Statistics
| Case | Control |
|---|---|
| 52130 | 408064 |
Phenotype Definition
Peripheral neuropathy is a general term for any disorder of the peripheral nervous system. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course. [HPO:sdoelken]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr10:21824727 | rs10828249 | MLLT10 | G>A | 38923 | 294989 | 45.91 | 1.241e-11 | 1.046 |
| chr10:21957229 | rs2183271 | MLLT10 | T>C | 40252 | 305713 | 44.9 | 2.076e-11 | 1.046 |
| chr10:21834536 | rs7098100 | MLLT10 | G>A | 38511 | 292091 | 42.24 | 8.077e-11 | 1.045 |
| chr10:21889083 | rs12356674 | MLLT10 | G>T | 31542 | 239294 | 31.23 | 2.287e-08 | 1.04 |
| chr2:60480973 | rs359250 | - | T>G | 38793 | 309799 | 27.08 | 1.956e-07 | 0.9658 |
| chr3:50070763 | rs7621352 | RBM6 | A>C | 51668 | 410392 | 26.96 | 2.073e-07 | 0.9673 |
| chr23:55287820 | rs5913807 | PAGE3 | G>T | 3230 | 22621 | 26.91 | 2.129e-07 | 1.105 |
| chr3:50174848 | rs7642934 | - | G>A | 52427 | 416391 | 26.86 | 2.184e-07 | 0.9674 |
| chr2:99989338 | rs7585721 | EIF5B | T>C | 48035 | 382159 | 26.78 | 2.276e-07 | 0.9672 |
| chr10:22037809 | rs6482190 | - | G>A | 28913 | 219678 | 26.26 | 2.991e-07 | 1.038 |
| chr2:60509080 | rs1553933 | - | T>C | 44618 | 355187 | 26.17 | 3.131e-07 | 0.9672 |
| chr1:159827011 | rs2494501 | AL590560.2 | C>T | 28381 | 215424 | 26.05 | 3.326e-07 | 1.038 |
| chr20:62309839 | rs6010620 | RTEL1 | G>A | 26444 | 212470 | 25.82 | 3.749e-07 | 0.9627 |
| chr3:49924940 | rs1062633 | MST1R | C>T | 53071 | 421100 | 25.48 | 4.459e-07 | 0.9682 |
| chr2:99992822 | Affx-20755096 | EIF5B | C>A | 48030 | 381766 | 25.39 | 4.694e-07 | 0.9681 |
| chr3:49941436 | rs2280406 | - | G>A | 55954 | 429884 | 24.99 | 5.757e-07 | 1.032 |
| chr3:49936102 | rs2230590 | MST1R | C>T | 53321 | 423071 | 24.98 | 5.784e-07 | 0.9685 |
| chr23:36258594 | rs7879188 | CFAP47 | G>A | 6272 | 45335 | 24.77 | 6.469e-07 | 1.072 |
| chr10:78199638 | rs11001781 | LRMDA | A>G | 1583 | 14076 | 24.54 | 7.297e-07 | 0.8762 |
| chr10:78189096 | rs16933537 | LRMDA | C>T | 1632 | 14480 | 24.46 | 7.588e-07 | 0.8781 |
| chr10:21824727 | rs10828249 | MLLT10 | G>A | 36712 | 279190 | 41.84 | 9.926e-11 | 1.046 |
| chr10:21957229 | rs2183271 | MLLT10 | T>C | 37742 | 287522 | 41.3 | 1.307e-10 | 1.045 |
| chr10:21834536 | rs7098100 | MLLT10 | G>A | 36129 | 275239 | 35.4 | 2.689e-09 | 1.042 |
| chr10:21889083 | rs12356674 | MLLT10 | G>T | 30483 | 231768 | 31.82 | 1.691e-08 | 1.042 |
| chr3:50070763 | rs7621352 | RBM6 | A>C | 47934 | 382115 | 27.29 | 1.749e-07 | 0.9661 |
| chr10:22037809 | rs6482190 | - | G>A | 27895 | 212417 | 26.59 | 2.51e-07 | 1.04 |
| chr2:60509080 | rs1553933 | - | T>C | 42178 | 336849 | 25.87 | 3.656e-07 | 0.9665 |
| chr3:49941436 | rs2280406 | - | G>A | 53480 | 411896 | 25.54 | 4.342e-07 | 1.034 |
| chr9:96392856 | rs17534161 | PHF2 | A>G | 10232 | 84199 | 25.27 | 4.989e-07 | 0.9461 |
| chr2:60480973 | rs359250 | - | T>G | 37106 | 297074 | 25.2 | 5.171e-07 | 0.9661 |
| chr3:49924940 | rs1062633 | MST1R | C>T | 49347 | 392912 | 25.1 | 5.438e-07 | 0.9674 |
| chr3:49936102 | rs2230590 | MST1R | C>T | 49573 | 394702 | 25.02 | 5.673e-07 | 0.9675 |
| chr9:96213291 | rs10992740 | FAM120AOS | A>G | 9834 | 80911 | 24.27 | 8.389e-07 | 0.9462 |
| chr3:50129399 | Affx-22412948 | RBM6 | C>T | 48950 | 389672 | 24.08 | 9.265e-07 | 0.9682 |
| chr9:73914256 | rs11142792 | TRPM3 | T>C | 18773 | 142049 | 23.97 | 9.793e-07 | 1.043 |
| chr16:1364281 | rs4984806 | UBE2I | C>T | 12761 | 104263 | 23.88 | 1.025e-06 | 0.9522 |
| chr3:50174848 | rs7642934 | - | G>A | 48695 | 387726 | 23.81 | 1.064e-06 | 0.9683 |
| chr14:49806075 | rs7158083 | - | C>T | 45602 | 363347 | 23.69 | 1.134e-06 | 0.9682 |
| chr2:22515568 | rs12373752 | - | A>G | 49752 | 383145 | 23.07 | 1.566e-06 | 1.032 |
| chr1:44289397 | rs37459 | AL451062.4 | A>G | 35952 | 287518 | 23.05 | 1.576e-06 | 0.9673 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:190874663 | rs73199614 | - | T>G | 11617 | 6140 | 21.65 | 3.279e-06 | 0.9249 |
| chr2:19269801 | rs114417078 | - | G>T | 3186 | 1355 | 21.53 | 3.485e-06 | 1.165 |
| chr7:104026492 | rs4730004 | LHFPL3 | A>G | 34039 | 17371 | 20.61 | 5.637e-06 | 0.9487 |
| chr2:100036592 | rs17763718 | REV1 | G>T | 5706 | 3103 | 20.53 | 5.883e-06 | 0.9011 |
| chr16:240338 | rs10153124 | LUC7L | T>C | 6840 | 3688 | 20.46 | 6.101e-06 | 0.9087 |
| chr16:317058 | rs113626738 | FAM234A | T>C | 7079 | 3806 | 20.12 | 7.255e-06 | 0.9107 |
| chr7:117477138 | rs981035 | CTTNBP2 | A>G | 27437 | 14066 | 19.59 | 9.596e-06 | 0.9477 |
| chr4:68577854 | rs6824220 | - | A>G | 40297 | 20462 | 19.43 | 1.046e-05 | 0.9525 |
| chr1:211900669 | rs55899252 | - | G>A | 1684 | 986 | 18.55 | 1.652e-05 | 0.8402 |
| chr15:68803448 | rs116906779 | - | G>A | 1808 | 1052 | 18.54 | 1.662e-05 | 0.845 |
| chr4:54722974 | rs7674066 | AC058822.1 | G>C | 11877 | 6237 | 18.31 | 1.876e-05 | 0.9312 |
| chr6:2803058 | rs111240521 | - | T>C | 1255 | 494 | 18.24 | 1.949e-05 | 1.255 |
| chr3:15563944 | rs116113290 | - | T>C | 2270 | 1295 | 17.87 | 2.37e-05 | 0.8617 |
| chr19:34358788 | rs11879262 | - | T>C | 34202 | 17420 | 17.77 | 2.495e-05 | 0.953 |
| chr4:68547809 | rs201908685 | UBA6 | A>ATAC | 40235 | 20409 | 17.76 | 2.51e-05 | 0.9545 |
| chr20:37358274 | rs76932288 | - | T>G | 46448 | 22336 | 17.73 | 2.545e-05 | 1.047 |
| chr6:32681631 | rs9275596 | - | T>C | 38947 | 19787 | 17.6 | 2.723e-05 | 0.9543 |
| chr13:50340340 | rs9562923 | KPNA3 | G>A | 10525 | 4844 | 17.54 | 2.81e-05 | 1.08 |
| chr19:31960060 | rs10421853 | - | A>C | 36970 | 18788 | 17.22 | 3.337e-05 | 0.9545 |
| chr1:193934464 | rs77051232 | - | G>A | 2057 | 1178 | 17.15 | 3.455e-05 | 0.8583 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|