472e-05 | 0.7702 |
| chr9:71215222 | rs10869081 | - | G>A | 891 | 1561 | 18.76 | 1.479e-05 | 1.221 |
| chr10:60240354 | rs17644676 | - | A>G | 978 | 2343 | 18.75 | 1.487e-05 | 0.8312 |
| chr22:43099957 | rs28992193 | A4GALT | C>T | 178 | 243 | 18.72 | 1.514e-05 | 1.538 |
| chr13:100544005 | rs72656015 | CLYBL | A>G | 274 | 410 | 18.41 | 1.781e-05 | 1.408 |
| chr2:240155662 | rs3791623 | HDAC4 | C>A | 488 | 799 | 18.35 | 1.834e-05 | 1.294 |
| chr23:143445884 | rs56989033 | - | G>T | 574 | 1084 | 18.32 | 1.872e-05 | 1.271 |
| chr2:115294661 | rs6542214 | DPP10 | T>C | 2031 | 3834 | 18.26 | 1.932e-05 | 1.163 |
| chr3:138071686 | rs11914711 | MRAS | T>C | 325 | 500 | 18.11 | 2.085e-05 | 1.366 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: A490 | Staphylococcal infection, unspecified | 2/20 |
| ICD: L089 | Local infection of skin and subcutaneous tissue, unspecified | 3/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: J152 | Pneumonia due to staphylococcus | 0/20 |
| ICD-10: L088 | Other specified local infections of skin and subcutaneous tissue | 0/20 |