Statistics
| Case | Control |
|---|---|
| 34892 | 425302 |
Phenotype Definition
Chronic pain in the limbs with no clear focal etiology. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr23:64367019 | rs7064929 | - | G>A | 1739 | 15827 | 105.2 | 1.08e-24 | 1.3 |
| chr23:148151708 | Affx-34694529 | - | A>C | 951 | 7900 | 104.3 | 1.738e-24 | 1.421 |
| chr23:110685534 | rs16986503 | - | C>T | 1271 | 11212 | 95.7 | 1.334e-22 | 1.339 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 1837 | 17540 | 91.8 | 9.611e-22 | 1.268 |
| chr15:45556163 | rs8023604 | SLC28A2 | T>C | 1274 | 11637 | 89.4 | 3.221e-21 | 1.324 |
| chr15:45695612 | rs1346265 | SPATA5L1 | C>T | 1164 | 10506 | 88.76 | 4.452e-21 | 1.339 |
| chr23:110722596 | rs73549358 | - | C>T | 1414 | 12841 | 86.78 | 1.211e-20 | 1.301 |
| chr9:137925543 | rs7027926 | - | G>A | 1605 | 15215 | 85.04 | 2.925e-20 | 1.276 |
| chr23:109671384 | rs768312 | AMMECR1 | T>C | 1532 | 14107 | 84.11 | 4.687e-20 | 1.283 |
| chr9:117110112 | Affx-52344420 | AKNA | T>TG | 1407 | 13172 | 82.19 | 1.238e-19 | 1.292 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 5742 | 61316 | 81.63 | 1.643e-19 | 1.138 |
| chr23:19215613 | rs5955734 | - | C>G | 2765 | 27260 | 80.5 | 2.901e-19 | 1.201 |
| chr15:45694768 | rs1834686 | SPATA5L1 | G>T | 1023 | 9196 | 80.13 | 3.502e-19 | 1.344 |
| chr23:63410110 | rs61730681 | AMER1 | T>C | 2260 | 21873 | 80.1 | 3.568e-19 | 1.223 |
| chr23:63423664 | rs5964740 | AMER1 | C>T | 2258 | 21842 | 80.09 | 3.583e-19 | 1.223 |
| chr16:129223 | rs710079 | MPG | C>T | 2534 | 25508 | 76.53 | 2.17e-18 | 1.203 |
| chr23:111065460 | rs3027743 | TRPC5 | T>C | 3130 | 31339 | 76.38 | 2.338e-18 | 1.183 |
| chr23:23293064 | rs16997587 | - | A>C | 2261 | 21996 | 75.93 | 2.944e-18 | 1.216 |
| chr16:17200759 | rs8044934 | XYLT1 | G>A | 1815 | 17680 | 75.91 | 2.971e-18 | 1.242 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 1108 | 9918 | 75.65 | 3.38e-18 | 1.319 |
| chr6:34546560 | rs2814982 | - | C>T | 7606 | 86246 | 40.58 | 1.883e-10 | 1.084 |
| chr6:34552797 | rs2814944 | - | G>A | 10730 | 124279 | 30.3 | 3.692e-08 | 1.062 |
| chr7:137618312 | rs273979 | CREB3L2 | T>C | 28314 | 353877 | 27.34 | 1.709e-07 | 0.9589 |
| chr19:1952841 | rs2396366 | CSNK1G2 | C>T | 25785 | 322646 | 27.07 | 1.962e-07 | 0.9584 |
| chr6:34618893 | rs2814993 | ILRUN | G>A | 10202 | 118382 | 26.61 | 2.494e-07 | 1.059 |
| chr1:63538050 | rs77665570 | - | A>G | 1605 | 17163 | 26.42 | 2.741e-07 | 1.145 |
| chr10:21889083 | rs12356674 | MLLT10 | G>T | 20472 | 241779 | 26.37 | 2.82e-07 | 1.046 |
| chr19:1957079 | rs11084923 | CSNK1G2 | T>C | 30420 | 379336 | 26.11 | 3.228e-07 | 0.9602 |
| chr3:50070763 | rs7621352 | RBM6 | A>C | 31947 | 398102 | 25.89 | 3.617e-07 | 0.9606 |
| chr6:34683635 | rs6938239 | - | A>G | 10196 | 118411 | 25.65 | 4.092e-07 | 1.058 |
| chr6:34616322 | rs3800461 | ILRUN | G>C | 8343 | 96370 | 25.54 | 4.332e-07 | 1.063 |
| chr3:49902544 | rs9821675 | CAMKV | A>G | 35743 | 427107 | 25.24 | 5.049e-07 | 1.04 |
| chr19:1952280 | rs11084921 | CSNK1G2 | C>T | 26761 | 334367 | 24.78 | 6.442e-07 | 0.9604 |
| chr3:49941436 | rs2280406 | - | G>A | 35913 | 429463 | 24.6 | 7.063e-07 | 1.04 |
| chr6:34825662 | rs16894959 | UHRF1BP1 | T>C | 10213 | 118723 | 24.56 | 7.192e-07 | 1.057 |
| chr19:1967121 | rs11671909 | CSNK1G2 | T>C | 26737 | 333885 | 24.3 | 8.223e-07 | 0.9607 |
| chr6:113710675 | rs62421554 | - | G>A | 8361 | 96698 | 23.9 | 1.015e-06 | 1.061 |
| chr1:94032097 | rs23766 | BCAR3 | G>A | 16302 | 191882 | 23.89 | 1.022e-06 | 1.047 |
| chr3:49924940 | rs1062633 | MST1R | C>T | 32909 | 409350 | 23.86 | 1.034e-06 | 0.9621 |
| chr11:115104610 | rs10891814 | CADM1 | C>A | 24766 | 309688 | 23.68 | 1.136e-06 | 0.9607 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:34546560 | rs2814982 | - | C>T | 7606 | 39953 | 31.65 | 1.848e-08 | 1.077 |
| chr7:70216429 | rs6957385 | AUTS2 | A>G | 18201 | 105446 | 28.09 | 1.155e-07 | 0.9511 |
| chr7:137618312 | rs273979 | CREB3L2 | T>C | 28314 | 163177 | 27.0 | 2.034e-07 | 0.9574 |
| chr7:137629146 | rs273995 | CREB3L2 | C>T | 33468 | 183916 | 24.59 | 7.087e-07 | 1.042 |
| chr1:63538050 | rs77665570 | - | A>G | 1605 | 7926 | 23.38 | 1.331e-06 | 1.143 |
| chr6:113710675 | rs62421554 | - | G>A | 8361 | 44546 | 21.9 | 2.88e-06 | 1.061 |
| chr1:169519049 | rs6025 | F5 | C>T | 1773 | 8842 | 21.26 | 4.004e-06 | 1.129 |
| chr2:176984544 | rs72923454 | HOXD10 | C>T | 1901 | 9554 | 19.83 | 8.466e-06 | 1.12 |
| chr11:50677929 | rs116884310 | - | C>T | 4330 | 22637 | 19.61 | 9.501e-06 | 1.079 |
| chr20:31028723 | rs1737897 | - | G>A | 3199 | 19503 | 19.59 | 9.6e-06 | 0.9172 |
| chr1:198572649 | Affx-6487435 | - | G>A | 3904 | 23607 | 19.37 | 1.076e-05 | 0.9247 |
| chr4:124465068 | rs74488842 | - | C>T | 2734 | 16768 | 19.32 | 1.106e-05 | 0.9117 |
| chr7:137615234 | rs273975 | CREB3L2 | G>A | 25635 | 147293 | 19.25 | 1.148e-05 | 0.9633 |
| chr5:11816618 | rs116127119 | CTNND2 | G>A | 1116 | 7206 | 19.21 | 1.171e-05 | 0.8676 |
| chr4:152765086 | rs2666979 | - | G>A | 34249 | 195795 | 19.11 | 1.232e-05 | 0.9647 |
| chr13:92818945 | rs9583998 | GPC5 | G>T | 10567 | 61903 | 19.06 | 1.267e-05 | 0.9513 |
| chr4:124472770 | rs13137423 | - | C>G | 6126 | 36421 | 19.0 | 1.308e-05 | 0.9389 |
| chr2:99932255 | rs7589893 | AC079447.1 | T>C | 28567 | 157014 | 18.98 | 1.323e-05 | 1.037 |
| chr22:33576898 | rs68035672 | LARGE1 | A>C | 10326 | 60467 | 18.91 | 1.372e-05 | 0.951 |
| chr10:116152354 | rs537432 | AFAP1L2 | G>A | 31115 | 178148 | 18.84 | 1.421e-05 | 0.9647 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M543 | Sciatica | 2/20 |
| ICD: M545 | Low back pain | 11/20 |
| ICD: M549 | Dorsalgia, unspecified | 10/20 |
| ICD: M796 | Pain in limb | 7/20 |