Statistics
| Case | Control |
|---|---|
| 12609 | 447585 |
Phenotype Definition
Nodular changes affecting the eyelids may have many different causes such as cystic lesions (chalaziae, hordeolae), lipogranulomas, melanomas, infectious diseases (Molluscum contagiosum) and many more. [HPO:sdoelken]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 514 | 27012 | 76.51 | 2.191e-18 | 0.6765 |
| chr20:2315543 | rs6132532 | AL121899.2 | A>G | 1070 | 48464 | 60.41 | 7.685e-15 | 0.783 |
| chr15:48392165 | rs1834640 | - | A>G | 656 | 30968 | 50.37 | 1.271e-12 | 0.7538 |
| chr15:45491394 | rs1648299 | SHF | T>C | 322 | 16837 | 46.32 | 1.006e-11 | 0.6819 |
| chr6:170242949 | rs9396958 | - | T>C | 306 | 15808 | 40.99 | 1.533e-10 | 0.691 |
| chr15:47388375 | rs55766414 | - | G>A | 336 | 16836 | 37.75 | 8.027e-10 | 0.7124 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 327 | 16413 | 37.23 | 1.051e-09 | 0.7109 |
| chr2:66725070 | rs12995572 | MEIS1 | G>C | 576 | 26575 | 36.99 | 1.184e-09 | 0.7724 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1574 | 65484 | 36.23 | 1.757e-09 | 0.8537 |
| chr18:4157690 | rs6506185 | DLGAP1 | T>C | 236 | 12474 | 35.69 | 2.317e-09 | 0.6758 |
| chr7:148327483 | rs713591 | - | T>C | 296 | 14984 | 35.33 | 2.78e-09 | 0.7053 |
| chr12:67834064 | rs1152882 | - | A>G | 387 | 18704 | 34.72 | 3.816e-09 | 0.7381 |
| chr15:73142636 | rs4777559 | - | C>T | 291 | 14695 | 34.26 | 4.821e-09 | 0.707 |
| chr6:37145523 | rs10223418 | - | G>T | 212 | 11331 | 33.99 | 5.548e-09 | 0.6683 |
| chr10:108672251 | rs1572457 | SORCS1 | C>T | 216 | 11502 | 33.86 | 5.912e-09 | 0.6712 |
| chr1:235181233 | rs73110938 | - | G>A | 724 | 32181 | 33.82 | 6.059e-09 | 0.8016 |
| chr2:242813574 | rs4075286 | RTP5 | T>C | 634 | 28578 | 33.56 | 6.896e-09 | 0.7906 |
| chr4:38798648 | rs5743618 | TLR1 | C>A | 5902 | 229047 | 33.11 | 8.727e-09 | 0.9164 |
| chr16:26054595 | rs4787807 | HS3ST4 | T>C | 275 | 13943 | 33.08 | 8.863e-09 | 0.7045 |
| chr5:147671850 | rs7724380 | - | G>A | 417 | 19766 | 32.64 | 1.108e-08 | 0.7527 |
| chr5:127548955 | rs36694 | - | A>C | 6894 | 230114 | 33.38 | 7.57e-09 | 1.086 |
| chr5:127552590 | rs2546147 | - | A>G | 6901 | 231307 | 30.72 | 2.977e-08 | 1.083 |
| chr8:9742841 | rs7828229 | - | T>C | 6178 | 207485 | 24.23 | 8.533e-07 | 1.076 |
| chr6:29324599 | rs10484546 | OR5V1 | A>C | 3147 | 120835 | 24.01 | 9.577e-07 | 0.9095 |
| chr6:30116078 | rs3132676 | TRIM40 | G>A | 4228 | 139976 | 23.61 | 1.182e-06 | 1.087 |
| chr6:30067681 | rs7763159 | - | G>A | 3446 | 113121 | 23.3 | 1.386e-06 | 1.094 |
| chr18:73178913 | rs62089506 | - | A>G | 7581 | 282018 | 23.25 | 1.424e-06 | 0.935 |
| chr8:9790912 | rs506276 | - | T>C | 8743 | 297238 | 23.23 | 1.439e-06 | 1.067 |
| chr6:29961580 | rs9260973 | - | G>A | 3445 | 113173 | 23.06 | 1.571e-06 | 1.093 |
| chr5:127468177 | rs806100 | SLC12A2 | C>T | 11885 | 408327 | 22.53 | 2.064e-06 | 1.063 |
| chr6:30002793 | rs3121593 | - | C>G | 3511 | 115565 | 22.38 | 2.231e-06 | 1.091 |
| chr18:73192446 | rs1865721 | - | C>T | 7625 | 283232 | 22.16 | 2.504e-06 | 0.9366 |
| chr11:4609282 | rs117484966 | OR52I2 | A>G | 777 | 23422 | 22.15 | 2.522e-06 | 1.19 |
| chr6:29934454 | rs3893259 | - | G>A | 3476 | 114400 | 22.14 | 2.538e-06 | 1.091 |
| chr6:25918225 | rs80215559 | SLC17A2 | T>C | 2105 | 67590 | 22.05 | 2.659e-06 | 1.115 |
| chr9:7963435 | rs62533943 | - | A>G | 937 | 28578 | 21.64 | 3.288e-06 | 1.17 |
| chr6:30030114 | rs9261269 | ZNRD1 | G>A | 3508 | 115668 | 21.45 | 3.634e-06 | 1.089 |
| chr6:29323905 | rs6930033 | OR5V1 | A>C | 3359 | 128492 | 21.39 | 3.743e-06 | 0.9168 |
| chr6:29935469 | rs9260761 | - | C>T | 3449 | 113698 | 21.3 | 3.922e-06 | 1.09 |
| chr5:127347013 | rs34145453 | - | A>G | 9593 | 327615 | 21.08 | 4.404e-06 | 1.062 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr12:65417419 | rs73127665 | - | C>T | 1384 | 3044 | 25.14 | 5.336e-07 | 1.182 |
| chr2:230666898 | rs10432554 | TRIP12 | A>G | 8176 | 22190 | 24.94 | 5.912e-07 | 0.9241 |
| chr5:127548955 | rs36694 | - | A>C | 6894 | 16714 | 24.06 | 9.362e-07 | 1.086 |
| chr7:155281641 | rs28639825 | CNPY1 | G>A | 880 | 1873 | 22.58 | 2.021e-06 | 1.218 |
| chr25:155058865 | rs73234550 | - | G>A | 923 | 1979 | 22.14 | 2.539e-06 | 1.21 |
| chr3:88418911 | rs1870266 | CSNKA2IP | T>G | 2631 | 7490 | 21.91 | 2.858e-06 | 0.8938 |
| chr11:1080894 | rs41453346 | MUC2 | C>T | 616 | 1960 | 21.51 | 3.525e-06 | 0.8052 |
| chr5:7316956 | rs11750162 | - | A>G | 6629 | 18072 | 21.2 | 4.148e-06 | 0.9256 |
| chr11:5906291 | rs11823842 | TRIM5 | T>C | 10380 | 27831 | 20.89 | 4.864e-06 | 0.9333 |
| chr5:127552590 | rs2546147 | - | A>G | 6901 | 16829 | 20.54 | 5.83e-06 | 1.079 |
| chr1:31291539 | rs4949305 | - | G>A | 3568 | 9956 | 19.95 | 7.954e-06 | 0.9101 |
| chr17:49918895 | rs76899275 | CA10 | A>G | 1112 | 2446 | 19.92 | 8.082e-06 | 1.179 |
| chr12:42657412 | rs117325967 | PPHLN1 | A>C | 325 | 1104 | 19.73 | 8.934e-06 | 0.7548 |
| chr11:5890516 | rs9666248 | TRIM5 | G>T | 10525 | 28155 | 19.58 | 9.623e-06 | 0.9355 |
| chr10:123818827 | rs2459093 | TACC2 | C>A | 8875 | 21866 | 19.46 | 1.03e-05 | 1.071 |
| chr18:73178913 | rs62089506 | - | A>G | 7581 | 20507 | 18.98 | 1.319e-05 | 0.9321 |
| chr9:19941355 | rs17244095 | - | C>A | 4433 | 10639 | 18.97 | 1.327e-05 | 1.089 |
| chr11:5880300 | rs35156366 | TRIM5 | G>A | 10594 | 28322 | 18.88 | 1.389e-05 | 0.9368 |
| chr2:38009280 | rs13404698 | - | A>G | 2950 | 8273 | 18.37 | 1.821e-05 | 0.9067 |
| chr14:45194762 | rs229748 | - | A>G | 8331 | 22433 | 18.27 | 1.919e-05 | 0.935 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: L031 | Cellulitis of other parts of limb | 8/20 |